AR032482A1 - Uso de tienopirimidinas - Google Patents
Uso de tienopirimidinasInfo
- Publication number
- AR032482A1 AR032482A1 ARP010105462A ARP010105462A AR032482A1 AR 032482 A1 AR032482 A1 AR 032482A1 AR P010105462 A ARP010105462 A AR P010105462A AR P010105462 A ARP010105462 A AR P010105462A AR 032482 A1 AR032482 A1 AR 032482A1
- Authority
- AR
- Argentina
- Prior art keywords
- treatment
- hypertension
- asthma
- allergic
- thienopyrimidines
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
Uso de tienopirimidinas de la formula (1) y sus sales aceptables para uso farmacéutico, donde R1, R2, R3, R4, X y n tienen los valores definidos en la reivindicacion 1, para la preparacion de un medicamento para el tratamiento de la angina, hipertension, hipertension pulmonar, deficiencia cardíaca congestiva, aterosclerosis, reduccion de la circulacion en los vasos cardíacos, enfermedades vasculares periféricas, apoplejía, bronquitis, asma alérgica, asma cronica, rinitis alérgica, glaucoma, síndrome de colon irritable, tumores, insuficiencia renal, cirrosis hepática y para el tratamiento de los trastornos sexuales femeninos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10058663A DE10058663A1 (de) | 2000-11-25 | 2000-11-25 | Verwendung von Thienopyrimidinen |
Publications (1)
Publication Number | Publication Date |
---|---|
AR032482A1 true AR032482A1 (es) | 2003-11-12 |
Family
ID=7664711
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP010105462A AR032482A1 (es) | 2000-11-25 | 2001-11-23 | Uso de tienopirimidinas |
Country Status (18)
Country | Link |
---|---|
US (1) | US20040034040A1 (es) |
EP (1) | EP1337256A2 (es) |
JP (1) | JP2004513966A (es) |
KR (1) | KR20030051867A (es) |
CN (1) | CN1474693A (es) |
AR (1) | AR032482A1 (es) |
AU (1) | AU2002224808A1 (es) |
BR (1) | BR0115247A (es) |
CA (1) | CA2429647A1 (es) |
CZ (1) | CZ20031618A3 (es) |
DE (1) | DE10058663A1 (es) |
HU (1) | HUP0400818A2 (es) |
MX (1) | MXPA03004582A (es) |
PL (1) | PL361277A1 (es) |
RU (1) | RU2003117478A (es) |
SK (1) | SK7352003A3 (es) |
WO (1) | WO2002041896A2 (es) |
ZA (1) | ZA200304909B (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60336576D1 (de) * | 2002-10-30 | 2011-05-12 | Merck Sharp & Dohme | Hemmer der akt aktivität |
CA2530281C (en) * | 2003-07-24 | 2013-02-12 | Bayer Pharmaceuticals Corporation | Substituted tetrahydrobenzothienopyrimidinamine compounds useful for treating hyper-proliferative disorders |
TWI417095B (zh) | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | 1,4-二取代之3-氰基-吡啶酮衍生物及其作為mGluR2-受體之正向異位性調節劑之用途 |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
ES2409215T3 (es) | 2007-09-14 | 2013-06-25 | Janssen Pharmaceuticals, Inc. | 4-fenil-1H-piridin-2-onas 1-3-disustituidas |
EA019085B1 (ru) | 2007-09-14 | 2014-01-30 | Янссен Фармасьютикалз, Инк. | 1',3-двузамещенные 4-(арил-х-фенил)-1н-пиридин-2-оны |
SI2203439T1 (sl) | 2007-09-14 | 2011-05-31 | Ortho Mcneil Janssen Pharm | 1',3'-disubstituirani 4-fenil-3,4,5,6-tetrahidro-2H-1'H-(1,4')bipiridinil-2'-oni |
RU2492170C9 (ru) | 2007-11-14 | 2013-12-27 | Орто-Макнейл-Янссен Фармасьютикалз, Инк. | Имидазо[1,2-а]пиридиновые производные и их применение в качестве положительных аллостерических модуляторов рецепторов mglur2 |
BRPI0918055A2 (pt) | 2008-09-02 | 2015-12-01 | Addex Pharmaceuticals Sa | derivados de 3-azabiciclo[3,1,0]hexila como moduladores de receptores metabotrópicos de glutamato. |
WO2010043396A1 (en) | 2008-10-16 | 2010-04-22 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
CN102232074B (zh) | 2008-11-28 | 2014-12-03 | 奥梅-杨森制药有限公司 | 作为代谢性谷氨酸盐受体调节剂的吲哚和苯并噁嗪衍生物 |
BRPI1010831A2 (pt) | 2009-05-12 | 2016-04-05 | Addex Pharmaceuticals Sa | derivados de 1,2,4-triazolo[4,3-a]piridina e seu como moduladores alostéricos positivos de receptores de mglur2 |
MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
ME01573B (me) | 2009-05-12 | 2014-09-20 | Addex Pharma Sa | DERIVATI 1,2,4-TRIAZOLO[4,3-a]PIRIDINA I NJIHOVA UPOTREBA U TRETMANU ILI PREVENCIJI NEUROLOŠKIH I PSIHIJATRIJSKIH POREMEĆAJA |
WO2012062751A1 (en) | 2010-11-08 | 2012-05-18 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
JP5852664B2 (ja) | 2010-11-08 | 2016-02-03 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | 1,2,4−トリアゾロ[4,3−a]ピリジン誘導体およびmGluR2受容体のポジティブアロステリックモジュレーターとしてのそれらの使用 |
US8993591B2 (en) | 2010-11-08 | 2015-03-31 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a] pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors |
AU2012284091B2 (en) | 2011-07-19 | 2015-11-12 | Infinity Pharmaceuticals Inc. | Heterocyclic compounds and uses thereof |
JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
SI3431106T1 (sl) | 2014-01-21 | 2021-03-31 | Janssen Pharmaceutica Nv | Kombinacije, ki vsebujejo pozitivne alosterične modulatorje metabotropnega glutamatergičnega receptorja podtipa 2 in njihova uporaba |
LT3096790T (lt) | 2014-01-21 | 2019-10-10 | Janssen Pharmaceutica, N.V. | Deriniai, apimantys 2 potipio metabotropinio glutamaterginio receptoriaus teigiamus alosterinius moduliatorius arba ortosterinius agonistus, ir jų panaudojimas |
FR3037956B1 (fr) * | 2015-06-23 | 2017-08-04 | Servier Lab | Nouveaux derives d'acide amine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6143746A (en) * | 1994-01-21 | 2000-11-07 | Icos Corporation | Tetracyclic cyclic GMP-specific phosphodiesterase inhibitors, process of preparation and use |
AU4400597A (en) * | 1996-10-08 | 1998-05-05 | Fujisawa Pharmaceutical Co., Ltd. | Indole derivatives |
DE19752952A1 (de) * | 1997-11-28 | 1999-06-02 | Merck Patent Gmbh | Thienopyrimidine |
PL196936B1 (pl) * | 1997-12-12 | 2008-02-29 | Cell Pathways | Pochodne N-benzylo-3-indenyloacetamidów, kompozycja farmaceutyczna zawierająca te związki oraz ich zastosowanie |
JP3721077B2 (ja) * | 1998-04-20 | 2005-11-30 | ファイザー・インク | 性的不全を治療するためのピラゾロピリミジノンcGMPPDE5阻害剤 |
US6087368A (en) * | 1998-06-08 | 2000-07-11 | Bristol-Myers Squibb Company | Quinazolinone inhibitors of cGMP phosphodiesterase |
DE19919828A1 (de) * | 1999-04-30 | 2000-11-02 | Aventis Pharma Gmbh | Verwendung von Xanthinderivaten zur Behandlung von Erektionsstörungen |
AU1025899A (en) * | 1998-09-16 | 2000-04-03 | Icos Corporation | Carboline derivatives as cgmp phosphodiesterase inhibitors |
US6133271A (en) * | 1998-11-19 | 2000-10-17 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells and related conditions by exposure thienopyrimidine derivatives |
FR2792635B1 (fr) * | 1999-04-20 | 2001-06-01 | Synthelabo | Derives de cyclobutene-3,4-dione leur preparation et leur application en therapeutique |
DE10042997A1 (de) * | 2000-09-01 | 2002-03-14 | Merck Patent Gmbh | Thienopyrimidine |
-
2000
- 2000-11-25 DE DE10058663A patent/DE10058663A1/de not_active Withdrawn
-
2001
- 2001-10-29 CA CA002429647A patent/CA2429647A1/en not_active Abandoned
- 2001-10-29 KR KR10-2003-7006921A patent/KR20030051867A/ko not_active Application Discontinuation
- 2001-10-29 BR BR0115247-5A patent/BR0115247A/pt not_active Application Discontinuation
- 2001-10-29 HU HU0400818A patent/HUP0400818A2/hu unknown
- 2001-10-29 RU RU2003117478/15A patent/RU2003117478A/ru not_active Application Discontinuation
- 2001-10-29 EP EP01994626A patent/EP1337256A2/de not_active Withdrawn
- 2001-10-29 US US10/432,778 patent/US20040034040A1/en not_active Abandoned
- 2001-10-29 PL PL01361277A patent/PL361277A1/xx unknown
- 2001-10-29 SK SK735-2003A patent/SK7352003A3/sk unknown
- 2001-10-29 JP JP2002544074A patent/JP2004513966A/ja active Pending
- 2001-10-29 AU AU2002224808A patent/AU2002224808A1/en not_active Abandoned
- 2001-10-29 CN CNA018191800A patent/CN1474693A/zh active Pending
- 2001-10-29 WO PCT/EP2001/012494 patent/WO2002041896A2/de not_active Application Discontinuation
- 2001-10-29 CZ CZ20031618A patent/CZ20031618A3/cs unknown
- 2001-10-29 MX MXPA03004582A patent/MXPA03004582A/es unknown
- 2001-11-23 AR ARP010105462A patent/AR032482A1/es unknown
-
2003
- 2003-06-24 ZA ZA200304909A patent/ZA200304909B/en unknown
Also Published As
Publication number | Publication date |
---|---|
PL361277A1 (en) | 2004-10-04 |
JP2004513966A (ja) | 2004-05-13 |
BR0115247A (pt) | 2003-08-12 |
US20040034040A1 (en) | 2004-02-19 |
HUP0400818A2 (hu) | 2004-07-28 |
SK7352003A3 (en) | 2003-11-04 |
DE10058663A1 (de) | 2002-05-29 |
CN1474693A (zh) | 2004-02-11 |
EP1337256A2 (de) | 2003-08-27 |
CZ20031618A3 (cs) | 2003-10-15 |
ZA200304909B (en) | 2004-08-25 |
KR20030051867A (ko) | 2003-06-25 |
RU2003117478A (ru) | 2004-11-27 |
WO2002041896A3 (de) | 2002-10-31 |
MXPA03004582A (es) | 2003-09-04 |
CA2429647A1 (en) | 2002-05-30 |
AU2002224808A1 (en) | 2002-06-03 |
WO2002041896A2 (de) | 2002-05-30 |
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Legal Events
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FB | Suspension of granting procedure |