DE60111520D1 - Hydroxyphenyl-piperazinyl-methyl-benzamid-derivate zur schmerzbehandlung - Google Patents
Hydroxyphenyl-piperazinyl-methyl-benzamid-derivate zur schmerzbehandlungInfo
- Publication number
- DE60111520D1 DE60111520D1 DE60111520T DE60111520T DE60111520D1 DE 60111520 D1 DE60111520 D1 DE 60111520D1 DE 60111520 T DE60111520 T DE 60111520T DE 60111520 T DE60111520 T DE 60111520T DE 60111520 D1 DE60111520 D1 DE 60111520D1
- Authority
- DE
- Germany
- Prior art keywords
- piperazinyl
- hydroxyphenyl
- methyl
- pain treatment
- benzamide derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0001209 | 2000-04-04 | ||
SE0001209A SE0001209D0 (sv) | 2000-04-04 | 2000-04-04 | Novel compounds |
PCT/SE2001/000709 WO2001074805A1 (en) | 2000-04-04 | 2001-03-30 | Hydroxyphenyl-piperazinyl-methyl-benzamide derivatives for the treatment of pain |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60111520D1 true DE60111520D1 (de) | 2005-07-21 |
DE60111520T2 DE60111520T2 (de) | 2006-05-11 |
Family
ID=20279148
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60111520T Expired - Fee Related DE60111520T2 (de) | 2000-04-04 | 2001-03-30 | Hydroxyphenyl-piperazinyl-methyl-benzamid-derivate zur schmerzbehandlung |
Country Status (24)
Country | Link |
---|---|
US (1) | US6696447B2 (de) |
EP (1) | EP1278740B1 (de) |
JP (1) | JP2003529597A (de) |
KR (1) | KR20020084284A (de) |
CN (1) | CN1422266A (de) |
AR (1) | AR033811A1 (de) |
AT (1) | ATE297914T1 (de) |
AU (1) | AU2001244983A1 (de) |
BR (1) | BR0109818A (de) |
CA (1) | CA2402705A1 (de) |
CZ (1) | CZ20023287A3 (de) |
DE (1) | DE60111520T2 (de) |
EE (1) | EE200200511A (de) |
HU (1) | HUP0300562A3 (de) |
IL (1) | IL151765A0 (de) |
IS (1) | IS6563A (de) |
MX (1) | MXPA02009758A (de) |
NO (1) | NO20024776L (de) |
NZ (1) | NZ521388A (de) |
PL (1) | PL357812A1 (de) |
SE (1) | SE0001209D0 (de) |
SK (1) | SK14262002A3 (de) |
WO (1) | WO2001074805A1 (de) |
ZA (1) | ZA200207381B (de) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9504661D0 (sv) * | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
SE0100764D0 (sv) * | 2001-03-07 | 2001-03-07 | Astrazeneca Ab | New assymetric process |
KR100885100B1 (ko) * | 2001-05-18 | 2009-02-20 | 아스트라제네카 아베 | 4(페닐-피페라지닐-메틸)벤즈아미드 유도체 및 통증,불안증 또는 위장관 장애 치료를 위한 이들의 용도 |
US8575169B2 (en) | 2001-10-29 | 2013-11-05 | Versi Group, Llc | Method of treating sexual dysfunctions with delta opioid receptor agonist compounds |
US8476280B2 (en) | 2002-05-09 | 2013-07-02 | Versi Group, Llc | Compositions and methods for combating lower urinary tract dysfunctions with delta opioid receptor agonists |
SE0203300D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
SE0203303D0 (sv) * | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
SE0203302D0 (sv) * | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
SE0400027D0 (sv) * | 2004-01-09 | 2004-01-09 | Astrazeneca Ab | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
SE0401968D0 (sv) * | 2004-08-02 | 2004-08-02 | Astrazeneca Ab | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
