AR060042A1 - Nanoparticulas que comprenden un inhibidor de tirosina quinasa del receptor de pdgf - Google Patents
Nanoparticulas que comprenden un inhibidor de tirosina quinasa del receptor de pdgfInfo
- Publication number
- AR060042A1 AR060042A1 ARP070101158A ARP070101158A AR060042A1 AR 060042 A1 AR060042 A1 AR 060042A1 AR P070101158 A ARP070101158 A AR P070101158A AR P070101158 A ARP070101158 A AR P070101158A AR 060042 A1 AR060042 A1 AR 060042A1
- Authority
- AR
- Argentina
- Prior art keywords
- lower alkyl
- free
- substituted
- amino
- nanoparticles
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
- A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/432—Inhibitors, antagonists
- A61L2300/434—Inhibitors, antagonists of enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
- A61L2300/624—Nanocapsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
Abstract
Nanopartículas que comprenden un inhibidor de tirosina quinasa del receptor PDGF, donde el inhibidor de tirosina quinasa del receptor PDGF tiene una solubilidad en agua a 20°C de entre alrededor de 2,5 g/100 ml y 250 g/100 ml, y es un derivado de N- fenil-2-pirimidin-amina de la formula (1), donde: R1 es 4-pirazinilo; 1-metil-1H-pirrolilo; fenilo sustituido con amino o amino alquilo inferior, donde el grupo amino en cada caso está libre, alquilado o acilado; 1H-indolilo o 1H-imidazolilo enlazado en un átomo de carbono de anillo de cinco miembros; o piridilo no sustituido o sustituido con alquilo inferior, enlazado en un átomo de carbono de anillo, y no sustituido o sustituido en el átomo de nitrogeno con oxígeno; R2 y R3 son, de manera independiente entre sí, hidrogeno o alquilo inferior; uno o dos de los radicales R4, R5, R6, R7 y R8 son nitro, alcoxi inferior sustituido con fluor, o un radical de formula -N(R9)-C(=X)-(Y)n-R10, donde: R9 es hidrogeno o alquilo inferior; X es oxo, tio imino, N-alquilo inferior-imino, hidroxiimino, u O-alquilo inferior-hidroxiimino; Y es oxígeno o el grupo NH; n es 0 o 1; y R10 es un radical alifático que tiene por lo menos 5 átomos de carbono; o un radical aromático, aromático- alifático, cicloalifático, cicloalifático-alifático, heterocíclico o heterocíclico-alifático; y los radicales restantes R4, R5, R6, R7 y R8 son, de manera independiente entre sí, hidrogeno, alquilo inferior no sustituido o sustituido con amino libre o alquilado, piperazinilo, piperidinilo, pirrolidinilo o con morfolinilo, o alcanoílo inferior, trifluorometilo, hidroxi libre, eterificado o esterificado, amino libre, alquilado o acilado, o carboxi libre o esterificado; o una sal de dicho compuesto que tiene por lo menos un grupo formador de sales; un proceso para su preparacion; sus composiciones farmacéuticas; y el uso de nanopartículas de acuerdo con cualquiera de las reivindicaciones 1 a 9, en la elaboracion de un producto farmacéutico para la estabilizacion de placas vulnerables en los vasos sanguíneos de un sujeto que necesita dicha estabilizacion, para la prevencion o el tratamiento de restenosis en pacientes diabéticos, o para la prevencion o reduccion de la disfuncion de acceso vascular asociada con la insercion o reparacion de una derivacion, fístula o un catéter permanentes, en un sujeto que lo necesita. Reivindicacion 4: Nanopartículas de acuerdo con la reivindicacion 3, donde el derivado de N- fenil-2-pirimidin-amina de formula (1) es N-{5-[4-(4-metil-piperazino-metil)-benzoilamido]-2-metilfenil}-4-(3-piridil)-2-pirimidin-amina (Imatinib).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78557606P | 2006-03-24 | 2006-03-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR060042A1 true AR060042A1 (es) | 2008-05-21 |
Family
ID=38122006
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070101158A AR060042A1 (es) | 2006-03-24 | 2007-03-21 | Nanoparticulas que comprenden un inhibidor de tirosina quinasa del receptor de pdgf |
Country Status (11)
Country | Link |
---|---|
US (1) | US20090136579A1 (es) |
JP (1) | JP2007254452A (es) |
KR (1) | KR20070096729A (es) |
AR (1) | AR060042A1 (es) |
BR (1) | BRPI0602338A (es) |
CA (1) | CA2550702A1 (es) |
CL (1) | CL2007000781A1 (es) |
MX (1) | MXPA06007070A (es) |
PE (1) | PE20071337A1 (es) |
TW (1) | TW200815053A (es) |
WO (1) | WO2007119601A2 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009042803A1 (en) | 2007-09-25 | 2009-04-02 | Teva Pharmaceutical Industries Ltd. | Imatinib compositions |
US20100216804A1 (en) * | 2008-12-15 | 2010-08-26 | Zale Stephen E | Long Circulating Nanoparticles for Sustained Release of Therapeutic Agents |
WO2010101240A1 (ja) * | 2009-03-06 | 2010-09-10 | 国立大学法人岡山大学 | 生分解性多孔質中空微粒子、その製造方法および用途 |
RU2469729C1 (ru) * | 2011-08-26 | 2012-12-20 | Учреждение Российской академии медицинских наук Научно-исследовательский институт кардиологии Сибирского отделения РАМН | Средство для деструктуризации атеросклеротических образований, формирующихся на стенках кровеносных сосудов |
WO2013124867A1 (en) * | 2012-02-21 | 2013-08-29 | Amrita Vishwa Vidyapeetham University | Polymer - polymer or polymer - protein core - shell nano medicine loaded with multiple drug molecules |
US20160015708A1 (en) | 2012-02-21 | 2016-01-21 | Ranbaxy Laboratories Limited | Stable dosage forms of imatinib mesylate |
US10143700B2 (en) | 2013-02-19 | 2018-12-04 | Amrita Vishwa Vidyapeetham | Nanoparticle formulations for delivering multiple therapeutic agents |
AU2014296032A1 (en) | 2013-07-31 | 2016-03-17 | Windward Pharma, Inc. | Aerosol tyrosine kinase inhibitor compounds and uses thereof |
US11007276B2 (en) | 2016-01-29 | 2021-05-18 | National University Corporation Hokkaido University | Intracellular substance transport system and use thereof |
US11464776B2 (en) | 2019-05-16 | 2022-10-11 | Aerovate Therapeutics, Inc. | Inhalable imatinib formulations, manufacture, and uses thereof |
AU2020274521A1 (en) | 2019-05-16 | 2021-12-16 | Aerovate Therapeutics, Inc. | Imatinib formulations, manufacture, and uses thereof |
JP2023550407A (ja) * | 2020-11-17 | 2023-12-01 | ユナイテッド セラピューティクス コーポレイション | 肺高血圧向けの吸入式イマチニブ |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5093330A (en) * | 1987-06-15 | 1992-03-03 | Ciba-Geigy Corporation | Staurosporine derivatives substituted at methylamino nitrogen |
US5521184A (en) * | 1992-04-03 | 1996-05-28 | Ciba-Geigy Corporation | Pyrimidine derivatives and processes for the preparation thereof |
CN101031287A (zh) * | 2004-03-02 | 2007-09-05 | 麻省理工学院 | 纳米细胞药物递送系统 |
AU2006255177A1 (en) * | 2005-06-03 | 2006-12-14 | Elan Pharma International, Limited | Nanoparticulate imatinib mesylate formulations |
CN1309422C (zh) * | 2005-08-29 | 2007-04-11 | 江征平 | 聚合物纳米粒子和药物胶囊及制备 |
US20070065477A1 (en) * | 2005-09-12 | 2007-03-22 | Conor Medsystems, Inc. | Composition, system, and method for modulating release kinetics in implantable drug delivery devices by modifying drug solubility |
-
2006
- 2006-06-20 KR KR1020060055374A patent/KR20070096729A/ko not_active Application Discontinuation
- 2006-06-20 CA CA002550702A patent/CA2550702A1/en not_active Abandoned
- 2006-06-20 BR BRPI0602338-0A patent/BRPI0602338A/pt not_active Application Discontinuation
- 2006-06-20 MX MXPA06007070A patent/MXPA06007070A/es unknown
- 2006-06-21 JP JP2006171514A patent/JP2007254452A/ja active Pending
-
2007
- 2007-03-21 AR ARP070101158A patent/AR060042A1/es unknown
- 2007-03-23 TW TW096110152A patent/TW200815053A/zh unknown
- 2007-03-23 PE PE2007000321A patent/PE20071337A1/es not_active Application Discontinuation
- 2007-03-23 CL CL200700781A patent/CL2007000781A1/es unknown
- 2007-03-23 WO PCT/JP2007/057024 patent/WO2007119601A2/en active Search and Examination
- 2007-03-23 US US12/225,539 patent/US20090136579A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
PE20071337A1 (es) | 2008-01-08 |
CL2007000781A1 (es) | 2008-03-14 |
KR20070096729A (ko) | 2007-10-02 |
TW200815053A (en) | 2008-04-01 |
CA2550702A1 (en) | 2007-09-24 |
US20090136579A1 (en) | 2009-05-28 |
MXPA06007070A (es) | 2007-09-24 |
WO2007119601A3 (en) | 2008-02-21 |
WO2007119601A2 (en) | 2007-10-25 |
JP2007254452A (ja) | 2007-10-04 |
BRPI0602338A (pt) | 2007-12-11 |
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