PE134399A1 - Ligandos del receptor h3 del tipo fenil-alquil-imidazoles - Google Patents
Ligandos del receptor h3 del tipo fenil-alquil-imidazolesInfo
- Publication number
- PE134399A1 PE134399A1 PE1998001070A PE00107098A PE134399A1 PE 134399 A1 PE134399 A1 PE 134399A1 PE 1998001070 A PE1998001070 A PE 1998001070A PE 00107098 A PE00107098 A PE 00107098A PE 134399 A1 PE134399 A1 PE 134399A1
- Authority
- PE
- Peru
- Prior art keywords
- compound
- diseases
- refers
- formula
- leaguards
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FOMULA I, DONDE "A" ES -CH2-NH-CO-NH-, -CH2-O-CO-NH-, -CH2CH2-CO-NH-(CH2)m-; m ES 0-2; R ES FENIL SUSTITUIDO CON R1, R2, R3, R4; DOS DE R1, R2, R3, R4 SON H Y LOS OTROS DOS SON H, HALOGENO, CH3, CF3, OCH3, OCF3, CN; CUANDO "A" ES -CH2-O-CO-NH-; R1, R3 Y R4 SON H; R2 NO ES CLORO. TAMBIEN SE REFIERE A UN COMPUESTO QUE NO ES UN COMPUESTO DE FORMULA II. TAMBIEN SE REFIERE A UNA COMPOSICION LA QUE PUEDE SER UTIL PARA EL TRATAMIENTO DE LAS ALERGIAS DE LAS VIAS RESPIRATORIAS ALTAS QUE COMPRENDE ADEMAS UN ANTAGONISTA DEL RECEPTOR H1 DE HISTAMINA COMO LORATADINA, DESCARBOETOXILORATADINA, FEXOFENADINA, CETIRIZINA. UN COMPUESTO PREFERIDO DE FORMULA Ia. EL COMPUESTO I ES UN ANTAGONISTA DEL RECEPTOR H3 DE HISTAMINA Y PUEDE SER UTIL PARA EL TRATAMIENTO DE ALERGIA, INFLAMACION, ENFERMEDADES CARDIOVASCULARES, HIPOTENSION, GLAUCOMA, TRASTORNOS DEL SUENO, ENFERMEDADES DEL SNC, ENFERMEDAD DE ALZHEIMER, ENFERMEDADES DEL TRACTO GASTROINTESTINAL, ESTADOS DE HIPER E HIPO ACTIVIDAD DEL TRACTO GASTROINTESTINAL, ESQUIZOFRENIA, OBESIDAD, MIGRANA
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US96634497A | 1997-11-07 | 1997-11-07 | |
US12971198A | 1998-08-05 | 1998-08-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE134399A1 true PE134399A1 (es) | 2000-01-10 |
Family
ID=26827847
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1998001070A PE134399A1 (es) | 1997-11-07 | 1998-11-06 | Ligandos del receptor h3 del tipo fenil-alquil-imidazoles |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP1028947B8 (es) |
JP (1) | JP2001522835A (es) |
KR (1) | KR20010031724A (es) |
CN (1) | CN1130349C (es) |
AR (1) | AR016672A1 (es) |
AT (1) | ATE219062T1 (es) |
AU (1) | AU1296699A (es) |
CA (1) | CA2308586A1 (es) |
CO (1) | CO5011065A1 (es) |
DE (1) | DE69806042T2 (es) |
ES (1) | ES2174510T3 (es) |
HK (1) | HK1025968A1 (es) |
HU (1) | HUP0004292A3 (es) |
IL (1) | IL135729A0 (es) |
NZ (1) | NZ504124A (es) |
PE (1) | PE134399A1 (es) |
TW (1) | TW421645B (es) |
WO (1) | WO1999024405A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20020507A1 (es) | 2000-10-17 | 2002-06-25 | Schering Corp | Compuestos no-imidazoles como antagonistas del receptor histamina h3 |
AU2002244271A1 (en) | 2001-03-13 | 2002-09-24 | Pharmacopeia, Inc. | Non-imidazole compounds as histamine h3 antagonists |
CN1705645A (zh) * | 2002-10-24 | 2005-12-07 | 默克专利有限公司 | 作为raf-激酶抑制剂的亚甲基脲衍生物 |
AU2006204724A1 (en) | 2005-01-14 | 2006-07-20 | Millennium Pharmaceuticals, Inc. | Cinnamide and hydrocinnamide derivatives with raf-kinase inhibitory activity |
EP1749523A1 (en) * | 2005-07-29 | 2007-02-07 | Neuropharma, S.A. | GSK-3 inhibitors |
