AR018590A1 - Oximil e hidroxilamino c11 prostaglandinas utiles como agonistas de receptores fp y su uso para fabricacion de medicamentos para tratar trastornososeos y glaucoma - Google Patents
Oximil e hidroxilamino c11 prostaglandinas utiles como agonistas de receptores fp y su uso para fabricacion de medicamentos para tratar trastornososeos y glaucomaInfo
- Publication number
- AR018590A1 AR018590A1 ARP990101443A ARP990101443A AR018590A1 AR 018590 A1 AR018590 A1 AR 018590A1 AR P990101443 A ARP990101443 A AR P990101443A AR P990101443 A ARP990101443 A AR P990101443A AR 018590 A1 AR018590 A1 AR 018590A1
- Authority
- AR
- Argentina
- Prior art keywords
- monocyclic
- ring
- aliphatic ring
- independently selected
- group
- Prior art date
Links
- 208000010412 Glaucoma Diseases 0.000 title 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 title 1
- 150000003180 prostaglandins Chemical class 0.000 title 1
- 239000000018 receptor agonist Substances 0.000 title 1
- 229940044601 receptor agonist Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 229910052717 sulfur Inorganic materials 0.000 abstract 4
- 101100516572 Caenorhabditis elegans nhr-8 gene Proteins 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- 125000002950 monocyclic group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 101100516568 Caenorhabditis elegans nhr-7 gene Proteins 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- 150000003949 imides Chemical class 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003536 tetrazoles Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Compuestos que tienen la estructura (I), donde: (a) R1 es CO2H, C(O)NHOH, CO2R7, CH2OH, S(O)2R7, C(O)2R7, C(O)NHR7, C(O)NHS(O)2R7, o tetrazol, donde R7, otetrazol, donde R7 es alquilo, heteroalquilo, anillo alifático carbocíclico monocíclico, anilloalifático heterocíclico monocíclico, anillo aromáticomonocíclico, o anillo heteroaromático monocíclico; (b) W es O, NH, S, S(O), S(O)2, O(CH2)m; donde m es un numero entero de 0 a 3; (c) R2 es H y R3 esH o alquilo inferior, o R2 y R3 juntos forman unenlace covalente; (d) R4 es H, alquilo, heteroalquilo, anillo alifático carbocíclico monocíclico, anilloalifático heterocíclico monocíclico, anillo aromático monocíclico, o anillo heteroaromático monocíclico; (e) cada R6 se selecciona independientemente delgrupo formado por H, CH3, y C2H5; (f) X es NHR8 u OR8, donde cada R8 se selecciona independientemente del grupo formado por H, acilo, alquilo,heteroalquilo, anillo alifático carbocíclico monocíclico, anillo alifático heterocíclico monocíclico, anillo aromático monocíclico, y anillo heteroaromáticomonocíclico; (g) cada R6 se selecciona independientemente del grupo formado por H, CH3, C2H5, OR8 y NHR8; (h) Y es O, NHR8, S, S(O), o S(O)2, siempreque ningun carbono tenga más de un heteroátomo unido a él; (i) Z es H, metilo, anillo alifático carbocíclico monocíclico, anillo alifático heterocíclicomonocíclico, anillo aromático monocíclico, anillo heteroaromático monocíclico, anillo alifático carbocíclico bicíclico, anillo alifático heterocíclicobicíclico, anillo aromático bicíclico, o anillo heteroaromático bicíclico, siempre que cuando Y es S,S(O), o S((O)2, y Z es H, q sea por lo menos 1;(j) a y b se seleccionan independientemente del grupo formado por enlace unico, enlace doble cis, y enlace doble trans; (k) p es un numero entero de 1 a 5,q es un numero entero de 0 a 5, y p+q es de 1 a 5; y cualquier isomero, diastereomero, enantiomero optico de la estructura anterior o una salfarmacéuticamente aceptable, o amida biohidrolizable, éster o imida de ellos. Los compuestos de la presente son utiles para el tratamiento de una
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8021698P | 1998-03-31 | 1998-03-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR018590A1 true AR018590A1 (es) | 2001-11-28 |
Family
ID=22155990
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990101443A AR018590A1 (es) | 1998-03-31 | 1999-03-30 | Oximil e hidroxilamino c11 prostaglandinas utiles como agonistas de receptores fp y su uso para fabricacion de medicamentos para tratar trastornososeos y glaucoma |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP1066254B1 (es) |
| JP (1) | JP2002509916A (es) |
| KR (1) | KR20010042285A (es) |
| CN (1) | CN1295559A (es) |
| AR (1) | AR018590A1 (es) |
| AT (1) | ATE296284T1 (es) |
| AU (1) | AU749540B2 (es) |
| BR (1) | BR9909268A (es) |
| CA (1) | CA2324590C (es) |
| DE (1) | DE69925475T2 (es) |
| ES (1) | ES2244208T3 (es) |
| HU (1) | HUP0103403A3 (es) |
| IL (1) | IL138447A0 (es) |
| NO (1) | NO20004903L (es) |
| NZ (1) | NZ506855A (es) |
| PE (1) | PE20000351A1 (es) |
| PL (1) | PL343125A1 (es) |
| SK (1) | SK14722000A3 (es) |
| TR (1) | TR200002795T2 (es) |
| WO (1) | WO1999050242A1 (es) |
| ZA (1) | ZA992394B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000051980A1 (en) | 1999-03-05 | 2000-09-08 | The Procter & Gamble Company | C16 unsaturated fp-selective prostaglandins analogs |
| US20020172693A1 (en) | 2000-03-31 | 2002-11-21 | Delong Michell Anthony | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
| US20020013294A1 (en) | 2000-03-31 | 2002-01-31 | Delong Mitchell Anthony | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
| KR100437873B1 (ko) * | 2001-05-08 | 2004-06-26 | 연성정밀화학(주) | 프로스타글란딘 유도체의 제조방법 및 그의 입체특이적출발물질 |
| WO2006047466A2 (en) | 2004-10-21 | 2006-05-04 | Duke University | Ophthamological drugs |
| WO2008060799A2 (en) * | 2006-11-09 | 2008-05-22 | Bausch & Lomb Incorporated | Synthesis of selected stereoisomers of certain substituted alcohols |
| US20110293549A1 (en) | 2009-02-03 | 2011-12-01 | Athena Cosmetics, Inc. | Composition, method and kit for enhancing hair |
| CN102101835B (zh) * | 2009-12-16 | 2015-07-22 | 武汉启瑞药业有限公司 | 前列腺素衍生物及其中间体的制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3538120A (en) * | 1967-05-22 | 1970-11-03 | Ciba Geigy Corp | Cyclopentyl-alkanoic acids |
| US3798275A (en) * | 1972-04-05 | 1974-03-19 | Ciba Geigy Corp | Etherified mercapto-methoxyamines |
-
1999
- 1999-03-22 JP JP2000541147A patent/JP2002509916A/ja not_active Withdrawn
- 1999-03-22 PL PL99343125A patent/PL343125A1/xx unknown
- 1999-03-22 DE DE69925475T patent/DE69925475T2/de not_active Expired - Fee Related
- 1999-03-22 SK SK1472-2000A patent/SK14722000A3/sk unknown
- 1999-03-22 BR BR9909268-9A patent/BR9909268A/pt not_active IP Right Cessation
- 1999-03-22 NZ NZ506855A patent/NZ506855A/xx unknown
- 1999-03-22 AT AT99942611T patent/ATE296284T1/de not_active IP Right Cessation
- 1999-03-22 KR KR1020007010828A patent/KR20010042285A/ko not_active Application Discontinuation
- 1999-03-22 HU HU0103403A patent/HUP0103403A3/hu unknown
- 1999-03-22 ES ES99942611T patent/ES2244208T3/es not_active Expired - Lifetime
- 1999-03-22 TR TR2000/02795T patent/TR200002795T2/xx unknown
- 1999-03-22 CA CA002324590A patent/CA2324590C/en not_active Expired - Fee Related
- 1999-03-22 IL IL13844799A patent/IL138447A0/xx unknown
- 1999-03-22 AU AU32702/99A patent/AU749540B2/en not_active Ceased
- 1999-03-22 EP EP99942611A patent/EP1066254B1/en not_active Expired - Lifetime
- 1999-03-22 WO PCT/IB1999/000480 patent/WO1999050242A1/en not_active Application Discontinuation
- 1999-03-22 CN CN99804644A patent/CN1295559A/zh active Pending
- 1999-03-29 ZA ZA9902394A patent/ZA992394B/xx unknown
- 1999-03-30 PE PE1999000251A patent/PE20000351A1/es not_active Application Discontinuation
- 1999-03-30 AR ARP990101443A patent/AR018590A1/es unknown
-
2000
- 2000-09-29 NO NO20004903A patent/NO20004903L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20010042285A (ko) | 2001-05-25 |
| BR9909268A (pt) | 2001-09-04 |
| CA2324590C (en) | 2006-06-13 |
| JP2002509916A (ja) | 2002-04-02 |
| EP1066254B1 (en) | 2005-05-25 |
| CN1295559A (zh) | 2001-05-16 |
| ES2244208T3 (es) | 2005-12-01 |
| CA2324590A1 (en) | 1999-10-07 |
| PL343125A1 (en) | 2001-07-30 |
| WO1999050242A1 (en) | 1999-10-07 |
| AU749540B2 (en) | 2002-06-27 |
| HUP0103403A3 (en) | 2002-12-28 |
| DE69925475T2 (de) | 2005-11-17 |
| DE69925475D1 (de) | 2005-06-30 |
| TR200002795T2 (tr) | 2001-01-22 |
| ZA992394B (en) | 1999-09-30 |
| NO20004903D0 (no) | 2000-09-29 |
| PE20000351A1 (es) | 2000-06-22 |
| ATE296284T1 (de) | 2005-06-15 |
| AU3270299A (en) | 1999-10-18 |
| IL138447A0 (en) | 2001-10-31 |
| NO20004903L (no) | 2000-11-29 |
| HUP0103403A2 (hu) | 2002-01-28 |
| SK14722000A3 (sk) | 2001-07-10 |
| NZ506855A (en) | 2003-02-28 |
| EP1066254A1 (en) | 2001-01-10 |
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