AR033811A1 - Derivados de hidroxifenil-piperazinil-metil-benzamida, proceso para su preparacion, intermediarios utiles para este proceso, usos de los mismos y composicion farmaceutica - Google Patents
Derivados de hidroxifenil-piperazinil-metil-benzamida, proceso para su preparacion, intermediarios utiles para este proceso, usos de los mismos y composicion farmaceuticaInfo
- Publication number
- AR033811A1 AR033811A1 ARP010101479A ARP010101479A AR033811A1 AR 033811 A1 AR033811 A1 AR 033811A1 AR P010101479 A ARP010101479 A AR P010101479A AR P010101479 A ARP010101479 A AR P010101479A AR 033811 A1 AR033811 A1 AR 033811A1
- Authority
- AR
- Argentina
- Prior art keywords
- derivatives
- useful
- hydroxifenil
- benzamida
- piperazinil
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- UDDPQOROCUUQOB-UHFFFAOYSA-N 5-hydroxy-2-methyl-4-phenyl-3-piperazin-1-ylbenzamide Chemical class C1CNCCN1C=1C(C)=C(C(N)=O)C=C(O)C=1C1=CC=CC=C1 UDDPQOROCUUQOB-UHFFFAOYSA-N 0.000 abstract 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000001425 triazolyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Furan Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0001209A SE0001209D0 (sv) | 2000-04-04 | 2000-04-04 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR033811A1 true AR033811A1 (es) | 2004-01-07 |
Family
ID=20279148
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010101479A AR033811A1 (es) | 2000-04-04 | 2001-03-28 | Derivados de hidroxifenil-piperazinil-metil-benzamida, proceso para su preparacion, intermediarios utiles para este proceso, usos de los mismos y composicion farmaceutica |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6696447B2 (enExample) |
| EP (1) | EP1278740B1 (enExample) |
| JP (1) | JP2003529597A (enExample) |
| KR (1) | KR20020084284A (enExample) |
| CN (1) | CN1422266A (enExample) |
| AR (1) | AR033811A1 (enExample) |
| AT (1) | ATE297914T1 (enExample) |
| AU (1) | AU2001244983A1 (enExample) |
| BR (1) | BR0109818A (enExample) |
| CA (1) | CA2402705A1 (enExample) |
| CZ (1) | CZ20023287A3 (enExample) |
| DE (1) | DE60111520T2 (enExample) |
| EE (1) | EE200200511A (enExample) |
| HU (1) | HUP0300562A3 (enExample) |
| IL (1) | IL151765A0 (enExample) |
| IS (1) | IS6563A (enExample) |
| MX (1) | MXPA02009758A (enExample) |
| NO (1) | NO20024776L (enExample) |
| NZ (1) | NZ521388A (enExample) |
| PL (1) | PL357812A1 (enExample) |
| SE (1) | SE0001209D0 (enExample) |
| SK (1) | SK14262002A3 (enExample) |
| WO (1) | WO2001074805A1 (enExample) |
| ZA (1) | ZA200207381B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9504661D0 (sv) * | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
| SE0100764D0 (sv) | 2001-03-07 | 2001-03-07 | Astrazeneca Ab | New assymetric process |
| ES2319876T3 (es) * | 2001-05-18 | 2009-05-14 | Astrazeneca Ab | Derivados de 4 (fenil-piperazinil-metil) benzamida y su uso para el tratamiento de la ansiedad o trastornos gastrointestinales. |
| TW200301701A (en) | 2002-01-02 | 2003-07-16 | Ardent Pharmaceuticals Inc | Method of treating sexual dysfunctions with delta opioid receptor agonist compounds |
| US8476280B2 (en) | 2002-05-09 | 2013-07-02 | Versi Group, Llc | Compositions and methods for combating lower urinary tract dysfunctions with delta opioid receptor agonists |
