AR061865A1 - Metodo para preparar analogos de insulina con extremo de cadena b dibasico - Google Patents
Metodo para preparar analogos de insulina con extremo de cadena b dibasicoInfo
- Publication number
- AR061865A1 AR061865A1 ARP070103059A ARP070103059A AR061865A1 AR 061865 A1 AR061865 A1 AR 061865A1 AR P070103059 A ARP070103059 A AR P070103059A AR P070103059 A ARP070103059 A AR P070103059A AR 061865 A1 AR061865 A1 AR 061865A1
- Authority
- AR
- Argentina
- Prior art keywords
- terminal
- insulin
- amino acid
- group
- amidated
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 9
- 238000000034 method Methods 0.000 title abstract 3
- 150000001413 amino acids Chemical class 0.000 abstract 4
- 125000006239 protecting group Chemical group 0.000 abstract 4
- 125000001433 C-terminal amino-acid group Chemical group 0.000 abstract 3
- 210000004899 c-terminal region Anatomy 0.000 abstract 3
- 239000004026 insulin derivative Substances 0.000 abstract 3
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 102000004877 Insulin Human genes 0.000 abstract 2
- 108090001061 Insulin Proteins 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 229940125396 insulin Drugs 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 239000004475 Arginine Substances 0.000 abstract 1
- ULEBESPCVWBNIF-BYPYZUCNSA-N L-arginine amide Chemical compound NC(=O)[C@@H](N)CCCNC(N)=N ULEBESPCVWBNIF-BYPYZUCNSA-N 0.000 abstract 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 1
- HKXLAGBDJVHRQG-YFKPBYRVSA-N L-lysinamide Chemical compound NCCCC[C@H](N)C(N)=O HKXLAGBDJVHRQG-YFKPBYRVSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 102000004142 Trypsin Human genes 0.000 abstract 1
- 108090000631 Trypsin Proteins 0.000 abstract 1
- 125000003368 amide group Chemical group 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 239000012588 trypsin Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006031955A DE102006031955A1 (de) | 2006-07-11 | 2006-07-11 | Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR061865A1 true AR061865A1 (es) | 2008-09-24 |
Family
ID=38468893
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070103059A AR061865A1 (es) | 2006-07-11 | 2007-07-10 | Metodo para preparar analogos de insulina con extremo de cadena b dibasico |
Country Status (19)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005046113A1 (de) * | 2005-09-27 | 2007-03-29 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Amidierung von Polypetiden mit C-terminalen basischen Aminosäuren unter Verwendung spezifischer Endoproteasen |
| CN101861333A (zh) | 2007-11-16 | 2010-10-13 | 诺沃-诺迪斯克有限公司 | 包含glp-1肽或毒蜥外泌肽-4和基础胰岛素肽的药物组合物 |
| JP5781308B2 (ja) * | 2008-02-19 | 2015-09-16 | バイオコン・リミテッドＢｉｏｃｏｎ Ｌｉｍｉｔｅｄ | 異種タンパク質を得る方法およびインスリン類似体 |
| JP2013535467A (ja) * | 2010-07-28 | 2013-09-12 | スマートセルズ・インコーポレイテツド | 組換えにより発現されたインスリンポリペプチドおよびその使用 |
| WO2013015697A1 (en) | 2011-07-28 | 2013-01-31 | Mabion S.A. | A recombinant protein, a polynucleotide encoding it as well as a method of obtaining insulin or its an analogue |
| CN102504022A (zh) * | 2011-11-30 | 2012-06-20 | 苏州元基生物技术有限公司 | 含有保护赖氨酸的胰岛素原及使用其制备胰岛素的方法 |
| PL233560B1 (pl) | 2014-12-05 | 2019-10-31 | Mabion Spolka Akcyjna | Sposób otrzymywania insuliny lub analogu insuliny z prekursora rekombinowanego białka |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55138393A (en) * | 1979-04-13 | 1980-10-29 | Shionogi & Co Ltd | Semisynthesis of insulin |
| DE3326473A1 (de) | 1983-07-22 | 1985-01-31 | Hoechst Ag, 6230 Frankfurt | Pharmazeutisches mittel zur behandlung des diabetes mellitus |
| DE3333640A1 (de) * | 1983-09-17 | 1985-04-25 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung |
| DK347086D0 (da) * | 1986-07-21 | 1986-07-21 | Novo Industri As | Novel peptides |
| DK113585D0 (da) * | 1985-03-12 | 1985-03-12 | Novo Industri As | Nye peptider |
| PH25772A (en) * | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| DE3636903A1 (de) | 1985-12-21 | 1987-07-02 | Hoechst Ag | Fusionsproteine mit eukaryotischem ballastanteil |
| GB8618152D0 (en) * | 1986-07-25 | 1986-09-03 | Renishaw Plc | Co-ordinate measuring |
| EP0294851A3 (de) * | 1987-06-12 | 1990-05-09 | Berlin-Chemie Ag | Verfahren zur Herstellung von Humaninsulin und seinen Derivaten |
| US6875589B1 (en) * | 1988-06-23 | 2005-04-05 | Hoechst Aktiengesellschaft | Mini-proinsulin, its preparation and use |
| DE3837825A1 (de) * | 1988-11-08 | 1990-05-10 | Hoechst Ag | Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
| DE3844211A1 (de) | 1988-12-29 | 1990-07-05 | Hoechst Ag | Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
| US5227293A (en) | 1989-08-29 | 1993-07-13 | The General Hospital Corporation | Fusion proteins, their preparation and use |
| DE4405179A1 (de) | 1994-02-18 | 1995-08-24 | Hoechst Ag | Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken |
| EP1076066A1 (en) | 1999-07-12 | 2001-02-14 | Zealand Pharmaceuticals A/S | Peptides for lowering blood glucose levels |
| AR025646A1 (es) * | 2000-09-13 | 2002-12-04 | Beta Lab Sa | Cepa de levaduras metilotroficas recombinantes productoras de un precursor de insulina, construcciones de adn y metodo para obtener la cepa. |
| DE10108100A1 (de) | 2001-02-20 | 2002-08-29 | Aventis Pharma Gmbh | Verwendung supersekretierbarer Peptide in Verfahren zu deren Herstellung und paralleler Verbesserung der Exportate eines oder mehrerer anderer Polypeptide von Interesse |
| DE10108211A1 (de) | 2001-02-20 | 2002-08-22 | Aventis Pharma Gmbh | Verwendung von Fusionsproteinen, deren N-terminaler Anteil aus einem Hirudinderivat besteht, zur Herstellung rekombinanter Proteine über Sekretion durch Hefen |
| DE10108212A1 (de) * | 2001-02-20 | 2002-08-22 | Aventis Pharma Gmbh | Fusionsprotein zur Sekretion von Wertprotein in bakterielle Überstände |
| CA2464616C (en) * | 2001-11-19 | 2012-07-24 | Are Bogsnes | Process for preparing insulin compounds |
| DE10227232A1 (de) | 2002-06-18 | 2004-01-15 | Aventis Pharma Deutschland Gmbh | Saure Insulinzubereitungen mit verbesserter Stabilität |
| MXPA04012497A (es) | 2002-07-04 | 2005-07-14 | Zealand Pharma As | Glp-1 y metodos para tratar la diabetes. |
| ES2309785T3 (es) | 2004-08-13 | 2008-12-16 | F. Hoffmann-La Roche Ag | Modificacion c-terminal de polipeptidos. |
| DE102004058306A1 (de) | 2004-12-01 | 2006-07-27 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Herstellung von Carboxy-terminal amidierten Peptiden |
| DE102005046113A1 (de) * | 2005-09-27 | 2007-03-29 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Amidierung von Polypetiden mit C-terminalen basischen Aminosäuren unter Verwendung spezifischer Endoproteasen |
-
2006
- 2006-07-11 DE DE102006031955A patent/DE102006031955A1/de not_active Withdrawn
-
2007
- 2007-07-05 CN CN2007800261387A patent/CN101490082B/zh not_active Expired - Fee Related
- 2007-07-05 PT PT77859031T patent/PT2041170E/pt unknown
- 2007-07-05 MY MYPI20085343A patent/MY148984A/en unknown
- 2007-07-05 ES ES07785903T patent/ES2423684T3/es active Active
- 2007-07-05 JP JP2009518756A patent/JP5331685B2/ja not_active Expired - Fee Related
- 2007-07-05 CA CA2657041A patent/CA2657041C/en not_active Expired - Fee Related
- 2007-07-05 EP EP07785903.1A patent/EP2041170B1/de not_active Not-in-force
- 2007-07-05 DK DK07785903.1T patent/DK2041170T3/da active
- 2007-07-05 AU AU2007272057A patent/AU2007272057B2/en not_active Ceased
- 2007-07-05 MX MX2009000275A patent/MX2009000275A/es active IP Right Grant
- 2007-07-05 WO PCT/EP2007/005933 patent/WO2008006497A1/de not_active Ceased
- 2007-07-05 BR BRPI0714297-8A patent/BRPI0714297A2/pt not_active IP Right Cessation
- 2007-07-05 KR KR1020097000429A patent/KR101439110B1/ko not_active Expired - Fee Related
- 2007-07-09 TW TW096124845A patent/TWI440717B/zh not_active IP Right Cessation
- 2007-07-10 AR ARP070103059A patent/AR061865A1/es unknown
-
2009
- 2009-01-05 IL IL196360A patent/IL196360A/en not_active IP Right Cessation
- 2009-01-07 US US12/349,854 patent/US8410048B2/en not_active Expired - Fee Related
- 2009-02-11 NO NO20090663A patent/NO20090663L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MX2009000275A (es) | 2009-01-26 |
| DE102006031955A1 (de) | 2008-01-17 |
| TWI440717B (zh) | 2014-06-11 |
| TW200817511A (en) | 2008-04-16 |
| IL196360A0 (en) | 2011-08-01 |
| JP5331685B2 (ja) | 2013-10-30 |
| AU2007272057B2 (en) | 2012-06-14 |
| CA2657041A1 (en) | 2008-01-17 |
| CN101490082B (zh) | 2013-08-14 |
| CA2657041C (en) | 2016-04-26 |
| PT2041170E (pt) | 2013-07-18 |
| EP2041170B1 (de) | 2013-05-01 |
| JP2009542235A (ja) | 2009-12-03 |
| HK1130815A1 (en) | 2010-01-08 |
| NO20090663L (no) | 2009-02-11 |
| BRPI0714297A2 (pt) | 2013-02-26 |
| AU2007272057A1 (en) | 2008-01-17 |
| US20090192073A1 (en) | 2009-07-30 |
| EP2041170A1 (de) | 2009-04-01 |
| MY148984A (en) | 2013-06-28 |
| US8410048B2 (en) | 2013-04-02 |
| KR20090038868A (ko) | 2009-04-21 |
| DK2041170T3 (da) | 2013-08-05 |
| IL196360A (en) | 2015-08-31 |
| WO2008006497A1 (de) | 2008-01-17 |
| CN101490082A (zh) | 2009-07-22 |
| ES2423684T3 (es) | 2013-09-23 |
| KR101439110B1 (ko) | 2014-09-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MY152979A (en) | Novel insulin derivatives having an extremely delayed time-action profile | |
| AR105822A1 (es) | Análogos de insulina | |
| NZ600690A (en) | Fkbp-l and uses thereof | |
| CR11511A (es) | Nuevos derivados de insulina con perfil tiempo/accion extremadamente retardado | |
| ATE533785T1 (de) | Peptidfragmente zur induzierung der synthese extrazellulärer matrixproteine | |
| EP4483952A3 (en) | Compositions suitable for treating collagen-mediated diseases | |
| MX2014000210A (es) | Peptidos procoagulantes y sus derivados, y usos para estos. | |
| SG191069A1 (en) | Cyclosporine analogue molecules modified at amino acid 1 and 3 | |
| PE20140186A1 (es) | Analogos de glucagon que presentan actividad de receptor de gip | |
| PE20100056A1 (es) | Analogos de glucagon como agonistas gip | |
| AR086078A1 (es) | Proteinas de fusion y vacunas de combinacion | |
| NZ588903A (en) | A process for concentration of galactosycerebrosidase or porphobuilinogen deaminase | |
| BRPI0923346A2 (pt) | Proteinas em super-helice antiparalela de cadeia simples | |
| AR061238A1 (es) | Compuestos de oxilmilo macrociclico inhibidores de proteasa de hepatitis c | |
| WO2009011544A3 (en) | Insulinotropic peptide derivative wherein its n-terminal amino acid is modified | |
| ES2193949T3 (es) | Nuevos derivados del acido lipoico, su preparacion y composiciones farmaceuticas que los contienen. | |
| NZ599774A (en) | Melanocortin-1 receptor-specific cyclic peptides | |
| SG178797A1 (en) | Oligosaccharide chain added glp-1 peptide | |
| MX366906B (es) | Purificacion de iduronato-2-sulfatasa. | |
| WO2012164488A3 (en) | New cosmetic or dermopharmaceutical topical use of a mixture of a ghk tripeptide and gqpr tetrapeptide | |
| UY30391A1 (es) | Compuesto de oximilo aciclico inhibidores de proteasa de hepatitis c | |
| PE20090683A1 (es) | Peptidos de senalizacion | |
| PH12012502018A1 (en) | Peptide for improving biostability of bioactive substance, and bioactive substance having improved biostability | |
| AR052099A1 (es) | Peptidos senal de defensa en plantas | |
| CL2012002560A1 (es) | Metodos para el tratamiento de ulceras de pie diabetico que comprende un peptido de al menos 5 aminoacidos contiguos de nle3 a(1-7) efectivo; formulacion farmacéutica que comprende hidroxietil celulosa (hec) y un peptido de al menos 5 aminoacidos contiguos de nle3 a(1-7). |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |