AR040141A1 - Derivados de piridazina como inhibidores de fosfodiesterasa iv - Google Patents
Derivados de piridazina como inhibidores de fosfodiesterasa ivInfo
- Publication number
- AR040141A1 AR040141A1 ARP030101978A ARP030101978A AR040141A1 AR 040141 A1 AR040141 A1 AR 040141A1 AR P030101978 A ARP030101978 A AR P030101978A AR P030101978 A ARP030101978 A AR P030101978A AR 040141 A1 AR040141 A1 AR 040141A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- groups
- atoms
- conha
- cooa
- Prior art date
Links
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 title abstract 2
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 title abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 7
- 229910052760 oxygen Inorganic materials 0.000 abstract 7
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 6
- 101001043818 Mus musculus Interleukin-31 receptor subunit alpha Proteins 0.000 abstract 5
- 125000002947 alkylene group Chemical group 0.000 abstract 5
- 125000004450 alkenylene group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 2
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 abstract 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical class C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 2
- 208000030507 AIDS Diseases 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- -1 COOA Chemical group 0.000 abstract 1
- 206010006895 Cachexia Diseases 0.000 abstract 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical group O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract 1
- 208000031229 Cardiomyopathies Diseases 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 1
- 235000010290 biphenyl Nutrition 0.000 abstract 1
- 239000004305 biphenyl Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002993 cycloalkylene group Chemical group 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
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- Communicable Diseases (AREA)
- Physical Education & Sports Medicine (AREA)
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- Immunology (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
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- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10224888A DE10224888A1 (de) | 2002-06-05 | 2002-06-05 | Pyridazinderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR040141A1 true AR040141A1 (es) | 2005-03-16 |
Family
ID=29594275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
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Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| MX2007012794A (es) | 2005-04-13 | 2008-02-22 | Astion Pharma As | Composiciones para el tratamiento de trastornos del tejido conectivo de la piel. |
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| GB2431927B (en) * | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
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| CA2667962A1 (en) | 2006-10-30 | 2008-05-08 | Novartis Ag | Heterocyclic compounds as antiinflammatory agents |
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| AU2008248598B2 (en) | 2007-05-07 | 2011-11-17 | Novartis Ag | Organic compounds |
| ES2654395T3 (es) | 2007-12-10 | 2018-02-13 | Novartis Ag | Análogos de amilorida espirocíclicos como bloqueantes de ENaC |
| JP5584138B2 (ja) | 2008-01-11 | 2014-09-03 | ノバルティス アーゲー | キナーゼ阻害剤としてのピリミジン類 |
| WO2009092040A2 (en) * | 2008-01-17 | 2009-07-23 | Gary Dean Bennett | Topical pain formulation |
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| CA2744898A1 (en) * | 2008-12-23 | 2010-07-01 | Amira Pharmaceuticals, Inc. | Topical formulations of flap inhibitors for administration to an eye |
| EP2381945A4 (en) * | 2008-12-23 | 2012-06-13 | Panmira Pharmaceuticals Llc | TOPICAL FORMULAS OF FLAP INHIBITORS FOR THE TREATMENT OF DERMATOLOGICAL DISEASES |
| DK2391366T3 (da) | 2009-01-29 | 2013-01-07 | Novartis Ag | Substituerede benzimidazoler til behandling af astrocytomer |
| US8389526B2 (en) | 2009-08-07 | 2013-03-05 | Novartis Ag | 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives |
| JP5781510B2 (ja) | 2009-08-12 | 2015-09-24 | ノバルティス アーゲー | ヘテロ環式ヒドラゾン化合物および癌および炎症の処置のためのそれらの使用 |
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| MX2012002179A (es) | 2009-08-20 | 2012-03-16 | Novartis Ag | Compuestos heterociclicos de oxima. |
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| WO2012034095A1 (en) | 2010-09-09 | 2012-03-15 | Irm Llc | Compounds and compositions as trk inhibitors |
| UY33597A (es) | 2010-09-09 | 2012-04-30 | Irm Llc | Compuestos y composiciones como inhibidores de la trk |
| US8372845B2 (en) | 2010-09-17 | 2013-02-12 | Novartis Ag | Pyrazine derivatives as enac blockers |
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| JP5808826B2 (ja) | 2011-02-23 | 2015-11-10 | インテリカイン, エルエルシー | 複素環化合物およびその使用 |
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| US9034879B2 (en) | 2011-09-16 | 2015-05-19 | Novartis Ag | Heterocyclic compounds for the treatment of CF |
| WO2013038381A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | Pyridine/pyrazine amide derivatives |
| WO2013038373A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | Pyridine amide derivatives |
| ES2882807T3 (es) | 2011-09-16 | 2021-12-02 | Novartis Ag | Heterociclil carboxamidas N-sustituidas |
| WO2013038378A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | Pyridine amide derivatives |
| JP6130391B2 (ja) | 2011-11-23 | 2017-05-17 | インテリカイン, エルエルシー | Mtor阻害剤を使用する強化された治療レジメン |
| US8809340B2 (en) | 2012-03-19 | 2014-08-19 | Novartis Ag | Crystalline form |
| WO2013149581A1 (en) | 2012-04-03 | 2013-10-10 | Novartis Ag | Combination products with tyrosine kinase inhibitors and their use |
| AU2013305759C1 (en) | 2012-08-23 | 2018-01-18 | Janssen Biopharma, Inc. | Compounds for the treatment of paramoxyvirus viral infections |
| US9446131B2 (en) | 2013-01-31 | 2016-09-20 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
| US8778365B1 (en) | 2013-01-31 | 2014-07-15 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
| US9433680B2 (en) | 2013-01-31 | 2016-09-06 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
| US9452173B2 (en) | 2013-01-31 | 2016-09-27 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
| US9073921B2 (en) | 2013-03-01 | 2015-07-07 | Novartis Ag | Salt forms of bicyclic heterocyclic derivatives |
| HK1219421A1 (zh) | 2013-03-15 | 2017-04-07 | 因特利凯有限责任公司 | 激酶抑制剂的组合及其用途 |
| TW201605450A (zh) | 2013-12-03 | 2016-02-16 | 諾華公司 | Mdm2抑制劑與BRAF抑制劑之組合及其用途 |
| WO2015162461A1 (en) | 2014-04-24 | 2015-10-29 | Novartis Ag | Pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors |
| MX2016013812A (es) | 2014-04-24 | 2017-03-09 | Novartis Ag | Derivados de amino-pirazina como inhibidores de fosfatidil-inositol-3-cinasa. |
| EA201692140A1 (ru) | 2014-04-24 | 2017-04-28 | Новартис Аг | Производные аминопиридина в качестве ингибиторов фосфатидилинозитол 3-киназы |
| WO2016011658A1 (en) | 2014-07-25 | 2016-01-28 | Novartis Ag | Combination therapy |
| BR112017001695A2 (pt) | 2014-07-31 | 2017-11-21 | Novartis Ag | terapia de combinação |
| WO2016149126A1 (en) | 2015-03-13 | 2016-09-22 | The Board Of Trustees Of The Leland Stanford Junior University | Ltb4 inhibition to prevent and treat human lymphedema |
| WO2018001948A1 (en) * | 2016-06-29 | 2018-01-04 | F. Hoffmann-La Roche Ag | Pyridazinone-based broad spectrum anti-influenza inhibitors |
| JP2022537667A (ja) | 2019-06-10 | 2022-08-29 | ノバルティス アーゲー | Cf、copd、及び気管支拡張症の治療のためのピリジン及びピラジン誘導体 |
| EP4021572A1 (en) | 2019-08-28 | 2022-07-06 | Novartis AG | Substituted 1,3-phenyl heteroaryl derivatives and their use in the treatment of disease |
| TW202140550A (zh) | 2020-01-29 | 2021-11-01 | 瑞士商諾華公司 | 使用抗tslp抗體治療炎性或阻塞性氣道疾病之方法 |
| US11116737B1 (en) | 2020-04-10 | 2021-09-14 | University Of Georgia Research Foundation, Inc. | Methods of using probenecid for treatment of coronavirus infections |
| US11844792B2 (en) * | 2020-07-10 | 2023-12-19 | Sean Downing | Treatment for severe acute respiratory illness associated with coronavirus |
| CN113143899A (zh) * | 2021-05-13 | 2021-07-23 | 中国人民解放军陆军军医大学第二附属医院 | 辣椒素在制备治疗溃疡性结肠炎药物中的应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19632549A1 (de) | 1996-08-13 | 1998-02-19 | Merck Patent Gmbh | Arylalkanoylpyridazine |
| DE19826841A1 (de) * | 1998-06-16 | 1999-12-23 | Merck Patent Gmbh | Arylalkanoylpyridazine |
| DE19915364A1 (de) * | 1999-04-06 | 2000-10-12 | Merck Patent Gmbh | Verwendung von Arylalkanoylpyridazinen |
| WO2001057025A1 (en) * | 2000-01-31 | 2001-08-09 | Pfizer Products Inc. | Pyrimidine carboxamides useful as inhibitors of pde4 isozymes |
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2002
- 2002-06-05 DE DE10224888A patent/DE10224888A1/de not_active Withdrawn
-
2003
- 2003-05-12 PL PL03371918A patent/PL371918A1/xx unknown
- 2003-05-12 DE DE50311783T patent/DE50311783D1/de not_active Expired - Lifetime
- 2003-05-12 JP JP2004511274A patent/JP4511925B2/ja not_active Expired - Fee Related
- 2003-05-12 BR BR0311343-4A patent/BR0311343A/pt not_active Application Discontinuation
- 2003-05-12 CA CA2488372A patent/CA2488372C/en not_active Expired - Fee Related
- 2003-05-12 MX MXPA04012009A patent/MXPA04012009A/es not_active Application Discontinuation
- 2003-05-12 AU AU2003227746A patent/AU2003227746B2/en not_active Ceased
- 2003-05-12 EP EP03725186A patent/EP1509506B1/de not_active Expired - Lifetime
- 2003-05-12 US US10/516,876 patent/US7129241B2/en not_active Expired - Fee Related
- 2003-05-12 KR KR10-2004-7019787A patent/KR20050009735A/ko not_active Withdrawn
- 2003-05-12 ES ES03725186T patent/ES2329670T3/es not_active Expired - Lifetime
- 2003-05-12 CN CN038128470A patent/CN1659147A/zh active Pending
- 2003-05-12 RU RU2004139032/04A patent/RU2004139032A/ru not_active Application Discontinuation
- 2003-05-12 AT AT03725186T patent/ATE438628T1/de not_active IP Right Cessation
- 2003-05-12 WO PCT/EP2003/004930 patent/WO2003104204A1/de not_active Ceased
- 2003-06-04 AR ARP030101978A patent/AR040141A1/es not_active Application Discontinuation
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2005
- 2005-01-04 ZA ZA200500071A patent/ZA200500071B/en unknown
-
2006
- 2006-08-02 US US11/497,241 patent/US7563790B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE438628T1 (de) | 2009-08-15 |
| CA2488372A1 (en) | 2003-12-18 |
| ES2329670T3 (es) | 2009-11-30 |
| AU2003227746B2 (en) | 2009-03-19 |
| US20060270681A1 (en) | 2006-11-30 |
| US7129241B2 (en) | 2006-10-31 |
| CN1659147A (zh) | 2005-08-24 |
| WO2003104204A1 (de) | 2003-12-18 |
| RU2004139032A (ru) | 2005-08-20 |
| PL371918A1 (en) | 2005-07-11 |
| DE10224888A1 (de) | 2003-12-24 |
| ZA200500071B (en) | 2006-07-26 |
| US7563790B2 (en) | 2009-07-21 |
| JP2005534660A (ja) | 2005-11-17 |
| US20050176714A1 (en) | 2005-08-11 |
| EP1509506A1 (de) | 2005-03-02 |
| BR0311343A (pt) | 2005-03-22 |
| KR20050009735A (ko) | 2005-01-25 |
| DE50311783D1 (de) | 2009-09-17 |
| AU2003227746A1 (en) | 2003-12-22 |
| JP4511925B2 (ja) | 2010-07-28 |
| CA2488372C (en) | 2012-02-21 |
| EP1509506B1 (de) | 2009-08-05 |
| MXPA04012009A (es) | 2005-03-07 |
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