AR070460A1 - Compuestos inhibidores de erk y composiciones farmaceuticas que los contienen - Google Patents

Compuestos inhibidores de erk y composiciones farmaceuticas que los contienen

Info

Publication number
AR070460A1
AR070460A1 ARP090100604A ARP090100604A AR070460A1 AR 070460 A1 AR070460 A1 AR 070460A1 AR P090100604 A ARP090100604 A AR P090100604A AR P090100604 A ARP090100604 A AR P090100604A AR 070460 A1 AR070460 A1 AR 070460A1
Authority
AR
Argentina
Prior art keywords
substituted
alkyl
group
independently selected
triazolyl
Prior art date
Application number
ARP090100604A
Other languages
English (en)
Spanish (es)
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40601237&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR070460(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of AR070460A1 publication Critical patent/AR070460A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ARP090100604A 2008-02-21 2009-02-20 Compuestos inhibidores de erk y composiciones farmaceuticas que los contienen AR070460A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3040708P 2008-02-21 2008-02-21

Publications (1)

Publication Number Publication Date
AR070460A1 true AR070460A1 (es) 2010-04-07

Family

ID=40601237

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090100604A AR070460A1 (es) 2008-02-21 2009-02-20 Compuestos inhibidores de erk y composiciones farmaceuticas que los contienen

Country Status (23)

Country Link
US (1) US8716483B2 (OSRAM)
EP (1) EP2260031B1 (OSRAM)
JP (1) JP5276676B2 (OSRAM)
KR (1) KR20100117123A (OSRAM)
CN (1) CN102015693B (OSRAM)
AR (1) AR070460A1 (OSRAM)
AU (1) AU2009215534B8 (OSRAM)
BR (1) BRPI0908120A8 (OSRAM)
CA (1) CA2714479A1 (OSRAM)
CL (1) CL2009000394A1 (OSRAM)
CO (1) CO6300939A2 (OSRAM)
EC (1) ECSP10010415A (OSRAM)
ES (1) ES2556353T3 (OSRAM)
IL (1) IL207530A (OSRAM)
MX (1) MX2010009268A (OSRAM)
MY (1) MY152271A (OSRAM)
NZ (1) NZ587504A (OSRAM)
PE (1) PE20091491A1 (OSRAM)
RU (1) RU2525389C2 (OSRAM)
SG (1) SG188179A1 (OSRAM)
TW (1) TWI398441B (OSRAM)
WO (1) WO2009105500A1 (OSRAM)
ZA (2) ZA201005909B (OSRAM)

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US8546404B2 (en) 2005-12-13 2013-10-01 Merck Sharp & Dohme Compounds that are ERK inhibitors
KR20080103996A (ko) 2006-02-16 2008-11-28 쉐링 코포레이션 Ｅｒｋ 억제제로서 피롤리딘 유도체
US8586543B2 (en) 2008-08-19 2013-11-19 Merck Sharp & Dohme Corp. IL-8 biomarker for monitoring cancer treatment with certain ERK inhibitors
US9229008B2 (en) 2008-08-19 2016-01-05 Merck Sharp & Dohme Corp. IL-8 level as a determinant of responsivity of a cancer to treatment
EP2448942B1 (en) 2009-07-02 2014-09-24 Merck Sharp & Dohme Corp. FUSED TRICYCLIC COMPOUNDS AS mTOR INHIBITORS
EP2483263B1 (en) 2009-09-30 2018-07-18 Merck Sharp & Dohme Corp. Heterocyclic compounds that are erk inhibitors
WO2011163330A1 (en) * 2010-06-24 2011-12-29 Merck Sharp & Dohme Corp. Novel heterocyclic compounds as erk inhibitors
EP2615916B1 (en) 2010-09-16 2017-01-04 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel erk inhibitors
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WO2014012360A1 (en) 2012-07-18 2014-01-23 Sunshine Lake Pharma Co., Ltd. Nitrogenous heterocyclic derivatives and their application in drugs
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EP2900223B1 (en) 2012-09-28 2017-10-25 Merck Sharp & Dohme Corp. Novel compounds that are erk inhibitors
RU2018109979A (ru) * 2013-03-13 2019-02-28 Ф. Хоффманн-Ля Рош Аг Способ получения бензоксазепиновых соединений
US8871966B2 (en) 2013-03-15 2014-10-28 Iowa State University Research Foundation, Inc. Regiospecific synthesis of terephthalates
PT3052096T (pt) 2013-10-03 2018-04-04 Kura Oncology Inc Inibidores de erk e métodos de utilização
US10428387B2 (en) 2014-05-16 2019-10-01 University Of Massachusetts Treating chronic myelogenous leukemia (CML)
WO2016025639A1 (en) * 2014-08-13 2016-02-18 Celgene Avilomics Research, Inc. Combinations of an erk inhibitor and a chemotherapeutic agent and related methods
WO2016095088A1 (en) * 2014-12-15 2016-06-23 Merck Sharp & Dohme Corp. Erk inhibitors
WO2016095089A1 (en) 2014-12-15 2016-06-23 Merck Sharp & Dohme Corp. Erk inhibitors
MX2017008077A (es) * 2014-12-18 2017-09-28 Merck Sharp & Dohme Composiciones de (s)-n-(3-(6-isopropoxipiridin-3-il)-1h-indazol-5- il)-1-(2-(4-(4-(1-metil-1h-1,2,4-triazol-3-il)fenil)-3,6-dihidrop iridin-1(2h)-il)-2-oxoetil)-3-(metiltio)pirrolidin-3-carboxamida para preparaciones farmaceuticas.
US10058544B2 (en) 2014-12-19 2018-08-28 Merck Sharp & Dohme Corp. (S)-N-(3-(6-isopropoxypyridin-3-yl)-1H-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2H)-yl)-2-oxoethyl)-3-(methylthio)pyrrolidine-3-carboxamide compositions for pharmaceutical preparations
SI3277690T1 (sl) * 2015-04-03 2020-07-31 Recurium Ip Holdings, Llc Spirociklične spojine
WO2017040362A1 (en) * 2015-09-03 2017-03-09 Merck Sharp & Dohme Corp. Process for preparing spray dried solid dispersions of (s)-n-(3-(6-isopropoxypyridin-3-yl)-1h-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2h)-yl)-2-oxoethyl)-3- (methylthio)pyrrolidine-3-carboxamide for pharmaceutical preparations
CN106432182B (zh) * 2016-09-06 2019-04-30 铜仁学院 特地唑胺中间体的合成方法
CN109020789B (zh) * 2017-06-12 2021-08-13 浙江医药股份有限公司新昌制药厂 一种制备2-甲氧基丙烯的方法
WO2021067266A1 (en) * 2019-10-01 2021-04-08 Recurium Ip Holdings, Llc Pyrrolidinyl-based compounds
CN114867529B (zh) 2019-10-09 2024-09-27 拜耳公司 作为农药的新的杂芳基三唑化合物
US12398153B2 (en) 2019-12-06 2025-08-26 D3 Bio (Wuxi) Co., Ltd. Spiro compound serving as ERK inhibitor, and application thereof

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Also Published As

Publication number Publication date
WO2009105500A1 (en) 2009-08-27
IL207530A0 (en) 2010-12-30
AU2009215534A8 (en) 2014-07-10
CN102015693B (zh) 2014-10-29
US8716483B2 (en) 2014-05-06
NZ587504A (en) 2012-09-28
TW200948799A (en) 2009-12-01
US20110189192A1 (en) 2011-08-04
PE20091491A1 (es) 2009-09-25
JP2011513225A (ja) 2011-04-28
ES2556353T8 (es) 2017-10-13
AU2009215534B2 (en) 2014-06-26
AU2009215534B8 (en) 2014-07-10
MY152271A (en) 2014-09-15
KR20100117123A (ko) 2010-11-02
ECSP10010415A (es) 2010-09-30
BRPI0908120A2 (OSRAM) 2017-08-22
JP5276676B2 (ja) 2013-08-28
AU2009215534A2 (en) 2010-12-23
ZA201400396B (en) 2014-12-23
MX2010009268A (es) 2010-09-14
IL207530A (en) 2014-08-31
CL2009000394A1 (es) 2011-02-11
BRPI0908120A8 (pt) 2017-10-24
CO6300939A2 (es) 2011-07-21
EP2260031A1 (en) 2010-12-15
SG188179A1 (en) 2013-03-28
EP2260031B1 (en) 2015-10-07
RU2010138635A (ru) 2012-03-27
ES2556353T3 (es) 2016-01-15
CA2714479A1 (en) 2009-08-27
CN102015693A (zh) 2011-04-13
ZA201005909B (en) 2014-03-26
TWI398441B (zh) 2013-06-11
RU2525389C2 (ru) 2014-08-10
AU2009215534A1 (en) 2009-08-27

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