CA2623025A1 (en) | 2005-09-20 | 2007-03-29 | Schering Corporation | 1- [ [1- [ (2-amin0-6-methyl-4-pyridinyl) methyl] -4-flu0r0-4-piperidinyl,] carbonyl] -4- [2- (2-pyridinyl) -3h-imidaz0 [4 , 5-b] pyridin-3-yl] piperidine useful as histamine h3 antagonist |
US20150225369A1 (en) * | 2012-08-29 | 2015-08-13 | Merck Patent Gmbh | Ddr2 inhibitors for the treatment of osteoarthritis |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2686084B1 (fr) * | 1992-01-10 | 1995-12-22 | Bioprojet Soc Civ | Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques. |
NZ276883A (en) * | 1993-11-15 | 1998-08-26 | Schering Corp | 1h-imidazol-4-yl)alkyl]benzene derivatives |
FR2732017B1 (fr) * | 1995-03-21 | 2000-09-22 | Inst Nat Sante Rech Med | Nouveaux derives de l'imidazole antagonistes et/ou agonistes du recepteur h3 de l'histamine, leur preparation et leurs applications therapeutiques |
EP0920315B1 (en) * | 1996-08-16 | 2005-12-28 | Schering Corporation | Treatment of upper airway allergic responses with a combination of histamine receptor antagonists |
-
1998
- 1998-11-05 TW TW087118436A patent/TW421645B/zh not_active IP Right Cessation
- 1998-11-05 IL IL13572998A patent/IL135729A0/xx unknown
- 1998-11-05 AT AT98956442T patent/ATE219062T1/de not_active IP Right Cessation
- 1998-11-05 NZ NZ504124A patent/NZ504124A/xx unknown
- 1998-11-05 CA CA002308586A patent/CA2308586A1/en not_active Abandoned
- 1998-11-05 HU HU0004292A patent/HUP0004292A3/hu unknown
- 1998-11-05 WO PCT/US1998/023223 patent/WO1999024405A1/en not_active Application Discontinuation
- 1998-11-05 DE DE69806042T patent/DE69806042T2/de not_active Expired - Fee Related
- 1998-11-05 JP JP2000520419A patent/JP2001522835A/ja not_active Ceased
- 1998-11-05 ES ES98956442T patent/ES2174510T3/es not_active Expired - Lifetime
- 1998-11-05 KR KR1020007004787A patent/KR20010031724A/ko not_active Application Discontinuation
- 1998-11-05 CN CN98812981A patent/CN1130349C/zh not_active Expired - Fee Related
- 1998-11-05 AU AU12966/99A patent/AU1296699A/en not_active Abandoned
- 1998-11-05 EP EP98956442A patent/EP1028947B8/en not_active Expired - Lifetime
- 1998-11-06 PE PE1998001070A patent/PE134399A1/es not_active Application Discontinuation
- 1998-11-06 CO CO98065582A patent/CO5011065A1/es unknown
- 1998-11-06 AR ARP980105622A patent/AR016672A1/es unknown
-
2000
- 2000-08-25 HK HK00105336A patent/HK1025968A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HUP0004292A3 (en) | 2001-12-28 |
TW421645B (en) | 2001-02-11 |
AR016672A1 (es) | 2001-07-25 |
AU1296699A (en) | 1999-05-31 |
CA2308586A1 (en) | 1999-05-20 |
CN1130349C (zh) | 2003-12-10 |
DE69806042T2 (de) | 2003-01-23 |
IL135729A0 (en) | 2001-05-20 |
WO1999024405A1 (en) | 1999-05-20 |
EP1028947B8 (en) | 2004-01-28 |
ES2174510T3 (es) | 2002-11-01 |
ATE219062T1 (de) | 2002-06-15 |
HK1025968A1 (en) | 2000-12-01 |
KR20010031724A (ko) | 2001-04-16 |
EP1028947B1 (en) | 2002-06-12 |
NZ504124A (en) | 2002-10-25 |
EP1028947A1 (en) | 2000-08-23 |
CN1285822A (zh) | 2001-02-28 |
JP2001522835A (ja) | 2001-11-20 |
DE69806042D1 (de) | 2002-07-18 |
HUP0004292A2 (hu) | 2001-11-28 |
CO5011065A1 (es) | 2001-02-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Refusal |