AR038644A1 - Formulaciones hfa de agonistas beta-2 de derivados de 2 (1h)-quinolinona de accion prolongada - Google Patents

Formulaciones hfa de agonistas beta-2 de derivados de 2 (1h)-quinolinona de accion prolongada

Info

Publication number
AR038644A1
AR038644A1 ARP030100687A ARP030100687A AR038644A1 AR 038644 A1 AR038644 A1 AR 038644A1 AR P030100687 A ARP030100687 A AR P030100687A AR P030100687 A ARP030100687 A AR P030100687A AR 038644 A1 AR038644 A1 AR 038644A1
Authority
AR
Argentina
Prior art keywords
formulation
hfa
straight
branched
agonists
Prior art date
Application number
ARP030100687A
Other languages
English (en)
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27790093&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR038644(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from EP02004786A external-priority patent/EP1340492A1/en
Priority claimed from EP02023589A external-priority patent/EP1415647A1/en
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Publication of AR038644A1 publication Critical patent/AR038644A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)

Abstract

Formulación farmacéutica para usar en la administración de agonistas b2 de derivados de 2(1H)-quinolinona de acción prolongada por inhalación. Formulación en solución HFA altamente eficiente, químicamente estable de TA 2005, que se administra por medio de inhaladores dosificadores presurizados (pMDI), caracterizada por una penetración pulmonar profunda, y métodos para preparar dicha formulación y usarla en enfermedades respiratorias, tales como el asma u la enfermedad obstructiva pulmonar crónica (COPD). Reivindicación 1: Una formulación farmacéutica en aerosol que puede administrarse por medio de inhaladores dosificadores presurizados, caracteriza porque comprende un ingrediente activo seleccionado entre un agonista beta2 de un derivado de (1H)-quinolinona de acción prolongada de fórmula (1): donde R1 es metilo y R2 es hidrógeno, o R1 y R2 forman un puente metilénico (CH2)n; n es 1 ó 2; R3, R4, R5 y R6 son cada uno independientemente hidrógeno, hidroxilo, alquilo C1-4 de cadena recta o ramificada, alquilo C1-4 de cadena recta o ramificada sustituido con uno o más entre halógeno y/o hidroxilo, halógeno, alcoxilo C1-4 de cadena recta o ramificada, un enatiómero, una sal o un solvato del mismo; en una solución con un propelente licuado de HFA y una cantidad adecuada de un co-solvente, y opcionalmente una cantidad de agua de hasta 5% del peso total de la formulación. Reivindicación 11: Una formulación farmacéutica de acuerdo con cualquier reivindicación precedente, caracterizado porque el propelente incluye uno o más hidrofluoroalcanos [HFA] seleccionados del grupo que comprende HFA 134a y HFA227
ARP030100687A 2002-03-01 2003-02-28 Formulaciones hfa de agonistas beta-2 de derivados de 2 (1h)-quinolinona de accion prolongada AR038644A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02004786A EP1340492A1 (en) 2002-03-01 2002-03-01 Aerosol formulations for pulmonary administration of medicaments having systemic effects
EP02023589A EP1415647A1 (en) 2002-10-23 2002-10-23 "Long-acting beta-2 agonists ultrafine formulations"

Publications (1)

Publication Number Publication Date
AR038644A1 true AR038644A1 (es) 2005-01-19

Family

ID=27790093

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP030100684A AR038641A1 (es) 2002-03-01 2003-02-28 Formulacion superfina de formoterol
ARP030100687A AR038644A1 (es) 2002-03-01 2003-02-28 Formulaciones hfa de agonistas beta-2 de derivados de 2 (1h)-quinolinona de accion prolongada

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP030100684A AR038641A1 (es) 2002-03-01 2003-02-28 Formulacion superfina de formoterol

Country Status (36)

Country Link
US (4) US20050152846A1 (es)
EP (6) EP3494995B1 (es)
JP (3) JP2005523905A (es)
KR (2) KR100947409B1 (es)
CN (2) CN100398094C (es)
AR (2) AR038641A1 (es)
AT (1) ATE465712T1 (es)
AU (2) AU2003222753B2 (es)
BR (2) BRPI0308274B8 (es)
CA (2) CA2477881C (es)
CO (2) CO5611091A2 (es)
CY (4) CY1111133T1 (es)
DE (1) DE60332321D1 (es)
DK (4) DK3536344T3 (es)
EA (2) EA007735B1 (es)
ES (4) ES2780127T3 (es)
GE (2) GEP20063986B (es)
HK (1) HK1079425A1 (es)
HR (2) HRP20040752B1 (es)
HU (3) HUE044926T2 (es)
IL (3) IL163843A0 (es)
LT (3) LT3536344T (es)
MA (1) MA27175A1 (es)
ME (3) MEP30108A (es)
MX (2) MXPA04008372A (es)
MY (2) MY137603A (es)
NO (2) NO20043625L (es)
NZ (2) NZ535018A (es)
PE (2) PE20030824A1 (es)
PL (2) PL209212B1 (es)
PT (4) PT3494995T (es)
RS (2) RS52387B (es)
SI (4) SI3494995T1 (es)
TN (2) TNSN04147A1 (es)
TW (2) TW200303752A (es)
WO (2) WO2003074024A1 (es)

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