DE69828998D1 - Indolderivate verwendbar zur behandlung von u.a. osteoporosis - Google Patents

Indolderivate verwendbar zur behandlung von u.a. osteoporosis

Info

Publication number
DE69828998D1
DE69828998D1 DE69828998T DE69828998T DE69828998D1 DE 69828998 D1 DE69828998 D1 DE 69828998D1 DE 69828998 T DE69828998 T DE 69828998T DE 69828998 T DE69828998 T DE 69828998T DE 69828998 D1 DE69828998 D1 DE 69828998D1
Authority
DE
Germany
Prior art keywords
osteoporosis
treatment
indole derivatives
derivatives use
indole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69828998T
Other languages
English (en)
Other versions
DE69828998T2 (de
Inventor
Stefania Gagliardi
Guy Marguerite Marie Ge Nadler
Pietro Novella
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NiKem Research SRL
Original Assignee
NiKem Research SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NiKem Research SRL filed Critical NiKem Research SRL
Application granted granted Critical
Publication of DE69828998D1 publication Critical patent/DE69828998D1/de
Publication of DE69828998T2 publication Critical patent/DE69828998T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69828998T 1997-12-24 1998-12-17 Indolderivate verwendbar zur behandlung von u.a. osteoporosis Expired - Fee Related DE69828998T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP97403154 1997-12-24
EP97403154 1997-12-24
PCT/EP1998/008561 WO1999033822A1 (en) 1997-12-24 1998-12-17 Indole derivatives useful a.o. for the treatment of osteoporosis

Publications (2)

Publication Number Publication Date
DE69828998D1 true DE69828998D1 (de) 2005-03-17
DE69828998T2 DE69828998T2 (de) 2006-05-04

Family

ID=8229937

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69828998T Expired - Fee Related DE69828998T2 (de) 1997-12-24 1998-12-17 Indolderivate verwendbar zur behandlung von u.a. osteoporosis

Country Status (23)

Country Link
EP (1) EP1042316B1 (de)
JP (1) JP4627881B2 (de)
KR (1) KR20010033528A (de)
CN (1) CN1208333C (de)
AR (1) AR018032A1 (de)
AT (1) ATE288909T1 (de)
AU (1) AU749319B2 (de)
BR (1) BR9814403A (de)
CA (1) CA2315723A1 (de)
CO (1) CO4970811A1 (de)
DE (1) DE69828998T2 (de)
ES (1) ES2236971T3 (de)
HK (1) HK1032953A1 (de)
HU (1) HUP0100785A3 (de)
IL (1) IL136720A0 (de)
NO (1) NO320272B1 (de)
NZ (1) NZ505060A (de)
PL (1) PL191633B1 (de)
SA (1) SA99200109B1 (de)
SI (1) SI1042316T1 (de)
TR (1) TR200001992T2 (de)
WO (1) WO1999033822A1 (de)
ZA (1) ZA9811758B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9914371D0 (en) * 1999-06-18 1999-08-18 Smithkline Beecham Plc Novel compounds
GB9914825D0 (en) * 1999-06-24 1999-08-25 Smithkline Beecham Spa Novel compounds
WO2001074815A2 (en) 2000-03-31 2001-10-11 Ortho Mcneil Pharmaceutical, Inc. Phenyl-substituted imidazopyridines
US6872834B2 (en) 2000-03-31 2005-03-29 Ortho-Mcneil Pharmaceutical, Inc. Phenyl-substituted indoles and indazoles
ATE430730T1 (de) * 2000-03-31 2009-05-15 Ortho Mcneil Pharm Inc Phenyl-substituierte indole als h3 histaminrezeptorantagonisten
ITMI20040875A1 (it) * 2004-04-30 2004-07-30 Ist Naz Stud Cura Dei Tumori Derivati indolici utili per il trattamento della resistenza agli agenti antitumorali
US20090142832A1 (en) * 2007-11-29 2009-06-04 James Dalton Indoles, Derivatives, and Analogs Thereof and Uses Therefor
AR072297A1 (es) 2008-06-27 2010-08-18 Novartis Ag Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona.
RS61013B1 (sr) * 2014-10-24 2020-11-30 Landos Biopharma Inc Terapeutski preparati zasnovani na lantionin sintetazi c- sličnom proteinu-2
EP3717633A1 (de) 2017-11-30 2020-10-07 Landos Biopharma, Inc. Therapien mit lanthionin-c-like-protein-2-liganden und damit hergestellte zellen
CN113748109B (zh) 2019-12-20 2023-07-21 朗多生物制药股份有限公司 羊毛硫氨酸c样蛋白2配体、用所述配体制备的细胞以及使用所述配体的疗法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3542827B2 (ja) * 1994-07-15 2004-07-14 帝国臓器製薬株式会社 新規な５−置換イソキサゾール−３−カルボン酸アミド誘導体
JPH10512251A (ja) * 1995-01-10 1998-11-24 スミスクライン・ビーチャム・ソシエタ・ペル・アチオニ 骨粗鬆症の治療に有用なインドール誘導体
US6207679B1 (en) * 1997-06-19 2001-03-27 Sepracor, Inc. Antimicrobial agents uses and compositions related thereto
JP2002505689A (ja) * 1997-06-19 2002-02-19 セプレイコー インコーポレイテッド キノリン−インドール抗菌剤、それらに関する用途及び組成物

Also Published As

Publication number Publication date
ES2236971T3 (es) 2005-07-16
BR9814403A (pt) 2000-10-10
PL191633B1 (pl) 2006-06-30
AR018032A1 (es) 2001-10-31
KR20010033528A (ko) 2001-04-25
ZA9811758B (en) 2000-06-22
EP1042316A1 (de) 2000-10-11
WO1999033822A1 (en) 1999-07-08
ATE288909T1 (de) 2005-02-15
CN1299357A (zh) 2001-06-13
JP2003532616A (ja) 2003-11-05
NO20003315D0 (no) 2000-06-23
HUP0100785A3 (en) 2001-09-28
NZ505060A (en) 2002-09-27
SA99200109B1 (ar) 2006-09-13
AU2715499A (en) 1999-07-19
AU749319B2 (en) 2002-06-20
NO20003315L (no) 2000-06-23
SI1042316T1 (de) 2005-08-31
TR200001992T2 (tr) 2001-01-22
JP4627881B2 (ja) 2011-02-09
DE69828998T2 (de) 2006-05-04
HUP0100785A2 (hu) 2001-08-28
CN1208333C (zh) 2005-06-29
EP1042316B1 (de) 2005-02-09
IL136720A0 (en) 2001-06-14
CA2315723A1 (en) 1999-07-08
NO320272B1 (no) 2005-11-14
HK1032953A1 (en) 2001-08-10
CO4970811A1 (es) 2000-11-07
PL341318A1 (en) 2001-04-09

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee