HK1025968A1 - H3 receptor ligands of the phenyl-alkyl-imidazoles type - Google Patents

H3 receptor ligands of the phenyl-alkyl-imidazoles type

Info

Publication number
HK1025968A1
HK1025968A1 HK00105336A HK00105336A HK1025968A1 HK 1025968 A1 HK1025968 A1 HK 1025968A1 HK 00105336 A HK00105336 A HK 00105336A HK 00105336 A HK00105336 A HK 00105336A HK 1025968 A1 HK1025968 A1 HK 1025968A1
Authority
HK
Hong Kong
Prior art keywords
phenyl
alkyl
receptor ligands
imidazoles type
imidazoles
Prior art date
Application number
HK00105336A
Other languages
English (en)
Inventor
Robert G Aslanian
Kevin D Mccormick
Mwangiwa Mutahi
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of HK1025968A1 publication Critical patent/HK1025968A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
HK00105336A 1997-11-07 2000-08-25 H3 receptor ligands of the phenyl-alkyl-imidazoles type HK1025968A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96634497A 1997-11-07 1997-11-07
US12971198A 1998-08-05 1998-08-05
PCT/US1998/023223 WO1999024405A1 (en) 1997-11-07 1998-11-05 H3 receptor ligands of the phenyl-alkyl-imidazoles type

Publications (1)

Publication Number Publication Date
HK1025968A1 true HK1025968A1 (en) 2000-12-01

Family

ID=26827847

Family Applications (1)

Application Number Title Priority Date Filing Date
HK00105336A HK1025968A1 (en) 1997-11-07 2000-08-25 H3 receptor ligands of the phenyl-alkyl-imidazoles type

Country Status (18)

Country Link
EP (1) EP1028947B8 (xx)
JP (1) JP2001522835A (xx)
KR (1) KR20010031724A (xx)
CN (1) CN1130349C (xx)
AR (1) AR016672A1 (xx)
AT (1) ATE219062T1 (xx)
AU (1) AU1296699A (xx)
CA (1) CA2308586A1 (xx)
CO (1) CO5011065A1 (xx)
DE (1) DE69806042T2 (xx)
ES (1) ES2174510T3 (xx)
HK (1) HK1025968A1 (xx)
HU (1) HUP0004292A3 (xx)
IL (1) IL135729A0 (xx)
NZ (1) NZ504124A (xx)
PE (1) PE134399A1 (xx)
TW (1) TW421645B (xx)
WO (1) WO1999024405A1 (xx)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20020507A1 (es) * 2000-10-17 2002-06-25 Schering Corp Compuestos no-imidazoles como antagonistas del receptor histamina h3
US6849621B2 (en) 2001-03-13 2005-02-01 Schering Corporation Piperidine compounds
JP4690889B2 (ja) * 2002-10-24 2011-06-01 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング メチレン尿素誘導体
US7652041B2 (en) 2005-01-14 2010-01-26 Millennium Pharmaceuticals, Inc. Cinnamide and hydrocinnamide derivatives with kinase inhibitory activity
EP1749523A1 (en) * 2005-07-29 2007-02-07 Neuropharma, S.A. GSK-3 inhibitors
EP1931665A1 (en) 2005-09-20 2008-06-18 Schering Corporation 1-[[1-[(2-amin0-6-methyl-4-pyridinyl)methyl]-4-flu0r0-4-piperidinyl,]carbonyl]-4-[2-(2-pyridinyl)-3h-imidaz0[4, 5-b]pyridin-3-yl]piperidine useful as histamine h3 antagonist
WO2014032755A2 (en) * 2012-08-29 2014-03-06 Merck Patent Gmbh Ddr2 inhibitors for the treatment of osteoarthritis

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2686084B1 (fr) * 1992-01-10 1995-12-22 Bioprojet Soc Civ Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques.
ATE234290T1 (de) * 1993-11-15 2003-03-15 Schering Corp Phenylalkyl-imidazole als h3-rezeptor- antagonisten
FR2732017B1 (fr) * 1995-03-21 2000-09-22 Inst Nat Sante Rech Med Nouveaux derives de l'imidazole antagonistes et/ou agonistes du recepteur h3 de l'histamine, leur preparation et leurs applications therapeutiques
JP3638289B2 (ja) * 1996-08-16 2005-04-13 シェーリング コーポレイション ヒスタミンレセプターアンタゴニストの組み合わせを用いる上気道アレルギー性応答の処置

Also Published As

Publication number Publication date
ATE219062T1 (de) 2002-06-15
EP1028947A1 (en) 2000-08-23
AU1296699A (en) 1999-05-31
CO5011065A1 (es) 2001-02-28
CN1130349C (zh) 2003-12-10
HUP0004292A3 (en) 2001-12-28
CA2308586A1 (en) 1999-05-20
NZ504124A (en) 2002-10-25
CN1285822A (zh) 2001-02-28
DE69806042T2 (de) 2003-01-23
DE69806042D1 (de) 2002-07-18
PE134399A1 (es) 2000-01-10
ES2174510T3 (es) 2002-11-01
EP1028947B8 (en) 2004-01-28
AR016672A1 (es) 2001-07-25
IL135729A0 (en) 2001-05-20
HUP0004292A2 (hu) 2001-11-28
TW421645B (en) 2001-02-11
JP2001522835A (ja) 2001-11-20
WO1999024405A1 (en) 1999-05-20
EP1028947B1 (en) 2002-06-12
KR20010031724A (ko) 2001-04-16

Similar Documents

Publication Publication Date Title
ZA985323B (en) New compounds
IL132085A0 (en) Compounds
GB9708694D0 (en) Compounds
GB9708805D0 (en) Compounds
GB2341180A9 (en) Compounds on the basis of polyalkyl-1-oxa diazaspirodecane compounds
ZA989839B (en) New spirocyciic compounds
IL135729A0 (en) H3 receptor ligands of the phenyl-alkyl-imidazoles type
ZA983736B (en) New compounds
EP0999205A4 (en) AMINOCYCLOALKAN CONNECTIONS
GB2341862B (en) Histamine H3 receptor ligands
GB9704522D0 (en) Compounds
ZA9810176B (en) H3 receptor ligands of the phenyl-alkyl-imidazoles type
GB9715814D0 (en) Histamine H3 receptor ligands
GB9702978D0 (en) Compounds
GB9815373D0 (en) Receptor ligands
HU9701558D0 (en) New compounds
GB9702646D0 (en) Compounds
GB9705188D0 (en) Compounds
GB9702608D0 (en) Compounds
GB9702240D0 (en) Compounds
GB9700393D0 (en) Compounds
GB9704490D0 (en) Compounds
GB9704520D0 (en) Compounds
GB9700255D0 (en) Compounds
GB9704523D0 (en) Compounds

Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20051105