AR015518A1 - Uso de derivados de tiadiazolo piridina para la produccion de un medicamento para el tratamiento de enfermedades que se modulan mediante la inhibicion delas fosfodiesterase(s) - Google Patents

Uso de derivados de tiadiazolo piridina para la produccion de un medicamento para el tratamiento de enfermedades que se modulan mediante la inhibicion delas fosfodiesterase(s)

Info

Publication number
AR015518A1
AR015518A1 ARP990100622A ARP990100622A AR015518A1 AR 015518 A1 AR015518 A1 AR 015518A1 AR P990100622 A ARP990100622 A AR P990100622A AR P990100622 A ARP990100622 A AR P990100622A AR 015518 A1 AR015518 A1 AR 015518A1
Authority
AR
Argentina
Prior art keywords
alkyl
phosphodiesterase
inhibition
treatment
production
Prior art date
Application number
ARP990100622A
Other languages
English (en)
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of AR015518A1 publication Critical patent/AR015518A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Uso de derivados de tiadiazolo piridina para la produccion de un medicamento para el tratamiento de enfermedades que se modulan mediante la inhibicion delas fosfodiesterasa(s), que comprende una cantida eficaz del compuesto de la formula I, donde: X1y X2, idénticos o diferentes, son hidrogeno, un radicalalquilo C1-6, o un átomo halogeno o si los mismos se encuentran en posiciones adyacentes, forman un anillo fenilo fusionado junto con los átomos de carbono quelo transportan; y R es un radical carbocíclico o heterocíclico, saturado o insaturado, que si se desea puede ser mono-o polisustituido con hálogeno, ciano,nitro, alquilo C1-6, haloalquilo C1-6, hidroxilo, alcoxi C1-6, metilendioxi, alquiltio C1-6, haloalquiltio C1-6, amino, alquilamino C1-6, dialquilamino C2-12,pirrolilo, carboxilo, carbamoilo, bencil-hidrosialquilo C1-6, carboxialquilo C2-7, alcoxicarbonil C2-7 -alquilo C1-6, carbamoil-alquilo C1-6, N-hidroxi-N-alquilcarbamoilo C1-6-alquilo C1-6 o alquenilo C2-6, así como también sus sales fisiologicamente tolerables.
ARP990100622A 1998-02-17 1999-02-16 Uso de derivados de tiadiazolo piridina para la produccion de un medicamento para el tratamiento de enfermedades que se modulan mediante la inhibicion delas fosfodiesterase(s) AR015518A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98102675 1998-02-17

Publications (1)

Publication Number Publication Date
AR015518A1 true AR015518A1 (es) 2001-05-02

Family

ID=8231426

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990100622A AR015518A1 (es) 1998-02-17 1999-02-16 Uso de derivados de tiadiazolo piridina para la produccion de un medicamento para el tratamiento de enfermedades que se modulan mediante la inhibicion delas fosfodiesterase(s)

Country Status (10)

Country Link
US (1) US6326378B1 (es)
EP (1) EP1054669B9 (es)
JP (1) JP3585838B2 (es)
AR (1) AR015518A1 (es)
AU (1) AU2926099A (es)
CA (1) CA2318237A1 (es)
DE (2) DE69909592D1 (es)
ES (1) ES2203086T3 (es)
WO (1) WO1999042089A2 (es)
ZA (1) ZA991233B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1193261A1 (en) * 2000-10-02 2002-04-03 Warner-Lambert Company New thiadiazoles and their use as phosphodiesterase-7 inhibitors
EP1348433A1 (en) * 2002-03-28 2003-10-01 Warner-Lambert Company LLC Thiazol-2-yl-imine compounds as PDE-7 inhibitors
US8034831B2 (en) 2002-11-06 2011-10-11 Celgene Corporation Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies
US7563810B2 (en) 2002-11-06 2009-07-21 Celgene Corporation Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases
US7034052B2 (en) * 2003-03-12 2006-04-25 Celgene Corporation 7-Amido-isoindolyl compounds and their pharmaceutical uses
US7564337B2 (en) 2005-03-03 2009-07-21 Littelfuse, Inc. Thermally decoupling fuse holder and assembly

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60246389A (ja) * 1984-05-22 1985-12-06 Nippon Soda Co Ltd ２−スルホニルイミノ−２Ｈ−１，２，４−チアジアゾロ〔２，３−ａ〕ピリジン誘導体及びその製造法
DE4131579A1 (de) * 1991-09-23 1993-03-25 Boehringer Mannheim Gmbh Thiadiazolo(4,3-a)pyridinderivate, verfahren zu ihrer herstellung und diese enthaltenden arzneimittel

Also Published As

Publication number Publication date
JP3585838B2 (ja) 2004-11-04
DE69909592T4 (de) 2005-03-24
AU2926099A (en) 1999-09-06
JP2002503688A (ja) 2002-02-05
EP1054669B1 (en) 2003-07-16
EP1054669A2 (en) 2000-11-29
WO1999042089A3 (en) 1999-10-14
WO1999042089A9 (en) 1999-10-28
CA2318237A1 (en) 1999-08-26
EP1054669B9 (en) 2004-09-15
ES2203086T3 (es) 2004-04-01
US6326378B1 (en) 2001-12-04
WO1999042089A2 (en) 1999-08-26
DE69909592D1 (de) 2003-08-21
ZA991233B (en) 1999-08-17
DE69909592T2 (de) 2004-06-03

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AR015518A1 (es) Uso de derivados de tiadiazolo piridina para la produccion de un medicamento para el tratamiento de enfermedades que se modulan mediante la inhibicion delas fosfodiesterase(s)