PE20040778A1 - Derivados de piperazina selectivamente activos sobre los receptores de melancortina mc-3 y mc-4 - Google Patents
Derivados de piperazina selectivamente activos sobre los receptores de melancortina mc-3 y mc-4Info
- Publication number
- PE20040778A1 PE20040778A1 PE2003001070A PE2003001070A PE20040778A1 PE 20040778 A1 PE20040778 A1 PE 20040778A1 PE 2003001070 A PE2003001070 A PE 2003001070A PE 2003001070 A PE2003001070 A PE 2003001070A PE 20040778 A1 PE20040778 A1 PE 20040778A1
- Authority
- PE
- Peru
- Prior art keywords
- rings
- formula
- substituted
- compounds
- melancortine
- Prior art date
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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- C07—ORGANIC CHEMISTRY
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
SE REFIERE A COMPUESTOS DE FORMULA I DONDE L ES UNA UNIDAD SELECCIONADA DE: (R2)p(CH=CH)q, (R2)y(X)zC(Y)w(X)z(R2)y, (R2)y(X)zS(Y)k(X)z(R2)y, ENTRE OTROS; X ES O, S, ENTRE OTROS; Y ES =O, =S, ENTRE OTROS; Z ES =N, -NR4-, ENTRE OTROS; k ES 0-2; p ES 0-12; q ES 0-3; w ES 0-2; y ES 0-1; z ES 0-1; R2 ES METILENO, SUSTITUIDO O NO, DE FORMULA II, EN DONDE R3a Y R3b SON H, HIDROCARBILO C1-C12, ENTRE OTROS; R ES UNA UNIDAD DE HIDROCARBILO SUSTITUIDO O NO SELECCIONADO DE ANILLOS CARBOCICLICOS, ANILLOS HETEROCICLICOS; W ES LA FORMULA III DONDE r ES 0-1; X ES 0-10; Q ES H, ANILLOS CARBOCICLICOS, ANILLOS HETEROCICLICOS, ENTRE OTROS, DONDE EL NUMERO DE ANILLOS ES DE 1-3; R5a Y R5b SON H, HIDROCARBONILO C1-C12, ENTRE OTROS; R1 ES ALQUILO C1-C12 LINEAL O RAMIFICADOS, SUSTITUIDO O NO, ALQUILO C3-C8 CICLICO, ALQUENILO C2-C12 LINEAL O RAMIFICADO, ENTRE OTROS; A, A1 Y A2 SON C(=O), C(=S), -N=, ENTRE OTROS; O DOS UNIDADES A PUEDEN JUNTO CON AL ATOMO ADYACENTE FORMAR UN ENLACE QUE TIENE LA FORMULA N=N, C=N, ENTRE OTROS; j ES 0-1. SON COMPUESTOS PREFERIDOS: 2-(S)-{3-(S)-ALIL-4-[2-(R)-AMINO-3-(4-FLUOROFENIL)PROPIONIL]-2-OXO-PIPERAZIN-1-IL}-N-METIL-3-NAFTALEN-2-IL-PROPIONAMIDA; 2-{4-[2-AMINO-3-(4-FLUOROFENIL)-PROPIONIL]-2-OXO-3-PROPIL-PIPERAZIN-1-IL}-3-(3,4-DICLOROFENIL)-N-METIL-PROPIONAMIDA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA . ESTOS COMPUESTOS SON UTILES PARA TRATAR TRASTORNOS MEDIADOS POR LIGANDOS RECEPTORES DE MELANOCORTINA (MC) EN ESPECIAL LOS MEDIADOS POR MC-3
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42057802P | 2002-10-23 | 2002-10-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20040778A1 true PE20040778A1 (es) | 2004-12-21 |
Family
ID=32176593
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2003001070A PE20040778A1 (es) | 2002-10-23 | 2003-10-22 | Derivados de piperazina selectivamente activos sobre los receptores de melancortina mc-3 y mc-4 |
Country Status (18)
Country | Link |
---|---|
US (2) | US7132539B2 (es) |
EP (1) | EP1556361A2 (es) |
JP (1) | JP2006506384A (es) |
KR (1) | KR20050072445A (es) |
CN (1) | CN1703221A (es) |
AR (1) | AR043054A1 (es) |
AU (1) | AU2003286557A1 (es) |
BR (1) | BR0315614A (es) |
CA (1) | CA2501231A1 (es) |
MA (1) | MA27478A1 (es) |
MX (1) | MXPA05004378A (es) |
NO (1) | NO20052476D0 (es) |
PE (1) | PE20040778A1 (es) |
PL (1) | PL376702A1 (es) |
RU (1) | RU2005111967A (es) |
TW (1) | TW200504033A (es) |
WO (1) | WO2004037797A2 (es) |
ZA (1) | ZA200502944B (es) |
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AU2007283113A1 (en) | 2006-08-08 | 2008-02-14 | Sanofi-Aventis | Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, processes for preparing them, medicaments comprising these compounds, and their use |
US8163779B2 (en) | 2006-12-20 | 2012-04-24 | Takeda San Diego, Inc. | Glucokinase activators |
US8173645B2 (en) * | 2007-03-21 | 2012-05-08 | Takeda San Diego, Inc. | Glucokinase activators |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
KR101478253B1 (ko) * | 2007-09-17 | 2014-12-31 | 국민대학교산학협력단 | 아룸 팔래스티눔(Arum palaestinunBoiss) 유래 항암용 피페라지움 화합물 |
AR072707A1 (es) | 2008-07-09 | 2010-09-15 | Sanofi Aventis | Compuestos heterociclicos, procesos para su preparacion, medicamentos que comprenden estos compuestos y el uso de los mismos |
EP2358200A4 (en) | 2008-11-17 | 2012-05-16 | Merck Sharp & Dohme | BICYCLIC AMINES SUBSTITUTED FOR THE TREATMENT OF DIABETES |
WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
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WO2012120051A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
US8901114B2 (en) | 2011-03-08 | 2014-12-02 | Sanofi | Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof |
EP2683701B1 (de) | 2011-03-08 | 2014-12-24 | Sanofi | Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
US8828994B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
EP2683699B1 (de) | 2011-03-08 | 2015-06-24 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
EP2683702B1 (de) | 2011-03-08 | 2014-12-24 | Sanofi | Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
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-
2003
- 2003-10-20 US US10/689,022 patent/US7132539B2/en not_active Expired - Fee Related
- 2003-10-20 TW TW092129035A patent/TW200504033A/zh unknown
- 2003-10-22 BR BR0315614-1A patent/BR0315614A/pt not_active IP Right Cessation
- 2003-10-22 CA CA002501231A patent/CA2501231A1/en not_active Abandoned
- 2003-10-22 EP EP03777759A patent/EP1556361A2/en not_active Withdrawn
- 2003-10-22 PE PE2003001070A patent/PE20040778A1/es not_active Application Discontinuation
- 2003-10-22 AU AU2003286557A patent/AU2003286557A1/en not_active Abandoned
- 2003-10-22 RU RU2005111967/04A patent/RU2005111967A/ru not_active Application Discontinuation
- 2003-10-22 AR ARP030103859A patent/AR043054A1/es not_active Application Discontinuation
- 2003-10-22 JP JP2004546990A patent/JP2006506384A/ja active Pending
- 2003-10-22 MX MXPA05004378A patent/MXPA05004378A/es unknown
- 2003-10-22 PL PL376702A patent/PL376702A1/pl not_active Application Discontinuation
- 2003-10-22 CN CNA2003801009342A patent/CN1703221A/zh active Pending
- 2003-10-22 WO PCT/US2003/033402 patent/WO2004037797A2/en active Application Filing
- 2003-10-22 KR KR1020057006836A patent/KR20050072445A/ko not_active Application Discontinuation
-
2005
- 2005-04-12 ZA ZA200502944A patent/ZA200502944B/en unknown
- 2005-04-25 MA MA28235A patent/MA27478A1/fr unknown
- 2005-05-23 NO NO20052476A patent/NO20052476D0/no not_active Application Discontinuation
-
2006
- 2006-06-23 US US11/473,972 patent/US20060247224A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
NO20052476L (no) | 2005-05-23 |
JP2006506384A (ja) | 2006-02-23 |
MXPA05004378A (es) | 2005-07-05 |
ZA200502944B (en) | 2006-02-22 |
WO2004037797A3 (en) | 2004-11-04 |
KR20050072445A (ko) | 2005-07-11 |
MA27478A1 (fr) | 2005-08-01 |
CA2501231A1 (en) | 2004-05-06 |
EP1556361A2 (en) | 2005-07-27 |
US7132539B2 (en) | 2006-11-07 |
TW200504033A (en) | 2005-02-01 |
NO20052476D0 (no) | 2005-05-23 |
RU2005111967A (ru) | 2006-01-20 |
WO2004037797A2 (en) | 2004-05-06 |
AR043054A1 (es) | 2005-07-13 |
BR0315614A (pt) | 2005-08-30 |
PL376702A1 (pl) | 2006-01-09 |
CN1703221A (zh) | 2005-11-30 |
US20050010031A1 (en) | 2005-01-13 |
US20060247224A1 (en) | 2006-11-02 |
AU2003286557A1 (en) | 2004-05-13 |
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