AR042242A1 - Formulacion pulverulenta que contiene tiotropio destinada a la inhalacion - Google Patents

Formulacion pulverulenta que contiene tiotropio destinada a la inhalacion

Info

Publication number
AR042242A1
AR042242A1 ARP030104393A ARP030104393A AR042242A1 AR 042242 A1 AR042242 A1 AR 042242A1 AR P030104393 A ARP030104393 A AR P030104393A AR P030104393 A ARP030104393 A AR P030104393A AR 042242 A1 AR042242 A1 AR 042242A1
Authority
AR
Argentina
Prior art keywords
inhalation
cover
housing
well
powder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
ARP030104393A
Other languages
English (en)
Inventor
Hartig Mareke Dr
Trunk Michael Dr
Walz Michael Dr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH Co KG
Original Assignee
Boehringer Ingelheim Pharma GmbH Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32308760&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR042242(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma GmbH Co KG filed Critical Boehringer Ingelheim Pharma GmbH Co KG
Publication of AR042242A1 publication Critical patent/AR042242A1/es
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A61M15/0025—Mouthpieces therefor with caps
    • A61M15/0026—Hinged caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Abstract

Formulaciones pulverulentas que contienen tiotropio para la inhalación a procedimientos para su producción, así como a su utilización para la preparación de un medicamento destinado al tratamiento de enfermedades de las vías respiratorias, en particular para el tratamiento de la COPD (chronic obstructive pulmonary disease = enfermedad pulmonar obstructuva crónica) y del asma. Reivindicación 1: Polvo para inhalación que contiene de 0,001 a 3% de tiotropio en mezcla con una sustancia coadyuvante fisiológicamente inocua, caracterizado porque la sustancia coadyuvante presenta un tamano medio de partículas de 10-50 micrones, una porción fina del 10 % de 0,5 a 6 micrones, así como una superficie específica de 0,1 a 2 m2/g. Reivindicación 6: Cápsulas que contienen un polvo para inhalación de acuerdo con una de las reivindicaciones 1 a 4. Reivindicación 10: Estuche para inhalación que consta de una cápsula de acuerdo con una de las reivindicaciones 6 a 9 y de un inhalador, que se puede utilizar para la aplicación de polvos para inhalación a partir de cápsulas que contienen polvos. Reivindicación 11: Estuche para inhalación de acuerdo con la reivindicación 10, caracterizado porque el inhalador está caracterizado por un alojamiento 1, que contiene dos ventanas 2, una cubierta 3, en la que se encuentran unos orificios para la entrada de aire y que está provista de un tamiz 5 fijado sobre un alojamiento 4 de tamiz, una cámara para inhalación 6 unida con la cubierta 3, junto a la que está previsto un gatillo 9 provisto de dos agujas 7 afiladas, que es movible contra un resorte 8, una embocadura 12 unida de modo abatible a través de un eje 10 con el alojamiento 1, la cubierta 3 y una caperuza 11, así como orificios 13 para el paso de aire, con el fin de ajustar la resistencia a la circulación.
ARP030104393A 2002-11-28 2003-11-28 Formulacion pulverulenta que contiene tiotropio destinada a la inhalacion Pending AR042242A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10255387A DE10255387A1 (de) 2002-11-28 2002-11-28 Neue Tiotropium-haltige Pulverformulierung für die Inhalation

Publications (1)

Publication Number Publication Date
AR042242A1 true AR042242A1 (es) 2005-06-15

Family

ID=32308760

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030104393A Pending AR042242A1 (es) 2002-11-28 2003-11-28 Formulacion pulverulenta que contiene tiotropio destinada a la inhalacion

Country Status (34)

Country Link
EP (1) EP1567135B1 (es)
JP (1) JP4977321B2 (es)
KR (1) KR101066805B1 (es)
CN (1) CN100574751C (es)
AR (1) AR042242A1 (es)
AT (1) ATE401861T1 (es)
AU (1) AU2003294714B2 (es)
BR (1) BR0316343A (es)
CA (1) CA2507579C (es)
CO (1) CO5580736A2 (es)
CY (1) CY1108420T1 (es)
DE (2) DE10255387A1 (es)
DK (1) DK1567135T3 (es)
EA (1) EA011549B1 (es)
EC (1) ECSP055821A (es)
ES (1) ES2310681T3 (es)
HK (1) HK1085918A1 (es)
HR (1) HRP20050468A2 (es)
IL (1) IL168810A (es)
ME (1) MEP51608A (es)
MX (1) MXPA05005485A (es)
MY (1) MY140890A (es)
NO (1) NO20053090L (es)
PE (1) PE20040848A1 (es)
PL (1) PL376229A1 (es)
PT (1) PT1567135E (es)
RS (1) RS20050400A (es)
SA (1) SA04240467B1 (es)
SI (1) SI1567135T1 (es)
TW (1) TWI332837B (es)
UA (1) UA81930C2 (es)
UY (1) UY28096A1 (es)
WO (1) WO2004047796A2 (es)
ZA (1) ZA200502859B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006016904A1 (de) 2006-04-11 2007-10-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Inhalator
DE102008014025A1 (de) 2008-03-13 2009-09-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Inhalator und Sieb für einen Inhalator
TR200909788A2 (tr) 2009-12-25 2011-07-21 Bi̇lgi̇ç Mahmut Tiotropyum içeren inhalasyona uygun kuru toz formülasyonu
AU2011287711B2 (en) * 2010-08-03 2016-10-27 Chiesi Farmaceutici S.P.A. Dry powder formulation comprising a phosphodiesterase inhibitor
BR112015010601B1 (pt) * 2012-11-09 2022-07-19 Civitas Therapeutics, Inc. Composição farmacêutica e uso da composição
KR101748796B1 (ko) * 2015-09-30 2017-06-19 한미약품 주식회사 활성성분의 전달량이 향상된 흡입용 캡슐제
KR101728116B1 (ko) * 2015-11-03 2017-04-18 한미약품 주식회사 티오트로피움 또는 이의 약학적으로 허용가능한 염을 함유하는 흡입용 건조분말 조성물
CN111514418B (zh) * 2019-06-12 2022-01-14 中南大学湘雅二医院 一种自吸式经鼻粉末材料给送装置

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1242211A (en) * 1967-08-08 1971-08-11 Fisons Pharmaceuticals Ltd Pharmaceutical composition
DE4140689B4 (de) * 1991-12-10 2007-11-22 Boehringer Ingelheim Kg Inhalationspulver und Verfahren zu ihrer Herstellung
DE4318455A1 (de) * 1993-06-03 1994-12-08 Boehringer Ingelheim Kg Kapselhalterung
GB9322014D0 (en) * 1993-10-26 1993-12-15 Co Ordinated Drug Dev Improvements in and relating to carrier particles for use in dry powder inhalers
DE4425255A1 (de) * 1994-07-16 1996-01-18 Asta Medica Ag Formulierung zur inhalativen Applikation
EP1862164A3 (de) * 1998-11-13 2012-12-26 Jagotec AG Trockenpulver zur Inhalation
GB9902689D0 (en) * 1999-02-08 1999-03-31 Novartis Ag Organic compounds
UA75375C2 (en) * 2000-10-12 2006-04-17 Boehringer Ingelheim Pharma Method for producing powdery preparations for inhaling
ES2227268T3 (es) * 2000-10-12 2005-04-01 BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG Nuevos polvos para inhalacion con contenido en tiotropio.
DE10126924A1 (de) * 2001-06-01 2002-12-05 Boehringer Ingelheim Pharma Inhalationskapseln
DE10141377A1 (de) * 2001-08-23 2003-03-13 Boehringer Ingelheim Pharma Aufstreuverfahren zur Herstellung von Pulverformulierungen
WO2003084509A1 (en) * 2002-04-04 2003-10-16 Boehringer Ingelheim Pharma Gmbh & Co. Kg Powder formulations suitable for inhalation
UA80123C2 (en) * 2002-04-09 2007-08-27 Boehringer Ingelheim Pharma Inhalation kit comprising inhalable powder of tiotropium

Also Published As

Publication number Publication date
PE20040848A1 (es) 2005-01-14
RS20050400A (en) 2007-04-10
EA011549B1 (ru) 2009-04-28
PT1567135E (pt) 2008-09-01
KR20050086887A (ko) 2005-08-30
HRP20050468A2 (en) 2006-07-31
DE10255387A1 (de) 2004-06-09
SI1567135T1 (sl) 2008-10-31
UY28096A1 (es) 2004-06-30
CY1108420T1 (el) 2014-04-09
HK1085918A1 (en) 2006-09-08
UA81930C2 (uk) 2008-02-25
MEP51608A (en) 2011-02-10
WO2004047796A2 (de) 2004-06-10
MY140890A (en) 2010-01-29
CA2507579C (en) 2011-07-19
EP1567135A2 (de) 2005-08-31
CA2507579A1 (en) 2004-06-10
NO20053090D0 (no) 2005-06-23
WO2004047796A3 (de) 2004-09-30
CO5580736A2 (es) 2005-11-30
TW200500066A (en) 2005-01-01
AU2003294714B2 (en) 2009-10-08
JP2006510622A (ja) 2006-03-30
PL376229A1 (en) 2005-12-27
ES2310681T3 (es) 2009-01-16
TWI332837B (en) 2010-11-11
EP1567135B1 (de) 2008-07-23
BR0316343A (pt) 2005-09-27
ZA200502859B (en) 2006-02-22
AU2003294714A1 (en) 2004-06-18
IL168810A (en) 2015-02-26
SA04240467B1 (ar) 2008-10-15
DK1567135T3 (da) 2008-10-27
ATE401861T1 (de) 2008-08-15
DE50310208D1 (de) 2008-09-04
ECSP055821A (es) 2005-08-11
CN100574751C (zh) 2009-12-30
KR101066805B1 (ko) 2011-09-22
MXPA05005485A (es) 2005-07-25
CN1717225A (zh) 2006-01-04
JP4977321B2 (ja) 2012-07-18
EA200500864A1 (ru) 2006-02-24
NO20053090L (no) 2005-06-23

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