AR019787A2 - Compuestos macrolidos, su uso en la preparacion de medicamentos, composiciones y metodo para la preparacion de los mismos - Google Patents
Compuestos macrolidos, su uso en la preparacion de medicamentos, composiciones y metodo para la preparacion de los mismosInfo
- Publication number
- AR019787A2 AR019787A2 ARP990106062A ARP990106062A AR019787A2 AR 019787 A2 AR019787 A2 AR 019787A2 AR P990106062 A ARP990106062 A AR P990106062A AR P990106062 A ARP990106062 A AR P990106062A AR 019787 A2 AR019787 A2 AR 019787A2
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- groups
- optionally substituted
- alkenyl
- group
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 5
- 125000000304 alkynyl group Chemical group 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 2
- 125000006350 alkyl thio alkyl group Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000004149 thio group Chemical group *S* 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 125000000081 (C5-C8) cycloalkenyl group Chemical group 0.000 abstract 1
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Un compuesto de formula (1)R20 = H o formula (2)o una de sus sales farmacéuticamente aceptables, en la que: Y es H,alquilo C1-10 alquenilo C2-10,alquiniloC2-10,-(CH2)m(arilo C6-10),-(CH2)m(heteroarilo de 5-10 eslabones),donde m es un entero que varíade 0 a 4 y donde los grupos alquilo,alquenilo,arilo,heteroarilo y alquinilo están opcionalmente sustituidos por 1 a 3 sustituyentes seleccionados independientemente de halogeno, ciano, nitro, trifluorometilo, azido,-C(O)R21, -OC(O)R21, -NR21C(O)R22,-C(O)NR21R22, hidroxi, alquilo C1-6, alcoxi C1-6, arilo C6-10 y heteroarilo de 5 a 10 eslabones; R1 es un grupo alquilo, alqenilo, alquinilo, alcoxialquilo o alquiltioalquilo C3-8 alfa ramificado, pudiendo estar cualquiera de los cuales opcionalmente sustituido por uno o más gruposhidroxilo; un grupo cicloalquilalquilo C5-8 en el que el grupo alquilo es un grupo alquilo C2-5 alfa-ramificado; un grupo cicloalquilo C3-8 o cicloalqueniloC5-8, cualquiera de los cuales puede estar opcionalmente sustituido por metilo o uno o más hidroxilo o uno o más grupos alquilo C1-4 o átomos de halogeno; o unanillo heterocíclico que contiene oxígeno o azufre de 3 a 6 eslabones que puede ser saturado o, total o parcialmente insaturado y que puede estar opcionalmentesustituido por uno o más grupos alquilo C1-4 o átomos de halogeno; o R1 es fenilo que puede estar opcionalmente sustituido con al menos un sustituyenteseleccionado de grupos alquilo C1-4, alcoxi C1-4 y (alquil C1-4)tio, átomos de halogeno, grupos hidroxilo, trifluorometilo y ciano; o R1 puede ser un grupo conuna formula (3) en la que X es O, S o -CH2-; a, b, c y d son cada uno, independientemente 0 a 2 y a + b + c + d < o = 5; o R1 es CH2R24, donde R24 es H,alquilo C1-6, alquenilo C2-6, alquinilo C2-6, alcoxialquilo o alquiltioalquilo, que contienen C1-6 en cada uno de los grupos alquilo o alcoxi, pudiendo estarcualquiera de dichos grupos alquilo, alcoxi, alquenilo o alquinilo sustituido por uno o más grupos hidroxilo o por uno o másátomos de halogeno; o uncicloalquilo C3-6 o cicloalquenilo C3-6, cualquiera de los cuales puede estar opcionalmente sustituido por metilo o uno o más grupos alquilo C1-4 o átomos de
