AR035824A1 - Un compuesto de pirazol util como inhibidor de proteinquinasas, composiciones farmaceuticas que lo contienen, un metodo para inhibir la actividad de quinasas en una muestra biologica, una composicion para recubrir un dispositivo implantable y un dispositivo implantable recubierto con dicha composici - Google Patents

Un compuesto de pirazol util como inhibidor de proteinquinasas, composiciones farmaceuticas que lo contienen, un metodo para inhibir la actividad de quinasas en una muestra biologica, una composicion para recubrir un dispositivo implantable y un dispositivo implantable recubierto con dicha composici

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AR035824A1
AR035824A1 ARP020101360A ARP020101360A AR035824A1 AR 035824 A1 AR035824 A1 AR 035824A1 AR P020101360 A ARP020101360 A AR P020101360A AR P020101360 A ARP020101360 A AR P020101360A AR 035824 A1 AR035824 A1 AR 035824A1
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Argentina
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independently selected
optionally substituted
nitrogen
useful
diseases
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ARP020101360A
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English (en)
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Jingrong Cao
Jeremy Green
Young-Choon Moon
Jian Wang
Mark Ledeboer
Edmund Harrington
Huai Gao
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Vertex Pharma
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Publication of AR035824A1 publication Critical patent/AR035824A1/es

