WO2009124966A3 - Conversion of stilbenoids - Google Patents

Conversion of stilbenoids Download PDF

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Publication number
WO2009124966A3
WO2009124966A3 PCT/EP2009/054217 EP2009054217W WO2009124966A3 WO 2009124966 A3 WO2009124966 A3 WO 2009124966A3 EP 2009054217 W EP2009054217 W EP 2009054217W WO 2009124966 A3 WO2009124966 A3 WO 2009124966A3
Authority
WO
WIPO (PCT)
Prior art keywords
stilbenoid
producing
substrate
group
stilbenoids
Prior art date
Application number
PCT/EP2009/054217
Other languages
French (fr)
Other versions
WO2009124966A2 (en
Inventor
Michael Katz
Thomas Thomasen Durhuus
Original Assignee
Fluxome Sciences A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fluxome Sciences A/S filed Critical Fluxome Sciences A/S
Publication of WO2009124966A2 publication Critical patent/WO2009124966A2/en
Publication of WO2009124966A3 publication Critical patent/WO2009124966A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A method for producing a target stilbenoid having the general formula (1) wherein each R group is -H or -OH provided that at least one -OH R group is produced by supplying to or producing in a micro-organism a substrate stilbenoid in which at least one of R group is -H and producing in said micro-organism an enzyme capable of hydroxylating said substrate stilbenoid to produce therefrom a said target stilbenoid having one or more -OH R groups more that the substrate stilbenoid.
PCT/EP2009/054217 2008-04-11 2009-04-08 Conversion of stilbenoids WO2009124966A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0806592.2 2008-04-11
GB0806592A GB0806592D0 (en) 2008-04-11 2008-04-11 Conversion of stilbenoids

Publications (2)

Publication Number Publication Date
WO2009124966A2 WO2009124966A2 (en) 2009-10-15
WO2009124966A3 true WO2009124966A3 (en) 2009-12-03

Family

ID=39433476

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2009/054217 WO2009124966A2 (en) 2008-04-11 2009-04-08 Conversion of stilbenoids

Country Status (2)

Country Link
GB (1) GB0806592D0 (en)
WO (1) WO2009124966A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0503657D0 (en) 2005-02-22 2005-03-30 Fluxome Sciences As Metabolically engineered cells for the production of resveratrol or an oligomeric or glycosidically-bound derivative thereof
GB0614442D0 (en) 2006-07-20 2006-08-30 Fluxome Sciences As Metabolically engineered cells for the production of pinosylvin
CN102220350B (en) * 2010-04-15 2012-09-19 上海科爱生物技术有限公司 Method for expressing resveratrol stilbene synthase and preparing resveratrol by utilizing insect system
GB201008826D0 (en) 2010-05-26 2010-07-14 Fluxome Sciences As Production of metabolites
CN106102454B (en) * 2013-11-01 2020-07-31 康纳根有限公司 Method for biosynthetic production of pterostilbene using O-methyltransferase
CN104611354B (en) * 2015-02-05 2017-09-05 北京农学院 Fusion protein Nt4CL5aPcSTS relevant biological material and its application
US10294499B2 (en) 2015-05-28 2019-05-21 Evolva Sa Biosynthesis of phenylpropanoids and phenylpropanoid derivatives

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006089898A1 (en) * 2005-02-22 2006-08-31 Fluxome Sciences A/S Metabolically engineered cells for the production of resveratrol or an oligomeric or glycosidically-bound derivative thereof
WO2008009728A1 (en) * 2006-07-20 2008-01-24 Fluxome Sciences A/S Metabolically engineered cells for the production of pinosylvin

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006089898A1 (en) * 2005-02-22 2006-08-31 Fluxome Sciences A/S Metabolically engineered cells for the production of resveratrol or an oligomeric or glycosidically-bound derivative thereof
WO2008009728A1 (en) * 2006-07-20 2008-01-24 Fluxome Sciences A/S Metabolically engineered cells for the production of pinosylvin

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
LI D N ET AL: "POLYMORPHISMS IN P450 CYP1B1 AFFECT THE CONVERSION OF ESTRADIOL TO THE POTENTIALLY CARCINOGENIC METABOLITE 4-HYDROXYESTRADIOL", PHARMACOGENETICS, CHAPMAN & HALL, LONDON, GB, vol. 10, no. 4, 1 January 2000 (2000-01-01), pages 343 - 353, XP008076763, ISSN: 0960-314X *
POTTER G A ET AL: "The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1", BRITISH JOURNAL OF CANCER, vol. 86, no. 5, 4 March 2002 (2002-03-04), pages 774 - 778, XP002546858, ISSN: 0007-0920 *
PURNAPATRE ET AL: "Cytochrome P450s in the development of target-based anticancer drugs", CANCER LETTERS, NEW YORK, NY, US, vol. 259, no. 1, 28 November 2007 (2007-11-28), pages 1 - 15, XP022385469, ISSN: 0304-3835 *
SANOH SEIGO ET AL: "Cytochrome P450 1A1/2 mediated metabolism of trans-stilbene in rats and humans", BIOLOGICAL AND PHARMACEUTICAL BULLETIN, vol. 25, no. 3, March 2002 (2002-03-01), pages 397 - 400, XP002546859, ISSN: 0918-6158 *
TYAGI A K ET AL: "Recombinant Bacillus subtilis Whole Cell System as a Catalyst for Enzymatic Synthesis of Cyclic Inositol Phosphate", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, vol. 39, no. 33, 13 August 1998 (1998-08-13), pages 6069 - 6072, XP004126801, ISSN: 0040-4039 *
WATTS KEVIN T ET AL: "Biosynthesis of plant-specific stilbene polyketides in metabolically engineered Escherichia coli", BMC BIOTECHNOLOGY, BIOMED CENTRAL LTD. LONDON, GB, vol. 6, no. 1, 21 March 2006 (2006-03-21), pages 22 - 33, XP021017048, ISSN: 1472-6750 *

Also Published As

Publication number Publication date
WO2009124966A2 (en) 2009-10-15
GB0806592D0 (en) 2008-05-14

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