MX2014000210A - Peptidos procoagulantes y sus derivados, y usos para estos. - Google Patents

Peptidos procoagulantes y sus derivados, y usos para estos.

Info

Publication number
MX2014000210A
MX2014000210A MX2014000210A MX2014000210A MX2014000210A MX 2014000210 A MX2014000210 A MX 2014000210A MX 2014000210 A MX2014000210 A MX 2014000210A MX 2014000210 A MX2014000210 A MX 2014000210A MX 2014000210 A MX2014000210 A MX 2014000210A
Authority
MX
Mexico
Prior art keywords
derivatives
uses therefor
sequence
scaffold
peptide
Prior art date
Application number
MX2014000210A
Other languages
English (en)
Other versions
MX347200B (es
Inventor
Yi-Lan Wang
Guanghui Zhang
Original Assignee
Ethicon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46465279&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2014000210(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ethicon Inc filed Critical Ethicon Inc
Publication of MX2014000210A publication Critical patent/MX2014000210A/es
Publication of MX347200B publication Critical patent/MX347200B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0052—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/108—Specific proteins or polypeptides not covered by groups A61L24/102 - A61L24/106
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/009—Materials resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/25—Peptides having up to 20 amino acids in a defined sequence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials Engineering (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención está dirigida a un material hemostático o de sellado tisular que tiene (a) un péptido que tiene una SEQ ID NO: 1 o una secuencia de aminoácidos análoga de este, y (b) un supercóntigo para ese péptido o secuencia de aminoácidos análoga, el supercóntigo es, preferentemente, hemostático, tal como un polímero absorbible natural o modificado genéticamente, un polímero absorbible sintético, o combinaciones de estos; los polímeros absorbibles naturales o modificados genéticamente se pueden seleccionar del grupo que consiste en una proteína, un polisacárido, o combinaciones de estos.
MX2014000210A 2011-06-30 2012-06-14 Péptidos procoagulantes y sus derivados, y usos para estos. MX347200B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13/173,013 US9149511B2 (en) 2011-06-30 2011-06-30 Procoagulant peptides and their derivatives and uses therefor
PCT/US2012/042346 WO2013003045A2 (en) 2011-06-30 2012-06-14 Procoagulant peptides and their derivatives and uses therefor

Publications (2)

Publication Number Publication Date
MX2014000210A true MX2014000210A (es) 2014-04-25
MX347200B MX347200B (es) 2017-04-18

Family

ID=46465279

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014000210A MX347200B (es) 2011-06-30 2012-06-14 Péptidos procoagulantes y sus derivados, y usos para estos.

Country Status (10)

Country Link
US (2) US9149511B2 (es)
EP (1) EP2726115B1 (es)
JP (1) JP6117198B2 (es)
CN (1) CN103687631B (es)
AU (1) AU2012275858B2 (es)
CA (1) CA2840290C (es)
ES (1) ES2647313T3 (es)
MX (1) MX347200B (es)
RU (1) RU2635510C2 (es)
WO (1) WO2013003045A2 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2550945C1 (ru) * 2014-05-29 2015-05-20 Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов" (ФГУП "ГосНИИгенетика") Гемостатическое лекарственное средство на основе синтетического трипептидного ингибитора плазмина

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9149511B2 (en) 2011-06-30 2015-10-06 Ethicon, Inc. Procoagulant peptides and their derivatives and uses therefor
CN103446619B (zh) * 2013-08-19 2015-08-19 青岛中腾生物技术有限公司 新型可吸收止血材料
CN103992381B (zh) * 2014-04-16 2018-04-24 成都威能士医疗科技有限公司 多肽、多肽组合物和多肽生物材料及其制备方法和用途
WO2016061611A1 (en) * 2014-10-23 2016-04-28 Q-Sera Pty Ltd Improved clotting composition
CN104623720B (zh) * 2015-02-04 2017-05-10 北京爱特康科贸有限责任公司 一种淀粉基止血海绵及其制备方法
GB201508014D0 (en) * 2015-05-11 2015-06-24 Haemostatix Ltd Haemostatic device
US10751444B2 (en) 2015-08-07 2020-08-25 Victor Matthew Phillips Flowable hemostatic gel composition and its methods of use
US10660945B2 (en) 2015-08-07 2020-05-26 Victor Matthew Phillips Flowable hemostatic gel composition and its methods of use
CA3004272C (en) * 2015-11-06 2023-11-07 Ethicon, Inc. Compacted hemostatic cellulosic aggregates
KR101901150B1 (ko) * 2015-12-14 2018-09-27 주식회사 앤씨비아이티 재조합 배트록소빈 혼합 조성물 및 이를 포함하는 지혈 분말 또는 지혈 패드
EP3463496A1 (en) * 2016-06-01 2019-04-10 3-D Matrix Ltd. Hemostatic powders with self-assembling peptide hydrogels
JP2019517299A (ja) * 2016-06-01 2019-06-24 株式会社スリー・ディー・マトリックス 自己集合性ペプチドヒドロゲルを有する止血用包帯
CN108498879B (zh) 2017-02-28 2021-12-28 苏州安德佳生物科技有限公司 黏膜下注射用组合物和试剂组合及其应用
RU2652270C1 (ru) * 2017-05-24 2018-04-25 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр гематологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ гематологии" Минздрава России) Гемостатический раствор на основе сульфатированных полисахаридов и получение гемостатических губок из этого раствора (варианты)
CN107376005A (zh) * 2017-08-04 2017-11-24 北京化工大学常州先进材料研究院 一种生物可降解医用止血纸及其制备方法
US11007299B2 (en) 2017-11-08 2021-05-18 Ethicon, Inc. Hemostatic paste having surface enriched with hemostasis-promoting agents and devices for delivery
CN110025821A (zh) 2018-01-12 2019-07-19 北京环球利康科技有限公司 使用生物相容性止血剂和组织封闭剂的组合物处理活动性出血的方法
US11998654B2 (en) 2018-07-12 2024-06-04 Bard Shannon Limited Securing implants and medical devices
CN109481728A (zh) * 2018-11-06 2019-03-19 上海兰明食品科技有限公司 一种用于伤口溃疡修复的果胶水凝胶敷料及其制备方法
CN109646707A (zh) * 2018-12-14 2019-04-19 广州润虹医药科技股份有限公司 一种快速止血材料及其制备方法
CN109646711A (zh) * 2019-01-29 2019-04-19 青岛中腾生物技术有限公司 一种医用止血封闭防黏连材料
CN113423369B (zh) * 2019-02-15 2023-08-18 巴德股份有限公司 止血活检道制品
CN110141677B (zh) * 2019-06-06 2022-07-08 东华大学 一种局部急性止血可吸收材料及其制备方法
CN110448719B (zh) * 2019-06-28 2020-05-22 浙江大学 一种促进凝血的丝素-多肽电纺膜及其制备方法
US20220023491A1 (en) 2020-07-21 2022-01-27 Ethicon, Inc. Hemostatic Composite Aggregate Materials Having Surface Enriched with Hemostatis
CN113134113B (zh) * 2021-04-07 2022-07-01 赛克赛斯生物科技股份有限公司 可吸收止血流体明胶的制备方法及可吸收止血流体明胶
CN113144277B (zh) * 2021-04-13 2022-06-14 武汉理工大学 一种可注射流体明胶及其制备方法和应用
CN113209357B (zh) * 2021-05-14 2023-02-17 南方科技大学 复合止血粉
CN114522268B (zh) * 2021-12-16 2023-02-10 浙江瑞谷生物科技有限公司 一种皮肤修复材料及其制备方法和应用
CN114425097B (zh) * 2022-04-07 2022-06-14 天新福（北京）医疗器材股份有限公司 一种可吸收组织闭合胶及其制备方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5190920A (en) 1990-09-24 1993-03-02 W. R. Grace & Co.-Conn. Method for using synthetic analogs of thrombospondin for inhibiting metastasis activity
US5399667A (en) * 1993-03-05 1995-03-21 Washington University Thrombospondin receptor binding peptides
WO1996040033A1 (en) 1995-06-07 1996-12-19 Clarion Pharmaceuticals Inc. Non-biological patch for hemostasis
US6063061A (en) 1996-08-27 2000-05-16 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US7435425B2 (en) * 2001-07-17 2008-10-14 Baxter International, Inc. Dry hemostatic compositions and methods for their preparation
US6045570A (en) 1997-02-11 2000-04-04 Biointerventional Corporation Biological sealant mixture and system for use in percutaneous occlusion of puncture sites and tracts in the human body and method
US6015474A (en) 1997-06-20 2000-01-18 Protein Polymer Technologies Methods of using primer molecules for enhancing the mechanical performance of tissue adhesives and sealants
WO2004028404A2 (en) 2002-09-30 2004-04-08 Fibrogen, Inc. Dry tissue sealant compositions
WO2007044026A2 (en) * 2004-11-23 2007-04-19 The Johns Hopkins University Compositions comprising modified collagen and uses therefore
EP2695896B1 (en) 2006-10-06 2018-08-22 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Prevention of tissue ischemia, related methods and compositions
EP2111239B1 (en) 2006-12-15 2013-03-06 Lifebond Ltd. Gelatin-transglutaminase hemostatic dressings and sealants
WO2009018126A2 (en) * 2007-08-01 2009-02-05 Ethicon, Inc. Collagen-related peptides and uses thereof
WO2009040068A2 (en) 2007-09-11 2009-04-02 Mondobiotech Laboratories Ag Use of a peptide as a therapeutic agent
EP2259803B2 (en) * 2008-02-29 2019-03-13 Ferrosan Medical Devices A/S Device for promotion of hemostasis and/or wound healing
US20110112573A1 (en) * 2008-06-18 2011-05-12 Orahn Preiss Bloom Methods and devices for use with sealants
US9889230B2 (en) 2008-10-17 2018-02-13 Covidien Lp Hemostatic implant
KR20100048751A (ko) * 2008-10-31 2010-05-11 주식회사 동성바이오레인 스프레이 가능한 캡슐화된 기능성 미립자 조성물과 그 제조방법
US9149511B2 (en) 2011-06-30 2015-10-06 Ethicon, Inc. Procoagulant peptides and their derivatives and uses therefor

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2550945C1 (ru) * 2014-05-29 2015-05-20 Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов" (ФГУП "ГосНИИгенетика") Гемостатическое лекарственное средство на основе синтетического трипептидного ингибитора плазмина

Also Published As

Publication number Publication date
RU2635510C2 (ru) 2017-11-13
AU2012275858B2 (en) 2016-02-04
AU2012275858A1 (en) 2014-01-16
WO2013003045A3 (en) 2013-04-25
EP2726115B1 (en) 2017-09-13
CN103687631B (zh) 2017-02-15
US9149511B2 (en) 2015-10-06
WO2013003045A2 (en) 2013-01-03
MX347200B (es) 2017-04-18
RU2014102975A (ru) 2015-08-10
EP2726115A2 (en) 2014-05-07
JP6117198B2 (ja) 2017-04-19
CN103687631A (zh) 2014-03-26
CA2840290C (en) 2021-03-16
JP2014523312A (ja) 2014-09-11
US20150359925A1 (en) 2015-12-17
ES2647313T3 (es) 2017-12-20
US9717820B2 (en) 2017-08-01
CA2840290A1 (en) 2013-01-03
US20130004478A1 (en) 2013-01-03

Similar Documents

Publication Publication Date Title
MX347200B (es) Péptidos procoagulantes y sus derivados, y usos para estos.
NZ598356A (en) Antigenic tau peptides and uses thereof
RS53505B1 (en) OXYTOMODULIN PEPTIDE ANALOG
IN2012DN02981A (es)
NZ602845A (en) Inhibiting peptides derived from trem-like transcript 1 (tlt-1) and uses thereof
UA118167C2 (uk) Пептид та його застосування
NZ602943A (en) Modified binding proteins inhibiting the vegf-a receptor interaction
MX2011011960A (es) Peptidos penetradores de celulas.
WO2010150233A3 (en) Multimeric polypeptides of hla-g including at least two alpha3 domains and pharmaceutical uses thereof
UA111141C2 (uk) Рекомбінантні антигени рсв
NZ609216A (en) Anticancer fusion protein
MX2008009493A (es) Peptido novedoso y uso del mismo.
NZ703560A (en) Method for activating helper t cell
NZ708990A (en) Method for activating helper t cell
NZ586074A (en) LCLRP peptides, constructs and uses thereof
NZ609916A (en) Hla-binding peptides derived from prostate-associated antigenic molecules and methods of use thereof
JP2020513810A5 (es)
NZ598932A (en) Identification of antigenic peptides from multiple myeloma cells
WO2019094938A3 (en) Methods and compositions for the treatment of wounds
RS54422B1 (en) APOPTOSIS INHIBITORS AND THEIR USES
EA201590601A1 (ru) Применение pedf-производных полипептидов для лечения остеоартрита
NZ589365A (en) Peptidyl diacylglycerides
NZ592461A (en) Rab6kifl/kif20a epitope peptide and vaccines containing the same
BR112017019241A2 (pt) análogo peptídico, composição, método para induzir uma resposta imune contra uma infecção, kit, composto e uso de um análogo peptídico
MY151307A (en) Peptides having antimicrobial activity

Legal Events

Date Code Title Description
FG Grant or registration