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7034398P | 1998-01-02 | 1998-01-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR019787A2 true AR019787A2 (es) | 2002-03-13 |
Family
ID=22094723
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980106717A AR014948A1 (es) | 1998-01-02 | 1998-12-29 | Compuestos macrolidos, composiciones, su uso para la manufactura de medicamentos y metodo para prepararlos. |
| ARP990106062A AR019787A2 (es) | 1998-01-02 | 1999-11-29 | Compuestos macrolidos, su uso en la preparacion de medicamentos, composiciones y metodo para la preparacion de los mismos |
| ARP990106063A AR020851A2 (es) | 1998-01-02 | 1999-11-29 | Compuestos macrolidos, composiciones y su uso para la preparacion de medicamentos |
| ARP990106064A AR020551A2 (es) | 1998-01-02 | 1999-11-29 | Compuestos macrolidos, composiciones y su uso para la preparacion de medicamentos. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980106717A AR014948A1 (es) | 1998-01-02 | 1998-12-29 | Compuestos macrolidos, composiciones, su uso para la manufactura de medicamentos y metodo para prepararlos. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990106063A AR020851A2 (es) | 1998-01-02 | 1999-11-29 | Compuestos macrolidos, composiciones y su uso para la preparacion de medicamentos |
| ARP990106064A AR020551A2 (es) | 1998-01-02 | 1999-11-29 | Compuestos macrolidos, composiciones y su uso para la preparacion de medicamentos. |
Country Status (34)
| Country | Link |
|---|---|
| US (2) | US6472371B1 (es) |
| EP (1) | EP1044207A1 (es) |
| JP (1) | JP2002500230A (es) |
| KR (1) | KR100352809B1 (es) |
| CN (1) | CN1284081A (es) |
| AP (1) | AP9801420A0 (es) |
| AR (4) | AR014948A1 (es) |
| AU (1) | AU756409B2 (es) |
| BG (1) | BG104644A (es) |
| BR (1) | BR9814601A (es) |
| CA (1) | CA2316919C (es) |
| CO (1) | CO4970821A1 (es) |
| CZ (1) | CZ20002458A3 (es) |
| DZ (1) | DZ2698A1 (es) |
| EA (1) | EA200000594A1 (es) |
| GT (1) | GT199800206A (es) |
| HR (1) | HRP20000442A2 (es) |
| HU (1) | HUP0100420A3 (es) |
| IL (1) | IL137024A0 (es) |
| IS (1) | IS5528A (es) |
| MA (1) | MA24729A1 (es) |
| NO (1) | NO20003347L (es) |
| NZ (1) | NZ504986A (es) |
| OA (1) | OA11438A (es) |
| PA (1) | PA8465301A1 (es) |
| PE (1) | PE20000049A1 (es) |
| PL (1) | PL341642A1 (es) |
| SK (1) | SK9782000A3 (es) |
| TN (1) | TNSN98238A1 (es) |
| TW (1) | TW520374B (es) |
| UY (2) | UY25330A1 (es) |
| WO (1) | WO1999035156A1 (es) |
| YU (1) | YU41500A (es) |
| ZA (1) | ZA9811939B (es) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AP1060A (en) | 1998-01-02 | 2002-04-23 | Pfizer Prod Inc | Novel erythromycin derivatives. |
| AP9801420A0 (en) | 1998-01-02 | 1998-12-31 | Pfizer Prod Inc | Novel macrolides. |
| US6043227A (en) * | 1998-08-19 | 2000-03-28 | Pfizer Inc. | C11 carbamates of macrolide antibacterials |
| EP1437360A3 (en) * | 1998-08-19 | 2005-04-06 | Pfizer Products Inc. | C11 Carbamates of macrolide antibacterials |
| EP1754700A3 (en) | 1999-01-27 | 2007-05-09 | Kosan Biosciences, Inc. | Synthesis of oligoketides |
| US6590083B1 (en) | 1999-04-16 | 2003-07-08 | Ortho-Mcneil Pharmaceutical, Inc. | Ketolide antibacterials |
| JP2002542197A (ja) | 1999-04-16 | 2002-12-10 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | ケトライド抗菌剤 |
| US6451768B1 (en) | 1999-04-16 | 2002-09-17 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
| OA11945A (en) | 1999-05-24 | 2006-04-13 | Pfizer Prod Inc | 13-Methyl erythromycin derivatives. |
| JPWO2003072589A1 (ja) * | 2002-02-26 | 2005-06-16 | 明治製菓株式会社 | 新規１５員環アザライド及び新規１６員環ジアザライド誘導体とその製造法 |
| ES2314724T3 (es) | 2004-09-23 | 2009-03-16 | Schering-Plough Ltd. | Control de parasitos en animales mediante el uso de nuevos derivados de eter de trifluorometanosulfonanilida oxima. |
| CA2587495A1 (en) * | 2004-11-19 | 2006-05-26 | Schering-Plough Ltd. | Control of parasites in animals by the use of parasiticidal 2-phenyl-3-(1h-pyrrol-2-yl) acrylonitrile derivatives |
| UA85937C2 (uk) | 2004-12-21 | 2009-03-10 | Пфайзер Продактс Інк. | Макроліди |
| MX2007015729A (es) * | 2005-06-09 | 2008-02-21 | Schering Plough Ltd | Control de parasitos en animales con derivados de n-[(feniloxi)fenil]-1,1,1-trifluorometansulfonamida y de n[(fenilsulfanil)fenil]-1,1,1-trifluorometansulfonamida. |
| US8119667B2 (en) * | 2005-12-29 | 2012-02-21 | Schering-Plough Animal Health Corporation | Carbonates of fenicol antibiotics |
| US20070238700A1 (en) * | 2006-04-10 | 2007-10-11 | Winzenberg Kevin N | N-phenyl-1,1,1-trifluoromethanesulfonamide hydrazone derivative compounds and their usage in controlling parasites |
| WO2008076259A1 (en) * | 2006-12-13 | 2008-06-26 | Schering-Plough Ltd. | Water-soluble prodrugs of florfenicol and its analogs |
| CN101600686A (zh) * | 2006-12-13 | 2009-12-09 | 先灵-普劳有限公司 | 氯霉素、甲砜霉素及其类似物的水溶性前药 |
| TWI430995B (zh) | 2007-06-26 | 2014-03-21 | Du Pont | 萘異唑啉無脊椎有害動物控制劑 |
| ES2549731T3 (es) | 2007-06-27 | 2015-11-02 | E. I. Du Pont De Nemours And Company | Método para el control de plagas en animales |
| US20090131343A1 (en) * | 2007-11-15 | 2009-05-21 | Ly Tam Phan | Use of bridged macrolides or tylosin derivatives in treating inflammatory bowel diseases |
| TWI401023B (zh) | 2008-02-06 | 2013-07-11 | Du Pont | 中離子農藥 |
| JP2011529895A (ja) * | 2008-07-30 | 2011-12-15 | インターベツト・インターナシヨナル・ベー・ベー | フロルフェニコール中間体として有用なオキサゾリン保護アミノジオール化合物を調製する方法 |
| JP2013501063A (ja) | 2009-08-05 | 2013-01-10 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | メソイオン性殺虫剤 |
| UA107804C2 (en) | 2009-08-05 | 2015-02-25 | Du Pont | Mixtures of pesticides mezoionnyh |
| EP2461684A2 (en) | 2009-08-05 | 2012-06-13 | E. I. du Pont de Nemours and Company | Mesoionic pesticides |
| UA110924C2 (uk) | 2009-08-05 | 2016-03-10 | Е. І. Дю Пон Де Немур Енд Компані | Мезоіонні пестициди |
| UY33397A (es) | 2010-05-27 | 2011-12-01 | Du Pont | Forma sólida de un naftaleno carboxamida |
| WO2012087630A1 (en) | 2010-12-20 | 2012-06-28 | E.I. Du Pont De Nemours And Company | Pyridine and pyrimidine compounds for controlling invertebrate |
| JPWO2012105562A1 (ja) * | 2011-01-31 | 2014-07-03 | Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 | 新規マクロライド誘導体 |
| JP2014520151A (ja) | 2011-06-20 | 2014-08-21 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 蠕虫感染を処置するためのヘテロ環式化合物 |
| CN102260306B (zh) * | 2011-07-22 | 2012-07-18 | 山东鲁抗舍里乐药业有限公司 | 一种制备泰拉霉素的方法 |
| CN103958476A (zh) | 2011-11-28 | 2014-07-30 | 纳幕尔杜邦公司 | N-(4-喹啉基甲基)磺酰胺衍生物以及它们作为驱肠虫剂的用途 |
| WO2013158422A1 (en) | 2012-04-17 | 2013-10-24 | E. I. Du Pont De Nemours And Company | Heterocyclic compounds for controlling invertebrate pests |
| WO2014099837A1 (en) | 2012-12-18 | 2014-06-26 | E. I. Du Pont De Nemours And Company | Sulfonamide anthelmintics |
| CN103965273B (zh) * | 2013-08-23 | 2016-05-25 | 普莱柯生物工程股份有限公司 | 一种大环内酯类化合物 |
| CN105669798B (zh) * | 2013-08-23 | 2019-07-26 | 普莱柯生物工程股份有限公司 | 一种大环内酯类化合物 |
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| AP1060A (en) | 1998-01-02 | 2002-04-23 | Pfizer Prod Inc | Novel erythromycin derivatives. |
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| US6043227A (en) | 1998-08-19 | 2000-03-28 | Pfizer Inc. | C11 carbamates of macrolide antibacterials |
| US6100240A (en) | 1998-10-09 | 2000-08-08 | Pfizer Inc | Macrolide derivatives |
| CN1376160A (zh) | 1998-11-03 | 2002-10-23 | 辉瑞产品公司 | 新的大环内酯抗生素 |
| UA70972C2 (uk) | 1998-11-20 | 2004-11-15 | Пфайзер Продактс Інк. | 13-членні азаліди і їх застосування як антибіотиків |
| OA11945A (en) | 1999-05-24 | 2006-04-13 | Pfizer Prod Inc | 13-Methyl erythromycin derivatives. |
| EP1101769A3 (en) | 1999-11-18 | 2001-10-24 | Pfizer Products Inc. | Nitrogen containing erythromycin derivatives |
| WO2003014136A1 (en) | 2001-08-08 | 2003-02-20 | Taisho Pharmaceutical Co., Ltd. | 11a-AZALIDE COMPOUNDS AND PROCESS FOR PRODUCING THE SAME |
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1998
- 1998-12-17 AP APAP/P/1998/001420A patent/AP9801420A0/en unknown
- 1998-12-21 CA CA002316919A patent/CA2316919C/en not_active Expired - Fee Related
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- 1998-12-21 PL PL98341642A patent/PL341642A1/xx unknown
- 1998-12-21 AU AU14447/99A patent/AU756409B2/en not_active Ceased
- 1998-12-21 YU YU41500A patent/YU41500A/sh unknown
- 1998-12-21 CN CN98813253A patent/CN1284081A/zh active Pending
- 1998-12-21 WO PCT/IB1998/002099 patent/WO1999035156A1/en not_active Ceased
- 1998-12-21 SK SK978-2000A patent/SK9782000A3/sk unknown
- 1998-12-21 KR KR1020007007313A patent/KR100352809B1/ko not_active Expired - Fee Related
- 1998-12-21 HU HU0100420A patent/HUP0100420A3/hu unknown
- 1998-12-21 JP JP2000527552A patent/JP2002500230A/ja active Pending
- 1998-12-21 EP EP98958384A patent/EP1044207A1/en not_active Withdrawn
- 1998-12-21 IL IL13702498A patent/IL137024A0/xx unknown
- 1998-12-21 CZ CZ20002458A patent/CZ20002458A3/cs unknown
- 1998-12-21 NZ NZ504986A patent/NZ504986A/xx unknown
- 1998-12-21 US US09/554,988 patent/US6472371B1/en not_active Expired - Fee Related
- 1998-12-21 HR HR20000442A patent/HRP20000442A2/hr not_active Application Discontinuation
- 1998-12-22 EA EA200000594A patent/EA200000594A1/ru unknown
- 1998-12-23 PA PA19988465301A patent/PA8465301A1/es unknown
- 1998-12-23 TW TW087121542A patent/TW520374B/zh not_active IP Right Cessation
- 1998-12-28 PE PE1998001287A patent/PE20000049A1/es not_active Application Discontinuation
- 1998-12-29 GT GT199800206A patent/GT199800206A/es unknown
- 1998-12-29 AR ARP980106717A patent/AR014948A1/es not_active Application Discontinuation
- 1998-12-30 TN TNTNSN98238A patent/TNSN98238A1/fr unknown
- 1998-12-30 MA MA25407A patent/MA24729A1/fr unknown
- 1998-12-30 DZ DZ980308A patent/DZ2698A1/xx active
- 1998-12-30 UY UY25330A patent/UY25330A1/es not_active Application Discontinuation
- 1998-12-30 CO CO98077585A patent/CO4970821A1/es unknown
- 1998-12-30 ZA ZA9811939A patent/ZA9811939B/xx unknown
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1999
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2000
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2002
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