AR024686A1 - Un metodo para sintetizar un peptido - Google Patents
Un metodo para sintetizar un peptidoInfo
- Publication number
- AR024686A1 AR024686A1 ARP000103508A ARP000103508A AR024686A1 AR 024686 A1 AR024686 A1 AR 024686A1 AR P000103508 A ARP000103508 A AR P000103508A AR P000103508 A ARP000103508 A AR P000103508A AR 024686 A1 AR024686 A1 AR 024686A1
- Authority
- AR
- Argentina
- Prior art keywords
- peptide
- peptides
- seq
- group
- protected side
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 8
- 238000000034 method Methods 0.000 title abstract 5
- 230000002194 synthesizing effect Effects 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108010033276 Peptide Fragments Proteins 0.000 abstract 2
- 102000007079 Peptide Fragments Human genes 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 108010037251 peptide T1249 Proteins 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 125000003368 amide group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 239000013067 intermediate product Substances 0.000 abstract 1
- 239000007791 liquid phase Substances 0.000 abstract 1
- 238000010647 peptide synthesis reaction Methods 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 239000007790 solid phase Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/349,205 US6469136B1 (en) | 1999-07-07 | 1999-07-07 | Methods and composition for peptide synthesis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR024686A1 true AR024686A1 (es) | 2002-10-23 |
Family
ID=23371340
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000103508A AR024686A1 (es) | 1999-07-07 | 2000-07-07 | Un metodo para sintetizar un peptido |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US6469136B1 (enExample) |
| EP (1) | EP1372686B1 (enExample) |
| JP (1) | JP2003530311A (enExample) |
| KR (1) | KR100631874B1 (enExample) |
| CN (1) | CN1267449C (enExample) |
| AR (1) | AR024686A1 (enExample) |
| AT (1) | ATE288278T1 (enExample) |
| AU (1) | AU4133701A (enExample) |
| BR (1) | BR0012249A (enExample) |
| CA (1) | CA2378086A1 (enExample) |
| DE (1) | DE60017955T2 (enExample) |
| DK (1) | DK1372686T3 (enExample) |
| ES (1) | ES2236043T3 (enExample) |
| MX (1) | MXPA02000021A (enExample) |
| PT (1) | PT1372686E (enExample) |
| TW (1) | TWI237640B (enExample) |
| WO (1) | WO2001034635A2 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6656906B1 (en) * | 1998-05-20 | 2003-12-02 | Trimeris, Inc. | Hybrid polypeptides with enhanced pharmacokinetic properties |
| SK782002A3 (en) | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| WO2004013165A1 (en) * | 2002-07-24 | 2004-02-12 | F. Hoffmann-La Roche Ag | Pegylated t1249 polypeptide |
| US20040158037A1 (en) * | 2003-02-12 | 2004-08-12 | Bohling James Charles | Amino acid loaded trityl alcohol resins, method of production of amino acid loaded trityl alcohol resins and biologically active substances and therapeutics produced therewith |
| AU2004200485A1 (en) * | 2003-02-25 | 2004-09-09 | Rohm And Haas Company | Method of manufacturing T-20 and T-1249 peptides at commercial scale, and T-20 and T-1249 compositions related thereto |
| US7348004B2 (en) | 2003-05-06 | 2008-03-25 | Syntonix Pharmaceuticals, Inc. | Immunoglobulin chimeric monomer-dimer hybrids |
| TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
| ES2558102T3 (es) * | 2003-05-06 | 2016-02-02 | Biogen Hemophilia Inc. | Proteínas quiméricas del factor de coagulación para el tratamiento de un trastorno hemostático |
| WO2005063792A2 (en) * | 2003-12-31 | 2005-07-14 | F. Hoffmann-La Roche Ag | Methods for recovering cleaved peptide from a support |
| ATE410437T1 (de) * | 2003-12-31 | 2008-10-15 | Hoffmann La Roche | Verfahren und systeme zur rückgewinnung von peptiden |
| EP1701971A2 (en) * | 2003-12-31 | 2006-09-20 | F.Hoffmann-La Roche Ag | Peptide synthesis using decanting filter |
| DE602004009710T2 (de) * | 2003-12-31 | 2008-08-07 | F. Hoffmann-La Roche Ag | Verfahren zur peptidsynthese unter verwendung einer reduzierten menge an entschützungsmittel |
| WO2005063799A2 (en) * | 2003-12-31 | 2005-07-14 | F.Hoffmann-La Roche Ag | Peptide synthesis and deprotection with co-solvent |
| JP4805911B2 (ja) * | 2004-03-15 | 2011-11-02 | ネクター セラピューティクス | Hiv侵入阻害剤のポリマー系組成物及び複合体 |
| DE602005017188D1 (de) * | 2004-12-30 | 2009-11-26 | Hoffmann La Roche | Synthese des peptides t-20 aus peptidfragmenten als zwischenprodukte |
| WO2006069779A1 (en) * | 2004-12-30 | 2006-07-06 | F. Hoffmann-La Roche Ag | Preparing of peptides with excellent solubility |
| CA2593866C (en) * | 2004-12-30 | 2013-08-06 | F. Hoffmann-La Roche Ag | Synthesis of peptide t-1249 using peptide intermediate fragments |
| WO2006069697A1 (en) * | 2004-12-30 | 2006-07-06 | F. Hoffmann-La Roche Ag | Colorimetrically assessing peptide characteristics |
| WO2006105199A2 (en) * | 2005-03-30 | 2006-10-05 | Trimeris, Inc. | Compositions and methods for synthesis of peptide and related conjugate |
| TW200745163A (en) * | 2006-02-17 | 2007-12-16 | Syntonix Pharmaceuticals Inc | Peptides that block the binding of IgG to FcRn |
| CA2651070A1 (en) | 2006-05-03 | 2007-11-15 | Mallinckrodt Inc. | Composition and method for the release of protected peptides from a resin |
| CN101195653B (zh) * | 2006-12-08 | 2010-05-12 | 吉尔生化(上海)有限公司 | 亮丙瑞林的固液合成法 |
| EA201070231A1 (ru) * | 2007-08-09 | 2010-10-29 | Синтоникс Фармасьютикалз, Инк. | Иммуномодулирующие пептиды |
| CA2700354A1 (en) * | 2007-09-25 | 2009-04-02 | Trimeris, Inc. | Novel methods of synthesis for therapeutic antiviral peptides |
| JP5473925B2 (ja) * | 2007-10-27 | 2014-04-16 | コーデン ファーマ コロラド インコーポレイテッド | 固相および溶液相の組み合わせ技法を使用するインスリン分泌性ペプチドの合成 |
| WO2009074483A2 (en) * | 2007-12-11 | 2009-06-18 | F. Hoffmann-La Roche Ag | Insulinotropic peptide synthesis using solid and solution phase combination techniques |
| US20100048488A1 (en) * | 2008-08-01 | 2010-02-25 | Syntonix Pharmaceuticals, Inc. | Immunomodulatory peptides |
| EA201291482A1 (ru) | 2010-07-09 | 2013-10-30 | Байоджен Айдек Хемофилия Инк. | Химерные факторы коагуляции |
| CN102268065A (zh) * | 2011-06-23 | 2011-12-07 | 成都圣诺科技发展有限公司 | 氨基保护丝氨酸寡肽及其制备方法和用途 |
| CN102603869B (zh) * | 2012-03-27 | 2013-03-27 | 西安华澳丽康生物工程有限公司 | 六胜肽的合成方法 |
| SG10201707600XA (en) | 2013-03-15 | 2017-11-29 | Biogen Ma Inc | Factor ix polypeptide formulations |
| EP2976331B1 (en) | 2013-03-21 | 2017-03-01 | Sanofi-Aventis Deutschland GmbH | Synthesis of hydantoin containing peptide products |
| CA2907521C (en) | 2013-03-21 | 2021-04-13 | Sanofi-Aventis Deutschland Gmbh | Synthesis of cyclic imide containing peptide products |
| CN108572171A (zh) * | 2017-03-10 | 2018-09-25 | 江苏金斯瑞生物科技有限公司 | 一种检测哌啶残留的方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2139017T3 (es) | 1992-07-20 | 2000-02-01 | Univ Duke | Compuestos que inhiben la replicacion del vih. |
| JP3401005B2 (ja) | 1992-12-11 | 2003-04-28 | ユニバーシティ オブ フロリダ | 有害生物の防除のための材料および方法 |
| US5464933A (en) | 1993-06-07 | 1995-11-07 | Duke University | Synthetic peptide inhibitors of HIV transmission |
| US6479055B1 (en) | 1993-06-07 | 2002-11-12 | Trimeris, Inc. | Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission |
| CA2164505A1 (en) | 1993-06-07 | 1994-12-22 | Phillip W. Berman | Hiv envelope polypeptides |
| ES2245505T3 (es) * | 1998-03-23 | 2006-01-01 | Trimeris Inc. | Metodos y composiciones para la sintesis de peptidos (t-20). |
| US6258782B1 (en) * | 1998-05-20 | 2001-07-10 | Trimeris, Inc. | Hybrid polypeptides with enhanced pharmacokinetic properties |
| US6217666B1 (en) | 1998-08-31 | 2001-04-17 | Danieli Technology, Inc. | Countercurrent reduction of oxides on moving metal |
-
1999
- 1999-07-07 US US09/349,205 patent/US6469136B1/en not_active Expired - Fee Related
-
2000
- 2000-07-05 DE DE60017955T patent/DE60017955T2/de not_active Expired - Fee Related
- 2000-07-05 PT PT00992116T patent/PT1372686E/pt unknown
- 2000-07-05 MX MXPA02000021A patent/MXPA02000021A/es active IP Right Grant
- 2000-07-05 WO PCT/US2000/035725 patent/WO2001034635A2/en not_active Ceased
- 2000-07-05 ES ES00992116T patent/ES2236043T3/es not_active Expired - Lifetime
- 2000-07-05 KR KR1020027000199A patent/KR100631874B1/ko not_active Expired - Fee Related
- 2000-07-05 EP EP00992116A patent/EP1372686B1/en not_active Expired - Lifetime
- 2000-07-05 CN CNB008125309A patent/CN1267449C/zh not_active Expired - Fee Related
- 2000-07-05 BR BR0012249-1A patent/BR0012249A/pt not_active IP Right Cessation
- 2000-07-05 AT AT00992116T patent/ATE288278T1/de not_active IP Right Cessation
- 2000-07-05 CA CA002378086A patent/CA2378086A1/en not_active Abandoned
- 2000-07-05 AU AU41337/01A patent/AU4133701A/en not_active Abandoned
- 2000-07-05 DK DK00992116T patent/DK1372686T3/da active
- 2000-07-05 JP JP2001537346A patent/JP2003530311A/ja not_active Ceased
- 2000-07-07 AR ARP000103508A patent/AR024686A1/es active IP Right Grant
- 2000-08-05 TW TW089113543A patent/TWI237640B/zh active
-
2002
- 2002-03-29 US US10/109,748 patent/US6767993B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA02000021A (es) | 2002-07-02 |
| WO2001034635A9 (en) | 2002-08-01 |
| ES2236043T3 (es) | 2005-07-16 |
| CA2378086A1 (en) | 2001-05-17 |
| DE60017955D1 (de) | 2005-03-10 |
| DE60017955T2 (de) | 2006-01-12 |
| CN1450906A (zh) | 2003-10-22 |
| CN1267449C (zh) | 2006-08-02 |
| TWI237640B (en) | 2005-08-11 |
| WO2001034635A2 (en) | 2001-05-17 |
| DK1372686T3 (da) | 2005-05-30 |
| JP2003530311A (ja) | 2003-10-14 |
| KR20020038676A (ko) | 2002-05-23 |
| US6767993B2 (en) | 2004-07-27 |
| EP1372686A2 (en) | 2004-01-02 |
| AU4133701A (en) | 2001-06-06 |
| US6469136B1 (en) | 2002-10-22 |
| PT1372686E (pt) | 2005-05-31 |
| EP1372686B1 (en) | 2005-02-02 |
| US20030125516A1 (en) | 2003-07-03 |
| WO2001034635A3 (en) | 2003-10-16 |
| BR0012249A (pt) | 2003-11-11 |
| KR100631874B1 (ko) | 2006-10-09 |
| EP1372686A4 (en) | 2004-01-02 |
| ATE288278T1 (de) | 2005-02-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |