AR050847A1 - Biotransformacion enantioselectiva para la prpeparacion de intermedios de inhibidores de la proteina tirosina quinasa - Google Patents

Biotransformacion enantioselectiva para la prpeparacion de intermedios de inhibidores de la proteina tirosina quinasa

Info

Publication number
AR050847A1
AR050847A1 ARP050103532A ARP050103532A AR050847A1 AR 050847 A1 AR050847 A1 AR 050847A1 AR P050103532 A ARP050103532 A AR P050103532A AR P050103532 A ARP050103532 A AR P050103532A AR 050847 A1 AR050847 A1 AR 050847A1
Authority
AR
Argentina
Prior art keywords
dichloro
prpeparation
enantioselective
biotransformation
intermediates
Prior art date
Application number
ARP050103532A
Other languages
English (en)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of AR050847A1 publication Critical patent/AR050847A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente se refiere a procedimientos biocatalíticos para preparar estereoisomeros enantioméricamente puros de 1-(2,6-dicloro-3-fluorfenil)etanol. Se describen procedimientos de preparacion el enantiomero (S) deseado, dichos procedimientos basándose en una combinacion de resolucion enzimática, esterificacion química e hidrolisis química con inversion de ésteres 1-(2,6-dicloro-3-fluorofenil)etanolicos o bio- reduccion estereoselectiva de 2,6-dicloro-3-fluoroacetofenona con un biocatalizador tal como una enzima o microorganismo. El enantiomero (S) quiral se puede usar en la síntesis de ciertos compuestos 2-aminopiridina unidos a éter enantioméricamente enriquecidos que inhiben potentemente la autofosforilacion de receptor de factor de crecimiento de hepatocitos humanos.
ARP050103532A 2004-08-26 2005-08-23 Biotransformacion enantioselectiva para la prpeparacion de intermedios de inhibidores de la proteina tirosina quinasa AR050847A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60511804P 2004-08-26 2004-08-26

Publications (1)

Publication Number Publication Date
AR050847A1 true AR050847A1 (es) 2006-11-29

Family

ID=35395953

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050103532A AR050847A1 (es) 2004-08-26 2005-08-23 Biotransformacion enantioselectiva para la prpeparacion de intermedios de inhibidores de la proteina tirosina quinasa

Country Status (16)

Country Link
US (1) US7465842B2 (es)
EP (1) EP1791965A1 (es)
JP (1) JP2008510791A (es)
KR (2) KR20080072105A (es)
CN (1) CN101027404A (es)
AR (1) AR050847A1 (es)
AU (1) AU2005276136A1 (es)
BR (1) BRPI0514422A (es)
CA (1) CA2578298A1 (es)
IL (1) IL181287A0 (es)
MX (1) MX2007002247A (es)
NO (1) NO20071298L (es)
RU (1) RU2007106863A (es)
TW (1) TW200621991A (es)
WO (1) WO2006021885A1 (es)
ZA (1) ZA200700922B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2341351T3 (es) * 2004-08-26 2010-06-18 Pfizer, Inc. Compuestos de aminoheteroarilo enantiomericamente puros como inhibidores de proteina cinasas.
ATE438729T1 (de) 2006-04-21 2009-08-15 Basf Se Verfahren zur racemisierung optisch aktiver sekundärer alkohole unter verwendung von alkoholdehydrogenasen
MX2009006266A (es) * 2006-12-13 2009-06-22 Pfizer Prod Inc Procedimientos de preparacion de 3-(4-(2,4-difluorobenciloxi)-3-br omo-6-metil-2-oxopiridin-1 (2h)-il)-n,4-dimetilbenzamida.
US8748143B2 (en) 2007-09-13 2014-06-10 Codexis, Inc. Ketoreductase polypeptides for the reduction of acetophenones
CN102925498A (zh) * 2012-11-17 2013-02-13 苏州卡耐博生物技术有限公司 一种（r）1-（2，6-二氯-3-氟-苯基）乙醇的制备方法
JP6291179B2 (ja) * 2013-07-26 2018-03-14 関東化學株式会社 光学活性２級アルコールの製造方法
CN104313064A (zh) * 2014-10-01 2015-01-28 青岛科技大学 一种细胞法生产手性溴苯基丙酸甲酯的方法
CN104328153A (zh) * 2014-10-13 2015-02-04 青岛科技大学 一种细胞法生产手性烯醇的方法
US10544434B2 (en) * 2015-06-29 2020-01-28 Noramco, Inc. Process for the preparation of lisdexamfetamine and related derivatives
LT3393655T (lt) * 2015-12-22 2021-03-25 Zogenix International Limited Fenfluramino kompozicijos ir jų paruošimo būdai
CN105906656B (zh) * 2016-05-17 2018-01-23 凯莱英医药集团（天津）股份有限公司 一种克唑替尼中间体的合成方法
CN109486896A (zh) * 2018-12-04 2019-03-19 南京工业大学 一种催化拆分制备异甘草酸的方法
CN110184245B (zh) * 2019-05-23 2023-09-05 安徽趣酶生物科技有限公司 酮还原酶突变体及其在制备克唑替尼手性醇中间体及其类似物中的应用
CN112301008A (zh) * 2019-07-24 2021-02-02 中国医学科学院药物研究所 一种醛还原酶的氨基酸序列及其应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3942872A1 (de) 1989-12-23 1991-06-27 Hoechst Ag Verfahren zur enantioselektiven darstellung von ((omega)-1)-hydroxyalkylxanthinen
US6703396B1 (en) 1990-02-01 2004-03-09 Emory University Method of resolution and antiviral activity of 1,3-oxathiolane nuclesoside enantiomers
WO1992014835A1 (en) * 1991-02-19 1992-09-03 Daicel Chemical Industries, Ltd. Process for producing optically active 3-chloro-1-phenyl-1-propanol and derivative thereof
CA2103932A1 (en) 1992-11-05 1994-05-06 Ramesh N. Patel Stereoselective reduction of ketones
DE69914458T2 (de) 1998-02-17 2004-10-28 G.D. Searle & Co., Chicago Verfahren zur enzymatischen auflösung von laktamen
US5928933A (en) 1998-06-26 1999-07-27 E. I. Du Pont De Nemours & Company Process for the enzymatic resolution of N-(alkoxycarbonyl)-4-ketoproline alkyl esters or N-(alkoxycarbonyl)-4-hydroxyproline alkyl esters using Candida antarctica lipase B
US6515134B1 (en) 1999-02-16 2003-02-04 Kaneka Corporation Substituted acetylpridine derivatives and process for the preparation of intermediates for optically active beta-3 agonist by the use of the same
US6451587B1 (en) 1999-09-29 2002-09-17 Pfizer Inc. Microbial asymmetric reduction of 2-chloro-1-[-6-(2,5-dimethyl-pyrrol-1-yl)-pyridin-3-yl]-ethanone
WO2002077258A1 (en) * 2001-03-22 2002-10-03 Bristol-Myers Squibb Company Stereoselective reduction of substituted acetophenone
JP4426437B2 (ja) 2002-04-30 2010-03-03 株式会社カネカ 新規カルボニル還元酵素、その遺伝子、およびその利用法
DK1603570T5 (da) 2003-02-26 2013-12-09 Sugen Inc Aminoheteroarylforbindelser som proteinkinaseinhibitorer

Also Published As

Publication number Publication date
TW200621991A (en) 2006-07-01
WO2006021885A1 (en) 2006-03-02
IL181287A0 (en) 2007-07-04
US7465842B2 (en) 2008-12-16
NO20071298L (no) 2007-05-29
KR20070038571A (ko) 2007-04-10
KR20080072105A (ko) 2008-08-05
JP2008510791A (ja) 2008-04-10
BRPI0514422A (pt) 2008-06-10
AU2005276136A1 (en) 2006-03-02
US20060046287A1 (en) 2006-03-02
ZA200700922B (en) 2008-08-27
RU2007106863A (ru) 2008-08-27
CA2578298A1 (en) 2006-03-02
CN101027404A (zh) 2007-08-29
MX2007002247A (es) 2007-04-20
EP1791965A1 (en) 2007-06-06

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