AR069374A2 - Sales de valsartan, proceso para su fabricacion, composiciones farmaceuticas y uso de dichas sales para la preparacion de medicamentos para el tratamiento de enfermedades mediadas por el bloqueo del receptor at1. - Google Patents
Sales de valsartan, proceso para su fabricacion, composiciones farmaceuticas y uso de dichas sales para la preparacion de medicamentos para el tratamiento de enfermedades mediadas por el bloqueo del receptor at1.Info
- Publication number
- AR069374A2 AR069374A2 ARP080105034A ARP080105034A AR069374A2 AR 069374 A2 AR069374 A2 AR 069374A2 AR P080105034 A ARP080105034 A AR P080105034A AR P080105034 A ARP080105034 A AR P080105034A AR 069374 A2 AR069374 A2 AR 069374A2
- Authority
- AR
- Argentina
- Prior art keywords
- salt
- bis
- valsartan
- water
- solvent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Una sal de valsartan, que se selecciona del grupo que consiste en la sal monosodica, la sal monopotásica, la sal disodica, la sal dipotásica, la sal magnésica, la sal cálcica, la sal de bis-dietilamonio, la sal de bis-dipropilamonio, la sal de bis-dibutilamonio, la sal de mono-L-arginina, la sal de bis-L-arginina, la sal de mono-L-lisina, y la sal de bis-L-lisina, así como mezclas de sal de las mismas; proceso para su fabricacion, composiciones farmacéuticas y uso de dichas sales para la preparacion de medicamentos. Reivindicacion 5: La sal de valsartan, caracterizada porque es el tetrahidrato de acuerdo con la reivindicacion 4, identificado por (i) un patron de polvos de rayos X tomado con una cámara Guinier que comprende los siguientes intervalos del plano inter-red: ? in [L]: 16,1+- 0,3, 9,9+- 0,2, 9,4+- 0,2, 7,03+- 0,1, 6,50+- 0,1, 5 5,87+- 0,05, 5,74+- 0,05, 4,95+- 0,05, 4,73+- 0,05, 4,33+- 0,05, 4,15+- 0,05, 4,12+- 0,05, 3,95+- 0,05; o (ii) un espectro de ATR-IR que tiene las siguientes bandas de absorcion expresadas en numeros de onda recíprocos (cm-1); 1621 (f); 1578 (m), 1458 (m); 1441 (m); 1417 (m); 1364 (m), 1012 (m); 758 (m); 738 (m); 696 (m); 666 (m). Reivindicacion 7: La sal de valsartan, caracterizada porque es el hexahidrato de acuerdo con la reivindicacion 6, identificado por: (i) un patron de polvos de rayos X tomados con una cámara Guinier que comprende los siguientes intervalos del plano inter-red: ? in [L]:19,7+- 0,3, 10,11+- 0,2, 9,8+- 0,2, 7,28+- 0,1, 5,81+- 0,05, 5,68+- 0,05, 5,03+- 0,05, 4,88+- 0,05, 4,18+- 0,05, 4,08+- 0,05, 3,46 +- 0,05; o (iii) un espectro de ATR-IR que tiene las siguientes ondas de absorcion expresadas en numeros de ondas recíprocos (cm-1): 3378 (m); 3274 (m); 2956 (m); 1619 (st); 1557 (m); 1464 (m); 1419 (m); 1394 (f); 1374 (m); 1175 (m); 836 (m), 820 (d); 766 (f); 751 (m); 741 (f); 732 (f). Reivindicacion 14: Un proceso para la fabricacion de una sal de acuerdo con la reivindicacion 1, caracterizado porque: (i) se agregan valsartan y la base apropiada a un solvente orgánico que contenga agua, (ii) se concentra el solvente, por ejemplo mediante calentamiento, si es necesario bajo presion reducida, o mediante evaporacion lenta, por ejemplo a temperatura ambiente, (iii) se equilibra el residuo de evaporacion con la cantidad requerida de agua: (a) suspendiendo el residuo de la evaporacion, que convenientemente todavía está tibio, y que todavía contiene algo de agua, en un solvente apropiado, o (b) equilibrando el exceso de agua en el solvente; lo mediante lo cual en a) y b) está presente el agua existente o agregada en una cantidad donde el agua se disuelva en el solvente orgánico y forme una fase adicional; y (iv) se aísla la sal obtenida.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00115556 | 2000-07-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR069374A2 true AR069374A2 (es) | 2010-01-20 |
Family
ID=8169294
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP010103417A AR032758A1 (es) | 2000-07-19 | 2001-07-17 | Sales valsartan, un proceso para su fabricacion, composiciones farmaceuticas y el uso de dichas sales para la preparacion de medicamentos |
ARP080105034A AR069374A2 (es) | 2000-07-19 | 2008-11-19 | Sales de valsartan, proceso para su fabricacion, composiciones farmaceuticas y uso de dichas sales para la preparacion de medicamentos para el tratamiento de enfermedades mediadas por el bloqueo del receptor at1. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP010103417A AR032758A1 (es) | 2000-07-19 | 2001-07-17 | Sales valsartan, un proceso para su fabricacion, composiciones farmaceuticas y el uso de dichas sales para la preparacion de medicamentos |
Country Status (31)
Country | Link |
---|---|
US (5) | US20030207930A1 (es) |
EP (1) | EP1313714B1 (es) |
JP (1) | JP4102664B2 (es) |
KR (1) | KR100529658B1 (es) |
CN (2) | CN1216873C (es) |
AR (2) | AR032758A1 (es) |
AT (1) | ATE406355T1 (es) |
AU (2) | AU2001289672B2 (es) |
BR (1) | BR0112665A (es) |
CA (1) | CA2415962C (es) |
CY (1) | CY1108559T1 (es) |
CZ (1) | CZ303389B6 (es) |
DE (1) | DE60135560D1 (es) |
DK (1) | DK1313714T3 (es) |
EC (1) | ECSP034436A (es) |
ES (1) | ES2309090T3 (es) |
HK (1) | HK1055963A1 (es) |
HU (1) | HU229280B1 (es) |
IL (2) | IL153882A0 (es) |
MX (1) | MXPA03000525A (es) |
MY (2) | MY152846A (es) |
NO (1) | NO326504B1 (es) |
NZ (1) | NZ523557A (es) |
PE (1) | PE20020613A1 (es) |
PL (1) | PL205715B1 (es) |
PT (1) | PT1313714E (es) |
RU (1) | RU2275363C2 (es) |
SI (1) | SI1313714T1 (es) |
SK (1) | SK287558B6 (es) |
WO (1) | WO2002006253A1 (es) |
ZA (1) | ZA200300285B (es) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2415962C (en) | 2000-07-19 | 2010-07-06 | Novartis Ag | Valsartan salts |
RU2334513C3 (ru) * | 2002-01-17 | 2017-10-24 | Новартис Аг | Фармацевтические композиции, включающие валсартан и ингибиторы нейтральной эндопептидазы (nep) |
US7468390B2 (en) | 2002-01-17 | 2008-12-23 | Novartis Ag | Methods of treatment and pharmaceutical composition |
US6869970B2 (en) * | 2002-02-04 | 2005-03-22 | Novartis Ag | Crystalline salt forms of valsartan |
AU2003223637A1 (en) * | 2002-04-15 | 2003-11-03 | Dr. Reddy's Laboratories Limited | Novel crystalline forms of (s)-n-(1-carboxy-2-methyl-prop-1-yl) -n-pentanoyl-n- (2'-(1h-tetrazol-5-yl-)- biphenyl-4-yl methyl) amine (valsartan) |
PL373202A1 (en) * | 2002-05-17 | 2005-08-22 | Novartis Ag | Combination of angiotensin ii receptor blocker and beta-blocker for secondary prevention of myocardial infarction |
EG24716A (en) * | 2002-05-17 | 2010-06-07 | Novartis Ag | Combination of organic compounds |
CA2486557A1 (en) * | 2002-06-13 | 2003-12-24 | Novartis Ag | Calcium salts of indole derived statins |
GB0222056D0 (en) * | 2002-09-23 | 2002-10-30 | Novartis Ag | Process for the manufacture of organic compounds |
CA2519490A1 (en) * | 2003-03-17 | 2004-09-30 | Teva Pharmaceutical Industries Ltd | Polymorphis of valsartan |
EP1950204A1 (en) | 2003-03-17 | 2008-07-30 | Teva Pharmaceutical Industries Ltd. | Amorphous form of valsartan |
US7199144B2 (en) | 2003-04-21 | 2007-04-03 | Teva Pharmaceuticals Industries, Ltd. | Process for the preparation of valsartan and intermediates thereof |
US20050165075A1 (en) * | 2003-03-31 | 2005-07-28 | Hetero Drugs Limited | Novel amorphous form of valsartan |
WO2004094392A1 (en) | 2003-04-21 | 2004-11-04 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of valsartan |
WO2005049587A1 (en) * | 2003-11-21 | 2005-06-02 | Ranbaxy Laboratories Limited | Process for preparation of biphenyl tetrazole |
WO2006002983A1 (en) * | 2004-07-06 | 2006-01-12 | Novartis Ag | Combination of organic compounds |
EP2033629B1 (en) * | 2004-12-24 | 2012-11-14 | Krka | Solid pharmaceutical composition comprising valsartan |
EP1674080A1 (en) * | 2004-12-24 | 2006-06-28 | KRKA, D.D., Novo Mesto | Solid pharmaceutical composition comprising valsartan |
GB0503062D0 (en) * | 2005-02-14 | 2005-03-23 | Novartis Ag | Combination of organic compounds |
EP1896433A4 (en) * | 2005-05-25 | 2010-06-02 | Ipca Lab Ltd | NOVEL CRYSTALLINE FORMS OF (S) -N- (1-CARBOXY-2-METHYL-PROP-1-YL) -N-PENTANOYL-N- [2 '- (1H-TETRAZOL-5-YL) BI-PHENYL-4 ylmethyl] amine |
FR2886642B1 (fr) * | 2005-06-06 | 2008-05-30 | Sanofi Aventis Sa | Sels alcalino-terreux d'irbesartan et leur preparation |
WO2007045663A2 (en) * | 2005-10-19 | 2007-04-26 | Novartis Ag | Combination of an ati receptor antagonist and a np inhibitor fro treating ia hypertension and heartfailure |
AR057882A1 (es) | 2005-11-09 | 2007-12-26 | Novartis Ag | Compuestos de accion doble de bloqueadores del receptor de angiotensina e inhibidores de endopeptidasa neutra |
RU2459809C2 (ru) * | 2005-11-09 | 2012-08-27 | Новартис Аг | Фармацевтические комбинации антагониста рецептора ангиотензина и ингибитора nep |
WO2007071750A1 (en) * | 2005-12-22 | 2007-06-28 | Enantia, S.L. | Intermediates and processes for the preparation of valsartan |
WO2008035364A2 (en) * | 2006-06-23 | 2008-03-27 | Usv Limited | Process for the preparation of micronized valsartan |
WO2008018843A1 (en) * | 2006-08-08 | 2008-02-14 | Ulkar Kimya Sanayi Ve Ticaret As | Process for producing useful salts form of biphenyl-tetrazole compounds |
WO2008076780A2 (en) * | 2006-12-14 | 2008-06-26 | Isp Investments Inc. | Amorphous valsartan and the production thereof |
JP2010526126A (ja) * | 2007-05-07 | 2010-07-29 | シプラ・リミテッド | バルサルタンの製造方法 |
ES2312162T3 (es) * | 2007-06-07 | 2009-02-16 | Inke, S.A. | Procedimiento para la obtencion de una sal de valsartan util para la preparacion de valsartan. |
EP2209786B1 (en) * | 2007-10-05 | 2013-02-27 | Verastem, Inc. | Pyrimidine substituted purine derivatives |
FI3067043T3 (fi) | 2007-11-06 | 2023-03-18 | Novartis Ag | Angiotensiinireseptoriantagonistin/-salpaajan (arb) ja neutraalin endopeptidaasin (nep) estäjän superrakenteisiin perustuvia farmaseuttisia koostumuksia |
WO2009064681A2 (en) | 2007-11-12 | 2009-05-22 | Novartis Ag | Liquid compositions comprising valsartan |
SG187007A1 (en) | 2010-08-03 | 2013-02-28 | Novartis Ag | Highly crystalline valsartan |
WO2012056294A1 (en) | 2010-10-29 | 2012-05-03 | Jubilant Life Sciences Ltd. | An improved process for the preparation of n-pentanoyl-n-[[2'-(1h-tetrazol-5-yi)[1,1'-biphenyl]-4-yi]methyl]-l-valine |
JP5981940B2 (ja) * | 2011-01-20 | 2016-08-31 | ジエンス ハンセン ファーマセウティカル カンパニー リミテッド | アジルサルタン有機アミン塩、その製造方法及び使用 |
US9006462B2 (en) | 2013-02-28 | 2015-04-14 | Dermira, Inc. | Glycopyrrolate salts |
US8558008B2 (en) | 2013-02-28 | 2013-10-15 | Dermira, Inc. | Crystalline glycopyrrolate tosylate |
EP2961734B1 (en) | 2013-02-28 | 2018-09-26 | Dermira, Inc. | Glycopyrrolate salts |
WO2017012600A1 (en) | 2015-07-20 | 2017-01-26 | Zentiva, K.S. | A pharmaceutical composition containing valsartan and sacubitril and methods for preparation and stabilization thereof |
WO2017042700A1 (en) * | 2015-09-07 | 2017-03-16 | Sun Pharmaceutical Industries Limited | Solid forms of valsartan and sacubitril |
CN105541741A (zh) * | 2016-01-14 | 2016-05-04 | 青岛友诚高新技术有限公司 | 一种具有治疗冠心病活性的化合物及其制备方法 |
WO2018002673A1 (en) | 2016-07-01 | 2018-01-04 | N4 Pharma Uk Limited | Novel formulations of angiotensin ii receptor antagonists |
CN106243056A (zh) * | 2016-07-29 | 2016-12-21 | 陈欣怡 | 一种缬沙坦的新型固体形式 |
TWI648267B (zh) * | 2016-09-02 | 2019-01-21 | 諾瑞特國際藥業股份有限公司 | 纈沙坦二鈉鹽新晶型 |
US10745363B2 (en) | 2016-09-02 | 2020-08-18 | Nanjing Noratech Pharmaceuticals Co., Ltd | Crystal forms of valsartan disodium salt |
US10995060B2 (en) | 2016-10-28 | 2021-05-04 | Biocon Limited | Amorphous Trisodium Sacubitril Valsartan and process for its preparation |
WO2018178295A1 (en) | 2017-03-31 | 2018-10-04 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Stable hot-melt extrudate containing valsartan and sacubitril |
WO2019008485A1 (en) | 2017-07-06 | 2019-01-10 | Mankind Pharma Ltd | FIXED DOSE PHARMACEUTICAL COMPOSITION BASED ON VALSARTAN AND SACUBITRIL |
PL3658122T3 (pl) | 2017-07-28 | 2021-10-18 | Synthon B.V. | Kompozycja farmaceutyczna zawierająca sakubitryl i walsartan |
US20200276129A1 (en) | 2017-10-13 | 2020-09-03 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Tablet containing valsartan and sacubitril |
EP3498698A1 (en) | 2017-12-15 | 2019-06-19 | Mankind Pharma Ltd | Solid forms of valsartan disodium and process of preparation thereof |
CN108794418A (zh) * | 2018-09-18 | 2018-11-13 | 中国药科大学 | 一种缬沙坦烟酰胺共无定形物 |
EP3766484B1 (en) | 2019-07-19 | 2021-08-25 | Zentiva, K.S. | Solid pharmaceutical dosage form comprising valsartan and sacubitril |
WO2021111464A1 (en) * | 2019-12-02 | 2021-06-10 | Harman Finochem Limited | A process for the preparation of highly pure valsartan |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4499017A (en) * | 1983-06-06 | 1985-02-12 | Pfizer Inc. | Beta-lactamase inhibiting 6-(alkoxyamino-methyl) penicillanic acid 1,1-dioxide and derivatives |
PH30484A (en) * | 1990-02-19 | 1997-05-28 | Ciba Geigy | Acy compounds pharmaceutical composition containing said compound and method of use thereof |
JPH05105698A (ja) * | 1991-06-13 | 1993-04-27 | Takeda Chem Ind Ltd | ホスホン酸誘導体、その製造法および用途 |
CN1143908A (zh) | 1994-03-17 | 1997-02-26 | 西巴-盖尔基股份公司 | 利用哇尔沙通(valsartan)治疗糖尿病型肾病 |
MX9707683A (es) | 1995-04-07 | 1997-12-31 | Novartis Ag | Composiciones de combinacion que contienen benazepril o benazeprilat y valsartan. |
AU7213296A (en) | 1995-10-06 | 1997-04-30 | Ciba-Geigy Ag | At1-receptor antagonists for preventing and treating postischemic renal failure and for protecting ischemic kidneys |
GB9613470D0 (en) | 1996-06-27 | 1996-08-28 | Ciba Geigy Ag | Small solid oral dosage form |
GT199800126A (es) | 1997-08-29 | 2000-01-29 | Terapia de combinacion. | |
IT1301759B1 (it) * | 1998-06-19 | 2000-07-07 | Nicox Sa | Sali nitrati di farmaci antiipertensivi |
US6383471B1 (en) * | 1999-04-06 | 2002-05-07 | Lipocine, Inc. | Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents |
CA2415962C (en) | 2000-07-19 | 2010-07-06 | Novartis Ag | Valsartan salts |
-
2001
- 2001-07-17 CA CA2415962A patent/CA2415962C/en not_active Expired - Fee Related
- 2001-07-17 ES ES01969407T patent/ES2309090T3/es not_active Expired - Lifetime
- 2001-07-17 EP EP01969407A patent/EP1313714B1/en not_active Expired - Lifetime
- 2001-07-17 AU AU2001289672A patent/AU2001289672B2/en not_active Ceased
- 2001-07-17 MX MXPA03000525A patent/MXPA03000525A/es active IP Right Grant
- 2001-07-17 AR ARP010103417A patent/AR032758A1/es not_active Application Discontinuation
- 2001-07-17 DE DE60135560T patent/DE60135560D1/de not_active Expired - Lifetime
- 2001-07-17 PL PL360737A patent/PL205715B1/pl not_active IP Right Cessation
- 2001-07-17 SI SI200130881T patent/SI1313714T1/sl unknown
- 2001-07-17 MY MYPI20064483 patent/MY152846A/en unknown
- 2001-07-17 NZ NZ52355701A patent/NZ523557A/xx not_active IP Right Cessation
- 2001-07-17 SK SK55-2003A patent/SK287558B6/sk not_active IP Right Cessation
- 2001-07-17 DK DK01969407T patent/DK1313714T3/da active
- 2001-07-17 JP JP2002512157A patent/JP4102664B2/ja not_active Expired - Fee Related
- 2001-07-17 CZ CZ20030117A patent/CZ303389B6/cs not_active IP Right Cessation
- 2001-07-17 WO PCT/EP2001/008253 patent/WO2002006253A1/en active IP Right Grant
- 2001-07-17 MY MYPI20013368A patent/MY136446A/en unknown
- 2001-07-17 RU RU2003104789/04A patent/RU2275363C2/ru not_active IP Right Cessation
- 2001-07-17 AT AT01969407T patent/ATE406355T1/de active
- 2001-07-17 CN CN018130399A patent/CN1216873C/zh not_active Expired - Lifetime
- 2001-07-17 BR BR0112665-2A patent/BR0112665A/pt not_active IP Right Cessation
- 2001-07-17 PT PT01969407T patent/PT1313714E/pt unknown
- 2001-07-17 AU AU8967201A patent/AU8967201A/xx active Pending
- 2001-07-17 CN CNB2005100077076A patent/CN100413852C/zh not_active Expired - Lifetime
- 2001-07-17 US US10/333,100 patent/US20030207930A1/en not_active Abandoned
- 2001-07-17 HU HU0300731A patent/HU229280B1/hu not_active IP Right Cessation
- 2001-07-17 KR KR10-2003-7000815A patent/KR100529658B1/ko not_active IP Right Cessation
- 2001-07-17 PE PE2001000723A patent/PE20020613A1/es not_active Application Discontinuation
- 2001-07-17 IL IL15388201A patent/IL153882A0/xx unknown
-
2003
- 2003-01-09 IL IL153882A patent/IL153882A/en active IP Right Grant
- 2003-01-10 ZA ZA200300285A patent/ZA200300285B/en unknown
- 2003-01-17 EC EC2003004436A patent/ECSP034436A/es unknown
- 2003-01-17 NO NO20030232A patent/NO326504B1/no not_active IP Right Cessation
- 2003-11-13 HK HK03108267.6A patent/HK1055963A1/xx not_active IP Right Cessation
-
2007
- 2007-02-23 US US11/678,284 patent/US20070149587A1/en not_active Abandoned
-
2008
- 2008-08-05 US US12/186,172 patent/US8278339B2/en active Active
- 2008-10-27 CY CY20081101215T patent/CY1108559T1/el unknown
- 2008-11-19 AR ARP080105034A patent/AR069374A2/es not_active Application Discontinuation
