BR9814403A - "derivados do indol úteis para o tratamento, entre outros, de osteoporose" - Google Patents
"derivados do indol úteis para o tratamento, entre outros, de osteoporose"Info
- Publication number
- BR9814403A BR9814403A BR9814403-0A BR9814403A BR9814403A BR 9814403 A BR9814403 A BR 9814403A BR 9814403 A BR9814403 A BR 9814403A BR 9814403 A BR9814403 A BR 9814403A
- Authority
- BR
- Brazil
- Prior art keywords
- optionally substituted
- compound
- alkyl
- group
- osteoporosis
- Prior art date
Links
- 208000001132 Osteoporosis Diseases 0.000 title abstract 2
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- 150000002475 indoles Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- -1 hydroxy, amino Chemical class 0.000 abstract 3
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical class 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical class 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000005017 substituted alkenyl group Chemical group 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Transplantation (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"DERIVADOS DO INDOL úTEIS PARA O TRATAMENTO, ENTRE OUTROS, DE OSTEOPOROSE" Trata-se de um composto de fórmula (I) ou um seu sal, ou um seu solvato, em que: A representa um grupo arila opcionalmente substituído, ou um grupo heterocíclico opcionalmente substituído; R~ a~ representa -CO-NR~ s~R~ t~ em que R~ s~ e R~ t~cada um representa, independentemente, hidrogênio, alquila, alquila substituída, alquenila opcionalmente substituída, arila opcionalmente substituída, arilalquila opcionalmente substituída, heterociclila opcionalmente substituída, ou um grupo heroclicloalquila opcionamente substituído, ou R~ s~ e R~ t~ juntamente com nitrogênio ao qual eles estão ligados para formar um grupo heterociclila; R~ 1~ e R~ 2~ cada um representa independentemente hidrogênio, hidróxi, amino, alcóxi, arilóxi opcionalmente substituído, benzilóxi opcionalmente substituído, alquilamino, dialquilamino, halo, triflúormetila, triflúormetóxi, nitro, alquila, carbóxi, carbalcóxi, cabamoil, alquilcarbamoil ou R~ 1~ e R~ 2~ juntos representam metilenodióxi, carbonildióxi ou carbonildiamino; e R~ 3~ representa hidrogênio, alcanoíla, alquila, aminoalquila, hidróxialquila, carbóxialquila, carbalcóxialquila, carbamoíla ou alquilsulfonila e arilsulfonila; um processo para a preparação de tal composto, uma composição farmacêutica contendo um tal composto e o uso de tal composto ou composição em medicina.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97403154 | 1997-12-24 | ||
| PCT/EP1998/008561 WO1999033822A1 (en) | 1997-12-24 | 1998-12-17 | Indole derivatives useful a.o. for the treatment of osteoporosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9814403A true BR9814403A (pt) | 2000-10-10 |
Family
ID=8229937
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9814403-0A BR9814403A (pt) | 1997-12-24 | 1998-12-17 | "derivados do indol úteis para o tratamento, entre outros, de osteoporose" |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP1042316B1 (pt) |
| JP (1) | JP4627881B2 (pt) |
| KR (1) | KR20010033528A (pt) |
| CN (1) | CN1208333C (pt) |
| AR (1) | AR018032A1 (pt) |
| AT (1) | ATE288909T1 (pt) |
| AU (1) | AU749319B2 (pt) |
| BR (1) | BR9814403A (pt) |
| CA (1) | CA2315723A1 (pt) |
| CO (1) | CO4970811A1 (pt) |
| DE (1) | DE69828998T2 (pt) |
| ES (1) | ES2236971T3 (pt) |
| HK (1) | HK1032953A1 (pt) |
| HU (1) | HUP0100785A3 (pt) |
| IL (1) | IL136720A0 (pt) |
| NO (1) | NO320272B1 (pt) |
| NZ (1) | NZ505060A (pt) |
| PL (1) | PL191633B1 (pt) |
| SA (1) | SA99200109B1 (pt) |
| SI (1) | SI1042316T1 (pt) |
| TR (1) | TR200001992T2 (pt) |
| WO (1) | WO1999033822A1 (pt) |
| ZA (1) | ZA9811758B (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9914371D0 (en) * | 1999-06-18 | 1999-08-18 | Smithkline Beecham Plc | Novel compounds |
| GB9914825D0 (en) | 1999-06-24 | 1999-08-25 | Smithkline Beecham Spa | Novel compounds |
| EP1268478B1 (en) | 2000-03-31 | 2007-05-02 | Ortho-McNeil Pharmaceutical, Inc. | Phenyl-substituted imidazopyridines |
| WO2001074773A2 (en) * | 2000-03-31 | 2001-10-11 | Ortho Mcneil Pharmaceutical, Inc. | Phenyl-substituted indoles as histamine h3-receptor antagonists |
| US6872834B2 (en) | 2000-03-31 | 2005-03-29 | Ortho-Mcneil Pharmaceutical, Inc. | Phenyl-substituted indoles and indazoles |
| ITMI20040875A1 (it) * | 2004-04-30 | 2004-07-30 | Ist Naz Stud Cura Dei Tumori | Derivati indolici utili per il trattamento della resistenza agli agenti antitumorali |
| US20090142832A1 (en) * | 2007-11-29 | 2009-06-04 | James Dalton | Indoles, Derivatives, and Analogs Thereof and Uses Therefor |
| AR072297A1 (es) | 2008-06-27 | 2010-08-18 | Novartis Ag | Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona. |
| PL3209655T3 (pl) * | 2014-10-24 | 2020-12-28 | Landos Biopharma, Inc. | Leczenie oparte na białku 2 podobnym do syntetazy lantioniny C |
| CA3083442A1 (en) | 2017-11-30 | 2019-06-06 | Landos Biopharma, Inc. | Therapies with lanthionine c-like protein 2 ligands and cells prepared therewith |
| BR112022002387A2 (pt) | 2019-12-20 | 2022-09-06 | Landos Biopharma Inc | Composto da fórmula z-y-q-y' ou um sal ou éster farmaceuticamente aceitável do mesmo |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3542827B2 (ja) * | 1994-07-15 | 2004-07-14 | 帝国臓器製薬株式会社 | 新規な５−置換イソキサゾール−３−カルボン酸アミド誘導体 |
| TR199700625T1 (xx) * | 1995-01-10 | 1998-02-21 | Smithkline Beecham S.P.A. | Osteoporoz (kemik erimesi) tedavisinde yararl� olan indol t�revleri. |
| US6207679B1 (en) * | 1997-06-19 | 2001-03-27 | Sepracor, Inc. | Antimicrobial agents uses and compositions related thereto |
| CA2293418A1 (en) * | 1997-06-19 | 1998-12-23 | Michael Z. Hoemann | Quinoline-indole antimicrobial agents, uses and compositions related thereto |
-
1998
- 1998-12-17 EP EP98966951A patent/EP1042316B1/en not_active Expired - Lifetime
- 1998-12-17 ES ES98966951T patent/ES2236971T3/es not_active Expired - Lifetime
- 1998-12-17 SI SI9830765T patent/SI1042316T1/xx unknown
- 1998-12-17 DE DE69828998T patent/DE69828998T2/de not_active Expired - Fee Related
- 1998-12-17 WO PCT/EP1998/008561 patent/WO1999033822A1/en not_active Application Discontinuation
- 1998-12-17 KR KR1020007007030A patent/KR20010033528A/ko not_active Application Discontinuation
- 1998-12-17 AU AU27154/99A patent/AU749319B2/en not_active Ceased
- 1998-12-17 IL IL13672098A patent/IL136720A0/xx unknown
- 1998-12-17 BR BR9814403-0A patent/BR9814403A/pt not_active Application Discontinuation
- 1998-12-17 HU HU0100785A patent/HUP0100785A3/hu unknown
- 1998-12-17 TR TR2000/01992T patent/TR200001992T2/xx unknown
- 1998-12-17 JP JP2000526504A patent/JP4627881B2/ja not_active Expired - Fee Related
- 1998-12-17 CN CNB988137917A patent/CN1208333C/zh not_active Expired - Fee Related
- 1998-12-17 AT AT98966951T patent/ATE288909T1/de not_active IP Right Cessation
- 1998-12-17 PL PL341318A patent/PL191633B1/pl not_active IP Right Cessation
- 1998-12-17 NZ NZ505060A patent/NZ505060A/xx unknown
- 1998-12-17 CA CA002315723A patent/CA2315723A1/en not_active Abandoned
- 1998-12-22 AR ARP980106609A patent/AR018032A1/es unknown
- 1998-12-22 ZA ZA9811758A patent/ZA9811758B/xx unknown
- 1998-12-23 CO CO98076414A patent/CO4970811A1/es unknown
-
1999
- 1999-05-11 SA SA99200109A patent/SA99200109B1/ar unknown
-
2000
- 2000-06-23 NO NO20003315A patent/NO320272B1/no unknown
-
2001
- 2001-03-15 HK HK01101878A patent/HK1032953A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AR018032A1 (es) | 2001-10-31 |
| WO1999033822A1 (en) | 1999-07-08 |
| NO20003315D0 (no) | 2000-06-23 |
| DE69828998D1 (de) | 2005-03-17 |
| ES2236971T3 (es) | 2005-07-16 |
| CN1299357A (zh) | 2001-06-13 |
| HUP0100785A3 (en) | 2001-09-28 |
| HUP0100785A2 (hu) | 2001-08-28 |
| CA2315723A1 (en) | 1999-07-08 |
| CO4970811A1 (es) | 2000-11-07 |
| EP1042316A1 (en) | 2000-10-11 |
| AU749319B2 (en) | 2002-06-20 |
| KR20010033528A (ko) | 2001-04-25 |
| HK1032953A1 (en) | 2001-08-10 |
| PL341318A1 (en) | 2001-04-09 |
| JP2003532616A (ja) | 2003-11-05 |
| AU2715499A (en) | 1999-07-19 |
| JP4627881B2 (ja) | 2011-02-09 |
| CN1208333C (zh) | 2005-06-29 |
| TR200001992T2 (tr) | 2001-01-22 |
| SI1042316T1 (pt) | 2005-08-31 |
| PL191633B1 (pl) | 2006-06-30 |
| SA99200109B1 (ar) | 2006-09-13 |
| EP1042316B1 (en) | 2005-02-09 |
| DE69828998T2 (de) | 2006-05-04 |
| ZA9811758B (en) | 2000-06-22 |
| NZ505060A (en) | 2002-09-27 |
| ATE288909T1 (de) | 2005-02-15 |
| NO320272B1 (no) | 2005-11-14 |
| NO20003315L (no) | 2000-06-23 |
| IL136720A0 (en) | 2001-06-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TC | Change of name | ||
| TE | Change of address | ||
| B25A | Requested transfer of rights approved |
Free format text: LABORATOIRE GLAXOSMITHKLINE (FR), GLAXO WELLCOME S.P.A. (IT) |
|
| B25D | Requested change of name of applicant approved | ||
| B25A | Requested transfer of rights approved |
Free format text: NIKEM RESEARCH S.R.L. (IT) |
|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO PELO PRESENTE PEDIDO DE PATENTE DE ACORDO COM ARTIGO 8O DA LPI. |