| SE0203300D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203302D0 (sv) * | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203303D0 (sv) * | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0400027D0 (sv) * | 2004-01-09 | 2004-01-09 | Astrazeneca Ab | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
| SE0401968D0 (sv) * | 2004-08-02 | 2004-08-02 | Astrazeneca Ab | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
| DK1781631T3 (da) * | 2004-08-02 | 2012-05-14 | Astrazeneca Ab | Diarylmethylpiperazinderivater, præparater dermed og anvendelser deraf |
| CN101128447A (zh) * | 2005-02-28 | 2008-02-20 | 阿斯利康(瑞典)有限公司 | 二芳基甲基哌嗪衍生物，其制备及其用途 |
| US20090291966A1 (en) * | 2008-05-20 | 2009-11-26 | Astrazeneca Ab | Method Of Treating Anxious Major Depressive Disorder |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH585209A5 (enExample) | 1973-06-29 | 1977-02-28 | Cermol Sa | |
| DE2900810A1 (de) | 1979-01-11 | 1980-07-24 | Cassella Ag | Substituierte n-benzhydryl-n'-p- hydroxybenzyl-piperazine und verfahren zu ihrer herstellung |
| IT1140978B (it) | 1980-05-23 | 1986-10-10 | Selvi & C Spa | 1-(4-clorobenzidril)-4-(2,3-diidros sipropil)-piperazina, metodi per la sua preparazione e relative composizione farmaceutiche |
| GB8320701D0 (en) | 1983-08-01 | 1983-09-01 | Wellcome Found | Chemotherapeutic agent |
| IT1196150B (it) | 1984-06-19 | 1988-11-10 | Poli Ind Chimica Spa | Derivati di 1-(bis-(4-fluorofenil)metil)-4-(3-fenil-2-propenil)-esaidro-1h-1,4-diazepina ad attivita' calcio antagonista,sua preparazione e composizioni che lo contengono |
| SE8500573D0 (sv) | 1985-02-08 | 1985-02-08 | Ferrosan Ab | Novel piperazinecarboxamides having a phenoxyalkyl or thiophenoxyalkyl side chain |
| US5028610A (en) | 1987-03-18 | 1991-07-02 | Sankyo Company Limited | N-benzhydryl-substituted heterocyclic derivatives, their preparation and their use |
| US4829065A (en) | 1987-04-24 | 1989-05-09 | Syntex Pharmaceuticals, Ltd. | Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives |
| US4826844A (en) | 1987-09-30 | 1989-05-02 | American Home Products Corporation | Substituted 1-(aralkyl-piperazinoalkyl) cycloalkanols |
| DE69033926T2 (de) | 1989-11-22 | 2002-10-24 | Janssen Pharmaceutica N.V., Beerse | Verwendung von Piperazin-Acetamid-Derivaten gegen Reperfusionsschaden |
| US5807858A (en) | 1996-06-05 | 1998-09-15 | Delta Pharmaceutical, Inc. | Compositions and methods for reducing respiratory depression |
| US5574159A (en) | 1992-02-03 | 1996-11-12 | Delta Pharmaceuticals, Inc. | Opioid compounds and methods for making therefor |
| US5681830A (en) | 1992-02-03 | 1997-10-28 | Delta Pharmaceuticals, Inc. | Opioid compounds |
| GB9202238D0 (en) | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
| FR2696744B1 (fr) | 1992-10-12 | 1994-12-30 | Logeais Labor Jacques | Dérivés de 2-pyrrolidone, leur procédé de préparation et leurs applications en thérapeutique. |
| DK0711289T3 (da) | 1993-07-30 | 2000-11-06 | Delta Pharmaceuticals Inc | Piperazinforbindelser til anvendelse i terapi |
| JP3352184B2 (ja) | 1993-11-12 | 2002-12-03 | 株式会社アズウェル | ピペラジン不飽和脂肪酸誘導体 |
| SE9504661D0 (sv) * | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
| TW548271B (en) * | 1996-12-20 | 2003-08-21 | Astra Pharma Inc | Novel piperidine derivatives having an exocyclic double bond with analgesic effects |
| SE9604786D0 (sv) | 1996-12-20 | 1996-12-20 | Astra Pharma Inc | New compounds |
| JP4754068B2 (ja) * | 1997-12-24 | 2011-08-24 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | δ−オピオイドレセプターに結合する４−［アリール（ピペリジン−４−イル）］アミノベンズアミド類 |
| GB9804734D0 (en) * | 1998-03-05 | 1998-04-29 | Pfizer Ltd | Compounds |
-
2000
- 2000-04-04 SE SE0001209A patent/SE0001209D0/xx unknown
-
2001
- 2001-03-28 AR ARP010101479A patent/AR033811A1/es not_active Application Discontinuation
- 2001-03-30 CA CA002402705A patent/CA2402705A1/en not_active Abandoned
- 2001-03-30 NZ NZ521388A patent/NZ521388A/en not_active Application Discontinuation
- 2001-03-30 BR BR0109818-7A patent/BR0109818A/pt not_active IP Right Cessation
- 2001-03-30 IL IL15176501A patent/IL151765A0/xx unknown
- 2001-03-30 CZ CZ20023287A patent/CZ20023287A3/cs unknown
- 2001-03-30 EP EP01918115A patent/EP1278740B1/en not_active Expired - Lifetime
- 2001-03-30 PL PL01357812A patent/PL357812A1/xx not_active Application Discontinuation
- 2001-03-30 AT AT01918115T patent/ATE297914T1/de not_active IP Right Cessation
- 2001-03-30 HU HU0300562A patent/HUP0300562A3/hu unknown
- 2001-03-30 DE DE60111520T patent/DE60111520T2/de not_active Expired - Fee Related
- 2001-03-30 US US10/240,037 patent/US6696447B2/en not_active Expired - Fee Related
- 2001-03-30 SK SK1426-2002A patent/SK14262002A3/sk not_active Application Discontinuation
- 2001-03-30 CN CN01807719A patent/CN1422266A/zh active Pending
- 2001-03-30 MX MXPA02009758A patent/MXPA02009758A/es unknown
- 2001-03-30 KR KR1020027013206A patent/KR20020084284A/ko not_active Withdrawn
- 2001-03-30 JP JP2001572495A patent/JP2003529597A/ja active Pending
- 2001-03-30 AU AU2001244983A patent/AU2001244983A1/en not_active Abandoned
- 2001-03-30 WO PCT/SE2001/000709 patent/WO2001074805A1/en not_active Ceased
- 2001-03-30 EE EEP200200511A patent/EE200200511A/xx unknown
-
2002
- 2002-09-13 ZA ZA200207381A patent/ZA200207381B/en unknown
- 2002-09-24 IS IS6563A patent/IS6563A/is unknown
- 2002-10-03 NO NO20024776A patent/NO20024776L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20020084284A (ko) | 2002-11-04 |
| BR0109818A (pt) | 2003-01-21 |
| DE60111520D1 (de) | 2005-07-21 |
| SK14262002A3 (sk) | 2003-05-02 |
| HUP0300562A3 (en) | 2006-02-28 |
| MXPA02009758A (es) | 2003-03-27 |
| CN1422266A (zh) | 2003-06-04 |
| EP1278740A1 (en) | 2003-01-29 |
| WO2001074805A1 (en) | 2001-10-11 |
| IL151765A0 (en) | 2003-04-10 |
| PL357812A1 (en) | 2004-07-26 |
| EE200200511A (et) | 2004-02-16 |
| DE60111520T2 (de) | 2006-05-11 |
| AU2001244983A1 (en) | 2001-10-15 |
| NO20024776L (no) | 2002-12-03 |
| SE0001209D0 (sv) | 2000-04-04 |
| NO20024776D0 (no) | 2002-10-03 |
| NZ521388A (en) | 2004-06-25 |
| ZA200207381B (en) | 2003-12-15 |
| IS6563A (is) | 2002-09-24 |
| JP2003529597A (ja) | 2003-10-07 |
| US20030139421A1 (en) | 2003-07-24 |
| HUP0300562A2 (hu) | 2003-08-28 |
| ATE297914T1 (de) | 2005-07-15 |
| CZ20023287A3 (cs) | 2003-03-12 |
| US6696447B2 (en) | 2004-02-24 |
| CA2402705A1 (en) | 2001-10-11 |
| EP1278740B1 (en) | 2005-06-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |