AR042745A1 - Derivados de acilaminotiazol, su preparacion y su utilizacion en terapeutica - Google Patents
Derivados de acilaminotiazol, su preparacion y su utilizacion en terapeuticaInfo
- Publication number
- AR042745A1 AR042745A1 ARP040100169A ARP040100169A AR042745A1 AR 042745 A1 AR042745 A1 AR 042745A1 AR P040100169 A ARP040100169 A AR P040100169A AR P040100169 A ARP040100169 A AR P040100169A AR 042745 A1 AR042745 A1 AR 042745A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- group
- optionally substituted
- groups
- hydrogen atom
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Compuesto de fórmula (1) de aplicación en forma terapéutica y composiciones farmacéuticas. Reivindicación 1: Compuesto que responde a la fórmula general (1), en la cual: X representa un átomo de oxígeno o de azufre; R1 representa un grupo alquilo C1-10 eventualmente sustituido por un cicloalquilo C3-7, un fenilo, un tienilo; o R1 representa un grupo cicloalquilo C3-7, tienilo, piridinilo, pirimidinilo; los grupos tienilo son eventualmente sustituidos por uno a 3 grupos alquilo C1-3; el grupo fenilo es eventualmente sustituido por uno a 5 átomos de halógeno o grupos alquilo C1-3, alcoxi C1-3, fluoroalquilo C1-3, fluoroalcoxi C1-3; R2 representa un grupo alquilo C1-6 eventualmente sustituido por un grupo cicloalquilo C3-7, fenilo, alcoxi C1-3, hidroxi; o R2 representa un grupo cicloalquilo C3-7, piperidinilo, fenilo o piridinilo; los grupos cicloalquilo C3-7 y piperidinilo son eventualmente sustituidos por uno o varios grupos alquilo C1-3, alcoxi C1-3, hidroxi, fluoroalquilo C1-3, fluoroalcoxi C1-3; los grupos fenilo y piridinilo son eventualmente sustituidos por uno o varios átomos de halógeno o grupos CN, alquilo C1-3, alcoxi C1-3, hidroxi, fluoroalquilo C1-3, fluoroalcoxi C1-3; R3 representa un átomo de hidrógeno o un grupo alquilo C1-6 eventualmente sustituidos por un grupo cicloalquilo C3-7; R4 representa un átomo de hidrógeno o un grupo alquilo C1-6; R5 y R5' representan independientemente entre sí, un átomo de hidrógeno, de halógeno, un grupo hidroxi, alquilo C1-3; o R5 y R5' forman juntos un grupo oxo u oxima tal como un resto de grupo de fórmula (2), donde R7 representa un átomo de hidrógeno o un alquilo C1-3; n representa un átomo de hidrógeno o un alquilo C1-3; n representa un número entero que va de 0 a 3; y R6 representa, independientemente entre sí cuando n = 2 0 3, un átomo de hidrógeno, de halógeno, un grupo hidroxi, alquilo C1-3, alcoxi C1-3, fluoroalquilo C1-3 o fluoroalcoxi C1-3; en estado de base, de sal de adición con un ácido, de hidrato o de solvato.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0300703A FR2850380B1 (fr) | 2003-01-23 | 2003-01-23 | Derives d'acylaminothiazole, leur preparation et leur utilisation en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR042745A1 true AR042745A1 (es) | 2005-06-29 |
Family
ID=32669150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040100169A AR042745A1 (es) | 2003-01-23 | 2004-01-22 | Derivados de acilaminotiazol, su preparacion y su utilizacion en terapeutica |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US7563903B2 (es) |
| EP (1) | EP1590337B1 (es) |
| JP (1) | JP2006515888A (es) |
| KR (1) | KR101059669B1 (es) |
| CN (1) | CN100532370C (es) |
| AR (1) | AR042745A1 (es) |
| AT (1) | ATE404545T1 (es) |
| AU (1) | AU2004207658B2 (es) |
| BR (1) | BRPI0406893A (es) |
| CA (1) | CA2511610A1 (es) |
| DE (1) | DE602004015726D1 (es) |
| FR (1) | FR2850380B1 (es) |
| HR (1) | HRP20050637A2 (es) |
| IL (1) | IL169428A (es) |
| MA (1) | MA27610A1 (es) |
| ME (1) | MEP16708A (es) |
| MX (1) | MXPA05007847A (es) |
| NO (1) | NO330415B1 (es) |
| NZ (1) | NZ541147A (es) |
| PL (1) | PL377999A1 (es) |
| RS (1) | RS51168B (es) |
| RU (1) | RU2360907C2 (es) |
| TW (1) | TWI320710B (es) |
| WO (1) | WO2004067520A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4220548B2 (ja) * | 2003-06-05 | 2009-02-04 | エラン ファーマシューティカルズ，インコーポレイテッド | アシル化されたアミノ酸・アミジルピラゾール、および関連化合物 |
| US7514566B2 (en) * | 2006-01-18 | 2009-04-07 | Amgen, Inc. | Thiazole compounds and methods of use |
| JP2010533715A (ja) | 2007-07-17 | 2010-10-28 | アムジエン・インコーポレーテツド | 複素環系ｐｋｂ調節剤 |
| AU2008276512A1 (en) * | 2007-07-17 | 2009-01-22 | Amgen Inc. | Thiadiazole modulators of PKB |
| WO2009108760A2 (en) | 2008-02-26 | 2009-09-03 | Board Of Regents, The University Of Texas System | Dendritic macroporous hydrogels prepared by crystal templating |
| EP2371421A1 (en) * | 2010-03-04 | 2011-10-05 | Université de Lille 2 Droit et Santé | Ligands of insulin degrading enzyme and their uses |
| EP2508511A1 (en) | 2011-04-07 | 2012-10-10 | Laboratoire Biodim | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
| CN103145692B (zh) * | 2013-03-12 | 2014-07-16 | 盐城工学院 | 一种4,5-二氢-6H-环戊烷并[b]噻吩-6-酮的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ID22499A (id) | 1996-11-22 | 1999-10-21 | Elan Pharmaceuticals Inc Cs | Amida-amida asam n-(aril/heteroaril/alkilasetil) amino, komposisi farmasi yang terdiri dari amida asam amino tersebut, dan metode untuk menghambat pelepasan b-amiloid peptida dan/atau pembuatannya dengan menggunakan senyawa-senyawa tersebut |
| NZ335583A (en) * | 1996-12-23 | 2001-03-30 | Lilly Co Eli | Cycloalkyl, lactam, lactone and analogs, and pharmaceutical compositions |
| JP2002518380A (ja) * | 1998-06-18 | 2002-06-25 | ブリストル−マイヤーズ スクイブ カンパニー | サイクリン依存キナーゼの炭素置換アミノチアゾール抑制剤 |
| WO2000024392A1 (fr) * | 1998-10-26 | 2000-05-04 | Sumitomo Pharmaceuticals Company, Limited | Inhibiteur de la formation de beta-amyloide |
| GB9823871D0 (en) * | 1998-10-30 | 1998-12-23 | Pharmacia & Upjohn Spa | 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents |
| AR039059A1 (es) * | 2001-08-06 | 2005-02-09 | Sanofi Aventis | Compuesto derivado de acilaminotiazol, su utilizacion, procedimientos para prepararlo, composicion farmaceutica que lo comprende, y compuestos intermediarios |
-
2003
- 2003-01-23 FR FR0300703A patent/FR2850380B1/fr not_active Expired - Fee Related
-
2004
- 2004-01-22 CA CA002511610A patent/CA2511610A1/en not_active Abandoned
- 2004-01-22 JP JP2006502115A patent/JP2006515888A/ja not_active Ceased
- 2004-01-22 RU RU2005126608/04A patent/RU2360907C2/ru not_active IP Right Cessation
- 2004-01-22 WO PCT/FR2004/000140 patent/WO2004067520A1/fr active IP Right Grant
- 2004-01-22 DE DE602004015726T patent/DE602004015726D1/de not_active Expired - Lifetime
- 2004-01-22 CN CNB2004800027812A patent/CN100532370C/zh not_active Expired - Fee Related
- 2004-01-22 BR BR0406893-9A patent/BRPI0406893A/pt not_active IP Right Cessation
- 2004-01-22 RS YUP-2005/0563A patent/RS51168B/sr unknown
- 2004-01-22 NZ NZ541147A patent/NZ541147A/en not_active IP Right Cessation
- 2004-01-22 ME MEP-167/08A patent/MEP16708A/xx unknown
- 2004-01-22 AR ARP040100169A patent/AR042745A1/es unknown
- 2004-01-22 EP EP04704255A patent/EP1590337B1/fr not_active Expired - Lifetime
- 2004-01-22 KR KR1020057013441A patent/KR101059669B1/ko not_active IP Right Cessation
- 2004-01-22 AU AU2004207658A patent/AU2004207658B2/en not_active Ceased
- 2004-01-22 PL PL377999A patent/PL377999A1/pl not_active Application Discontinuation
- 2004-01-22 MX MXPA05007847A patent/MXPA05007847A/es active IP Right Grant
- 2004-01-22 AT AT04704255T patent/ATE404545T1/de not_active IP Right Cessation
- 2004-01-27 TW TW093101748A patent/TWI320710B/zh not_active IP Right Cessation
-
2005
- 2005-06-27 IL IL169428A patent/IL169428A/en not_active IP Right Cessation
- 2005-07-12 HR HR20050637A patent/HRP20050637A2/hr not_active Application Discontinuation
- 2005-07-12 MA MA28385A patent/MA27610A1/fr unknown
- 2005-07-21 US US11/186,507 patent/US7563903B2/en not_active Expired - Fee Related
- 2005-07-22 NO NO20053588A patent/NO330415B1/no not_active IP Right Cessation
-
2009
- 2009-06-22 US US12/488,658 patent/US7879889B2/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |