HUP9901096A2 - Indolszármazékok, előállításuk és alkalmazásuk, a vegyületeket tartalmazó gyógyászati készítmények - Google Patents

Indolszármazékok, előállításuk és alkalmazásuk, a vegyületeket tartalmazó gyógyászati készítmények

Info

Publication number
HUP9901096A2
HUP9901096A2 HU9901096A HUP9901096A HUP9901096A2 HU P9901096 A2 HUP9901096 A2 HU P9901096A2 HU 9901096 A HU9901096 A HU 9901096A HU P9901096 A HUP9901096 A HU P9901096A HU P9901096 A2 HUP9901096 A2 HU P9901096A2
Authority
HU
Hungary
Prior art keywords
alkyl
optionally substituted
tubular
represent
hydrogen atom
Prior art date
Application number
HU9901096A
Other languages
English (en)
Inventor
Carlo Farina
Stefania Gagliardi
Marcel Jean-Marie Morvan
Guy Marguerite Marie Gérard Nadler
Carlo Parini
Mario Pinza
Original Assignee
Smithkline Beecham S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI950030A external-priority patent/IT1272878B/it
Priority claimed from IT95MI001687 external-priority patent/IT1307328B1/it
Application filed by Smithkline Beecham S.P.A. filed Critical Smithkline Beecham S.P.A.
Publication of HUP9901096A2 publication Critical patent/HUP9901096A2/hu
Publication of HUP9901096A3 publication Critical patent/HUP9901096A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems

Abstract

A cím szerinti vegyületek (I) általánős képletében Ra jelentése R5,ahől R5 hidrőgénatőm, alkil- vagy adőtt esetben szűbsztitűáltarilcsőpőrt, és Rb jelentése (a) általánős képletű csőpőrt, amelyben Xjelentése hidrőxil- vagy adőtt esetben szűbsztitűált alkőxicsőpőrt,vagy X jelentése -NRsRt általánős képletű csőpőrt, amelyben Rs és Rtjelentése hidrőgénatőm, adőtt esetben szűbsztitűált alkil-, alkenil-,aril-, aralkil-, heterőciklűsős csőpőrt vagy heterőciklűsős csőpőrttalszűbsztitűált alkilcsőpőrt, vagy Rs és Rt együtt egy heterőciklűsőscsőpőrtőt képez, R1 jelentése alkil- vagy adőtt esetben szűbsztitűáltarilcsőpőrt, R2, R3 és R4 jelentése hidrőgénatőm, alkil- vagy adőttesetben szűbsztitűált arilcsőpőrt, vagy Ra jelentése (a) általánősképletű csőpőrt, és Rb jelentése a fentiekben meghatárőzőtt R5jelentésű R6 és R7 jelentése hidrőgénatőm, hidrőxil-, aminő-, alkőxi-,adőtt esetben szűbsztitűált aril-őxi-, benzil-őxi-, alkil-aminő-,dialkil-aminő-csőpőrt, halőgénatőm- triflűőr-metil-, triflűőr-metőxi-,nitrő-, alkil-, karbőxil-, alkőxi-karbőnil-, karbamőil-, alkil-karbőmőil-csőpőrt, vagy R6 és R7 együtt metilén-diőxi-, karbőnil-diőxi- vagy karbőnil-diaminő-csőpőrtőt jelent, és R8 hidrőgénatőm,hidrőxil-, alkanőil-, alkil-, aminő-alkil-, hidrőxi-alkil-, karbőxi-alkil-, alkőxi-karbőnil-alkil-, karbamőil- vagy aminő-szűlfőnil-csőpőrt. A vegyületeket tartalmazó gyógyászati készítmények ősteő-pőrősis vagy ezzel kapcsőlatős csőntbetegségek kezelésébenalkalmazhatók. ŕ
HU9901096A 1995-01-10 1996-01-08 Indole derivatives, preparation and use thereof, pharmaceutical composition containing these compounds HUP9901096A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI950030A IT1272878B (it) 1995-01-10 1995-01-10 Composti indolici
IT95MI001687 IT1307328B1 (it) 1995-08-01 1995-08-01 Composti indolici

Publications (2)

Publication Number Publication Date
HUP9901096A2 true HUP9901096A2 (hu) 1999-07-28
HUP9901096A3 HUP9901096A3 (en) 2000-12-28

Family

ID=26331230

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9901096A HUP9901096A3 (en) 1995-01-10 1996-01-08 Indole derivatives, preparation and use thereof, pharmaceutical composition containing these compounds

Country Status (19)

Country Link
US (1) US5981525A (hu)
EP (1) EP0802902A1 (hu)
JP (1) JPH10512251A (hu)
KR (1) KR19980701330A (hu)
AP (1) AP648A (hu)
AU (1) AU4536096A (hu)
BG (1) BG101769A (hu)
BR (1) BR9606743A (hu)
CA (1) CA2209936A1 (hu)
CZ (1) CZ217697A3 (hu)
EA (1) EA199700098A1 (hu)
FI (1) FI972919A (hu)
HU (1) HUP9901096A3 (hu)
NO (1) NO973178L (hu)
OA (1) OA10611A (hu)
PL (1) PL321263A1 (hu)
SK (1) SK93297A3 (hu)
TR (1) TR199700625T1 (hu)
WO (1) WO1996021644A1 (hu)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5977125A (en) * 1994-10-31 1999-11-02 Eisai Co., Ltd. Mono-or polyenic carboxylic acid derivatives
GB9614347D0 (en) * 1996-07-09 1996-09-04 Smithkline Beecham Spa Novel compounds
AU3620597A (en) 1996-07-09 1998-02-02 Smithkline Beecham Laboratoires Pharmaceutiques Indole derivatives for the treatment of osteoporosis
GB9614366D0 (en) * 1996-07-09 1996-09-04 Smithkline Beecham Spa Novel compounds
GB9703109D0 (en) * 1997-02-14 1997-04-02 Smith & Nephew Compositions
AU6229698A (en) 1997-02-21 1998-09-09 Takeda Chemical Industries Ltd. Fused ring compounds, process for producing the same and use thereof
WO1998039344A1 (en) 1997-03-07 1998-09-11 Metabasis Therapeutics, Inc. Novel purine inhibitors of fructose-1,6-bisphosphatase
AU6691798A (en) * 1997-03-07 1998-09-22 Metabasis Therapeutics, Inc. Novel indole and azaindole inhibitors of fructose-1,6-bisphosphatase
US6506758B2 (en) 1997-12-24 2003-01-14 Smithkline Beecham Laboratoires Pharmceutiques Indole derivatives useful A.O. for the treatment of osteoporosis
CN1208333C (zh) * 1997-12-24 2005-06-29 Nikem研究有限公司 主要用于治疗骨质疏松的吲哚衍生物
US6673827B1 (en) 1999-06-29 2004-01-06 The Uab Research Foundation Methods of treating fungal infections with inhibitors of NAD synthetase enzyme
US6861448B2 (en) * 1998-01-14 2005-03-01 Virtual Drug Development, Inc. NAD synthetase inhibitors and uses thereof
WO1999036422A1 (en) 1998-01-14 1999-07-22 The Uab Research Foundation Methods of synthesizing and screening inhibitors of bacterial nad synthetase enzyme, compounds thereof, and methods of treating bacterial and microbial infections with inhibitors of bacterial nad synthetase enzyme
GB9914371D0 (en) 1999-06-18 1999-08-18 Smithkline Beecham Plc Novel compounds
SE9903760D0 (sv) * 1999-10-18 1999-10-18 Astra Ab New compounds
SE9904176D0 (sv) * 1999-11-18 1999-11-18 Astra Ab New use
US6710068B2 (en) 2001-04-11 2004-03-23 Idenix Pharmaceuticals, Inc. Phenylindoles for the treatment of HIV
US20040259909A1 (en) * 2001-10-16 2004-12-23 Mccarthy Dennis Treatment of fibromyalgia syndrome
US7365090B2 (en) * 2002-08-07 2008-04-29 Idenix Pharmaceuticals, Inc. Substituted phenylindoles for the treatment of HIV
ITMI20040875A1 (it) * 2004-04-30 2004-07-30 Ist Naz Stud Cura Dei Tumori Derivati indolici utili per il trattamento della resistenza agli agenti antitumorali
EP1799696B1 (en) 2004-09-17 2008-11-12 IDENIX Pharmaceuticals, Inc. Phosphoindoles as hiv inhibitors
EP2298766B1 (en) * 2005-03-03 2013-09-18 H. Lundbeck A/S Pharmaceutical formulations comrpising a substituted pyridine derivative
AU2007305447A1 (en) 2006-09-29 2008-04-10 Idenix Pharmaceuticals, Inc Enantiomerically pure phosphoindoles as HIV inhibitors
LU91725B1 (en) 2010-09-02 2012-03-05 Ct De Rech Public De La Sante Novel uses of V-ATPASE inhibitors
US9115128B2 (en) 2013-06-06 2015-08-25 Anthem Biosciences Pvt. Ltd. Compounds of 3-(5-substituted Oxy-2, 4-dinitrophenyl)-2-oxo-propionic acid ester, synthesis and applications thereof

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EP0449496B1 (en) * 1990-03-20 1994-07-20 Sharp Kabushiki Kaisha Method for mounting a semiconductor device
CA2038925A1 (en) * 1990-03-26 1991-09-27 Takashi Sohda Indole derivatives, their production and use
US5312928A (en) * 1991-02-11 1994-05-17 Cambridge Neuroscience Calcium channel antagonists and methodology for their identification

Also Published As

Publication number Publication date
NO973178D0 (no) 1997-07-09
NO973178L (no) 1997-09-09
CZ217697A3 (cs) 1998-03-18
BR9606743A (pt) 1997-12-30
BG101769A (en) 1998-04-30
HUP9901096A3 (en) 2000-12-28
TR199700625T1 (xx) 1998-02-21
OA10611A (en) 2002-09-03
EP0802902A1 (en) 1997-10-29
PL321263A1 (en) 1997-11-24
CA2209936A1 (en) 1996-07-18
AP9701029A0 (en) 1997-07-31
AU4536096A (en) 1996-07-31
EA199700098A1 (ru) 1997-12-30
WO1996021644A1 (en) 1996-07-18
SK93297A3 (en) 1998-02-04
FI972919A0 (fi) 1997-07-09
JPH10512251A (ja) 1998-11-24
FI972919A (fi) 1997-09-09
AP648A (en) 1998-05-25
KR19980701330A (ko) 1998-05-15
US5981525A (en) 1999-11-09
MX9705243A (es) 1997-10-31

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