EA201001174A1 - ПРОИЗВОДНЫЕ β-АМИНОКИСЛОТ ДЛЯ ЛЕЧЕНИЯ ДИАБЕТА - Google Patents

ПРОИЗВОДНЫЕ β-АМИНОКИСЛОТ ДЛЯ ЛЕЧЕНИЯ ДИАБЕТА

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Publication number
EA201001174A1
EA201001174A1 EA201001174A EA201001174A EA201001174A1 EA 201001174 A1 EA201001174 A1 EA 201001174A1 EA 201001174 A EA201001174 A EA 201001174A EA 201001174 A EA201001174 A EA 201001174A EA 201001174 A1 EA201001174 A1 EA 201001174A1
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EA
Eurasian Patent Office
Prior art keywords
diabetes
derivatives
treatment
amino acids
type
Prior art date
Application number
EA201001174A
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English (en)
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EA017775B1 (ru
Inventor
Штефан Бендер
Ларс Торе Бургдорф
Ульрих Эмде
Норберт Байер
Иоганнес Глайтц
Кристин Шарон
Original Assignee
Мерк Патент Гмбх
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Application filed by Мерк Патент Гмбх filed Critical Мерк Патент Гмбх
Publication of EA201001174A1 publication Critical patent/EA201001174A1/ru
Publication of EA017775B1 publication Critical patent/EA017775B1/ru

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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

Новые гетероциклические соединения формулы 1в которой R, R, R, R, R, R, R, R, Rи Rимеют значения, указанные в п.1, являются активаторами глюкокиназы и могут использоваться для предотвращения и/или лечения диабета 1 и 2 типа, ожирения, невропатии и/или нефропатии.
EA201001174A 2008-01-24 2008-12-23 ПРОИЗВОДНЫЕ β-АМИНОКИСЛОТ ДЛЯ ЛЕЧЕНИЯ ДИАБЕТА EA017775B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08001305 2008-01-24
PCT/EP2008/011099 WO2009092432A1 (en) 2008-01-24 2008-12-23 Beta-amino acid derivatives for treatment of diabetes

Publications (2)

Publication Number Publication Date
EA201001174A1 true EA201001174A1 (ru) 2011-02-28
EA017775B1 EA017775B1 (ru) 2013-03-29

Family

ID=40386192

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201001174A EA017775B1 (ru) 2008-01-24 2008-12-23 ПРОИЗВОДНЫЕ β-АМИНОКИСЛОТ ДЛЯ ЛЕЧЕНИЯ ДИАБЕТА

Country Status (21)

Country Link
US (1) US8431602B2 (ru)
EP (1) EP2231640B1 (ru)
JP (1) JP5623914B2 (ru)
KR (1) KR20100110367A (ru)
CN (1) CN101925596B (ru)
AR (1) AR070232A1 (ru)
AU (1) AU2008348817B2 (ru)
BR (1) BRPI0821827A2 (ru)
CA (1) CA2712998A1 (ru)
CY (1) CY1112919T1 (ru)
DK (1) DK2231640T3 (ru)
EA (1) EA017775B1 (ru)
ES (1) ES2388475T3 (ru)
HR (1) HRP20120510T1 (ru)
IL (1) IL206904A0 (ru)
MX (1) MX2010007926A (ru)
PL (1) PL2231640T3 (ru)
PT (1) PT2231640E (ru)
SI (1) SI2231640T1 (ru)
WO (1) WO2009092432A1 (ru)
ZA (1) ZA201006002B (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
MX2018004643A (es) 2015-10-21 2018-08-01 Otsuka Pharma Co Ltd Compuestos de benzolactama como inhibidores de la proteina cinasa.
GB201706327D0 (en) 2017-04-20 2017-06-07 Otsuka Pharma Co Ltd A pharmaceutical compound

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5698579A (en) * 1993-07-02 1997-12-16 Celgene Corporation Cyclic amides
US6482951B2 (en) * 2000-12-13 2002-11-19 Hoffmann-La Roche Inc. Isoindolin-1-one glucokinase activators
JP2006510606A (ja) * 2002-10-15 2006-03-30 セルジーン・コーポレーション 骨髄異形成症候群を治療および管理するための選択的サイトカイン阻害剤の使用方法およびそれを含む組成物
KR20050090435A (ko) * 2002-12-30 2005-09-13 셀진 코포레이션 플루오로알콕시-치환된 1,3-디히드로-이소인돌릴 화합물 및그의 제약학적 용도
MX2007005040A (es) * 2004-10-28 2007-06-19 Celgene Corp Metodos y composiciones usando moduladores de pde4 para el tratamiento y manejo de lesion al sistema nervioso central.
US8008332B2 (en) * 2006-05-31 2011-08-30 Takeda San Diego, Inc. Substituted indazoles as glucokinase activators

Also Published As

Publication number Publication date
AR070232A1 (es) 2010-03-25
JP2011510029A (ja) 2011-03-31
US8431602B2 (en) 2013-04-30
US20100331346A1 (en) 2010-12-30
EA017775B1 (ru) 2013-03-29
CN101925596B (zh) 2014-05-28
AU2008348817A1 (en) 2009-07-30
HRP20120510T1 (hr) 2012-07-31
IL206904A0 (en) 2010-12-30
CA2712998A1 (en) 2009-07-30
ZA201006002B (en) 2011-04-28
AU2008348817B2 (en) 2011-12-15
ES2388475T3 (es) 2012-10-15
SI2231640T1 (sl) 2012-09-28
CN101925596A (zh) 2010-12-22
EP2231640B1 (en) 2012-06-06
EP2231640A1 (en) 2010-09-29
BRPI0821827A2 (pt) 2015-06-16
CY1112919T1 (el) 2016-04-13
KR20100110367A (ko) 2010-10-12
WO2009092432A1 (en) 2009-07-30
PT2231640E (pt) 2012-08-23
PL2231640T3 (pl) 2012-09-28
MX2010007926A (es) 2010-08-09
DK2231640T3 (da) 2012-07-16
JP5623914B2 (ja) 2014-11-12

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