KR101234421B1 (ko) * | 2004-08-02 | 2013-02-18 | 아스트라제네카 아베 | 디아릴메틸 피페라진 유도체, 이의 제조 방법 및 용도 |
WO2006091160A1 (en) * | 2005-02-28 | 2006-08-31 | Astrazeneca Ab | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
NZ590041A (en) * | 2008-05-20 | 2012-11-30 | Astrazeneca Ab | Method of treating anxious major depressive disorder |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH583713A5 (de) | 1973-06-29 | 1977-01-14 | Cermol Sa | |
DE2900810A1 (de) | 1979-01-11 | 1980-07-24 | Cassella Ag | Substituierte n-benzhydryl-n'-p- hydroxybenzyl-piperazine und verfahren zu ihrer herstellung |
IT1140978B (it) | 1980-05-23 | 1986-10-10 | Selvi & C Spa | 1-(4-clorobenzidril)-4-(2,3-diidros sipropil)-piperazina, metodi per la sua preparazione e relative composizione farmaceutiche |
GB8320701D0 (en) | 1983-08-01 | 1983-09-01 | Wellcome Found | Chemotherapeutic agent |
IT1196150B (it) | 1984-06-19 | 1988-11-10 | Poli Ind Chimica Spa | Derivati di 1-(bis-(4-fluorofenil)metil)-4-(3-fenil-2-propenil)-esaidro-1h-1,4-diazepina ad attivita' calcio antagonista,sua preparazione e composizioni che lo contengono |
SE8500573D0 (sv) | 1985-02-08 | 1985-02-08 | Ferrosan Ab | Novel piperazinecarboxamides having a phenoxyalkyl or thiophenoxyalkyl side chain |
US5028610A (en) | 1987-03-18 | 1991-07-02 | Sankyo Company Limited | N-benzhydryl-substituted heterocyclic derivatives, their preparation and their use |
US4829065A (en) | 1987-04-24 | 1989-05-09 | Syntex Pharmaceuticals, Ltd. | Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives |
US4826844A (en) | 1987-09-30 | 1989-05-02 | American Home Products Corporation | Substituted 1-(aralkyl-piperazinoalkyl) cycloalkanols |
RU2093156C1 (ru) | 1989-11-22 | 1997-10-20 | Жансен Фармасетика Н.В. | L-(-)-2-(аминокарбонил)-n-(4-амино-2,6-дихлорфенил-4[5,5-бис(4-фторфенил)пентил]-1-пиперазинацетамид, его фармацевтически приемлемая кислотно-аддитивная соль или гидрат, способ его получения и средство для хранения сердца донора |
US5574159A (en) | 1992-02-03 | 1996-11-12 | Delta Pharmaceuticals, Inc. | Opioid compounds and methods for making therefor |
US5807858A (en) | 1996-06-05 | 1998-09-15 | Delta Pharmaceutical, Inc. | Compositions and methods for reducing respiratory depression |
US5681830A (en) | 1992-02-03 | 1997-10-28 | Delta Pharmaceuticals, Inc. | Opioid compounds |
GB9202238D0 (en) | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
FR2696744B1 (fr) | 1992-10-12 | 1994-12-30 | Logeais Labor Jacques | Dérivés de 2-pyrrolidone, leur procédé de préparation et leurs applications en thérapeutique. |
HU221726B1 (hu) | 1993-07-30 | 2002-12-28 | Ardent Pharmaceuticals Inc. | Piperazinszármazékok, e vegyületeket tartalmazó gyógyászati készítmények és eljárás a vegyületek előállítására |
JP3352184B2 (ja) | 1993-11-12 | 2002-12-03 | 株式会社アズウェル | ピペラジン不飽和脂肪酸誘導体 |
SE9504661D0 (sv) * | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
TW548271B (en) | 1996-12-20 | 2003-08-21 | Astra Pharma Inc | Novel piperidine derivatives having an exocyclic double bond with analgesic effects |
