AR016672A1 - Ligandos del receptor h3 del tipo fenil-alquil-imidazoles, composicion farmaceutica que los contiene y el uso de los mismos para la manufactura de unmedicamento - Google Patents

Ligandos del receptor h3 del tipo fenil-alquil-imidazoles, composicion farmaceutica que los contiene y el uso de los mismos para la manufactura de unmedicamento

Info

Publication number
AR016672A1
AR016672A1 ARP980105622A ARP980105622A AR016672A1 AR 016672 A1 AR016672 A1 AR 016672A1 AR P980105622 A ARP980105622 A AR P980105622A AR P980105622 A ARP980105622 A AR P980105622A AR 016672 A1 AR016672 A1 AR 016672A1
Authority
AR
Argentina
Prior art keywords
formula
compound
phenyl
manufacture
pharmaceutical composition
Prior art date
Application number
ARP980105622A
Other languages
English (en)
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of AR016672A1 publication Critical patent/AR016672A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

Abstract

Ligandos del receptor H3 del tipo fenilo-alquil-imidazoles que tienen la formula (I) o su sal de adicion ácida farmacéuticamente aceptable o su tautomero;donde A es -CH2-NH-CO-NH-, -CH2-O-CO-NH- o -CH2CH2-CO-NH-(CH2)m-; m es 0, 1 o 2; R es el grupod e formula (II), donde al menos dos de R1, R2, R3 y R4 sonhidrogeno y los otros dos se seleccionan independientemente de H, halogeno (por ejemplo: Br, I, F, o Cl), CH3, CF3, OCF3 o CN; y con la condicion de que cuandoA es -CH-O-CO-NH- y R1, R3 y R4so n todos hidrogeno, luego R2 no puede ser Cl. Y con la condicion de que el compuesto no es de formula (III); composicionfarmacéutica que los contiene y el uso de los mismos para la manufactura de un medicamento util para tratar la alergia,inflamacion , enfermedadescardiovasculares, hipotension, glaucoma, trastornos del sueno, enfermedades del tracto gastrointestinal, estados de hipes e hipo-movilidad del tractogastrointestinal, enfermedades del sistema nervioso central, hipo ehiperactividad del sistema nervioso central, enfermedad de Alzheimer, esquizofrenia,obesidad y migranas, que comprenden una cantidad efectiva de un compuesto de la formula (I) (o su sal o solvato) y para el tratamiento de las respuestasalérgicas delas vías aéreas supe riores que comprende un compuesto, su sal o solvato de la formula (I) en combinacion o mezcla con un antagonista del receptorH1 de histamina.
ARP980105622A 1997-11-07 1998-11-06 Ligandos del receptor h3 del tipo fenil-alquil-imidazoles, composicion farmaceutica que los contiene y el uso de los mismos para la manufactura de unmedicamento AR016672A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96634497A 1997-11-07 1997-11-07
US12971198A 1998-08-05 1998-08-05

Publications (1)

Publication Number Publication Date
AR016672A1 true AR016672A1 (es) 2001-07-25

Family

ID=26827847

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980105622A AR016672A1 (es) 1997-11-07 1998-11-06 Ligandos del receptor h3 del tipo fenil-alquil-imidazoles, composicion farmaceutica que los contiene y el uso de los mismos para la manufactura de unmedicamento

Country Status (18)

Country Link
EP (1) EP1028947B8 (es)
JP (1) JP2001522835A (es)
KR (1) KR20010031724A (es)
CN (1) CN1130349C (es)
AR (1) AR016672A1 (es)
AT (1) ATE219062T1 (es)
AU (1) AU1296699A (es)
CA (1) CA2308586A1 (es)
CO (1) CO5011065A1 (es)
DE (1) DE69806042T2 (es)
ES (1) ES2174510T3 (es)
HK (1) HK1025968A1 (es)
HU (1) HUP0004292A3 (es)
IL (1) IL135729A0 (es)
NZ (1) NZ504124A (es)
PE (1) PE134399A1 (es)
TW (1) TW421645B (es)
WO (1) WO1999024405A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20020507A1 (es) * 2000-10-17 2002-06-25 Schering Corp Compuestos no-imidazoles como antagonistas del receptor histamina h3
US6849621B2 (en) 2001-03-13 2005-02-01 Schering Corporation Piperidine compounds
JP4690889B2 (ja) * 2002-10-24 2011-06-01 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング メチレン尿素誘導体
US7652041B2 (en) 2005-01-14 2010-01-26 Millennium Pharmaceuticals, Inc. Cinnamide and hydrocinnamide derivatives with kinase inhibitory activity
EP1749523A1 (en) * 2005-07-29 2007-02-07 Neuropharma, S.A. GSK-3 inhibitors
EP1931665A1 (en) 2005-09-20 2008-06-18 Schering Corporation 1-[[1-[(2-amin0-6-methyl-4-pyridinyl)methyl]-4-flu0r0-4-piperidinyl,]carbonyl]-4-[2-(2-pyridinyl)-3h-imidaz0[4, 5-b]pyridin-3-yl]piperidine useful as histamine h3 antagonist
WO2014032755A2 (en) * 2012-08-29 2014-03-06 Merck Patent Gmbh Ddr2 inhibitors for the treatment of osteoarthritis

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2686084B1 (fr) * 1992-01-10 1995-12-22 Bioprojet Soc Civ Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques.
ATE234290T1 (de) * 1993-11-15 2003-03-15 Schering Corp Phenylalkyl-imidazole als h3-rezeptor- antagonisten
FR2732017B1 (fr) * 1995-03-21 2000-09-22 Inst Nat Sante Rech Med Nouveaux derives de l'imidazole antagonistes et/ou agonistes du recepteur h3 de l'histamine, leur preparation et leurs applications therapeutiques
JP3638289B2 (ja) * 1996-08-16 2005-04-13 シェーリング コーポレイション ヒスタミンレセプターアンタゴニストの組み合わせを用いる上気道アレルギー性応答の処置

Also Published As

Publication number Publication date
ATE219062T1 (de) 2002-06-15
EP1028947A1 (en) 2000-08-23
AU1296699A (en) 1999-05-31
CO5011065A1 (es) 2001-02-28
CN1130349C (zh) 2003-12-10
HUP0004292A3 (en) 2001-12-28
CA2308586A1 (en) 1999-05-20
NZ504124A (en) 2002-10-25
CN1285822A (zh) 2001-02-28
DE69806042T2 (de) 2003-01-23
DE69806042D1 (de) 2002-07-18
PE134399A1 (es) 2000-01-10
ES2174510T3 (es) 2002-11-01
EP1028947B8 (en) 2004-01-28
IL135729A0 (en) 2001-05-20
HUP0004292A2 (hu) 2001-11-28
TW421645B (en) 2001-02-11
JP2001522835A (ja) 2001-11-20
WO1999024405A1 (en) 1999-05-20
EP1028947B1 (en) 2002-06-12
KR20010031724A (ko) 2001-04-16
HK1025968A1 (en) 2000-12-01

Similar Documents

Publication Publication Date Title
US7718674B2 (en) Methods of relieving neuropathic pain with the S-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine
US20060079558A1 (en) R-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine and other dermal anesthetics
US8420600B2 (en) Injectable capsaicin
US20060148903A1 (en) Capsaicinoid gel formulation and uses thereof
US20060269628A1 (en) Infiltration of capsaicin into surgical sites and open wounds
JP4787148B2 (ja) 新規アリールピペラジニル化合物
ATE316076T1 (de) Benzimidazol-derivate und diese enthaltende pharmazeutische zusammensetzungen
CA2597069A1 (en) Pyridazine derivatives and their use as therapeutic agents
JP2004518653A (ja) 不安障害を治療する方法
TW200526631A (en) Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
ATE143806T1 (de) Verbesserungen von oder in bezug auf exzitatorische aminosäurenrezeptorantagonisten
AR029190A1 (es) Composiciones que contienen derivados del acido hidroxieicosatetraenoico y uso para la manufactura de un medicamento en el tratamiento de trastornos del ojo seco
CN112638386A (zh) 异喹啉-类固醇缀合物及其用途
AR016672A1 (es) Ligandos del receptor h3 del tipo fenil-alquil-imidazoles, composicion farmaceutica que los contiene y el uso de los mismos para la manufactura de unmedicamento
ES2215990T3 (es) Antagonistas del receptor 5-ht2 para tratar enfermedades venosas.
ES2223143T3 (es) Derivados de 5-(2-imidazolinilamino)-bencimidazol, preparacion y uso de los mismos como agonistas de adrenorreceptores alfa con estabilidad metabolica mejorada.
JPH09511483A (ja) α−２−アドレノセプター作動剤として有用な６−（２−イミダゾリニルアミノ）キノリン化合物
DE69827233T2 (de) Diaminderivate und diese enthaltende arzneimittel
JP2018538352A (ja) Ｃｆｔｒ制御因子及びこの使用方法
CA2423628A1 (en) Derivatives of tryptamine and analogous compounds, and pharmaceutical formulations containing them
CA2153083A1 (en) Pharmaceutical compositions and a process for the preparation thereof
JP2002504134A (ja) 疼痛を治療するためのドラフラジン類似体の使用
EA200501040A1 (ru) Замещенные производные 1-пиперидин-3-ил-4-пиперидин-4-илпиперазина и их применение в качестве антагонистов нейрокинина
JPS6335547A (ja) 置換２−アミノテトラリンおよびその製造方法
AU2001253807B2 (en) Compositions containing a benzamide disulfide derivative for treating allergic diseases

Legal Events

Date Code Title Description
FB Suspension of granting procedure