AR033760A1 - Derivados de 4-(fenil-(piperidin-4-il)amino)benzamida - Google Patents

Derivados de 4-(fenil-(piperidin-4-il)amino)benzamida

Info

Publication number
AR033760A1
AR033760A1 ARP020101816A ARP020101816A AR033760A1 AR 033760 A1 AR033760 A1 AR 033760A1 AR P020101816 A ARP020101816 A AR P020101816A AR P020101816 A ARP020101816 A AR P020101816A AR 033760 A1 AR033760 A1 AR 033760A1
Authority
AR
Argentina
Prior art keywords
phenyl
ring
benzamida
piperidin
derivatives
Prior art date
Application number
ARP020101816A
Other languages
English (en)
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR033760A1 publication Critical patent/AR033760A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

Se describen y reivindican compuestos de la fórmula 1 en la cual R1 es seleccionado entre cualquiera de fenilo, piridinilo, tienilo, furanilo, imidazolilo, triazolilo, pirrolilo, tiazolilo y piridin-N-óxido, donde cada anillo de fenilo R1 y anillo heteroaromático R1 puede estar optativa e independientemente sustituido además con 1, 2 o 3 sustituyentes seleccionados entre alquilo C1-C6 de cadena recta y ramificada, NO2, CF3, alcoxi C1-C6, cloro, fluoro, bromo y iodo. Las sustituciones en el anillo de fenilo y el anillo heteroaromático pueden tener lugar en cualquier posición de dichos sistemas de anillos. Se describen también las sales y composiciones farmacéuticas que comprenden los novedosos compuestos, así como su uso en terapia, en especial en el control del dolor, la ansiedad o los trastornos funcionales gastrointestinales.
ARP020101816A 2001-05-18 2002-05-16 Derivados de 4-(fenil-(piperidin-4-il)amino)benzamida AR033760A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0101771A SE0101771D0 (sv) 2001-05-18 2001-05-18 Novel compounds

Publications (1)

Publication Number Publication Date
AR033760A1 true AR033760A1 (es) 2004-01-07

Family

ID=20284174

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020101816A AR033760A1 (es) 2001-05-18 2002-05-16 Derivados de 4-(fenil-(piperidin-4-il)amino)benzamida

Country Status (23)

Country Link
US (1) US7186733B2 (es)
EP (1) EP1395556A1 (es)
JP (1) JP2005508290A (es)
KR (1) KR20040000470A (es)
CN (1) CN1541203A (es)
AR (1) AR033760A1 (es)
BG (1) BG108332A (es)
BR (1) BR0209675A (es)
CA (1) CA2446316A1 (es)
CO (1) CO5540318A2 (es)
CZ (1) CZ20033091A3 (es)
EE (1) EE200300535A (es)
HU (1) HUP0401324A2 (es)
IL (1) IL158630A0 (es)
IS (1) IS7029A (es)
MX (1) MXPA03010442A (es)
NO (1) NO20035114D0 (es)
PL (1) PL366770A1 (es)
RU (1) RU2003131965A (es)
SE (1) SE0101771D0 (es)
SK (1) SK13972003A3 (es)
WO (1) WO2002094784A1 (es)
ZA (1) ZA200308641B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA007272B1 (ru) * 2002-03-13 2006-08-25 Янссен Фармацевтика Н. В. Новые ингибиторы гистондеацетилазы
SE0300987D0 (sv) * 2003-04-03 2003-04-03 Astrazeneca Ab Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
WO2005033073A2 (en) 2003-10-01 2005-04-14 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
US7598261B2 (en) 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
US7576207B2 (en) 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
CN103724366B (zh) * 2014-01-21 2016-04-27 贵州威顿晶磷电子材料股份有限公司 一种对羧基苯硼酸的制备方法
LT3233825T (lt) * 2014-12-19 2020-08-10 Pharmnovo Ab Diarilmetilideno piperidino dariniai ir jų naudojimas kaip delta opioidinių receptorių agonistų

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4091096A (en) 1976-03-19 1978-05-23 Eli Lilly And Company Dinitroanilines for the control of phytopathogens
EG12406A (en) 1976-08-12 1979-03-31 Janssen Pharmaceutica Nv Process for preparing of novel n-aryl-n-(1-l-4-piperidinyl)-arylacetamides
SE441448B (sv) 1977-05-23 1985-10-07 Pfizer Sett att framstella hexahydro-gamma-karbolinforeningar
US4252812A (en) 1977-05-23 1981-02-24 Pfizer Inc. 2-Substituted-trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles
DE3200304A1 (de) 1981-01-16 1982-08-26 Sandoz-Patent-GmbH, 7850 Lörrach 3-aminopropoxyaryl-derivate, ihre herstellung und sie enthaltende arzneimittel
DE3563964D1 (en) 1984-10-16 1988-09-01 Synthelabo Piperidine derivatives, their preparation and their therapeutical application
US5188693A (en) * 1986-04-18 1993-02-23 Aishin Kakou K.K. Process for applying polyvinyl chloride sealing material having low thixotropic index
KR940003491B1 (ko) 1989-08-10 1994-04-23 리히터 게데온 베기에스제티 기아르 알.티 4,4-이중 치환된 피페리딘 유도체와 그 제조방법 및 상기 화합물을 함유하는 약제학적 조성물
YU150489A (sh) 1989-08-10 1992-12-21 W.L. Gore & Co. Gmbh. Uređaj za ispitivanje odevnih predmeta na nepromočivost
US5854245A (en) 1996-06-28 1998-12-29 Merck & Co., Inc. Fibrinogen receptor antagonists
TW548271B (en) * 1996-12-20 2003-08-21 Astra Pharma Inc Novel piperidine derivatives having an exocyclic double bond with analgesic effects
SE9604786D0 (sv) 1996-12-20 1996-12-20 Astra Pharma Inc New compounds
AU2009799A (en) 1997-12-24 1999-07-19 Ortho-Mcneil Pharmaceutical, Inc. 4-(aryl(piperidin-4-yl)) aminobenzamides which bind to the delta-opioid receptor
WO1999045925A1 (en) 1998-03-10 1999-09-16 Research Triangle Institute Novel opiate compounds, methods of making and methods of use
SE9904675D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
US6552036B2 (en) * 2000-03-03 2003-04-22 Ortho-Mcneil Pharmaceutical, Inc. 3-(Diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives
US6556387B1 (en) * 2000-03-31 2003-04-29 Seagate Technology Llc Controlling mechanical response characteristics of a disc drive actuator by adjusting a fastener engaging the actuator shaft to vary axial force on the bearing assembly
SE0001207D0 (sv) * 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds

Also Published As

Publication number Publication date
NO20035114D0 (no) 2003-11-17
HUP0401324A2 (hu) 2004-11-29
US20040142965A1 (en) 2004-07-22
JP2005508290A (ja) 2005-03-31
MXPA03010442A (es) 2004-03-09
IL158630A0 (en) 2004-05-12
CA2446316A1 (en) 2002-11-28
IS7029A (is) 2003-11-12
BG108332A (bg) 2004-12-30
CN1541203A (zh) 2004-10-27
EE200300535A (et) 2004-02-16
RU2003131965A (ru) 2005-05-10
PL366770A1 (en) 2005-02-07
CO5540318A2 (es) 2005-07-29
SK13972003A3 (en) 2004-10-05
SE0101771D0 (sv) 2001-05-18
WO2002094784A1 (en) 2002-11-28
US7186733B2 (en) 2007-03-06
CZ20033091A3 (cs) 2004-07-14
ZA200308641B (en) 2005-02-07
EP1395556A1 (en) 2004-03-10
BR0209675A (pt) 2004-07-27
KR20040000470A (ko) 2004-01-03

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