SE9604786D0 (sv) | 1996-12-20 | 1996-12-20 | Astra Pharma Inc | New compounds |
ATE306472T1 (de) * | 1997-12-24 | 2005-10-15 | Ortho Mcneil Pharm Inc | (4)-(aryl(piperidin-4-yl) aminobenzamidderivate die an delta-opioid rezeptor binden |
GB9804734D0 (en) * | 1998-03-05 | 1998-04-29 | Pfizer Ltd | Compounds |
-
2000
- 2000-04-04 SE SE0001209A patent/SE0001209D0/xx unknown
-
2001
- 2001-03-28 AR ARP010101479A patent/AR033811A1/es not_active Application Discontinuation
- 2001-03-30 SK SK1426-2002A patent/SK14262002A3/sk not_active Application Discontinuation
- 2001-03-30 MX MXPA02009758A patent/MXPA02009758A/es unknown
- 2001-03-30 CA CA002402705A patent/CA2402705A1/en not_active Abandoned
- 2001-03-30 EE EEP200200511A patent/EE200200511A/xx unknown
- 2001-03-30 DE DE60111520T patent/DE60111520T2/de not_active Expired - Fee Related
- 2001-03-30 PL PL01357812A patent/PL357812A1/xx not_active Application Discontinuation
- 2001-03-30 US US10/240,037 patent/US6696447B2/en not_active Expired - Fee Related
- 2001-03-30 IL IL15176501A patent/IL151765A0/xx unknown
- 2001-03-30 KR KR1020027013206A patent/KR20020084284A/ko not_active Application Discontinuation
- 2001-03-30 AT AT01918115T patent/ATE297914T1/de not_active IP Right Cessation
- 2001-03-30 CZ CZ20023287A patent/CZ20023287A3/cs unknown
- 2001-03-30 CN CN01807719A patent/CN1422266A/zh active Pending
- 2001-03-30 NZ NZ521388A patent/NZ521388A/en not_active Application Discontinuation
- 2001-03-30 AU AU2001244983A patent/AU2001244983A1/en not_active Abandoned
- 2001-03-30 HU HU0300562A patent/HUP0300562A3/hu unknown
- 2001-03-30 BR BR0109818-7A patent/BR0109818A/pt not_active IP Right Cessation
- 2001-03-30 WO PCT/SE2001/000709 patent/WO2001074805A1/en active IP Right Grant
- 2001-03-30 JP JP2001572495A patent/JP2003529597A/ja active Pending
- 2001-03-30 EP EP01918115A patent/EP1278740B1/de not_active Expired - Lifetime
-
2002
- 2002-09-13 ZA ZA200207381A patent/ZA200207381B/en unknown
- 2002-09-24 IS IS6563A patent/IS6563A/is unknown
- 2002-10-03 NO NO20024776A patent/NO20024776L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
BR0109818A (pt) | 2003-01-21 |
AR033811A1 (es) | 2004-01-07 |
IS6563A (is) | 2002-09-24 |
ATE297914T1 (de) | 2005-07-15 |
MXPA02009758A (es) | 2003-03-27 |
CN1422266A (zh) | 2003-06-04 |
HUP0300562A3 (en) | 2006-02-28 |
ZA200207381B (en) | 2003-12-15 |
EE200200511A (et) | 2004-02-16 |
NO20024776L (no) | 2002-12-03 |
KR20020084284A (ko) | 2002-11-04 |
SK14262002A3 (sk) | 2003-05-02 |
EP1278740B1 (de) | 2005-06-15 |
IL151765A0 (en) | 2003-04-10 |
JP2003529597A (ja) | 2003-10-07 |
AU2001244983A1 (en) | 2001-10-15 |
DE60111520T2 (de) | 2006-05-11 |
US20030139421A1 (en) | 2003-07-24 |
SE0001209D0 (sv) | 2000-04-04 |
NZ521388A (en) | 2004-06-25 |
EP1278740A1 (de) | 2003-01-29 |
WO2001074805A1 (en) | 2001-10-11 |
CA2402705A1 (en) | 2001-10-11 |
CZ20023287A3 (cs) | 2003-03-12 |
HUP0300562A2 (hu) | 2003-08-28 |
NO20024776D0 (no) | 2002-10-03 |
US6696447B2 (en) | 2004-02-24 |
PL357812A1 (en) | 2004-07-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |