AR033757A1 - Derivados de 4-(fenil-piperidin-4-iliden-metil)benzamida - Google Patents
Derivados de 4-(fenil-piperidin-4-iliden-metil)benzamidaInfo
- Publication number
- AR033757A1 AR033757A1 ARP020101813A ARP020101813A AR033757A1 AR 033757 A1 AR033757 A1 AR 033757A1 AR P020101813 A ARP020101813 A AR P020101813A AR P020101813 A ARP020101813 A AR P020101813A AR 033757 A1 AR033757 A1 AR 033757A1
- Authority
- AR
- Argentina
- Prior art keywords
- phenyl
- benzamida
- iliden
- fenil
- metil
- Prior art date
Links
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 230000036407 pain Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- -1 pyridyl N-oxide Chemical class 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000168 pyrrolyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000001425 triazolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Transplantation (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se revelan y reivindican compuestos de la Fórmula General 1 en la cual R1 es seleccionado de entre el grupo consistente en: fenilo, piridinilo; pirrolilo; tienilo; furanilo; imidazolilo; triazolilo; tiazolilo y N-óxido de piridilo en los cuales cada uno de los anillos fenilo R1y heteroaromático R1 pude opcionalmente e independientemente de los demás estar adicionalmente sustituido por 1, 2 o 3 sustituyentes seleccionados de entre el grupo consistente en alquilo de C1-6 lineal o ramificado, NO2 CF3, alcoxi de C1- 6, cloro, flúor, bromo e iodo. Las sustituciones en el anillo fenilo y en el anillo heteroaromático pueden tener lugar en cualquier posición en dichos sistemas-anillo; como también sus sales y las composiciones farmacéuticas que comprenden los novedosos compuestos y su utilización en la terapia, en particular en el tratamiento del dolor, ansiedad, y trastornos funcionales gastrointestinales
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0101768A SE0101768D0 (sv) | 2001-05-18 | 2001-05-18 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR033757A1 true AR033757A1 (es) | 2004-01-07 |
Family
ID=20284171
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020101813A AR033757A1 (es) | 2001-05-18 | 2002-05-16 | Derivados de 4-(fenil-piperidin-4-iliden-metil)benzamida |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6838468B2 (es) |
| EP (1) | EP1395575B1 (es) |
| JP (1) | JP2005508858A (es) |
| KR (1) | KR20030094424A (es) |
| CN (1) | CN1527828A (es) |
| AR (1) | AR033757A1 (es) |
| AT (1) | ATE333452T1 (es) |
| BG (1) | BG108329A (es) |
| BR (1) | BR0209668A (es) |
| CA (1) | CA2446154A1 (es) |
| CO (1) | CO5540321A2 (es) |
| CZ (1) | CZ20033088A3 (es) |
| DE (1) | DE60213234T2 (es) |
| EE (1) | EE200300542A (es) |
| ES (1) | ES2268037T3 (es) |
| HU (1) | HUP0400975A2 (es) |
| IL (1) | IL158632A0 (es) |
| IS (1) | IS7025A (es) |
| MX (1) | MXPA03010437A (es) |
| NO (1) | NO20035117D0 (es) |
| PL (1) | PL366388A1 (es) |
| RU (1) | RU2003131969A (es) |
| SE (1) | SE0101768D0 (es) |
| SK (1) | SK13942003A3 (es) |
| WO (1) | WO2002094811A1 (es) |
| ZA (1) | ZA200308636B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0101768D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| MXPA05012117A (es) * | 2003-05-16 | 2006-02-08 | Astrazeneca Ab | Derivados de diarilmetiliden piperidina, preparaciones de los mismos y usos de los mismos. |
| KR101255074B1 (ko) | 2003-10-01 | 2013-04-16 | 아돌로 코포레이션 | 스피로시클릭 헤테로시클릭 유도체 및 이의 사용 방법 |
| SE0400026D0 (sv) * | 2004-01-09 | 2004-01-09 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| US7598261B2 (en) | 2005-03-31 | 2009-10-06 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| US7576207B2 (en) | 2006-04-06 | 2009-08-18 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| EP2063886A2 (en) | 2006-09-12 | 2009-06-03 | Adolor Corporation | Use of n-containing spirocompounds for the enhancement of cognitive function |
| MY148880A (en) * | 2006-10-20 | 2013-06-14 | Astrazeneca Ab | N-(2-hydroxyethyl)-n-methyl-4-(quinolin-8-yl(1-(thiazol-4-ylmethyl)piperidin-4-ylidene)methyl)benzamide, the process of making it as well as its use for the treatment of pain, anxiety and depression |
| KR200453972Y1 (ko) * | 2009-08-31 | 2011-06-09 | (주)아모레퍼시픽 | 잔량확인이 가능한 에어리스 화장품용기 |
| DK3233825T3 (da) * | 2014-12-19 | 2020-06-29 | Pharmnovo Ab | Diarylmethylidenpiperidinderivater og deres anvendelse som deltaopioidreceptoragonister |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2898339A (en) | 1957-07-29 | 1959-08-04 | Wm S Merrell Co | N-substituted benzhydrol, benzhydryl, and benzhydrylidene piperidine |
| US4581171A (en) | 1983-07-27 | 1986-04-08 | Janssen Pharmaceutica, N.V. | [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders |
| US4816586A (en) | 1987-07-29 | 1989-03-28 | Regents Of The University Of Minnesota | Delta opioid receptor antagonists |
| US5140029A (en) | 1989-01-09 | 1992-08-18 | Janssen Pharmaceutica N.V. | 2-aminopyrimidinone derivatives |
| US4939137A (en) | 1989-06-28 | 1990-07-03 | Ortho Pharmaceutical Corporation | Ring-fused thienopyrimidinedione derivatives |
| US5683998A (en) | 1991-04-23 | 1997-11-04 | Toray Industries, Inc. | Tricyclic triazolo derivatives, processes for producing the same and the uses of the same |
| GB9202238D0 (en) | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
| US5574159A (en) | 1992-02-03 | 1996-11-12 | Delta Pharmaceuticals, Inc. | Opioid compounds and methods for making therefor |
| SE9504661D0 (sv) | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
| TW548271B (en) | 1996-12-20 | 2003-08-21 | Astra Pharma Inc | Novel piperidine derivatives having an exocyclic double bond with analgesic effects |
| JP4754068B2 (ja) | 1997-12-24 | 2011-08-24 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | δ−オピオイドレセプターに結合する4−[アリール(ピペリジン−4−イル)]アミノベンズアミド類 |
| SE0001207D0 (sv) | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
| SE0001208D0 (sv) * | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
| SE0101768D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
-
2001
- 2001-05-18 SE SE0101768A patent/SE0101768D0/xx unknown
-
2002
- 2002-05-16 RU RU2003131969/04A patent/RU2003131969A/ru not_active Application Discontinuation
- 2002-05-16 AT AT02733704T patent/ATE333452T1/de not_active IP Right Cessation
- 2002-05-16 PL PL02366388A patent/PL366388A1/xx not_active Application Discontinuation
- 2002-05-16 SK SK1394-2003A patent/SK13942003A3/sk unknown
- 2002-05-16 DE DE60213234T patent/DE60213234T2/de not_active Expired - Fee Related
- 2002-05-16 KR KR10-2003-7014945A patent/KR20030094424A/ko not_active Withdrawn
- 2002-05-16 ES ES02733704T patent/ES2268037T3/es not_active Expired - Lifetime
- 2002-05-16 EE EEP200300542A patent/EE200300542A/xx unknown
- 2002-05-16 MX MXPA03010437A patent/MXPA03010437A/es not_active Application Discontinuation
- 2002-05-16 WO PCT/SE2002/000947 patent/WO2002094811A1/en not_active Ceased
- 2002-05-16 BR BR0209668-4A patent/BR0209668A/pt not_active Application Discontinuation
- 2002-05-16 EP EP02733704A patent/EP1395575B1/en not_active Expired - Lifetime
- 2002-05-16 CA CA002446154A patent/CA2446154A1/en not_active Abandoned
- 2002-05-16 JP JP2002591484A patent/JP2005508858A/ja active Pending
- 2002-05-16 IL IL15863202A patent/IL158632A0/xx unknown
- 2002-05-16 CZ CZ20033088A patent/CZ20033088A3/cs unknown
- 2002-05-16 HU HU0400975A patent/HUP0400975A2/hu unknown
- 2002-05-16 US US10/477,641 patent/US6838468B2/en not_active Expired - Fee Related
- 2002-05-16 CN CNA028101812A patent/CN1527828A/zh active Pending
- 2002-05-16 AR ARP020101813A patent/AR033757A1/es not_active Application Discontinuation
-
2003
- 2003-11-05 ZA ZA200308636A patent/ZA200308636B/en unknown
- 2003-11-07 BG BG108329A patent/BG108329A/bg unknown
- 2003-11-11 IS IS7025A patent/IS7025A/is unknown
- 2003-11-12 CO CO03100162A patent/CO5540321A2/es not_active Application Discontinuation
- 2003-11-17 NO NO20035117A patent/NO20035117D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1395575A1 (en) | 2004-03-10 |
| JP2005508858A (ja) | 2005-04-07 |
| BR0209668A (pt) | 2004-04-20 |
| CZ20033088A3 (cs) | 2004-05-12 |
| IL158632A0 (en) | 2004-05-12 |
| SK13942003A3 (sk) | 2004-04-06 |
| CN1527828A (zh) | 2004-09-08 |
| EP1395575B1 (en) | 2006-07-19 |
| ATE333452T1 (de) | 2006-08-15 |
| US20040147553A1 (en) | 2004-07-29 |
| HUP0400975A2 (hu) | 2004-08-30 |
| DE60213234T2 (de) | 2007-06-14 |
| MXPA03010437A (es) | 2004-03-09 |
| CA2446154A1 (en) | 2002-11-28 |
| BG108329A (bg) | 2004-12-30 |
| RU2003131969A (ru) | 2005-05-10 |
| KR20030094424A (ko) | 2003-12-11 |
| WO2002094811A1 (en) | 2002-11-28 |
| NO20035117D0 (no) | 2003-11-17 |
| SE0101768D0 (sv) | 2001-05-18 |
| CO5540321A2 (es) | 2005-07-29 |
| EE200300542A (et) | 2004-02-16 |
| US6838468B2 (en) | 2005-01-04 |
| PL366388A1 (en) | 2005-01-24 |
| DE60213234D1 (de) | 2006-08-31 |
| ZA200308636B (en) | 2005-06-21 |
| IS7025A (is) | 2003-11-11 |
| ES2268037T3 (es) | 2007-03-16 |
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