AR049292A1 - Metodo para tratar lupus con un anticuerpo cd20 - Google Patents
Metodo para tratar lupus con un anticuerpo cd20Info
- Publication number
- AR049292A1 AR049292A1 ARP050102269A ARP050102269A AR049292A1 AR 049292 A1 AR049292 A1 AR 049292A1 AR P050102269 A ARP050102269 A AR P050102269A AR P050102269 A ARP050102269 A AR P050102269A AR 049292 A1 AR049292 A1 AR 049292A1
- Authority
- AR
- Argentina
- Prior art keywords
- antibody
- exposure
- medicament
- subject
- agent
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 7
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 title abstract 4
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 title abstract 4
- 206010025135 lupus erythematosus Diseases 0.000 title abstract 3
- 229940127089 cytotoxic agent Drugs 0.000 abstract 4
- 239000003814 drug Substances 0.000 abstract 4
- 229940123038 Integrin antagonist Drugs 0.000 abstract 2
- 239000002246 antineoplastic agent Substances 0.000 abstract 2
- 239000000430 cytokine receptor antagonist Substances 0.000 abstract 2
- 239000002254 cytotoxic agent Substances 0.000 abstract 2
- 231100000599 cytotoxic agent Toxicity 0.000 abstract 2
- 239000005556 hormone Substances 0.000 abstract 2
- 229940088597 hormone Drugs 0.000 abstract 2
- 229940125721 immunosuppressive agent Drugs 0.000 abstract 2
- 239000003018 immunosuppressive agent Substances 0.000 abstract 2
- GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 abstract 2
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 abstract 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 abstract 1
- LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 abstract 1
- 229960002170 azathioprine Drugs 0.000 abstract 1
- 239000003246 corticosteroid Substances 0.000 abstract 1
- 229960004397 cyclophosphamide Drugs 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229960001428 mercaptopurine Drugs 0.000 abstract 1
- 229960000485 methotrexate Drugs 0.000 abstract 1
- RTGDFNSFWBGLEC-SYZQJQIISA-N mycophenolate mofetil Chemical compound COC1=C(C)C=2COC(=O)C=2C(O)=C1C\C=C(/C)CCC(=O)OCCN1CCOCC1 RTGDFNSFWBGLEC-SYZQJQIISA-N 0.000 abstract 1
- 229960004866 mycophenolate mofetil Drugs 0.000 abstract 1
- 229960004641 rituximab Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57723504P | 2004-06-04 | 2004-06-04 | |
| US61799704P | 2004-10-11 | 2004-10-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR049292A1 true AR049292A1 (es) | 2006-07-12 |
Family
ID=35503635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050102269A AR049292A1 (es) | 2004-06-04 | 2005-06-02 | Metodo para tratar lupus con un anticuerpo cd20 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US20060024295A1 (enExample) |
| EP (1) | EP1765400A2 (enExample) |
| JP (1) | JP2008501706A (enExample) |
| AR (1) | AR049292A1 (enExample) |
| AU (1) | AU2005251764A1 (enExample) |
| BR (1) | BRPI0510885A (enExample) |
| CA (1) | CA2568336A1 (enExample) |
| DO (1) | DOP2005000108A (enExample) |
| IL (1) | IL179325A0 (enExample) |
| MX (1) | MXPA06014067A (enExample) |
| PA (1) | PA8635501A1 (enExample) |
| PE (1) | PE20060688A1 (enExample) |
| RU (1) | RU2396980C2 (enExample) |
| SV (1) | SV2006002131A (enExample) |
| TW (1) | TW200608994A (enExample) |
| WO (1) | WO2005120437A2 (enExample) |
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| KR20020027311A (ko) * | 1999-05-07 | 2002-04-13 | 제넨테크, 인크. | B 세포 표면 마커에 결합하는 길항물질을 이용한자가면역 질환의 치료 |
| JP2004508420A (ja) * | 2000-09-18 | 2004-03-18 | アイデック ファーマスーティカルズ コーポレイション | B細胞枯渇抗体/免疫調節性抗体の組合せを用いて自己免疫疾患を治療するための併用療法 |
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| BRPI0416262B1 (pt) * | 2003-11-05 | 2022-04-12 | Roche Glycart Ag | Anticorpo anti-cd20 humano tipo ii humanizado, seu método de produção, seus usos, bem como polinucleotídeo isolado, vetor de expressão e composição farmacêutica |
| JP2008526998A (ja) * | 2005-01-13 | 2008-07-24 | ジェネンテック・インコーポレーテッド | 治療方法 |
| DK2332408T3 (da) | 2005-02-17 | 2013-12-02 | Biogen Idec Inc | Behandling af neurologiske sygdomme |
| PL1874818T3 (pl) | 2005-04-22 | 2011-09-30 | Lilly Co Eli | Przeciwciała swoiste wobec TGF-beta 1 |
| WO2006138219A2 (en) | 2005-06-13 | 2006-12-28 | Biogen Idec Ma Inc. | Methods of diagnosis / prognosis of inflammatory conditions |
| SI1912675T1 (sl) | 2005-07-25 | 2014-07-31 | Emergent Product Development Seattle, Llc | zmanjšanje števila celic B z uporabo molekul, ki se specifično vežejo na CD37 in CD20 |
| US20080279848A1 (en) * | 2006-03-16 | 2008-11-13 | Genentech, Inc. | Methods of treating lupus using CD4 antibodies |
| BRPI0708902A2 (pt) * | 2006-03-16 | 2011-06-14 | Genentech Inc | mÉtodos de tratar lupus usando anticorpos cd4 |
| US9683026B2 (en) | 2006-07-19 | 2017-06-20 | The Trustees Of The University Of Pennslyvania | WSX-1/P28 as a target for anti-inflammatory responses |
| AU2008282152B2 (en) * | 2007-07-31 | 2013-12-19 | Regeneron Pharmaceuticals, Inc. | Human antibodies to human CD20 and method of using thereof |
| DE102007057513B4 (de) | 2007-11-29 | 2016-08-04 | BSH Hausgeräte GmbH | Haushaltsgerät, insbesondere Geschirrspülmaschine |
| SG189772A1 (en) | 2008-04-11 | 2013-05-31 | Trubion Pharmaceuticals Inc | Cd37 immunotherapeutic and combination with bifunctional chemotherapeutic thereof |
| US20100021460A1 (en) * | 2008-07-15 | 2010-01-28 | Genentech, Inc. | Methods of Treating Autoimmune Diseases Using CD4 Antibodies |
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| MX2012002766A (es) | 2009-09-03 | 2012-04-02 | Genentech Inc | Metodos para el tratamiento, diagnosis y monitoreo de artritis reumatoide. |
| AR078161A1 (es) | 2009-09-11 | 2011-10-19 | Hoffmann La Roche | Formulaciones farmaceuticas muy concentradas de un anticuerpo anti cd20. uso de la formulacion. metodo de tratamiento. |
| WO2011100403A1 (en) | 2010-02-10 | 2011-08-18 | Immunogen, Inc | Cd20 antibodies and uses thereof |
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| CA2827859A1 (en) | 2011-02-28 | 2012-09-07 | Genentech, Inc. | Biological markers and methods for predicting response to b-cell antagonists |
| SG195072A1 (en) | 2011-05-21 | 2013-12-30 | Macrogenics Inc | Cd3-binding molecules capable of binding to human and non-human cd3 |
| JOP20200236A1 (ar) | 2012-09-21 | 2017-06-16 | Regeneron Pharma | الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها |
| WO2015051234A2 (en) * | 2013-10-04 | 2015-04-09 | Biogen Idec Ma Inc. | Tweak antagonists for treating lupus nephritis and muscle atrophy |
| TWI754319B (zh) | 2014-03-19 | 2022-02-01 | 美商再生元醫藥公司 | 用於腫瘤治療之方法及抗體組成物 |
| EP3699198B1 (en) | 2014-11-17 | 2025-03-26 | Regeneron Pharmaceuticals, Inc. | Methods for tumor treatment using cd3xcd20 bispecific antibody |
| AR104368A1 (es) | 2015-04-03 | 2017-07-19 | Lilly Co Eli | Anticuerpos biespecíficos anti-cd20- / anti-baff |
| EP4450524A3 (en) * | 2015-05-11 | 2025-05-14 | F. Hoffmann-La Roche AG | Compositions and methods of treating lupus nephritis |
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| BR112018010766A8 (pt) | 2015-11-27 | 2019-02-26 | Csl Ltd | proteínas de ligação ao cd131 e usos das mesmas |
| DK3844189T3 (da) | 2018-08-31 | 2025-02-24 | Regeneron Pharma | Doseringsstrategi, der mindsker cytokinfrigivelsessyndrom for CD3/CD20-bispecifikke antistoffer |
| CN109406775A (zh) * | 2018-10-12 | 2019-03-01 | 东莞市暨科生物科技有限公司 | 自身免疫性疾病患者免疫功能评估试剂盒及评估方法 |
| KR20220062304A (ko) * | 2019-09-12 | 2022-05-16 | 제넨테크, 인크. | 루푸스 신장염을 치료하는 조성물과 방법 |
| US12122839B2 (en) | 2020-08-05 | 2024-10-22 | Synthekine, Inc. | IFNGR binding synthetic cytokines and methods of use |
| US12291572B2 (en) | 2020-08-05 | 2025-05-06 | Synthekine, Inc. | IL12 receptor synthetic cytokines and methods of use |
| US12077594B2 (en) | 2020-08-05 | 2024-09-03 | Synthekine, Inc. | IL2RG binding molecules and methods of use |
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| CN116829585A (zh) | 2020-08-05 | 2023-09-29 | 辛德凯因股份有限公司 | Il27受体结合相关的组合物和方法 |
| WO2022031885A2 (en) | 2020-08-05 | 2022-02-10 | Synthekine, Inc. | Il10ra binding molecules and methods of use |
| US11859001B2 (en) | 2020-08-05 | 2024-01-02 | Synthekine, Inc. | IL12RB1-Binding molecules and methods of use |
| CN117242088A (zh) | 2020-08-05 | 2023-12-15 | 辛德凯因股份有限公司 | Il10受体结合分子和使用方法 |
| WO2022032023A2 (en) | 2020-08-05 | 2022-02-10 | Synthekine, Inc. | Il23r binding molecules and methods of use |
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| JP2024504923A (ja) * | 2021-01-11 | 2024-02-02 | シンセカイン インコーポレイテッド | 受容体ペア形成に関する組成物および方法 |
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-
2005
- 2005-06-02 DO DO2005000108A patent/DOP2005000108A/es unknown
- 2005-06-02 BR BRPI0510885-3A patent/BRPI0510885A/pt not_active IP Right Cessation
- 2005-06-02 TW TW094118187A patent/TW200608994A/zh unknown
- 2005-06-02 EP EP05786559A patent/EP1765400A2/en not_active Withdrawn
- 2005-06-02 CA CA002568336A patent/CA2568336A1/en not_active Abandoned
- 2005-06-02 RU RU2006146927/14A patent/RU2396980C2/ru not_active IP Right Cessation
- 2005-06-02 JP JP2007515612A patent/JP2008501706A/ja active Pending
- 2005-06-02 US US11/143,077 patent/US20060024295A1/en not_active Abandoned
- 2005-06-02 SV SV2005002131A patent/SV2006002131A/es unknown
- 2005-06-02 AU AU2005251764A patent/AU2005251764A1/en not_active Abandoned
- 2005-06-02 WO PCT/US2005/019550 patent/WO2005120437A2/en not_active Ceased
- 2005-06-02 PA PA20058635501A patent/PA8635501A1/es unknown
- 2005-06-02 AR ARP050102269A patent/AR049292A1/es not_active Application Discontinuation
- 2005-06-02 MX MXPA06014067A patent/MXPA06014067A/es not_active Application Discontinuation
- 2005-08-17 PE PE2005000625A patent/PE20060688A1/es not_active Application Discontinuation
-
2006
- 2006-09-28 US US11/536,580 patent/US20070025988A1/en not_active Abandoned
- 2006-11-16 IL IL179325A patent/IL179325A0/en unknown
-
2010
- 2010-07-23 US US12/842,529 patent/US20100303810A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| RU2006146927A (ru) | 2008-08-10 |
| JP2008501706A (ja) | 2008-01-24 |
| US20070025988A1 (en) | 2007-02-01 |
| SV2006002131A (es) | 2006-01-26 |
| WO2005120437A2 (en) | 2005-12-22 |
| AU2005251764A1 (en) | 2005-12-22 |
| TW200608994A (en) | 2006-03-16 |
| PE20060688A1 (es) | 2006-09-23 |
| EP1765400A2 (en) | 2007-03-28 |
| US20100303810A1 (en) | 2010-12-02 |
| BRPI0510885A (pt) | 2007-12-26 |
| CA2568336A1 (en) | 2005-12-22 |
| DOP2005000108A (es) | 2007-06-15 |
| WO2005120437A3 (en) | 2006-06-29 |
| PA8635501A1 (es) | 2006-06-02 |
| MXPA06014067A (es) | 2007-02-15 |
| RU2396980C2 (ru) | 2010-08-20 |
| IL179325A0 (en) | 2007-03-08 |
| US20060024295A1 (en) | 2006-02-02 |
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