RS51168B - Derivati acilaminotiazola, njihovo dobijanje i njihova upotreba kao inhibitora proizvodnje beta-amiloid peptida - Google Patents
Derivati acilaminotiazola, njihovo dobijanje i njihova upotreba kao inhibitora proizvodnje beta-amiloid peptidaInfo
- Publication number
- RS51168B RS51168B YUP-2005/0563A YUP20050563A RS51168B RS 51168 B RS51168 B RS 51168B YU P20050563 A YUP20050563 A YU P20050563A RS 51168 B RS51168 B RS 51168B
- Authority
- RS
- Serbia
- Prior art keywords
- group
- alkyl
- cycloalkyl
- optionally substituted
- groups
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Jedinjenje koje odgovara opštoj formuli (I):gde:X predstavlja jedan atom kiseonika ili sumpora ;R1 predstavlja grupu C1-10 alkil po izboru supstituisanu sa C3-7 cikloalkil, fenil ili tienil grupom; ili R1 predstavlja C3-7 cikloalkil, tienil, piridinil ili pirimidinil grupu;gde tienil grupe mogu eventualno po izboru da budu supstituisane jednom do 3 C1-3 alkil grupe; fenil grupa može po izboru da bude supstituisana sa jedan do 5 atoma halogena ili C1-3alkil, C1-3 alkoksi, C1-3fluoroalkil, C1-3fluoroalkoksi grupama;R2 predstavlja grupu C1-6 alkil po izboru supstituisanu C3-7 cikloalkil, fenil, C1-3alkoksi, hidroksilnom grupom; ili R2 predstavlja C3-7cikloalkil, piperidinil, fenil ili piridinil grupu;C3-7 cikloalkil i piperidinil grupe su po izboru supstituisane jednom ili više C1-3 alkil, C1-3 alkoksi, hidroksil, C1-3fluoroalkil, C1-3 fluoroalkoksi grupa;fenil i piridinil grupe su po izboru supstituisane sa jednim ili više atoma halogena ili,C1-3 alkil, C1-3 alkoksi, hidroksil, C1-3 fluoroalkil, C1-3fluoroalkoksi grupama;R3 predstavlja atom halogena ili C1-6 alkil grupu po izboru supstituisanu C3-7 cikloalkil grupom;R4 predstavlja atom vodonika ili C1-6 alkil grupu;R5 i R5' predstavljaju nezavisno jedan od drugog atom vodonika, halogena, hidroksilnu, ili C1-3 alkil grupu; ili R5 i R5' formiraju zajedno okso ili oksim grupu kao što je:gde R7 predstavlja atom vodonika ili C1-3alkil; n predstavlja ceo broj od 0 do 3 ; iR6 predstavlja nezavisno jedan od drugoga kada je n = 2 ili 3, atom vodonika ili halogena, hidroksilnu, C1-3 alkil, C1-3alkoksi, C1-3fluoroalkil ili C1-3 fluoroalkoksi grupu.Prijava sadrži još 10 patentnih zahteva.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0300703A FR2850380B1 (fr) | 2003-01-23 | 2003-01-23 | Derives d'acylaminothiazole, leur preparation et leur utilisation en therapeutique |
| PCT/FR2004/000140 WO2004067520A1 (fr) | 2003-01-23 | 2004-01-22 | Derives d'acylaminothiazole, leur preparation et leur utilisation en tant qu’inhibiteurs de la production du peptide beta-amyloide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RS20050563A RS20050563A (en) | 2007-06-04 |
| RS51168B true RS51168B (sr) | 2010-10-31 |
Family
ID=32669150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YUP-2005/0563A RS51168B (sr) | 2003-01-23 | 2004-01-22 | Derivati acilaminotiazola, njihovo dobijanje i njihova upotreba kao inhibitora proizvodnje beta-amiloid peptida |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US7563903B2 (sr) |
| EP (1) | EP1590337B1 (sr) |
| JP (1) | JP2006515888A (sr) |
| KR (1) | KR101059669B1 (sr) |
| CN (1) | CN100532370C (sr) |
| AR (1) | AR042745A1 (sr) |
| AT (1) | ATE404545T1 (sr) |
| AU (1) | AU2004207658B2 (sr) |
| BR (1) | BRPI0406893A (sr) |
| CA (1) | CA2511610A1 (sr) |
| DE (1) | DE602004015726D1 (sr) |
| FR (1) | FR2850380B1 (sr) |
| HR (1) | HRP20050637A2 (sr) |
| IL (1) | IL169428A (sr) |
| MA (1) | MA27610A1 (sr) |
| ME (1) | MEP16708A (sr) |
| MX (1) | MXPA05007847A (sr) |
| NO (1) | NO330415B1 (sr) |
| NZ (1) | NZ541147A (sr) |
| PL (1) | PL377999A1 (sr) |
| RS (1) | RS51168B (sr) |
| RU (1) | RU2360907C2 (sr) |
| TW (1) | TWI320710B (sr) |
| WO (1) | WO2004067520A1 (sr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1633350B1 (en) * | 2003-06-05 | 2012-10-03 | Elan Pharmaceuticals, Inc. | Acylated amino acid amidyl pyrazoles and related compounds |
| ES2389062T3 (es) * | 2006-01-18 | 2012-10-22 | Amgen, Inc | Compuestos de tiazol como inhibidores de proteína cinasa B (PKB) |
| AU2008276521B2 (en) | 2007-07-17 | 2011-11-03 | Amgen Inc. | Heterocyclic modulators of PKB |
| AU2008276512A1 (en) * | 2007-07-17 | 2009-01-22 | Amgen Inc. | Thiadiazole modulators of PKB |
| US8668863B2 (en) | 2008-02-26 | 2014-03-11 | Board Of Regents, The University Of Texas System | Dendritic macroporous hydrogels prepared by crystal templating |
| EP2371421A1 (en) * | 2010-03-04 | 2011-10-05 | Université de Lille 2 Droit et Santé | Ligands of insulin degrading enzyme and their uses |
| EP2508511A1 (en) * | 2011-04-07 | 2012-10-10 | Laboratoire Biodim | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
| CN103145692B (zh) * | 2013-03-12 | 2014-07-16 | 盐城工学院 | 一种4,5-二氢-6H-环戊烷并[b]噻吩-6-酮的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE296797T1 (de) * | 1996-11-22 | 2005-06-15 | Elan Pharm Inc | N-(aryl/heteroaryl/alkylacetyl) amino saüre amide,pharmazeutische zusammensetzungen damit, und methodenzur inhibierung beta-amyloid peptid freisetzung oder synthese |
| PL196641B1 (pl) * | 1996-12-23 | 2008-01-31 | Elan Pharm Inc | Związki laktamowe i środek farmaceutyczny |
| EP1087951B9 (en) * | 1998-06-18 | 2006-09-13 | Bristol-Myers Squibb Company | Carbon substituted aminothiazole inhibitors of cyclin dependent kinases |
| AU6229699A (en) * | 1998-10-26 | 2000-05-15 | Sumitomo Pharmaceuticals Company, Limited | Beta-amyloid formation inhibitors |
| GB9823871D0 (en) * | 1998-10-30 | 1998-12-23 | Pharmacia & Upjohn Spa | 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents |
| AR039059A1 (es) * | 2001-08-06 | 2005-02-09 | Sanofi Aventis | Compuesto derivado de acilaminotiazol, su utilizacion, procedimientos para prepararlo, composicion farmaceutica que lo comprende, y compuestos intermediarios |
-
2003
- 2003-01-23 FR FR0300703A patent/FR2850380B1/fr not_active Expired - Fee Related
-
2004
- 2004-01-22 MX MXPA05007847A patent/MXPA05007847A/es active IP Right Grant
- 2004-01-22 BR BR0406893-9A patent/BRPI0406893A/pt not_active IP Right Cessation
- 2004-01-22 JP JP2006502115A patent/JP2006515888A/ja not_active Ceased
- 2004-01-22 EP EP04704255A patent/EP1590337B1/fr not_active Expired - Lifetime
- 2004-01-22 CA CA002511610A patent/CA2511610A1/en not_active Abandoned
- 2004-01-22 AR ARP040100169A patent/AR042745A1/es unknown
- 2004-01-22 RS YUP-2005/0563A patent/RS51168B/sr unknown
- 2004-01-22 KR KR1020057013441A patent/KR101059669B1/ko not_active IP Right Cessation
- 2004-01-22 AT AT04704255T patent/ATE404545T1/de not_active IP Right Cessation
- 2004-01-22 NZ NZ541147A patent/NZ541147A/en not_active IP Right Cessation
- 2004-01-22 RU RU2005126608/04A patent/RU2360907C2/ru not_active IP Right Cessation
- 2004-01-22 ME MEP-167/08A patent/MEP16708A/xx unknown
- 2004-01-22 DE DE602004015726T patent/DE602004015726D1/de not_active Expired - Lifetime
- 2004-01-22 CN CNB2004800027812A patent/CN100532370C/zh not_active Expired - Fee Related
- 2004-01-22 AU AU2004207658A patent/AU2004207658B2/en not_active Ceased
- 2004-01-22 PL PL377999A patent/PL377999A1/pl not_active Application Discontinuation
- 2004-01-22 WO PCT/FR2004/000140 patent/WO2004067520A1/fr active IP Right Grant
- 2004-01-27 TW TW093101748A patent/TWI320710B/zh not_active IP Right Cessation
-
2005
- 2005-06-27 IL IL169428A patent/IL169428A/en not_active IP Right Cessation
- 2005-07-12 HR HR20050637A patent/HRP20050637A2/hr not_active Application Discontinuation
- 2005-07-12 MA MA28385A patent/MA27610A1/fr unknown
- 2005-07-21 US US11/186,507 patent/US7563903B2/en not_active Expired - Fee Related
- 2005-07-22 NO NO20053588A patent/NO330415B1/no not_active IP Right Cessation
-
2009
- 2009-06-22 US US12/488,658 patent/US7879889B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20065578L (no) | Substituerte metylaryl eller heteroarylamidforbindelser | |
| TR199801942T2 (xx) | Piperazin ve piperidin bile�ikleri. | |
| RS51280B (sr) | Novi derivati hidantoina za tretman obstruktivnih bolesti dišnih puteva | |
| TW200505834A (en) | Sulfamide derivative and the pharmaceutical composition thereof | |
| RS52953B (sr) | Piridopirimidinonski inhibitori pi3 kalfa | |
| MEP7808A (en) | Process for preparing 4-trifluoromethylsulphinylpyrazole derivative | |
| MY152535A (en) | Novel 6-triazolopyridazinesulfanyl benzothiazole and benzimidazole derivatives, method for production thereof and application as medicaments and pharmaceutical compositions and novel use as met inhibitors | |
| EA200601830A1 (ru) | Ортозамещённые арильные или гетероарильные амидные соединения | |
| RS53180B (sr) | Novi inhibitori seh i njihova upotreba | |
| MEP10709A (en) | 2-ARYL-6-PHENYLIMIDAZO[1,2-alpha]PYRIDINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | |
| RS51136B (sr) | Supstituisani pirolopiridini, kompozicije koje ih sadrže, postupak za njihovo dobijanje i upotreba | |
| RS51454B (sr) | 5,6-dialkil-7-aminotriazolopirimidini, postupci za njihovo dobijanje, njihova primena za kontrolu patogenih gljiva, kao i sredstva koja sadrže pomenuta jedinjenja | |
| RS54506B1 (sr) | Derivati pikolinamida kao inhibitori kinaza | |
| RS51471B (sr) | Derivati bifeniloksisirćetne kiseline za tretman bolesti dišnog trakta | |
| HRP20020175B1 (en) | N-heterocyclikc derivatives as nos inhibitors | |
| TW200724136A (en) | Pharmaceutical compositions comprising PPAR modulator | |
| RS50606B (sr) | Supstituisani morfolin i tiomorfolin derivati | |
| WO2008107502A8 (es) | Composicion para el tratamiento de enfermedades infecciosas | |
| RS54047B1 (sr) | Postupak za dobijanje jedinjenja 4-oksohinolina | |
| TW200712127A (en) | The polysilicone composition for the use for stripping film | |
| CY1110034T1 (el) | Παραγωγα 1,2,4,5-τετραϋδρο-3h-βενζαζεπινων, μεθοδος παρασκευης αυτων και οι φαρμακευτικες συνθεσεις που τα περιεχουν | |
| WO2009118473A3 (fr) | Composés dérivés d'azétidines, leur préparation et leur application en thérapeutique | |
| TNSN06356A1 (en) | Tetrahydroisoquinoline sulfonamide derivatives, the preparation thereof, and the use of the same in therapeutics | |
| RS53414B (sr) | Derivati pirazinooksazepina | |
| RS51168B (sr) | Derivati acilaminotiazola, njihovo dobijanje i njihova upotreba kao inhibitora proizvodnje beta-amiloid peptida |