AR018032A1 - Derivados del indol-aril sustituidos, un procedimiento para su preparacion, composicion farmaceutica que los comprende y el uso de dichos compuestos parala fabricacion de un medicamento - Google Patents
Derivados del indol-aril sustituidos, un procedimiento para su preparacion, composicion farmaceutica que los comprende y el uso de dichos compuestos parala fabricacion de un medicamentoInfo
- Publication number
- AR018032A1 AR018032A1 ARP980106609A ARP980106609A AR018032A1 AR 018032 A1 AR018032 A1 AR 018032A1 AR P980106609 A ARP980106609 A AR P980106609A AR P980106609 A ARP980106609 A AR P980106609A AR 018032 A1 AR018032 A1 AR 018032A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- alkyl
- manufacture
- pharmaceutical composition
- preparation
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 1
- -1 hydroxy, amino Chemical group 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000005115 alkyl carbamoyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000005017 substituted alkenyl group Chemical group 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Transplantation (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Derivados del indol-aril substituidos de formula (I) o una sal del mismo, o un solvato del mismo en la que: A representa un grupo arilo opcionalmentesustituido o un grupo heterociclilo opcionalmente sustituido; Ra representa -CO-NRsRt, en la que Rsy Rt, en cada caso independientemente, representanhidrogeno, alquilo, alquilo sustituido, alquenilo opcionalmente sustituido, arilo opcionalmente sustituido, arilalquilo opcionalmente sustituido, heterocicliloopcionalmente sustituido, o un grupoheter ociclialquilo opcionalmente sustituido, o Rs y Rt junto con el nitrogeno al que están unidos forman un grupoheterociclilo; R1 y R2, en cada caso independientemente, representan hidrogeno, hidroxi, amino, alcoxi, ariloxi opcionalmentesustituido, benc iloxiopcionalmente sustituido, alquilamino, dialquilamino, halo, trifluorometilo, trifluorometoxi, nitro, alquilo, carboxi, carbalcoxi, carbamoílo, alquilcarbamoíloo R1 y R2 juntos representan metilendioxi, carbonildioxi ocarbonildiamino; y R3 repre senta hidrogeno, alcanoílo, alquilo, aminoalquilo, hidroxialquilo,carboxialquilo, carbalcoxialquilo, carbamoílo, o alquilsulfonilo y arilsulfonilo; un procedimiento para la preparacion de tal compuesto, unacomposicionfarmacéutica que contiene tal co mpuesto y la utilizacion de tal compuesto para la fabricacion de un medicamento.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97403154 | 1997-12-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR018032A1 true AR018032A1 (es) | 2001-10-31 |
Family
ID=8229937
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980106609A AR018032A1 (es) | 1997-12-24 | 1998-12-22 | Derivados del indol-aril sustituidos, un procedimiento para su preparacion, composicion farmaceutica que los comprende y el uso de dichos compuestos parala fabricacion de un medicamento |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP1042316B1 (es) |
| JP (1) | JP4627881B2 (es) |
| KR (1) | KR20010033528A (es) |
| CN (1) | CN1208333C (es) |
| AR (1) | AR018032A1 (es) |
| AT (1) | ATE288909T1 (es) |
| AU (1) | AU749319B2 (es) |
| BR (1) | BR9814403A (es) |
| CA (1) | CA2315723A1 (es) |
| CO (1) | CO4970811A1 (es) |
| DE (1) | DE69828998T2 (es) |
| ES (1) | ES2236971T3 (es) |
| HK (1) | HK1032953A1 (es) |
| HU (1) | HUP0100785A3 (es) |
| IL (1) | IL136720A0 (es) |
| NO (1) | NO320272B1 (es) |
| NZ (1) | NZ505060A (es) |
| PL (1) | PL191633B1 (es) |
| SA (1) | SA99200109B1 (es) |
| SI (1) | SI1042316T1 (es) |
| TR (1) | TR200001992T2 (es) |
| WO (1) | WO1999033822A1 (es) |
| ZA (1) | ZA9811758B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9914371D0 (en) * | 1999-06-18 | 1999-08-18 | Smithkline Beecham Plc | Novel compounds |
| GB9914825D0 (en) * | 1999-06-24 | 1999-08-25 | Smithkline Beecham Spa | Novel compounds |
| WO2001074815A2 (en) | 2000-03-31 | 2001-10-11 | Ortho Mcneil Pharmaceutical, Inc. | Phenyl-substituted imidazopyridines |
| US6872834B2 (en) | 2000-03-31 | 2005-03-29 | Ortho-Mcneil Pharmaceutical, Inc. | Phenyl-substituted indoles and indazoles |
| ATE430730T1 (de) * | 2000-03-31 | 2009-05-15 | Ortho Mcneil Pharm Inc | Phenyl-substituierte indole als h3 histaminrezeptorantagonisten |
| ITMI20040875A1 (it) * | 2004-04-30 | 2004-07-30 | Ist Naz Stud Cura Dei Tumori | Derivati indolici utili per il trattamento della resistenza agli agenti antitumorali |
| US20090142832A1 (en) * | 2007-11-29 | 2009-06-04 | James Dalton | Indoles, Derivatives, and Analogs Thereof and Uses Therefor |
| AR072297A1 (es) | 2008-06-27 | 2010-08-18 | Novartis Ag | Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona. |
| RS61013B1 (sr) * | 2014-10-24 | 2020-11-30 | Landos Biopharma Inc | Terapeutski preparati zasnovani na lantionin sintetazi c- sličnom proteinu-2 |
| EP3717633A1 (en) | 2017-11-30 | 2020-10-07 | Landos Biopharma, Inc. | Therapies with lanthionine c-like protein 2 ligands and cells prepared therewith |
| CN113748109B (zh) | 2019-12-20 | 2023-07-21 | 朗多生物制药股份有限公司 | 羊毛硫氨酸c样蛋白2配体、用所述配体制备的细胞以及使用所述配体的疗法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3542827B2 (ja) * | 1994-07-15 | 2004-07-14 | 帝国臓器製薬株式会社 | 新規な５−置換イソキサゾール−３−カルボン酸アミド誘導体 |
| JPH10512251A (ja) * | 1995-01-10 | 1998-11-24 | スミスクライン・ビーチャム・ソシエタ・ペル・アチオニ | 骨粗鬆症の治療に有用なインドール誘導体 |
| US6207679B1 (en) * | 1997-06-19 | 2001-03-27 | Sepracor, Inc. | Antimicrobial agents uses and compositions related thereto |
| JP2002505689A (ja) * | 1997-06-19 | 2002-02-19 | セプレイコー インコーポレイテッド | キノリン−インドール抗菌剤、それらに関する用途及び組成物 |
-
1998
- 1998-12-17 AT AT98966951T patent/ATE288909T1/de not_active IP Right Cessation
- 1998-12-17 EP EP98966951A patent/EP1042316B1/en not_active Expired - Lifetime
- 1998-12-17 IL IL13672098A patent/IL136720A0/xx unknown
- 1998-12-17 KR KR1020007007030A patent/KR20010033528A/ko not_active Application Discontinuation
- 1998-12-17 PL PL341318A patent/PL191633B1/pl not_active IP Right Cessation
- 1998-12-17 TR TR2000/01992T patent/TR200001992T2/xx unknown
- 1998-12-17 HU HU0100785A patent/HUP0100785A3/hu unknown
- 1998-12-17 WO PCT/EP1998/008561 patent/WO1999033822A1/en not_active Application Discontinuation
- 1998-12-17 NZ NZ505060A patent/NZ505060A/xx unknown
- 1998-12-17 ES ES98966951T patent/ES2236971T3/es not_active Expired - Lifetime
- 1998-12-17 CA CA002315723A patent/CA2315723A1/en not_active Abandoned
- 1998-12-17 DE DE69828998T patent/DE69828998T2/de not_active Expired - Fee Related
- 1998-12-17 AU AU27154/99A patent/AU749319B2/en not_active Ceased
- 1998-12-17 CN CNB988137917A patent/CN1208333C/zh not_active Expired - Fee Related
- 1998-12-17 BR BR9814403-0A patent/BR9814403A/pt not_active Application Discontinuation
- 1998-12-17 SI SI9830765T patent/SI1042316T1/xx unknown
- 1998-12-17 JP JP2000526504A patent/JP4627881B2/ja not_active Expired - Fee Related
- 1998-12-22 AR ARP980106609A patent/AR018032A1/es unknown
- 1998-12-22 ZA ZA9811758A patent/ZA9811758B/xx unknown
- 1998-12-23 CO CO98076414A patent/CO4970811A1/es unknown
-
1999
- 1999-05-11 SA SA99200109A patent/SA99200109B1/ar unknown
-
2000
- 2000-06-23 NO NO20003315A patent/NO320272B1/no unknown
-
2001
- 2001-03-15 HK HK01101878A patent/HK1032953A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2236971T3 (es) | 2005-07-16 |
| BR9814403A (pt) | 2000-10-10 |
| PL191633B1 (pl) | 2006-06-30 |
| KR20010033528A (ko) | 2001-04-25 |
| ZA9811758B (en) | 2000-06-22 |
| EP1042316A1 (en) | 2000-10-11 |
| WO1999033822A1 (en) | 1999-07-08 |
| ATE288909T1 (de) | 2005-02-15 |
| CN1299357A (zh) | 2001-06-13 |
| JP2003532616A (ja) | 2003-11-05 |
| NO20003315D0 (no) | 2000-06-23 |
| HUP0100785A3 (en) | 2001-09-28 |
| NZ505060A (en) | 2002-09-27 |
| SA99200109B1 (ar) | 2006-09-13 |
| AU2715499A (en) | 1999-07-19 |
| AU749319B2 (en) | 2002-06-20 |
| NO20003315L (no) | 2000-06-23 |
| SI1042316T1 (es) | 2005-08-31 |
| TR200001992T2 (tr) | 2001-01-22 |
| JP4627881B2 (ja) | 2011-02-09 |
| DE69828998T2 (de) | 2006-05-04 |
| HUP0100785A2 (hu) | 2001-08-28 |
| CN1208333C (zh) | 2005-06-29 |
| EP1042316B1 (en) | 2005-02-09 |
| IL136720A0 (en) | 2001-06-14 |
| CA2315723A1 (en) | 1999-07-08 |
| NO320272B1 (no) | 2005-11-14 |
| HK1032953A1 (en) | 2001-08-10 |
| DE69828998D1 (de) | 2005-03-17 |
| CO4970811A1 (es) | 2000-11-07 |
| PL341318A1 (en) | 2001-04-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |