AR043962A1 - Compuestos derivados de bencimidazol, medicamentos que los contienen y su uso para preparar dichos medicamentos. - Google Patents
Compuestos derivados de bencimidazol, medicamentos que los contienen y su uso para preparar dichos medicamentos.Info
- Publication number
- AR043962A1 AR043962A1 ARP040101125A ARP040101125A AR043962A1 AR 043962 A1 AR043962 A1 AR 043962A1 AR P040101125 A ARP040101125 A AR P040101125A AR P040101125 A ARP040101125 A AR P040101125A AR 043962 A1 AR043962 A1 AR 043962A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkoxy
- hydroxy
- hydrogen
- alkoxycarbonyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Los compuestos tienen excelentes propiedades de acción inhibidora de la secreción gástrica y de acción protectora intestinal; con lo cual pueden ser usados para la preparación de medicamentos para el tratamiento y prevención de desórdenes gastrointestinales. Reivindicación 1: Compuestos de fórmula (1), en la cual: R1 es hidrógeno, halógeno, hidroxilo, alquilo C1-4, cicloalquilo C3-7, cicloalquilo(C3-7)-alquilo(C1-4), alcoxi C1-4, alcoxi(C1-4)-alquilo(C1-4), alcoxicarbonilo C1-4, alquenilo C2-4, alquinilo C2-4, fluoro-alquilo (C1-4), hidroxi-alquilo (C1-4) o mono- o di-(alquilamino C1-4); R2 es hidrógeno, alquilo C1-4, alcoxi C1-4, alcoxi(C1-4)-alquilo(C1-4), arilo, cicloalquilo C3-7, cicloalquil(C3-7)-alquilo(C1-4), alcoxicarbonilo C1-4, mono- o di-(alquilamino (C1-4))-alquilcarbonilo (C1-4), hidroxi-alquilo (C1-4), fluoro-alquilo (C2-4); R3 es hidrógeno, halógeno, fluoro-alquilo (C1-4), carboxilo, alcoxicarbonilo C1-4, hidroxi-alquilo (C1-4), alcoxi(C1-4)-alquilo(C1-4), alcoxi(C1-4)-alcoxi(C1-4)-alquilo(C1-4), fluoro-alcoxi(C1-4)-alquilo(C1-4), alcoxi(C1-4)-alcoxi(C1-4), alquilcarbonilamino C1-4, alquilcarbonil(C1-4)-N-alquilamino(C1-4), alcoxi(C1-4)-alquilcarbonilamino(C1-4) o el grupo -CO-NR31R32, en donde: R31 es hidrógeno, hidroxilo, alquilo C1-7, cicloalquilo C3-7, hidroxi-alquilo (C1-4) o alcoxi(C1-4)-alquilo(C1-4) y R32 es hidrógeno, alquilo C1-7, cicloalquilo C3-7, hidroxi-alquilo (C1-4) o alcoxi(C1-4)-alcoxi(C1-4), o en donde: R31 y R32 juntos, incluyendo el átomo de nitrógeno al cual ambos están unidos, son un grupo pirrolidino, hidroxi-pirrolidino, aziridino, azetidino, piperidino, piperazino, N-alquilpiperazino (C1-4) o morfolino; X es O (oxígeno) o NH y Ar es un residuo aromático mono- bicíclico, sustituido con R4, R5, R6 y R7, el cual es seleccionado del grupo que consiste de fenilo, naftilo, pirrolilo, pirazolilo, imidazolilo, 1,2,3-triazolilo, indolilo, bencimidazolilo, furilo, benzofurilo, tienilo, benzotienilo, tiazolilo, isoxazolilo, piridinilo, pirimidinilo, quinolinilo y isoquinolinilo, en donde: R4 es hidrógeno, alquilo C1-4, hidroxi-alquilo (C1-4), alcoxi C1-4, alqueniloxi C2-4, alquilcarbonilo C1-4, carboxi, alcoxicarbonilo C1-4, carboxi-alquilo (C1-4), alcoxicarbonil(C1-4)-alquilo(C1-4), halógeno, hidroxi, arilo, aril-alquilo (C1-4), ariloxi, aril-alcoxi (C1-4), trifluorometilo, nitro, amino, mono- o di-alquilamino (C1-4), alquilcarbonilamino C1-4, alcoxicarbonilamino C1-4, alcoxi(C1-4)-alcoxicarbonilamino(C1-4) o sulfonilo; R5 es hidrógeno, alquilo C1-4, alcoxi C1-4, alcoxicarbonilo C1-4, halógeno, trifluorometilo o hidroxi; R6 es hidrógeno, alquilo C1-4 o halógeno; y R7 es hidrógeno, alquilo C1-4 o halógeno, y en donde, arilo es fenilo o fenilo sustituido con uno, dos o tres sustituyentes iguales o diferentes del grupo alquilo C1-4, alcoxi C1-4, carboxi, alcoxicarbonilo (C1-4), halógeno, trifluorometilo, nitro, trifluorometoxi, hidroxi y ciano, y las sales de estos compuestos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03007780 | 2003-04-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR043962A1 true AR043962A1 (es) | 2005-08-17 |
Family
ID=33104052
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP040101125A AR043962A1 (es) | 2003-04-04 | 2004-04-02 | Compuestos derivados de bencimidazol, medicamentos que los contienen y su uso para preparar dichos medicamentos. |
Country Status (19)
Country | Link |
---|---|
US (2) | US7307084B2 (es) |
EP (1) | EP1613626A1 (es) |
JP (1) | JP2006522071A (es) |
KR (1) | KR20060015483A (es) |
CN (1) | CN100393720C (es) |
AR (1) | AR043962A1 (es) |
AU (1) | AU2004226180A1 (es) |
BR (1) | BRPI0408893A (es) |
CA (1) | CA2520581A1 (es) |
EA (1) | EA200501537A1 (es) |
HK (1) | HK1088898A1 (es) |
IS (1) | IS8091A (es) |
MX (1) | MXPA05010310A (es) |
NO (1) | NO20055033L (es) |
NZ (1) | NZ542177A (es) |
RS (1) | RS20050730A (es) |
TW (1) | TW200510410A (es) |
WO (1) | WO2004087701A1 (es) |
ZA (1) | ZA200506905B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR048869A1 (es) * | 2004-04-26 | 2006-06-07 | Altana Pharma Ag | Bencimidazoles triciclicos |
CA2568856A1 (en) * | 2004-06-09 | 2005-12-22 | Altana Pharma Ag | Substituted tricyclic benzimidazoles |
EP1863820A1 (en) * | 2005-03-24 | 2007-12-12 | Nycomed GmbH | Thioamide-substituted tricyclic benzimidazoles useful for the treatment of gastrointestinal diseases |
AR057061A1 (es) * | 2005-06-16 | 2007-11-14 | Altana Pharma Ag | Espiro-bencimidazoles farmaceuticamente activos y su uso en la fabricacion de medicamentos |
CA2612112A1 (en) * | 2005-06-22 | 2006-12-28 | Nycomed Gmbh | Process for the production of intermediates for the preparation of tricyclic benzimidazoles |
WO2007072142A2 (en) * | 2005-12-19 | 2007-06-28 | Pfizer Japan Inc. | Benzimidazole-5-carboxamide derivatives |
BRPI0717102A2 (pt) * | 2006-09-21 | 2013-10-29 | Raqualia Pharma Inc | Derivados de benzimidazol como inibidores seletivos de bomba de ácido |
ES2365560T3 (es) * | 2006-09-21 | 2011-10-06 | Raqualia Pharma Inc | Derivados de bencilmidazoles como inhibidores selectivos de bombas de ácido. |
WO2008071765A1 (en) * | 2006-12-14 | 2008-06-19 | Nycomed Gmbh | Pharmaceutically active spiro-substituted benzimidazole derivatives |
WO2008074858A1 (en) * | 2006-12-21 | 2008-06-26 | Nycomed Gmbh | Intermediates and process for the production of 5-substituted tricyclic benzimidazoles |
WO2008095912A2 (en) * | 2007-02-06 | 2008-08-14 | Nycomed Gmbh | Enantiopure pharmacologically active tricyclic benzimidazoles |
WO2008114123A1 (en) * | 2007-03-21 | 2008-09-25 | Raqualia Pharma Inc. | Spiro benzimidazole derivatives as acid pump inhibitors |
WO2008151927A2 (en) * | 2007-06-15 | 2008-12-18 | Nycomed Gmbh | 6-n-substituted benz imidazole derivatives as acid pump antagonists |
WO2011004882A1 (ja) | 2009-07-09 | 2011-01-13 | ラクオリア創薬株式会社 | 消化管運動異常が関与する疾患を治療するためのアシッドポンプ拮抗剤 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE8604566D0 (sv) * | 1986-10-27 | 1986-10-27 | Haessle Ab | Novel compunds |
SE9401197D0 (sv) | 1994-04-11 | 1994-04-11 | Astra Ab | Active compounds |
SE9602286D0 (sv) * | 1996-06-10 | 1996-06-10 | Astra Ab | New compounds |
KR20040023739A (ko) * | 2001-08-10 | 2004-03-18 | 알타나 파마 아게 | 삼환식 이미다조피리딘 |
AR043063A1 (es) | 2002-12-13 | 2005-07-13 | Altana Pharma Ag | Bencimidazoles 6-sustituidos y su uso como inhibidores de secreciones gastricas |
AR046893A1 (es) * | 2003-12-16 | 2005-12-28 | Altana Pharma Ag | Bencimidazoles triciclicos |
-
2004
- 2004-04-02 AR ARP040101125A patent/AR043962A1/es not_active Application Discontinuation
- 2004-04-02 AU AU2004226180A patent/AU2004226180A1/en not_active Abandoned
- 2004-04-02 BR BRPI0408893-0A patent/BRPI0408893A/pt not_active IP Right Cessation
- 2004-04-02 RS YUP-2005/0730A patent/RS20050730A/sr unknown
- 2004-04-02 KR KR1020057018211A patent/KR20060015483A/ko not_active Application Discontinuation
- 2004-04-02 WO PCT/EP2004/050428 patent/WO2004087701A1/en active Application Filing
- 2004-04-02 EP EP04725396A patent/EP1613626A1/en not_active Withdrawn
- 2004-04-02 EA EA200501537A patent/EA200501537A1/ru unknown
- 2004-04-02 JP JP2006505516A patent/JP2006522071A/ja not_active Withdrawn
- 2004-04-02 US US10/551,049 patent/US7307084B2/en not_active Expired - Fee Related
- 2004-04-02 CN CNB2004800083456A patent/CN100393720C/zh not_active Expired - Fee Related
- 2004-04-02 MX MXPA05010310A patent/MXPA05010310A/es active IP Right Grant
- 2004-04-02 TW TW093109270A patent/TW200510410A/zh unknown
- 2004-04-02 CA CA002520581A patent/CA2520581A1/en not_active Abandoned
- 2004-04-02 NZ NZ542177A patent/NZ542177A/en unknown
-
2005
- 2005-08-29 ZA ZA200506905A patent/ZA200506905B/en unknown
- 2005-10-26 IS IS8091A patent/IS8091A/is unknown
- 2005-10-28 NO NO20055033A patent/NO20055033L/no not_active Application Discontinuation
-
2006
- 2006-08-17 HK HK06109149.5A patent/HK1088898A1/xx not_active IP Right Cessation
-
2007
- 2007-11-01 US US11/979,292 patent/US20080113963A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
NO20055033L (no) | 2005-10-28 |
CN1764662A (zh) | 2006-04-26 |
IS8091A (is) | 2005-10-26 |
HK1088898A1 (en) | 2006-11-17 |
CA2520581A1 (en) | 2004-10-14 |
EA200501537A1 (ru) | 2006-06-30 |
BRPI0408893A (pt) | 2006-04-11 |
CN100393720C (zh) | 2008-06-11 |
WO2004087701A8 (en) | 2005-03-03 |
US20080113963A1 (en) | 2008-05-15 |
KR20060015483A (ko) | 2006-02-17 |
AU2004226180A1 (en) | 2004-10-14 |
WO2004087701A1 (en) | 2004-10-14 |
RS20050730A (en) | 2007-11-15 |
MXPA05010310A (es) | 2005-11-17 |
US20060194968A1 (en) | 2006-08-31 |
EP1613626A1 (en) | 2006-01-11 |
US7307084B2 (en) | 2007-12-11 |
TW200510410A (en) | 2005-03-16 |
JP2006522071A (ja) | 2006-09-28 |
ZA200506905B (en) | 2007-01-31 |
NZ542177A (en) | 2009-02-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR043962A1 (es) | Compuestos derivados de bencimidazol, medicamentos que los contienen y su uso para preparar dichos medicamentos. | |
EA200901473A1 (ru) | Внутривенные и пероральные лекарственные формы прямого и обратимого ингибитора p2y12 | |
EA202090676A1 (ru) | Способы введения некоторых vmat2-ингибиторов | |
AR054612A1 (es) | Derivados de espiroquetas y composiciones farmaceuticas para su utilizacion como agente terapeutico para diabetes | |
EA200601125A1 (ru) | 6-замещённые циклогексилалкил 2-замещённые хинолиноны и 2-хиноксалиноны в качестве ингибиторов поли(adp-рибоза)полимеразы | |
EA201270215A1 (ru) | Apaf-1 ингибиторные соединения | |
GT200800211A (es) | Derivados de dihidropirazolopirimidinona | |
EA201590674A1 (ru) | Производные 5-фенокси-3h-пиримидин-4-она и их применение в качестве ингибиторов обратной транскрипазы вич | |
NO20063449L (no) | Substituerte heterocykler og deres anvendelse | |
NO20080963L (no) | Piperidinyl-substiuerte isokinolinderivater som Rho-kinaseinhibitorer | |
EA200971051A1 (ru) | Ингибиторы p70 s6 киназы | |
AR050969A1 (es) | 5-heterociclil pirimidinas inhibidoras del vih; composiciones farmaceuticas que las contienen y uso de las mismas como medicamentos | |
PE20130244A1 (es) | Inhibidores del virus de la hepatitis c | |
CY1114521T1 (el) | Ενωσεις βενζαμιδιου χρησιμες ως αναστολεις αποακετυλασων ιστονων | |
PA8719401A1 (es) | Compuestos de tetrahidropiridotienopirimidina y metodos para su empleo | |
WO2009024611A3 (en) | 4-benzylaminoquinolines, pharmaceutical compositions containing them and their use | |
ES2391373T3 (es) | Derivados de quinoleína como inhibidores de la cinasa AXL | |
AR037754A1 (es) | Herbicidas | |
BR112015002153A2 (pt) | composto heterocíclico parcialmente saturado contendo nitrogênio | |
AR060042A1 (es) | Nanoparticulas que comprenden un inhibidor de tirosina quinasa del receptor de pdgf | |
NO20054340L (no) | Nye sammenkoplede heterocykler og deres anvendelse | |
MX2016004936A (es) | Derivados de aminocromano, aminotiocromano y amino-1,2,3,4-tetrahi droquinilina, composiciones farmaceuticas que los contienen, y su uso en terapia. | |
AR072149A1 (es) | Derivados de heteroaril-carboxamida | |
AR049861A1 (es) | Derivados de bencimidazol, procesos de preparacion y composiciones farmaceuticas que los co0ntienen. | |
AR061583A1 (es) | Acidos 6-(bencilo sustituido con heterociclil)-4-oxiquinolin carboxilicos, inhibidores de vih-integrasas, composiciones farmaceuticas que los contienen y usos como agentes anti-vih. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |