AR054800A1 - Amidas sustituidas con heteroarilo que comprenden un grupo enlazador saturado, y su uso como agentes farmaceuticos - Google Patents

Amidas sustituidas con heteroarilo que comprenden un grupo enlazador saturado, y su uso como agentes farmaceuticos

Info

Publication number
AR054800A1
AR054800A1 ARP060102736A ARP060102736A AR054800A1 AR 054800 A1 AR054800 A1 AR 054800A1 AR P060102736 A ARP060102736 A AR P060102736A AR P060102736 A ARP060102736 A AR P060102736A AR 054800 A1 AR054800 A1 AR 054800A1
Authority
AR
Argentina
Prior art keywords
alkyl
group
chosen
substituted
alkyloxy
Prior art date
Application number
ARP060102736A
Other languages
English (en)
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of AR054800A1 publication Critical patent/AR054800A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Reivindicacion 1: Un compuesto de formula (1), en la que: A se elige entre -CH2-CH2-, -CH2-CH2-CH2- y -Y-CH2-CH2-, donde todos los grupos CH2 pueden estar sustituidos con uno o más sustituyentes R4 iguales o diferentes, y donde Y se elige entre O, S y NR11 e Y se une al grupo Het; Het es un grupo aromático, monocíclico, de 5 miembros o de 6 miembros que contiene uno o dos miembros hetero en el anillo iguales o diferentes elegidos entre N, NR13, O y S y que pueden estar sustituidos con uno o más sustituyentes R5 iguales o diferentes; X se elige entre un enlace directo, CH2 O y NH; R1 y R2, junto con el grupo N-CO que los tiene, forman un anillo monocíclico o bicíclico, saturado o insaturado, de 4 miembros a 10 miembros que, además del átomo de nitrogeno que forma parte del grupo N-CO, puede contener uno o dos miembros hetero adicionales en el anillo elegidos entre N, NR12, O, S, SO y SO2 que pueden ser iguales o diferentes, con la condicion de que dos miembros del anillo de las series O, S, SO y SO2 no pueden estar presentes en posiciones adyacentes del anillo, donde el anillo formado por R1 y R2 y el grupo N-CO que los tiene puede estar sustituido con uno o más sustituyentes R8 iguales o diferentes; R3 se elige entre fenilo, naftalenilo y heteroarilo pudiendo estar todos sustituidos con uno o más sustituyentes iguales o diferentes elegido entre halogeno, alquilo C1-4, alquiloxiC1-4-alquiloC1-2-, OH, alquiloxi C1-4 que puede estar sustituido con uno o más átomos de fluor, alquilendioxi C1-2 que puede estar sustituido con uno o más átomos de fluor, alquilmercapto C1-4, NH2, alquilamino C1-4, di(alquil1-4)amino, alquilC1-4-CONH-, di(alquilC1-4)aminocarbonilo-, (alquilC1-4)aminocarbonilo, (alquiloxiC1-4)carbonilo- , COOH, CONH2, CN, CF3, H2SO2- y alquilC1-4-SO2-; R4 se elige entre alquilo C1-4 y fluor; R5 se elige entre halogeno, alquilo C1-4, alquiloxiC1-4-alquiloC1-2-, OH, alquiloxi C1-4 que puede estar sustituido con uno o más átomos de fluor, alquilmercapto C1-4, NH2, alquilamino C1-4, di(alquilC1-4)amino, alquilC1-4-CONH-, di(alquilC1-4)aminocarbonilo-, (alquilC1-4)aminocarbonilo-, (alquiloxiC1-4)carbonilo-, COOH, CONH2, CN, CF3, y alquilC1-4-SO2-; R8 se elige entre halogeno, alquilo C1- 4, cicloalquilC3-7-CnH2n-, fenil-CnH2n-, heteroaril-CnH2n-, alquiloxiC1-4-alquiloC1-2-, OH, oxo, alquiloxi C1-4 que puede estar sustituido con uno o más átomos de fluor, alquilmercapto C1-4, NH2, alquilamino C1-4, di(alquilC1-4)amino, alquilC1-4- CONH-, di(alquilC1-4)aminocarbonilo-, (alquilC1-4)aminocarbonilo-, (alquiloxiC1-4)carbonilo-, COOH, CONH2, CN, CF3, H2NSO2- y alquilC1-4-SO2-, donde todos los grupos fenilo y grupos heteroarilo pueden estar independientemente sustituidos entre sí con uno o más sustituyentes iguales o diferentes elegidos entre halogeno, alquilo C1-4, CF3 y alquiloxi C1-4; R11 se elige entre hidrogeno, alquilo C1-4 y alquilC1-4-CO-; R12 se elige entre hidrogeno, alquilo C1-4, cicloalquilC3-7-CnH2n-, fenil-Cn- H2n-, heteroaril-Cn-H2n, alquilC1-4-CO-, cicloalquilC3-7-CnH2n-CO-, fenil-Cn-H2n-CO-, heteroaril-CnH2n-CO-, alquilC1-4-O-CO- y fenil-CnH2n-O-CO-, donde todos los grupos fenilo y grupos heteroarilo pueden estar sustituidos con uno o más sustituyentes iguales o diferentes elegidos entre halogeno, alquilo C1-4, CF3 y alquiloxi C1-4; R13 se elige entre hidrogeno, alquilo C1-4 y fenil-CnH2n-, donde el grupo fenilo puede estar sustituido con uno o más sustituyentes iguales o diferentes elegidos entre halogeno, alquilo C1-4, CF3 y alquiloxi C1-4, donde todos los grupos R13 son independientes entre sí y pueden ser iguales o diferentes; heteroarilo es un grupo aromático, monocíclico, de 5 miembros o de 6 miembros que contiene uno, dos o tres miembros hetero en el anillo iguales o diferentes elegidos entre N, NR13, O y S; n es 0, 1 o 2, donde todos los numeros n son independientes entre sí y pueden ser iguales o diferentes; en cualquiera de sus formas estereoisoméricas o una mezcla de formas estereoisoméricas en cualquier relacion, o una sal fisiologicamente aceptables de los mismos; con la condicion de que el grupo -N(R2)-CO-R1 no puede ser un grupo 2-oxopirrolidin-1-ilo sin sustituir o un grupo 2-oxoimidazolin-1-ilo sin sustituir si simultáneamente el grupo R3-X-Het- es un grupo de formula (2), donde el enlace mediante el cual el grupo se conecta al grupo A se representa por la línea que parte de la posicion 2 del anillo piridina, y en la que R90 se elige entre imidazol-1-ilo, isoxazol-5-ilo, isotiazol-5-ilo, 1,2,4-triazol-1-ilo, pirazin-2-ilo y pirazol-3-ilo pudiendo estar todos sustituidos con alquilo C1-4, y que pueden estar sustituidos en el anillo piridina con hasta cuatro sustituyentes elegidos entre alquilo C1-4, alquiloxi C1-4 y halogeno; y con la condicion de que el grupo -N(R2)-CO-R1 no puede ser un grupo 1,3-dioxoisoindol-2-ilo de formula (3), donde el enlace mediante el cual el grupo se conecta al grupo A se representa por la línea que parte del átomo de nitrogeno.
ARP060102736A 2005-06-28 2006-06-26 Amidas sustituidas con heteroarilo que comprenden un grupo enlazador saturado, y su uso como agentes farmaceuticos AR054800A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05013870A EP1741709A1 (en) 2005-06-28 2005-06-28 Heteroaryl-substituted amides comprising a saturated linker group, and their use as pharmaceuticals

Publications (1)

Publication Number Publication Date
AR054800A1 true AR054800A1 (es) 2007-07-18

Family

ID=35478793

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060102736A AR054800A1 (es) 2005-06-28 2006-06-26 Amidas sustituidas con heteroarilo que comprenden un grupo enlazador saturado, y su uso como agentes farmaceuticos

Country Status (33)

Country Link
US (1) US8518976B2 (es)
EP (2) EP1741709A1 (es)
JP (1) JP5149794B2 (es)
KR (1) KR20080027801A (es)
CN (1) CN101208328B (es)
AR (1) AR054800A1 (es)
AT (1) ATE539072T1 (es)
AU (1) AU2006264049B2 (es)
BR (1) BRPI0613717A2 (es)
CA (1) CA2611953A1 (es)
CY (1) CY1112869T1 (es)
DK (1) DK1899321T3 (es)
DO (1) DOP2006000146A (es)
ES (1) ES2378894T3 (es)
GT (1) GT200600274A (es)
HK (1) HK1122551A1 (es)
HR (1) HRP20120167T1 (es)
IL (1) IL188382A0 (es)
MA (1) MA29552B1 (es)
MX (1) MX2008000044A (es)
NO (1) NO20080523L (es)
NZ (1) NZ565041A (es)
PA (1) PA8683901A1 (es)
PE (1) PE20070102A1 (es)
PL (1) PL1899321T3 (es)
PT (1) PT1899321E (es)
RS (1) RS52266B (es)
RU (1) RU2412181C2 (es)
SI (1) SI1899321T1 (es)
TW (1) TWI378095B (es)
UY (1) UY29640A1 (es)
WO (1) WO2007000246A1 (es)
ZA (1) ZA200710002B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1939181A1 (en) * 2006-12-27 2008-07-02 sanofi-aventis Heteroaryl-substituted carboxamides and use thereof for the stimulation of the expression of NO synthase
EP2310372B1 (en) 2008-07-09 2012-05-23 Sanofi Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
US8815772B2 (en) 2012-06-29 2014-08-26 E I Du Pont De Nemours And Company Fungicidal heterocyclic carboxamides
CN110172055B (zh) 2013-04-12 2021-10-29 瓦伦塔有限责任公司 戊二酰亚胺衍生物、其用途、基于所述衍生物的药物组合物及戊二酰亚胺衍生物的制备方法
RU2552929C1 (ru) 2013-11-14 2015-06-10 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" Фармацевтическая композиция, содержащая производные глутаримидов, и их применение для лечения эозинофильных заболеваний

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4429656Y1 (es) 1967-03-16 1969-12-08
GB1188416A (en) * 1968-04-01 1970-04-15 Ici Ltd Heterocyclic Amines
GB1231829A (es) * 1968-09-19 1971-05-12
GB1341375A (en) * 1969-11-19 1973-12-19 Smith Kline French Lab Aminoalkylimidazoles and process for their production
FR2510997A1 (fr) 1981-08-10 1983-02-11 Sanofi Sa Nouveaux derives de la methyl-4 phenyl-6 pyridazine, procede pour leur preparation et medicaments actifs sur le systeme nerveux central en contenant
US4565814A (en) 1983-01-28 1986-01-21 Sanofi Pyridazine derivatives having a psychotropic action and compositions
ATE77817T1 (de) * 1985-04-30 1992-07-15 Dresden Arzneimittel 3-cyan-pyridine, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung.
US4710502A (en) 1985-11-04 1987-12-01 American Cyanamid Company 3-heteroarylalkyl-4-quinazolinones
US4701502A (en) * 1985-12-13 1987-10-20 E. I. Du Pont De Nemours And Company Chip resistant primer composition V'
NL8800998A (nl) * 1988-04-18 1989-11-16 Cedona Pharm Bv Werkwijze voor het bereiden van een al of niet gesubstitueerd 4(5)-(omega-aminoalkyl) imidazool.
TW224974B (es) * 1991-07-02 1994-06-11 Hoffmann La Roche
GB9127304D0 (en) * 1991-12-23 1992-02-19 Boots Co Plc Therapeutic agents
AU4515696A (en) * 1994-12-12 1996-07-03 Merck & Co., Inc. Substituted 2-aminopyridines as inhibitors of nitric oxide synthase
JP4272261B2 (ja) 1996-12-10 2009-06-03 アボツト・ラボラトリーズ ３−ピリジルエナンチオマーおよび鎮痛薬としてのその使用
US6180597B1 (en) 1998-03-19 2001-01-30 Brigham And Women's Hospital, Inc. Upregulation of Type III endothelial cell nitric oxide synthase by rho GTPase function inhibitors
AU4990599A (en) 1998-07-14 2000-02-07 Brigham And Women's Hospital Upregulation of type iii endothelial cell nitric oxide synthase by agents that disrupt actin cytoskeletal organization
SE9803518D0 (sv) * 1998-10-15 1998-10-15 Astra Pharma Prod Novel compounds
WO2000051623A2 (en) * 1999-03-05 2000-09-08 The Trustees Of University Technology Corporation Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide-induced clinical conditions
DE19947154A1 (de) * 1999-10-01 2001-10-04 Bayer Ag Substituierte 2-Thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung
JP2002255971A (ja) * 2000-03-31 2002-09-11 Takeda Chem Ind Ltd 縮合複素環誘導体、その製造法および用途
CA2400858A1 (en) 2000-03-31 2001-10-11 Shokyo Miki Fused heterocyclic derivatives, their production and use
KR20030026979A (ko) * 2000-07-18 2003-04-03 야마노우치세이야쿠 가부시키가이샤 디시아노피리딘 유도체를 포함하는 의약
TWI241190B (en) 2001-02-13 2005-10-11 Aventis Pharma Gmbh 4-Fluoro-N-indan-2-yl benzamide and its use as pharmaceutical
TWI243164B (en) * 2001-02-13 2005-11-11 Aventis Pharma Gmbh Acylated indanyl amines and their use as pharmaceuticals
MY136316A (en) 2001-02-13 2008-09-30 Sanofi Aventis Deutschland Acylated 6,7,8,9-tetrahydro-5h-benzocycloheptenyl amines and their use as pharmaceutical.
PE20020856A1 (es) 2001-02-13 2002-11-11 Aventis Pharma Gmbh 1,2,3,4-tetrahidronaftil aminas aciladas
DE10110747A1 (de) 2001-03-07 2002-09-12 Bayer Ag Substituierte 2,6-Diamino-3,5-dicyano-4-aryl-pyridine und ihre Verwendung
EP1392662B1 (de) 2001-05-29 2009-01-07 Bayer Schering Pharma Aktiengesellschaft Cdk inhibitorische pyrimidine, deren herstellung und verwendung als arzneimittel
JPWO2003022821A1 (ja) * 2001-09-06 2004-12-24 大正製薬株式会社 ２０−ｈｅｔｅ産生酵素阻害作用を有するヘテロ環誘導体
ES2314106T3 (es) * 2001-10-17 2009-03-16 BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG Derivados de pirimidina, agentes farmaceuticos que contiene dichos compuestos, uso y metodo para su obtencion.
DE10201240A1 (de) 2002-01-15 2003-07-24 Bayer Ag Substituierte Alkyluracile und ihre Verwendung
FR2837201A1 (fr) 2002-03-18 2003-09-19 Servier Lab Nouveaux composes derives de la quinazoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU2003225964B2 (en) * 2002-03-28 2008-11-20 Merck Sharp & Dohme Corp. Substituted 2,3-diphenyl pyridines
WO2003094845A2 (en) * 2002-05-08 2003-11-20 Bristol-Myers Squibb Company Pyridine-based thyroid receptor ligands
US7186735B2 (en) 2002-08-07 2007-03-06 Sanofi-Aventis Deutschland Gmbh Acylated arylcycloalkylamines and their use as pharmaceuticals
EP1388535A1 (en) * 2002-08-07 2004-02-11 Aventis Pharma Deutschland GmbH Acylated arylcycloalkylamines and their use as pharmaceuticals
EP1388341A1 (en) 2002-08-07 2004-02-11 Aventis Pharma Deutschland GmbH Acylamino-substituted heteroaromatic compounds and their use as pharmaceuticals
EP1388342A1 (en) 2002-08-07 2004-02-11 Aventis Pharma Deutschland GmbH Acylated, heteroaryl-condensed cycloalkenylamines and their use as pharmaceuticals
CA2529611C (en) * 2002-12-20 2009-12-15 Pfizer Products Inc. Pyrimidine derivatives for the treatment of abnormal cell growth
US20040147561A1 (en) * 2002-12-27 2004-07-29 Wenge Zhong Pyrid-2-one derivatives and methods of use
US20040223963A1 (en) * 2003-01-31 2004-11-11 Raymond Cheung Method for treating ischemic stroke with melatonin
JP2004262890A (ja) * 2003-03-04 2004-09-24 Taisho Pharmaceut Co Ltd ２０−ｈｅｔｅ産生阻害作用を有するアゾール誘導体
JP2004269469A (ja) * 2003-03-12 2004-09-30 Yamanouchi Pharmaceut Co Ltd ピリミジン誘導体又はその塩
US20040204455A1 (en) 2003-04-10 2004-10-14 Cody Wayne Livingston Piperidine derivative rennin inhibitors
EP1471066A1 (en) 2003-04-24 2004-10-27 Aventis Pharma Deutschland GmbH Triaza- and tetraaza-anthracenedione derivates, their preparation and their use as pharmaceuticals
US7538233B2 (en) * 2003-09-05 2009-05-26 Aventis Pharmaceuticals Inc. Coumarins as iNOS inhibitors
EP1696877A4 (en) * 2003-11-13 2010-06-09 Gen Hospital Corp PROCESS FOR PAIN TREATMENT
ZA200605624B (en) * 2004-01-12 2007-11-28 Applied Research Systems Thiazole derivatives and use thereof
GB0402809D0 (en) * 2004-02-09 2004-03-10 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
CN101208328B (zh) 2012-02-29
EP1899321A1 (en) 2008-03-19
UY29640A1 (es) 2007-01-31
RU2412181C2 (ru) 2011-02-20
DK1899321T3 (da) 2012-04-16
JP2008543958A (ja) 2008-12-04
MX2008000044A (es) 2008-03-19
CN101208328A (zh) 2008-06-25
WO2007000246A1 (en) 2007-01-04
AU2006264049A1 (en) 2007-01-04
GT200600274A (es) 2007-02-05
PE20070102A1 (es) 2007-03-02
ZA200710002B (en) 2008-11-26
ES2378894T3 (es) 2012-04-18
RU2008102966A (ru) 2009-08-10
IL188382A0 (en) 2008-04-13
US8518976B2 (en) 2013-08-27
HRP20120167T1 (hr) 2012-03-31
JP5149794B2 (ja) 2013-02-20
PL1899321T3 (pl) 2012-05-31
NZ565041A (en) 2011-03-31
RS52266B (en) 2012-10-31
CA2611953A1 (en) 2007-01-04
MA29552B1 (fr) 2008-06-02
KR20080027801A (ko) 2008-03-28
EP1899321B1 (en) 2011-12-28
SI1899321T1 (sl) 2012-04-30
PA8683901A1 (es) 2007-01-17
US20080171739A1 (en) 2008-07-17
NO20080523L (no) 2008-01-28
TW200738673A (en) 2007-10-16
TWI378095B (en) 2012-12-01
AU2006264049B2 (en) 2012-04-12
EP1741709A1 (en) 2007-01-10
HK1122551A1 (en) 2009-05-22
PT1899321E (pt) 2012-03-19
BRPI0613717A2 (pt) 2011-02-08
CY1112869T1 (el) 2016-04-13
ATE539072T1 (de) 2012-01-15
DOP2006000146A (es) 2006-12-31

Similar Documents

Publication Publication Date Title
PE20210128A1 (es) Inhibidores de la ectonucleotido pirofosfatasa-fosfodiesterasa 1 (enpp-1) y usos de los mismos
AR058769A1 (es) Inhibidores de peptidil-deformilasa(pdf),utiles para el tratamiento de la tuberculosis y composiciones farmaceuticas que los contienen.
PE20140302A1 (es) Inhibidores del virus de la hepatitis c
ES2515194T3 (es) Derivados de pirrolidina
UY29703A1 (es) "inhibidores macrocíclicos del virus de la hepatitis c"
AR059961A1 (es) Compuesto derivado de fenil tetrahidro-indazol, composiciones farmaceuticas que lo comprenden, usos para preparar un medicamento para el tratamiento de una enfermedad mediada por una reduccion o desequilibrio en la funcion del receptor de glutamato y procesos para su preparacion
AR045387A1 (es) Compuestos bencimidazolil n-sustituidos inhibidores de c-kit; composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de un trastorno proliferativo
AR056893A1 (es) Compuestos heterociclicos fusionados y no fusionados, antagonistas de receptores mineralocorticoides
CR9459A (es) Derivados benzodioxano y benzodioxolano y usos de los mismos
AR056347A1 (es) Uso de compuestos de pteridina para fabricar medicamentos y composiciones farmaceuticas
UY29705A1 (es) " inhibidores macrocíclicos del virus de la hepatitis c"
AR064197A1 (es) Derivados de pirimidina y piridina inhibidores de la proteina quinasa
AR075022A1 (es) Derivados oxadiazole como agonistas de los receptores de esfingosina-1-fosfato (s1p1)
PA8603801A1 (es) Derivados de la quinazolina
ES2531256T3 (es) Amidas fungicidas
AR054800A1 (es) Amidas sustituidas con heteroarilo que comprenden un grupo enlazador saturado, y su uso como agentes farmaceuticos
ECSP067013A (es) 2-quinolil-oxazoles sustituidos útiles como inhibidores de pde4
AR079541A1 (es) Compuestos sustituidos de n-(1h-indazol-4-il) imidazo (1,2-a) piridin-3-carboxamida como inhibidores de cfms
PA8607001A1 (es) Derivados de triazolopirimidinas como inhibidores de la glucogeno sintasa quinasa 3
PE20080197A1 (es) Combinaciones que involucran el (los) inhibidor (es) de la proteasa del hcv, y metodos de tratamiento relacionado al (los) mismos(s)
RU2010102229A (ru) Производные бензазепина, пригодные для использования в качестве антагонистов вазопрессина
AR043059A1 (es) Derivados de indolil pirazinona utiles para el tratamiento de trastornos hiper-proliferativos
AR066583A1 (es) Derivados de 3,3-espiroindolinona
PE20151413A1 (es) Inhibidores de bmi-1 de pirimidina inversa sustituida
AR099498A1 (es) Compuestos de triazina y su uso farmacéutico

Legal Events

Date Code Title Description
FA Abandonment or withdrawal