AR070436A1 - Estabilizacion de deshidrogenasas con coenzimas estables - Google Patents
Estabilizacion de deshidrogenasas con coenzimas establesInfo
- Publication number
- AR070436A1 AR070436A1 ARP090100571A ARP090100571A AR070436A1 AR 070436 A1 AR070436 A1 AR 070436A1 AR P090100571 A ARP090100571 A AR P090100571A AR P090100571 A ARP090100571 A AR P090100571A AR 070436 A1 AR070436 A1 AR 070436A1
- Authority
- AR
- Argentina
- Prior art keywords
- case independently
- stable
- enzyme
- stable coenzyme
- stabilization
- Prior art date
Links
- 230000006641 stabilisation Effects 0.000 title abstract 2
- 238000011105 stabilization Methods 0.000 title abstract 2
- 108020005199 Dehydrogenases Proteins 0.000 title 1
- 239000005515 coenzyme Substances 0.000 abstract 4
- 102000004190 Enzymes Human genes 0.000 abstract 3
- 108090000790 Enzymes Proteins 0.000 abstract 3
- XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- BAWFJGJZGIEFAR-NNYOXOHSSA-N NAD zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004122 cyclic group Chemical group 0.000 abstract 2
- 229950006238 nadide Drugs 0.000 abstract 2
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 abstract 2
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 abstract 2
- UUFQTNFCRMXOAE-UHFFFAOYSA-N 1-methylmethylene Chemical compound C[CH] UUFQTNFCRMXOAE-UHFFFAOYSA-N 0.000 abstract 1
- 229930024421 Adenine Natural products 0.000 abstract 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 abstract 1
- 101100167062 Caenorhabditis elegans chch-3 gene Proteins 0.000 abstract 1
- 101710088194 Dehydrogenase Proteins 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
- 229960000643 adenine Drugs 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
- C12N9/0016—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with NAD or NADP as acceptor (1.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01001—Alcohol dehydrogenase (1.1.1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01006—Glycerol dehydrogenase (1.1.1.6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01027—L-Lactate dehydrogenase (1.1.1.27)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01028—D-Lactate dehydrogenase (1.1.1.28)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01037—Malate dehydrogenase (1.1.1.37)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01047—Glucose 1-dehydrogenase (1.1.1.47)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y104/00—Oxidoreductases acting on the CH-NH2 group of donors (1.4)
- C12Y104/01—Oxidoreductases acting on the CH-NH2 group of donors (1.4) with NAD+ or NADP+ as acceptor (1.4.1)
- C12Y104/01005—L-Amino-acid dehydrogenase (1.4.1.5)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08003054A EP2093284A1 (de) | 2008-02-19 | 2008-02-19 | Stabilisierung von Dehydrogenasen mit stabilen Coenzymen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR070436A1 true AR070436A1 (es) | 2010-04-07 |
Family
ID=39768713
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090100571A AR070436A1 (es) | 2008-02-19 | 2009-02-19 | Estabilizacion de deshidrogenasas con coenzimas estables |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US9896666B2 (enExample) |
| EP (2) | EP2093284A1 (enExample) |
| JP (2) | JP5758128B2 (enExample) |
| KR (3) | KR20120134142A (enExample) |
| CN (3) | CN104450659A (enExample) |
| AR (1) | AR070436A1 (enExample) |
| AU (1) | AU2009216908B9 (enExample) |
| BR (1) | BRPI0907839A2 (enExample) |
| CA (1) | CA2721718C (enExample) |
| HK (1) | HK1208703A1 (enExample) |
| MX (1) | MX2010008920A (enExample) |
| RU (1) | RU2499834C2 (enExample) |
| TW (1) | TWI482860B (enExample) |
| WO (1) | WO2009103540A1 (enExample) |
| ZA (1) | ZA201006638B (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4786451B2 (ja) * | 2005-07-28 | 2011-10-05 | エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト | Ｎａｄ／ｎａｄｈの安定化 |
| EP2093284A1 (de) | 2008-02-19 | 2009-08-26 | F.Hoffmann-La Roche Ag | Stabilisierung von Dehydrogenasen mit stabilen Coenzymen |
| WO2010094632A1 (de) * | 2009-02-19 | 2010-08-26 | F. Hoffmann-La Roche Ag | Schnelle reaktionskinetik von enzymen mit niedriger aktivität in trockenen chemieschichten |
| CN102325496B (zh) | 2009-02-19 | 2015-10-07 | 霍夫曼-拉罗奇有限公司 | 分析辅助工具的节省空间的储存 |
| EP2398909B1 (de) | 2009-02-19 | 2015-07-22 | F. Hoffmann-La Roche AG | Schnelle reaktionskinetik von enzymen mit niedriger aktivität in trockenen chemieschichten |
| EP2226008A1 (de) | 2009-02-19 | 2010-09-08 | Roche Diagnostics GmbH | Verfahren zur Herstellung eines analytischen Magazins |
| EP2226007A1 (de) | 2009-02-19 | 2010-09-08 | Roche Diagnostics GmbH | Testelementmagazin mit abgedeckten Testfeldern |
| EP2292751A1 (de) * | 2009-08-20 | 2011-03-09 | Roche Diagnostics GmbH | Stabilisierung von Enzymen mit stabilen Coenzymen |
| JP5777633B2 (ja) * | 2009-12-16 | 2015-09-09 | エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト | 保護された分析物の制御された放出によるテストエレメントにおける酵素の分解の検出 |
| EP2636750A1 (en) * | 2012-03-06 | 2013-09-11 | Roche Diagniostics GmbH | Compatible solute ectoine as well as derivatives thereof for enzyme stabilization |
| CA2872215C (en) | 2012-06-22 | 2018-03-13 | F. Hoffmann-La Roche Ag | Method and device for detecting an analyte in a body fluid |
| US8920628B2 (en) | 2012-11-02 | 2014-12-30 | Roche Diagnostics Operations, Inc. | Systems and methods for multiple analyte analysis |
| US8921061B2 (en) | 2012-11-02 | 2014-12-30 | Roche Diagnostics Operations, Inc. | Reagent materials and associated test elements |
| WO2014096174A1 (en) | 2012-12-20 | 2014-06-26 | Roche Diagnostics Gmbh | Method for evaluating medical measurement curves |
| CN104854457B (zh) | 2012-12-20 | 2016-09-14 | 霍夫曼-拉罗奇有限公司 | 用于分析体液样本的方法 |
| EP2781919A1 (en) | 2013-03-19 | 2014-09-24 | Roche Diagniostics GmbH | Method / device for generating a corrected value of an analyte concentration in a sample of a body fluid |
| WO2014180939A1 (en) | 2013-05-08 | 2014-11-13 | Roche Diagnostics Gmbh | Stabilization of enzymes by nicotinic acid |
| JP2016528175A (ja) * | 2013-06-04 | 2016-09-15 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｆｒｅｔに有用な新規化合物およびそれに関連する方法 |
| WO2015063025A1 (en) | 2013-10-29 | 2015-05-07 | F. Hoffmann-La Roche Ag | Nano-enzyme containers for test elements |
| WO2015078899A1 (en) | 2013-11-27 | 2015-06-04 | Roche Diagnostics Gmbh | Composition comprising up-converting phosphors for detecting an analyte |
| EP2927319A1 (en) | 2014-03-31 | 2015-10-07 | Roche Diagnostics GmbH | High load enzyme immobilization by crosslinking |
| JP6522003B2 (ja) | 2014-04-14 | 2019-05-29 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | フェナジニウムメディエーター |
| EP3757096B1 (en) | 2014-08-22 | 2025-03-12 | Roche Diagnostics GmbH | Redoxindicators for a use in cell viability testing |
| CN107779459B (zh) * | 2016-08-31 | 2021-06-08 | 安琪酵母股份有限公司 | 葡萄糖脱氢酶dna分子、载体和菌株及应用 |
| CA3035874C (en) | 2016-10-05 | 2025-09-09 | F. Hoffmann-La Roche Ag | DETECTION REAGENTS AND ELECTRODE ARRANGEMENTS FOR MULTI-ANALYTICAL DIAGNOSTIC TEST ELEMENTS, AS WELL AS THEIR METHODS OF USE |
| EP3339431A1 (en) | 2016-12-22 | 2018-06-27 | Roche Diabetes Care GmbH | Glucose dehydrogenase variants with improved properties |
| HUE064713T2 (hu) | 2018-02-28 | 2024-04-28 | Hoffmann La Roche | Biokompatibilitási bevonat folyamatos analitméréshez |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1043568A1 (ru) * | 1981-06-11 | 1983-09-23 | Московский Ордена Ленина,Ордена Октябрьской Революции И Ордена Трудового Красного Знамени Государственный Университет Им.М.В.Ломоносова | Способ определени активности дегидрогеназ крови |
| DE19543493A1 (de) * | 1995-11-22 | 1997-05-28 | Boehringer Mannheim Gmbh | Stabilisierte Coenzym-Lösungen und deren Verwendung zur Bestimmung von Dehydrogenasen bzw. deren Substrate im alkalischen Milieu |
| US5801006A (en) | 1997-02-04 | 1998-09-01 | Specialty Assays, Inc. | Use of NADPH and NADH analogs in the measurement of enzyme activities and metabolites |
| US6380380B1 (en) | 1999-01-04 | 2002-04-30 | Specialty Assays, Inc. | Use of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucliotide phosphate (NADP) analogs to measure enzyme activities metabolites and substrates |
| WO2001094370A1 (en) | 2000-06-07 | 2001-12-13 | Wako Pure Chemical Industries, Ltd. | Coenzyme derivatives and enzymes appropriate therefor |
| WO2002036779A1 (fr) | 2000-10-31 | 2002-05-10 | Koji Sode | Nouvelle glucose deshydrogenase et procede de production de la deshydrogenase |
| JP2003310274A (ja) * | 2002-04-30 | 2003-11-05 | Amano Enzyme Inc | グルコース脱水素酵素およびそれをコードする遺伝子 |
| AU2003240260B2 (en) | 2002-05-16 | 2008-05-22 | F. Hoffmann-La Roche Ag | Method and reagent system having a non-regenerative enzyme-coenzyme complex |
| EP1660648B1 (en) | 2003-08-11 | 2013-10-09 | Codexis, Inc. | Improved glucose dehydrogenase polypeptides and related polynucleotides |
| PT2705792E (pt) | 2004-03-06 | 2015-07-07 | Hoffmann La Roche | Dispositivo de amostragem de fluido corporal |
| US7172890B2 (en) * | 2004-10-28 | 2007-02-06 | Roche Diagnostics Gmbh | Inactivated enzyme variants and associated process and reagent system |
| JP4786451B2 (ja) | 2005-07-28 | 2011-10-05 | エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト | Ｎａｄ／ｎａｄｈの安定化 |
| DE102005035461A1 (de) * | 2005-07-28 | 2007-02-15 | Roche Diagnostics Gmbh | Stabile NAD/NADH-Derivate |
| EP2093284A1 (de) * | 2008-02-19 | 2009-08-26 | F.Hoffmann-La Roche Ag | Stabilisierung von Dehydrogenasen mit stabilen Coenzymen |
| US20110313009A1 (en) | 2008-07-17 | 2011-12-22 | Horizon Pharma Usa, Inc. | Nsaid dose unit formulations with h2-receptor antagonists and methods of use |
| EP2398909B1 (de) | 2009-02-19 | 2015-07-22 | F. Hoffmann-La Roche AG | Schnelle reaktionskinetik von enzymen mit niedriger aktivität in trockenen chemieschichten |
-
2008
- 2008-02-19 EP EP08003054A patent/EP2093284A1/de not_active Ceased
-
2009
- 2009-02-18 TW TW098105120A patent/TWI482860B/zh not_active IP Right Cessation
- 2009-02-19 KR KR1020127027270A patent/KR20120134142A/ko not_active Ceased
- 2009-02-19 AR ARP090100571A patent/AR070436A1/es not_active Application Discontinuation
- 2009-02-19 CN CN201410680334.8A patent/CN104450659A/zh active Pending
- 2009-02-19 BR BRPI0907839-8A patent/BRPI0907839A2/pt not_active Application Discontinuation
- 2009-02-19 EP EP09712033.1A patent/EP2245152B1/de active Active
- 2009-02-19 WO PCT/EP2009/001206 patent/WO2009103540A1/de not_active Ceased
- 2009-02-19 JP JP2010547110A patent/JP5758128B2/ja not_active Expired - Fee Related
- 2009-02-19 RU RU2010138610/10A patent/RU2499834C2/ru not_active IP Right Cessation
- 2009-02-19 CA CA2721718A patent/CA2721718C/en not_active Expired - Fee Related
- 2009-02-19 AU AU2009216908A patent/AU2009216908B9/en not_active Revoked
- 2009-02-19 KR KR1020107020894A patent/KR101381004B1/ko not_active Expired - Fee Related
- 2009-02-19 KR KR1020137013118A patent/KR20130081300A/ko not_active Withdrawn
- 2009-02-19 CN CN200980105640.6A patent/CN101945999B/zh not_active Expired - Fee Related
- 2009-02-19 MX MX2010008920A patent/MX2010008920A/es active IP Right Grant
-
2010
- 2010-02-12 CN CN2010800085457A patent/CN102325896A/zh active Pending
- 2010-02-12 JP JP2011550531A patent/JP6113405B2/ja not_active Expired - Fee Related
- 2010-08-19 US US12/859,654 patent/US9896666B2/en active Active
- 2010-09-16 ZA ZA2010/06638A patent/ZA201006638B/en unknown
-
2015
- 2015-09-23 HK HK15109305.4A patent/HK1208703A1/xx unknown
-
2018
- 2018-01-11 US US15/868,055 patent/US11220674B2/en active Active
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