-
2012
- 2012-08-30 US US13/599,032 patent/US20120329844A1/en not_active Abandoned
-
2013
- 2013-11-15 US US14/081,441 patent/US9499499B2/en not_active Expired - Lifetime
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR069374A2 (es) | Sales de valsartan, proceso para su fabricacion, composiciones farmaceuticas y uso de dichas sales para la preparacion de medicamentos para el tratamiento de enfermedades mediadas por el bloqueo del receptor at1. | |
AR068086A2 (es) | Polimorfos del compuesto triazolo (4,5-d) pirimidina , una mezcla , proceso para su preparacion , composicion farmaceutica y uso de estos compuestos para la fabricacion de medicamentos | |
AR009292A1 (es) | Derivados del acido arilsulfonilamino hidroxamico, procesos para su preparacion y composiciones farmaceuticas que lo contienen | |
RU2008100042A (ru) | Новое производное кислоты тритерпенового ряда и содержащий его препарат для наружного применения для кожи | |
ES2186677T3 (es) | Derivados de deuteroporfirina sustituidos en las posiciones 3 y 8, agentes farmaceuticos que contienen estos derivados y procedimientos para su preparacion. | |
SE8802635L (sv) | Saltprodukt | |
KumaráBarui et al. | meso-Substituted BODIPY fluorescent probes for cellular bio-imaging and anticancer activity | |
Adeyemo et al. | Coordination-driven self-assembly of ruthenium (II) architectures: synthesis, characterization and cytotoxicity studies | |
CN104151173B (zh) | 一种寡聚苯乙炔化合物及其制备方法和应用 | |
PT828721E (pt) | 2-amino-benxoxazinonas para o tratamento de infeccoes virais | |
CA2404969A1 (en) | Removal of chloride from phosphonomethyliminodiacetic acid process | |
IS7910A (is) | Samsett lyf | |
Parveen et al. | Facile template synthesis of water-soluble triazine-based Schiff base ligand bridged-coordination polymers of Co (ii), Ni (ii), and Cu (ii): structure, biomolecular interactions, and cytotoxic activity | |
CN104151174B (zh) | 一种寡聚苯乙炔化合物及其制备方法与应用 | |
Chappelow Jr et al. | The Phenylation and Methylation of Alkoxychlorosilanes1 | |
da SM Forezi et al. | 2, 3-Dichloro-1, 4-naphthoquinone in organic synthesis: Recent advances | |
Karimova et al. | Synthesis and antioxidant activity of quercetin ethers | |
AR037527A1 (es) | Un proceso para preparar un producto de reaccion de alcaloides que puede ser convertido en una forma soluble en agua, un producto de reaccion obtenido con dicho proceso, una mezcla de estos productos de reaccion, y el uso de los mismos en calidad de farmacos | |
Cann et al. | Rearrangements of a cation of the neopentyl-type containing a diphenyl-phosphinyl substituent | |
Brandt et al. | New monospirocyclic tetrakis (aziridinyl) cyclotriphosphazene derivatives as potential antitumor drugs | |
US2962519A (en) | Phosphates of 2, 3-dimethoxy-5-methyl hydroquinones | |
Ganin et al. | From chains to ladders in co-crystals with 2, 3-thiophene-15-crown-5, 2, 3-naphtho-15-crown-5, and bis-(18-crown-6)-stilbene constructed by weak hydrogen bonding | |
Norman et al. | 37. The reactions of pyrene with free radicals and with sodium | |
ES2291120B2 (es) | Sintesis y utilizacion del complejo ternario cu-fenantrolina-acido iodohipurico y compuestos relacionados como farmacos antitumorales. | |
RU94035677A (ru) | Способ получения хлорангидридов кислот |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |