AR043997A1 - Compuestos de isoquinolina, un procedimiento para su preparacion y composiciones farmaceuticas que los contienen - Google Patents
Compuestos de isoquinolina, un procedimiento para su preparacion y composiciones farmaceuticas que los contienenInfo
- Publication number
- AR043997A1 AR043997A1 ARP040101179A ARP040101179A AR043997A1 AR 043997 A1 AR043997 A1 AR 043997A1 AR P040101179 A ARP040101179 A AR P040101179A AR P040101179 A ARP040101179 A AR P040101179A AR 043997 A1 AR043997 A1 AR 043997A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- branched
- linear
- alkyl
- disorders
- Prior art date
Links
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical class C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 10
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000003545 alkoxy group Chemical group 0.000 abstract 5
- 125000001072 heteroaryl group Chemical group 0.000 abstract 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- 208000035475 disorder Diseases 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 238000004519 manufacturing process Methods 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical compound C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 abstract 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 abstract 2
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 206010022437 insomnia Diseases 0.000 abstract 2
- -1 nitro, cyano, hydroxymethyl Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000006621 (C3-C8) cycloalkyl-(C1-C6) alkyl group Chemical group 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 208000000044 Amnesia Diseases 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000027559 Appetite disease Diseases 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
- 208000026139 Memory disease Diseases 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 206010033664 Panic attack Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 206010039966 Senile dementia Diseases 0.000 abstract 1
- 201000001880 Sexual dysfunction Diseases 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000032683 aging Effects 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 125000003435 aroyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- RFRXIWQYSOIBDI-UHFFFAOYSA-N benzarone Chemical compound CCC=1OC2=CC=CC=C2C=1C(=O)C1=CC=C(O)C=C1 RFRXIWQYSOIBDI-UHFFFAOYSA-N 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- VZWXIQHBIQLMPN-UHFFFAOYSA-N chromane Chemical compound C1=CC=C2CCCOC2=C1 VZWXIQHBIQLMPN-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 210000002249 digestive system Anatomy 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- MTNDZQHUAFNZQY-UHFFFAOYSA-N imidazoline Chemical compound C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 abstract 1
- 239000002955 immunomodulating agent Substances 0.000 abstract 1
- 229940121354 immunomodulator Drugs 0.000 abstract 1
- 230000002584 immunomodulator Effects 0.000 abstract 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 abstract 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000001193 melatoninergic effect Effects 0.000 abstract 1
- 230000006984 memory degeneration Effects 0.000 abstract 1
- 208000023060 memory loss Diseases 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 230000016087 ovulation Effects 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 208000019906 panic disease Diseases 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000168 pyrrolyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 208000012672 seasonal affective disease Diseases 0.000 abstract 1
- 231100000872 sexual dysfunction Toxicity 0.000 abstract 1
- 208000019116 sleep disease Diseases 0.000 abstract 1
- 230000035882 stress Effects 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 229930192474 thiophene Natural products 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A45—HAND OR TRAVELLING ARTICLES
- A45F—TRAVELLING OR CAMP EQUIPMENT: SACKS OR PACKS CARRIED ON THE BODY
