AR032130A1 - Un compuesto inhibidor de quinasas proteicas, una composicion farmaceutica que lo incluye, y un metodo para tratar afecciones con dicho compuesto - Google Patents
Un compuesto inhibidor de quinasas proteicas, una composicion farmaceutica que lo incluye, y un metodo para tratar afecciones con dicho compuestoInfo
- Publication number
- AR032130A1 AR032130A1 ARP000104188A ARP000104188A AR032130A1 AR 032130 A1 AR032130 A1 AR 032130A1 AR P000104188 A ARP000104188 A AR P000104188A AR P000104188 A ARP000104188 A AR P000104188A AR 032130 A1 AR032130 A1 AR 032130A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- heterocyclyl
- aryl
- optionally
- inhibitors
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 5
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 102000001253 Protein Kinase Human genes 0.000 title abstract 3
- 108060006633 protein kinase Proteins 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 8
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000003107 substituted aryl group Chemical group 0.000 abstract 3
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 150000001721 carbon Chemical group 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 101100240678 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) NNR2 gene Proteins 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
- 125000006355 carbonyl methylene group Chemical group [H]C([H])([*:2])C([*:1])=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 230000030833 cell death Effects 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229940043355 kinase inhibitor Drugs 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Psychology (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Otolaryngology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14879599P | 1999-08-13 | 1999-08-13 | |
| US16692299P | 1999-11-22 | 1999-11-22 | |
| US21151700P | 2000-06-14 | 2000-06-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR032130A1 true AR032130A1 (es) | 2003-10-29 |
Family
ID=27386739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000104188A AR032130A1 (es) | 1999-08-13 | 2000-08-11 | Un compuesto inhibidor de quinasas proteicas, una composicion farmaceutica que lo incluye, y un metodo para tratar afecciones con dicho compuesto |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US6693108B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1218369B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2003531103A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20020030791A (cg-RX-API-DMAC7.html) |
| CN (1) | CN1222520C (cg-RX-API-DMAC7.html) |
| AR (1) | AR032130A1 (cg-RX-API-DMAC7.html) |
| AT (1) | ATE402163T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU6909600A (cg-RX-API-DMAC7.html) |
| BR (1) | BR0013551A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2381882C (cg-RX-API-DMAC7.html) |
| CO (1) | CO5200770A1 (cg-RX-API-DMAC7.html) |
| CZ (1) | CZ2002534A3 (cg-RX-API-DMAC7.html) |
| DE (1) | DE60039616D1 (cg-RX-API-DMAC7.html) |
| HK (1) | HK1045507A1 (cg-RX-API-DMAC7.html) |
| HU (1) | HUP0300340A3 (cg-RX-API-DMAC7.html) |
| MX (1) | MXPA02001565A (cg-RX-API-DMAC7.html) |
| MY (1) | MY133159A (cg-RX-API-DMAC7.html) |
| NO (1) | NO20020713L (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ517694A (cg-RX-API-DMAC7.html) |
| PL (1) | PL366110A1 (cg-RX-API-DMAC7.html) |
| SK (1) | SK3572002A3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2001012621A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (102)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7125875B2 (en) | 1999-04-15 | 2006-10-24 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
| ES2391550T3 (es) | 1999-04-15 | 2012-11-27 | Bristol-Myers Squibb Company | Inhibidores cíclicos de la proteína tirosina quinasa |
| US7119114B1 (en) | 1999-08-19 | 2006-10-10 | Signal Pharmaceuticals, Llc | Pyrazoloanthrone and derivatives thereof as JNK inhibitors and compositions and methods related thereto |
| US20040072888A1 (en) | 1999-08-19 | 2004-04-15 | Bennett Brydon L. | Methods for treating inflammatory conditions or inhibiting JNK |
| US6897231B2 (en) | 2000-07-31 | 2005-05-24 | Signal Pharmaceuticals, Inc. | Indazole derivatives as JNK inhibitors and compositions and methods related thereto |
| US7211594B2 (en) | 2000-07-31 | 2007-05-01 | Signal Pharmaceuticals, Llc | Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith |
| US7473691B2 (en) | 2000-09-15 | 2009-01-06 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| CA2422367C (en) | 2000-09-15 | 2010-05-18 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| US6660731B2 (en) | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| US7122544B2 (en) * | 2000-12-06 | 2006-10-17 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto |
| US7429599B2 (en) | 2000-12-06 | 2008-09-30 | Signal Pharmaceuticals, Llc | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK |
| US7129242B2 (en) | 2000-12-06 | 2006-10-31 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto |
| EP1345926B1 (en) | 2000-12-21 | 2006-05-17 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| CA2437248A1 (en) * | 2001-02-02 | 2002-08-15 | Takeda Chemical Industries, Ltd. | Jnk inhibitor |
| US6987184B2 (en) | 2001-02-15 | 2006-01-17 | Signal Pharmaceuticals, Llc | Isothiazoloanthrones, isoxazoloanthrones, isoindolanthrones and derivatives thereof as JNK inhibitors and compositions and methods related |
| EP1377572A1 (en) * | 2001-04-10 | 2004-01-07 | Vertex Pharmaceuticals Incorporated | Isoxaxole derivatives as inhibitors of src and other protein kinases |
| DE60214701T2 (de) * | 2001-04-13 | 2007-09-13 | Vertex Pharmaceuticals Inc., Cambridge | Inhibitoren von c-jun-n-terminalen-kinasen (jnk) und anderen proteinkinasen |
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| DE4408084A1 (de) * | 1994-03-10 | 1995-09-14 | Hoechst Ag | 3,5-Disubstituierte und 3,4,5-trisubstituierte 2-Isoxazoline und Isoxazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
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| TR200000235T2 (tr) * | 1997-05-22 | 2000-05-22 | G.D. Searle &Co. | p38 kinaz inhibitörleri olarak ikame edilmiş pirazoller. |
-
2000
- 2000-08-11 NZ NZ517694A patent/NZ517694A/en unknown
- 2000-08-11 BR BR0013551-8A patent/BR0013551A/pt not_active IP Right Cessation
- 2000-08-11 DE DE60039616T patent/DE60039616D1/de not_active Expired - Lifetime
- 2000-08-11 SK SK357-2002A patent/SK3572002A3/sk unknown
- 2000-08-11 CN CNB008141789A patent/CN1222520C/zh not_active Expired - Fee Related
- 2000-08-11 HU HU0300340A patent/HUP0300340A3/hu unknown
- 2000-08-11 EP EP00957485A patent/EP1218369B1/en not_active Expired - Lifetime
- 2000-08-11 CA CA2381882A patent/CA2381882C/en not_active Expired - Fee Related
- 2000-08-11 CZ CZ2002534A patent/CZ2002534A3/cs unknown
- 2000-08-11 AT AT00957485T patent/ATE402163T1/de not_active IP Right Cessation
- 2000-08-11 MY MYPI20003684 patent/MY133159A/en unknown
- 2000-08-11 WO PCT/US2000/022445 patent/WO2001012621A1/en not_active Ceased
- 2000-08-11 KR KR1020027001947A patent/KR20020030791A/ko not_active Withdrawn
- 2000-08-11 PL PL00366110A patent/PL366110A1/xx not_active Application Discontinuation
- 2000-08-11 MX MXPA02001565A patent/MXPA02001565A/es not_active Application Discontinuation
- 2000-08-11 HK HK02106918.4A patent/HK1045507A1/zh unknown
- 2000-08-11 AU AU69096/00A patent/AU6909600A/en not_active Abandoned
- 2000-08-11 AR ARP000104188A patent/AR032130A1/es not_active Application Discontinuation
- 2000-08-11 JP JP2001517519A patent/JP2003531103A/ja active Pending
- 2000-08-14 CO CO00060686A patent/CO5200770A1/es not_active Application Discontinuation
-
2002
- 2002-02-12 NO NO20020713A patent/NO20020713L/no not_active Application Discontinuation
- 2002-02-12 US US10/074,177 patent/US6693108B2/en not_active Expired - Fee Related
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| CZ2002534A3 (cs) | 2002-07-17 |
| US6693108B2 (en) | 2004-02-17 |
| NZ517694A (en) | 2005-03-24 |
| HUP0300340A3 (en) | 2005-04-28 |
| CA2381882A1 (en) | 2001-02-22 |
| CN1222520C (zh) | 2005-10-12 |
| HK1045507A1 (zh) | 2002-11-29 |
| JP2003531103A (ja) | 2003-10-21 |
| BR0013551A (pt) | 2003-06-17 |
| SK3572002A3 (en) | 2002-07-02 |
| MXPA02001565A (es) | 2005-07-14 |
| US20050026967A1 (en) | 2005-02-03 |
| EP1218369A4 (en) | 2005-06-22 |
| CN1378541A (zh) | 2002-11-06 |
| US7169798B2 (en) | 2007-01-30 |
| PL366110A1 (en) | 2005-01-24 |
| EP1218369B1 (en) | 2008-07-23 |
| MY133159A (en) | 2007-10-31 |
| ATE402163T1 (de) | 2008-08-15 |
| AU6909600A (en) | 2001-03-13 |
| WO2001012621A1 (en) | 2001-02-22 |
| DE60039616D1 (de) | 2008-09-04 |
| NO20020713L (no) | 2002-04-12 |
| CO5200770A1 (es) | 2002-09-27 |
| EP1218369A1 (en) | 2002-07-03 |
| HUP0300340A2 (hu) | 2003-06-28 |
| US20030149051A1 (en) | 2003-08-07 |
| KR20020030791A (ko) | 2002-04-25 |
| CA2381882C (en) | 2011-01-25 |
| NO20020713D0 (no) | 2002-02-12 |
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