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Abstract

Un compuesto de pirazol útil como inhibidor de proteínquinasas que tiene la formula (1) o un derivado farmacéuticamente aceptable del mismo, donde: A y B se seleccionan independientemente entre N y CH; R1 y R2 se seleccionan independientemente cada uno entre halógeno, CN, NO2, N(R)2, OR, SR y (T)n-R5; R3 se selecciona entre un anillo carbocíclico o heterocíclico de 3 a 6 miembros que tenga 1 o 2 heteroátomos seleccionados independientemente entre nitrógeno, oxígeno o azufre, fenilo, o un anillo de heteroarilo de 5 a 6 miembros que tenga de 1 a 3 heteroátomos seleccionados independientemente entre nitrógeno, oxígeno y azufre, en donde dicho anillo fenilo o de heteroarilo está sustituido opcionalmente con un (T)n-Ar y de 1 a 2 R7; cada n se selecciona independientemente entre 0 y 1. T es una cadena de alquilideno C1-6, en donde una unidad de metileno de T se sustituye opcionalmente con CO, CO2, COCO, CONR, OCONR, NRNR, NRNRCO, NRCO, NRCO2, NRCONR, SO2, NRSO2, SO2NR, NRSO2NR, O, S o NR; cada R se selecciona independientemente entre hidrógeno o un grupo alifático C1-6 sustituido opcionalmente; o dos R en el mismo átomo de nitrógeno se pueden juntar con el nitrógeno para formar un anillo heterocíclico saturado o no saturado de 4 a 8 miembros que contenga de 1 a 3 heteroátomos seleccionados independientemente entre nitrógeno, oxígeno y azufre; R4 es (T)n-R, (T)n-Ar o (T)n-Ar1; Ra se selecciona entre Rb, halógeno, NO2, ORb, SRb y N(Rb)2; Rb se selecciona entre hidrógeno y un grupo alifático C1-4 sustituido opcionalmente con oxo, OH, SH, NH2, halógeno, NO2 o CN; R5 es un C1-6 alifático o Ar sustituido opcionalmente; Ar es un anillo monocíclico saturado, parcialmente insaturado o de arilo de 5 o 6 miembros que tiene de 0 a 3 heteroátomos seleccionados independientemente entre nitrógeno, azufre y oxígeno, o un anillo bicíclico saturado, parcialmente insaturado o arilo de 8 a 10 miembros que tiene de 0 a 4 heteroátomos seleccionados independientemente entre nitrógeno, azufre y oxígeno, en donde Ar está sustituido opcionalmente con de 1 a 3 R7; Ar1 es un anillo de arilo de 6 miembros que tiene de 0 a 2 nitrógenos, en donde dicho anillo está sustituido con un grupo Z-R6 y sustituido opcionalmente con de 1 a 3 R7; Z es una cadena de alquilideno C1-6 en donde hasta 2 unidades de metileno no adyacentes de Z se reemplazan opcionalmente con CO, CO2, COCO, CONR, OCONR, NRNR, NRNRNCO, NRCO, NRCO2, NRCONR, SO, SO2, NRSO2, SO2NR, NRSO2NR, O, S o NR; siempre y cuando dicha unidad de metileno de Z reemplazada opcionalmente sea una unidad de metileno no adyacente a R6; R6 se selecciona entre Ar, R, halógeno, NO2, CN, OR, SR, N(R)2, NRC(O)R, NRC(O)N(R)2, NRCO2R, C(O)R, CO2R, OC(O)R, C(O)N(R)2, OC(O)N(R)2, SOR, SO2R, SO2N(R)2, NRSO2R, NRSO2N(R)2, C(O)C(O)R y C(O)CH2C(O)R; y cada R7 se selecciona independientemente entre R, halógeno, NO2, CN, OR, SR, N(R)2, NRC(O)R, NRC(O)N(R)2, NRCO2R, C(O)R, CO2R, C(O)N(R)2, OC(O)N(R)2, SOR, SO2R, SO2N(R)2, NRSO2R, NRSO2N(R)2, C(O)C(O)R y C(O)CH2C(O)R; o dos R7 en posiciones adyacentes de Ar1 se pueden juntar para formar un anillo de 5 a 7 miembros saturado, parcialmente insaturado o completamente insaturado, que contenga de 0 a 3 heteroátomos seleccionados entre O, S y N. La presente también proporcionar una composición farmacéutica que comprende un compuesto de la fórmula (1), un método para inhibir la actividad de quinasas en una muestra biológica, una composición para recubrir un dispositivo implantable y un dispositivo implantable recubierto con dicha composición. Los compuestos y composiciones farmacéuticas de la presente son útiles como inhibidores de quinasas N-terminales c-Jun (JNK) y quinasas de la familia Src, incluyendo Src y Lck. Por lo tanto, también son útiles en métodos para tratar o prevenir una amplia variedad de afecciones, como enfermedad cardíaca, afecciones de inmunodeficiencia, enfermedades inflamatorias, enfermedades alérgicas, enfermedades autoinmunes, afecciones oseodestructivas como osteoporosis, afecciones proliferativas, enfermedades infecciosas y enfermedades virales. Las composiciones también son útiles en métodos para prevenir la muerte celular e hiperplasia y por lo tanto se pueden usar para tratar o prevenir reperfusión/isquemia en embolia, ataques cardíacos e hipoxia de órganos. Las composiciones también son útiles en métodos para prevenir la agregación de plaquetas inducida por trombina. Las composiciones son especialmente útiles para afecciones como leucemia mielogénica crónica (CML), artritis reumatoide, asma, osteoartritis, isquemia, cáncer, enfermedades de hígado, incluyendo la isquemia hepática, enfermedades cardíacas como el infarto al miocardio y la insuficiencia cardíaca congestiva, afecciones inmunes patológicas que impliquen la activación de células T y trastornos neurodegenerativos.
ARP020101360A 2001-04-13 2002-04-12 Un compuesto de pirazol util como inhibidor de proteinquinasas, composiciones farmaceuticas que lo contienen, un metodo para inhibir la actividad de quinasas en una muestra biologica, una composicion para recubrir un dispositivo implantable y un dispositivo implantable recubierto con dicha composici AR035824A1 (es)

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US28362101P 2001-04-13 2001-04-13
US29297401P 2001-05-23 2001-05-23
US32944001P 2001-10-15 2001-10-15

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US (2) US6642227B2 (es)
EP (1) EP1389206B1 (es)
JP (1) JP2004535381A (es)
AR (1) AR035824A1 (es)
AT (1) ATE339416T1 (es)
AU (1) AU2002338642A1 (es)
CA (1) CA2443487A1 (es)
DE (1) DE60214701T2 (es)
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BR0112969A (pt) 2000-08-04 2004-06-22 Dmi Biosciences Inc Método de utilização de dicetopiperazinas e composições contendo-as
US6660731B2 (en) * 2000-09-15 2003-12-09 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
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