- A45F5/00—Holders or carriers for hand articles; Holders or carriers for use while travelling or camping
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P15/18—Feminine contraceptives
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- A—HUMAN NECESSITIES
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- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16B—DEVICES FOR FASTENING OR SECURING CONSTRUCTIONAL ELEMENTS OR MACHINE PARTS TOGETHER, e.g. NAILS, BOLTS, CIRCLIPS, CLAMPS, CLIPS OR WEDGES; JOINTS OR JOINTING
- F16B45/00—Hooks; Eyes
- F16B45/02—Hooks with pivoting or elastically bending closing member
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- A—HUMAN NECESSITIES
- A45—HAND OR TRAVELLING ARTICLES
- A45F—TRAVELLING OR CAMP EQUIPMENT: SACKS OR PACKS CARRIED ON THE BODY
- A45F5/00—Holders or carriers for hand articles; Holders or carriers for use while travelling or camping
- A45F2005/006—Holders or carriers for hand articles; Holders or carriers for use while travelling or camping comprising a suspension strap or lanyard
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- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- General Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Nutrition Science (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Mechanical Engineering (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Child & Adolescent Psychology (AREA)
Abstract
Reivindicación 1: Compuesto de fórmula (1), caracterizado porque: n es 1, 2 ó 3; A representa un grupo de fórmula (2), o grupo de fórmula (3); Z representa un átomo de azufre o un átomo de oxígeno; cada uno de R y R'', que pueden ser idénticos o diferentes, representa un átomo de hidrógeno o un grupo alquilo (C1-6) lineal o ramificado; y R' representa un grupo alquilo (C1-6) lineal o ramificado, un grupo alquenilo (C2-6) lineal o ramificado, un grupo alquinilo (C2-6) lineal o ramificado, un grupo cicloalquilo (C3-8), un grupo cicloalquilo(C3-8)-alquilo(C1-6) donde la parte alquilo es lineal o ramificada, un grupo arilo, un grupo arilo-alquilo(C1-6) donde la parte alquilo es lineal o ramificada, un grupo heteroarilo o un grupo heteroarilo alquilo(C1-6) donde la parte alquilo es lineal o ramificada; X representa un átomo de nitrógeno o un grupo N-R1 donde R1 representa un átomo de hidrógeno o un grupo alquilo (C1-6) lineal o ramificado, un grupo cicloalquilo (C3-8), un grupo ciclo(C3-8)-alquil-alquilo(C1-6) donde la parte alquilo es lineal o ramificada, un grupo arilo, un grupo aroilo, un grupo arilo-alquilo(C1-6) donde la parte alquilo es lineal o ramificada, un grupo heteroarilo, un grupo heteroarilo o un grupo heteroaril-alquilo(C1-6) donde la parte alquilo es lineal o ramificada; R2 representa un grupo alcoxi (C1-6) lineal o ramificada, un grupo cicloalquiloxi (C3-8) o cicloalquil(C3-8)-alquiloxi(C1-6) donde la parte alquiloxi es lineal o ramificada; la línea de puntos denota que el enlace es simple o doble, proveyéndose que la valencia de los átomos de respeta, donde: se entenderá que "arilo" se refiere a un grupo fenilo o naftilo, estos grupos están insustituidos o sustituidos por entre uno y tres grupos idénticos o diferentes seleccionados entre alquilo (C1-6) lineal o ramificado, alcoxi (C1-6) lineal o ramificado, OH, COHH, alcoxicarbonilo donde la parte alcoxi es lineal o ramificada, formilo, nitro, ciano, hidroximetilo, amino (opcionalmente sustituido por uno o dos grupos alquilo (C1-6) lineales o ramificada) y átomos de halógeno; se entenderá que "heteroarilo" se refiere a cualquier grupo mono- o bicíclico que contiene entre 5 y 10 miembros de anillo y puede contener entre 1 y 3 heteroátomos seleccionados entre oxígeno, azufre y nitrógeno, como ser los grupos furano, tiofeno, pirrol, imidazolina, piridina, quinolina, isoquinolina, cromano, indol, benzotiofeno o benzofurano, pudiendo estar estos grupos parcialmente hidrogenados, insustituidos o sustituidos por uno a tres grupos idénticos o diferentes seleccionados entre alquilo (C1-6) lineal o ramificado, alcoxi (C1-6) lineal o ramificado, OH, COOH, alcoxicarbonilo donde la parte alcoxi es lineal o ramificada, formilo, nitro, ciano, amino (opcionalmente sustituido por uno o dos grupos alquilo (C1-6) lineales o ramificados), hidroximetilo y átomos de halógeno, sus enantiómeros y diastereoisómeros y también a sus sales de adición con un ácido o base farmacéuticamente aceptable. Reivindicación 17: Composiciones farmacéuticas de acuerdo con la reivindicación 16, para usar en la fabricación de medicamentos para tratar desórdenes del sistema melatoninérgico Reivindicación 18: Composiciones farmacéuticas de acuerdo con la reivindicación 16, para usar en la fabricación en la fabricación de medicamentos para el tratamiento de desórdenes del sueno, stress, ansiedad, desórdenes afectivos estacionales o depresión grave, patologías cardiovasculares, patologías del aparato digestivo, insomnio y fatiga debidos a desfase de horarios, esquizofrenia, ataques de pánico, melancolía, desórdenes del apetito, obesidad, insomnio, desórdenes psicóticos, epilepsia, diabetes, enfermedad de Parkinson, demencia senil, desórdenes varios asociados con el envejecimiento normal o patológico, migrana, pérdida de la memoria, enfermedad de Alzheimer, desórdenes en la circulación cerebral, y también para la disfunción sexual, como inhibidores de la ovulación, inmunomoduladores y en el tratamiento de cánceres.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0304381A FR2853649B1 (fr) | 2003-04-09 | 2003-04-09 | Nouveaux derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR043997A1 true AR043997A1 (es) | 2005-08-17 |
Family
ID=32865399
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040101179A AR043997A1 (es) | 2003-04-09 | 2004-04-07 | Compuestos de isoquinolina, un procedimiento para su preparacion y composiciones farmaceuticas que los contienen |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US7214689B2 (es) |
| EP (1) | EP1466604B1 (es) |
| JP (1) | JP4195869B2 (es) |
| KR (1) | KR100673702B1 (es) |
| CN (1) | CN100497313C (es) |
| AR (1) | AR043997A1 (es) |
| AT (1) | ATE377421T1 (es) |
| AU (1) | AU2004201595B2 (es) |
| BR (1) | BRPI0401031A (es) |
| CA (1) | CA2462939C (es) |
| CY (1) | CY1107158T1 (es) |
| DE (1) | DE602004009849T2 (es) |
| DK (1) | DK1466604T3 (es) |
| EA (1) | EA007714B1 (es) |
| EG (1) | EG24369A (es) |
| ES (1) | ES2295794T3 (es) |
| FR (1) | FR2853649B1 (es) |
| GE (1) | GEP20053636B (es) |
| HK (1) | HK1067121A1 (es) |
| HR (1) | HRP20070549T3 (es) |
| MA (1) | MA27070A1 (es) |
| MX (1) | MXPA04003200A (es) |
| MY (1) | MY136928A (es) |
| NO (1) | NO327107B1 (es) |
| NZ (1) | NZ532221A (es) |
| PL (1) | PL1466604T3 (es) |
| PT (1) | PT1466604E (es) |
| SG (1) | SG145542A1 (es) |
| SI (1) | SI1466604T1 (es) |
| UA (1) | UA81610C2 (es) |
| ZA (1) | ZA200402657B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2881138B1 (fr) * | 2005-01-27 | 2007-03-02 | Servier Lab | Nouveaux derives d'oximes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| EP1731507A1 (en) | 2005-04-26 | 2006-12-13 | Institut National des Sciences Appliquees de Rouen (INSA) | New heterocyclic compounds, their preparation and their use as medicaments, in particular as anti-alzheimer agents |
| CN100386319C (zh) * | 2005-12-05 | 2008-05-07 | 中国人民解放军第二军医大学 | 具有抗生育和抗真菌活性的四氢异喹啉类化合物或其盐类 |
| CN101583601B (zh) * | 2007-01-17 | 2013-06-05 | 香港科技大学 | 作为褪黑素受体mt1和mt2的亚型选择性激动剂的异喹诺酮化合物 |
| WO2009118765A2 (en) * | 2008-03-28 | 2009-10-01 | Panacea Biotec Limited | Novel monoamine re-uptake inhibitor |
| ES2580702B1 (es) | 2015-02-25 | 2017-06-08 | Palobiofarma, S.L. | Derivados de 2-aminopiridina como antagonistas del receptor A2b de adenosina y ligandos del receptor MT3 de melatonina |
| WO2022022542A1 (zh) * | 2020-07-28 | 2022-02-03 | 上海翰森生物医药科技有限公司 | 双环类衍生物调节剂、其制备方法和应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU189764B (en) * | 1983-10-25 | 1986-07-28 | Richter Gedeon Vegyeszeti Gyar Rt,Hu | Process for preparing 1-(bis (substituted methyl)-methyl)-isoquinoline-derivatives |
| US4584379A (en) * | 1985-01-22 | 1986-04-22 | Merrell Dow Pharmaceuticals Inc. | Isoquinoline thromboxane synthetase inhibitors |
| DE3640641A1 (de) * | 1986-11-28 | 1988-07-14 | Thomae Gmbh Dr K | Neue heteroaromatische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| DE3718570A1 (de) * | 1987-06-03 | 1988-12-15 | Boehringer Ingelheim Kg | Benzo- und thieno-3,4-dihydro-1- pyridinylessigsaeurederivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| FR2658818B1 (fr) * | 1990-02-27 | 1993-12-31 | Adir Cie | Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| CA2178088A1 (en) * | 1993-12-21 | 1995-06-29 | Walter Losel | Anellated dihydropyridines and their use in the production of pharmaceutical preparations |
| FR2729147A1 (fr) * | 1995-01-11 | 1996-07-12 | Adir | Nouveaux composes (hetero) cycliques alkyles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| ATE275132T1 (de) * | 1995-06-27 | 2004-09-15 | Takeda Chemical Industries Ltd | 4-acylamino(halogen)alkyl-chinolin derivate, deren herstellung und deren verwendung als melatonin-agonisten |
| FR2778662B1 (fr) * | 1998-05-12 | 2000-06-16 | Adir | Nouveaux composes cycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2801885B1 (fr) * | 1999-12-06 | 2002-01-11 | Adir | Nouveaux derives (dihydro)benzoxaziniques et (dihydro) benzothiaziniques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| ES2172376B1 (es) * | 2000-01-28 | 2003-11-16 | Servier Lab | Nuevos derivados de isoquinoleinas, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. |
-
2003
- 2003-04-09 FR FR0304381A patent/FR2853649B1/fr not_active Expired - Fee Related
-
2004
- 2004-01-01 ZA ZA200402657A patent/ZA200402657B/xx unknown
- 2004-03-26 MA MA27596A patent/MA27070A1/fr unknown
- 2004-03-30 NO NO20041313A patent/NO327107B1/no not_active IP Right Cessation
- 2004-03-31 JP JP2004104291A patent/JP4195869B2/ja not_active Expired - Lifetime
- 2004-04-02 SG SG200401893-3A patent/SG145542A1/en unknown
- 2004-04-05 MX MXPA04003200A patent/MXPA04003200A/es active IP Right Grant
- 2004-04-06 CA CA2462939A patent/CA2462939C/fr not_active Expired - Fee Related
- 2004-04-07 EP EP04290918A patent/EP1466604B1/fr not_active Expired - Lifetime
- 2004-04-07 DK DK04290918T patent/DK1466604T3/da active
- 2004-04-07 EG EG2004040161A patent/EG24369A/xx active
- 2004-04-07 AT AT04290918T patent/ATE377421T1/de active
- 2004-04-07 BR BR0401031-0A patent/BRPI0401031A/pt not_active IP Right Cessation
- 2004-04-07 GE GE5500A patent/GEP20053636B/en unknown
- 2004-04-07 PL PL04290918T patent/PL1466604T3/pl unknown
- 2004-04-07 SI SI200430535T patent/SI1466604T1/sl unknown
- 2004-04-07 AR ARP040101179A patent/AR043997A1/es active IP Right Grant
- 2004-04-07 PT PT04290918T patent/PT1466604E/pt unknown
- 2004-04-07 CN CNB2004100310343A patent/CN100497313C/zh not_active Expired - Fee Related
- 2004-04-07 UA UA2004042636A patent/UA81610C2/ru unknown
- 2004-04-07 DE DE602004009849T patent/DE602004009849T2/de not_active Expired - Lifetime
- 2004-04-07 ES ES04290918T patent/ES2295794T3/es not_active Expired - Lifetime
- 2004-04-08 EA EA200400409A patent/EA007714B1/ru not_active IP Right Cessation
- 2004-04-08 AU AU2004201595A patent/AU2004201595B2/en not_active Ceased
- 2004-04-08 NZ NZ532221A patent/NZ532221A/en not_active IP Right Cessation
- 2004-04-08 US US10/820,904 patent/US7214689B2/en not_active Expired - Fee Related
- 2004-04-08 MY MYPI20041285A patent/MY136928A/en unknown
- 2004-04-09 KR KR1020040024442A patent/KR100673702B1/ko not_active IP Right Cessation
- 2004-12-21 HK HK04110086.0A patent/HK1067121A1/xx not_active IP Right Cessation
-
2007
- 2007-03-20 US US11/725,855 patent/US20070191328A1/en not_active Abandoned
- 2007-12-04 HR HR20070549T patent/HRP20070549T3/xx unknown
-
2008
- 2008-01-28 CY CY20081100097T patent/CY1107158T1/el unknown
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