AR040344A1 - Piperidinas espirosustituidas como antagonistas selectivos del receptor de la hormona concentradora de melanina para el tratamiento de la obesidad - Google Patents
Piperidinas espirosustituidas como antagonistas selectivos del receptor de la hormona concentradora de melanina para el tratamiento de la obesidadInfo
- Publication number
- AR040344A1 AR040344A1 ARP030102294A ARP030102294A AR040344A1 AR 040344 A1 AR040344 A1 AR 040344A1 AR P030102294 A ARP030102294 A AR P030102294A AR P030102294 A ARP030102294 A AR P030102294A AR 040344 A1 AR040344 A1 AR 040344A1
- Authority
- AR
- Argentina
- Prior art keywords
- nr8r9
- cr2r3
- alkyl
- aryl
- heteroaryl
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 3
- 208000008589 Obesity Diseases 0.000 title abstract 2
- 229940088597 hormone Drugs 0.000 title abstract 2
- 239000005556 hormone Substances 0.000 title abstract 2
- 235000020824 obesity Nutrition 0.000 title abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 7
- 125000003118 aryl group Chemical group 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- -1 methylenedioxy Chemical group 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 208000030814 Eating disease Diseases 0.000 abstract 1
- 208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010020710 Hyperphagia Diseases 0.000 abstract 1
- 229920000877 Melamine resin Polymers 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 235000014632 disordered eating Nutrition 0.000 abstract 1
- 125000004475 heteroaralkyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- JDSHMPZPIAZGSV-UHFFFAOYSA-N melamine Chemical compound NC1=NC(N)=NC(N)=N1 JDSHMPZPIAZGSV-UHFFFAOYSA-N 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Child & Adolescent Psychology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39181302P | 2002-06-27 | 2002-06-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR040344A1 true AR040344A1 (es) | 2005-03-30 |
Family
ID=30000757
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030102294A AR040344A1 (es) | 2002-06-27 | 2003-06-26 | Piperidinas espirosustituidas como antagonistas selectivos del receptor de la hormona concentradora de melanina para el tratamiento de la obesidad |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7109207B2 (enExample) |
| EP (1) | EP1532147B1 (enExample) |
| JP (1) | JP4522853B2 (enExample) |
| CN (1) | CN100374440C (enExample) |
| AR (1) | AR040344A1 (enExample) |
| AT (1) | ATE334983T1 (enExample) |
| AU (1) | AU2003258957A1 (enExample) |
| CA (1) | CA2490531C (enExample) |
| DE (1) | DE60307289T2 (enExample) |
| ES (1) | ES2266861T3 (enExample) |
| MX (1) | MXPA05000185A (enExample) |
| PE (1) | PE20040749A1 (enExample) |
| TW (1) | TW200401777A (enExample) |
| WO (1) | WO2004002987A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002352878B2 (en) | 2001-11-27 | 2007-11-22 | Merck Sharp & Dohme Corp. | 2-Aminoquinoline compounds |
| JPWO2004069798A1 (ja) | 2003-02-10 | 2006-05-25 | 萬有製薬株式会社 | ピペリジン誘導体を有効成分とするメラニン凝集ホルモン受容体拮抗剤 |
| ES2305735T3 (es) * | 2003-02-28 | 2008-11-01 | Schering Corporation | Biariltetrahidroisoquinolin-piperidinas como antagonistas del receptor de mch selectivos, para el tratamiento de obesidad y trastornos relacionados. |
| CA2563164A1 (en) | 2004-03-29 | 2005-10-06 | Pfizer Inc. | Alpha aryl or heteroaryl methyl beta piperidino propanoic acid compounds as orl1-receptor antagonists |
| TW200630337A (en) * | 2004-10-14 | 2006-09-01 | Euro Celtique Sa | Piperidinyl compounds and the use thereof |
| JPWO2006104136A1 (ja) * | 2005-03-29 | 2008-09-11 | 萬有製薬株式会社 | 非アルコール性脂肪性肝疾患の治療剤、及び非アルコール性脂肪性肝疾患の治療又は予防のための薬剤の候補化合物のスクリーニング方法 |
| US8247442B2 (en) * | 2006-03-29 | 2012-08-21 | Purdue Pharma L.P. | Benzenesulfonamide compounds and their use |
| US8791264B2 (en) * | 2006-04-13 | 2014-07-29 | Purdue Pharma L.P. | Benzenesulfonamide compounds and their use as blockers of calcium channels |
| WO2007118854A1 (en) * | 2006-04-13 | 2007-10-25 | Euro-Celtique S.A. | Benzenesulfonamide compounds and the use thereof |
| WO2008038692A1 (en) * | 2006-09-28 | 2008-04-03 | Banyu Pharmaceutical Co., Ltd. | Diaryl ketimine derivative |
| US8399486B2 (en) * | 2007-04-09 | 2013-03-19 | Purdue Pharma L.P. | Benzenesulfonyl compounds and the use thereof |
| WO2009040659A2 (en) * | 2007-09-28 | 2009-04-02 | Purdue Pharma L.P. | Benzenesulfonamide compounds and the use thereof |
| US9090084B2 (en) | 2010-05-21 | 2015-07-28 | Hewlett-Packard Development Company, L.P. | Fluid ejection device including recirculation system |
| US9963739B2 (en) | 2010-05-21 | 2018-05-08 | Hewlett-Packard Development Company, L.P. | Polymerase chain reaction systems |
| MX2017006437A (es) * | 2014-11-21 | 2017-08-08 | Esteve Labor Dr | Compuestos espiroisoquinolin-1,4'-piperidinicos con actividad multimodal contra el dolor. |
| CN107312056B (zh) * | 2017-08-24 | 2019-10-25 | 广西师范学院 | 2-(3’-羟基-17’-孕甾烷基)-5-氟苯并咪唑的合成方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5908830A (en) * | 1996-10-31 | 1999-06-01 | Merck & Co., Inc. | Combination therapy for the treatment of diabetes and obesity |
| TWI279402B (en) * | 1999-08-20 | 2007-04-21 | Banyu Pharma Co Ltd | Spiro compounds having NPY antagonistic activities and agents containing the same |
| CA2381111A1 (en) * | 1999-08-26 | 2001-03-01 | Leah M. Giupponi | Npy antagonists: spiroisoquinolinone derivatives |
| AU4928101A (en) | 2000-03-23 | 2001-10-03 | Merck & Co Inc | Spiropiperidine derivatives as melanocortin receptor agonists |
| WO2002006245A1 (en) * | 2000-07-05 | 2002-01-24 | Synaptic Pharmarceutical Corporation | Selective melanin concentrating hormone-1 (mch1) receptor antagonists and uses thereof |
-
2003
- 2003-06-26 AR ARP030102294A patent/AR040344A1/es unknown
- 2003-06-26 PE PE2003000647A patent/PE20040749A1/es not_active Application Discontinuation
- 2003-06-26 EP EP03762050A patent/EP1532147B1/en not_active Expired - Lifetime
- 2003-06-26 WO PCT/US2003/020088 patent/WO2004002987A1/en not_active Ceased
- 2003-06-26 MX MXPA05000185A patent/MXPA05000185A/es active IP Right Grant
- 2003-06-26 ES ES03762050T patent/ES2266861T3/es not_active Expired - Lifetime
- 2003-06-26 US US10/607,051 patent/US7109207B2/en not_active Expired - Fee Related
- 2003-06-26 JP JP2004517838A patent/JP4522853B2/ja not_active Expired - Fee Related
- 2003-06-26 DE DE60307289T patent/DE60307289T2/de not_active Expired - Lifetime
- 2003-06-26 CA CA2490531A patent/CA2490531C/en not_active Expired - Fee Related
- 2003-06-26 AU AU2003258957A patent/AU2003258957A1/en not_active Abandoned
- 2003-06-26 CN CNB038151936A patent/CN100374440C/zh not_active Expired - Fee Related
- 2003-06-26 TW TW092117445A patent/TW200401777A/zh unknown
- 2003-06-26 AT AT03762050T patent/ATE334983T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2490531A1 (en) | 2004-01-08 |
| TW200401777A (en) | 2004-02-01 |
| JP4522853B2 (ja) | 2010-08-11 |
| EP1532147A1 (en) | 2005-05-25 |
| EP1532147B1 (en) | 2006-08-02 |
| CA2490531C (en) | 2011-03-22 |
| ES2266861T3 (es) | 2007-03-01 |
| JP2005535641A (ja) | 2005-11-24 |
| HK1071567A1 (en) | 2005-07-22 |
| CN100374440C (zh) | 2008-03-12 |
| US7109207B2 (en) | 2006-09-19 |
| US20040024002A1 (en) | 2004-02-05 |
| ATE334983T1 (de) | 2006-08-15 |
| AU2003258957A1 (en) | 2004-01-19 |
| DE60307289D1 (de) | 2006-09-14 |
| DE60307289T2 (de) | 2007-10-18 |
| MXPA05000185A (es) | 2005-04-08 |
| PE20040749A1 (es) | 2004-10-23 |
| CN1665812A (zh) | 2005-09-07 |
| WO2004002987A1 (en) | 2004-01-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR040344A1 (es) | Piperidinas espirosustituidas como antagonistas selectivos del receptor de la hormona concentradora de melanina para el tratamiento de la obesidad | |
| JP6421241B2 (ja) | タンパク質キナーゼ阻害剤としての６−アミノ−７−ビシクロ−７−デアザ−プリン誘導体 | |
| CO6160312A2 (es) | Derivados de quiniclidina de acido (hetero) arilcicloheptano carboxilico como antagonistas del receptor muscarinico | |
| ES2339456T3 (es) | Derivados de pirrol(2,3-b)piridina activos como inhibidores de quinasa, procedimientos para su preparacion y composiciones farmaceuticas que los comprenden. | |
| MX2015004787A (es) | Compuestos antiviricos para el virus sincitial respiratorio. | |
| AR067475A1 (es) | Antagonistas no basico s del receptor de la hormona concentradora de melanina 1 | |
| ES2594409T3 (es) | Derivados de heteroarilo como moduladores del nAChR á7 | |
| AU616185B2 (en) | Oxazolidinones | |
| NZ523839A (en) | 3,4-dihydroisoquinoline derivative compounds and drugs containing these compounds as the active ingredient | |
| RU2014123434A (ru) | Фармацевтические соединения | |
| AR072816A1 (es) | Derivados heterociclicos de piridazina, inhibidores de smo, composiciones farmaceuticas que los comprenden y uso de los mismos como agentes anticancer. | |
| AR083831A1 (es) | Antagonistas del receptor del cgrp de piperidinona carboxamida azaindano | |
| AR035716A1 (es) | Compuestos agonistas del receptor beta3-adrenergico, uso de los mismos en la fabricacion de medicamentos y composiciones farmaceuticas conteniendo los mismos | |
| ECSP034475A (es) | Derivados de 4-fenil-piridin como antagonistas del receptor de neuroquinina-1 | |
| AR072906A1 (es) | Nucleosidos modificados utiles como antivirales | |
| JP2003503403A (ja) | 呼吸合胞体ウイルス複製阻害剤 | |
| AR060404A1 (es) | Compuestos organicos utiles como inhibidores de dipeptidil-peptidasa iv | |
| AR056979A1 (es) | Derivados de dihidrobenzofuranos y usos de los mismos | |
| AR036939A1 (es) | Antagonistas de la hormona de concentracion de melanina (mch) composiciones farmaceuticas, un proceso para su elaboracion y el uso de dichos compuestos, solos o en combinacion, para la elaboracion de un medicamento para el tratamiento de obesidad | |
| AR037907A1 (es) | Derivados de azaindolilalquilamina como ligandos de 5-hidroxitriptamina-6 | |
| JPH04334366A (ja) | インドール誘導体 | |
| AR063373A1 (es) | Derivados de benzodioxano y sus usos | |
| JPH05230059A (ja) | ベンゾジオキサン誘導体 | |
| UY26048A1 (es) | Derivados de piridopiranoacepinas, su preparacion y su aplicacion terapeutica | |
| CO6210819A2 (es) | Agonistas de adrenoreceptores alfa2c funcionalmente selectivos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |