AR014626A1 - Piridino arilpiperazinas sustituidas utiles en el tratamiento de hiperplasia prostatica benigna, una composicion farmaceutica que las comprende y el uso de las mismas para la fabricacion de un medicamento. - Google Patents
Piridino arilpiperazinas sustituidas utiles en el tratamiento de hiperplasia prostatica benigna, una composicion farmaceutica que las comprende y el uso de las mismas para la fabricacion de un medicamento.Info
- Publication number
- AR014626A1 AR014626A1 ARP990100675A ARP990100675A AR014626A1 AR 014626 A1 AR014626 A1 AR 014626A1 AR P990100675 A ARP990100675 A AR P990100675A AR P990100675 A ARP990100675 A AR P990100675A AR 014626 A1 AR014626 A1 AR 014626A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- substituted
- independently selected
- phenyl
- substituents
- Prior art date
Links
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 title 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 9
- 125000003545 alkoxy group Chemical group 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 150000002367 halogens Chemical group 0.000 abstract 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 150000002431 hydrogen Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 4
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- 125000005129 aryl carbonyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000005243 carbonyl alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7532198P | 1998-02-20 | 1998-02-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR014626A1 true AR014626A1 (es) | 2001-03-28 |
Family
ID=22124955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990100675A AR014626A1 (es) | 1998-02-20 | 1999-02-23 | Piridino arilpiperazinas sustituidas utiles en el tratamiento de hiperplasia prostatica benigna, una composicion farmaceutica que las comprende y el uso de las mismas para la fabricacion de un medicamento. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6218396B1 (https=) |
| EP (1) | EP1054868B1 (https=) |
| JP (1) | JP2002503724A (https=) |
| KR (1) | KR100591028B1 (https=) |
| CN (1) | CN1121390C (https=) |
| AR (1) | AR014626A1 (https=) |
| AT (1) | ATE250580T1 (https=) |
| AU (1) | AU766398B2 (https=) |
| BR (1) | BR9909647A (https=) |
| CZ (1) | CZ294136B6 (https=) |
| DE (1) | DE69911582T2 (https=) |
| DK (1) | DK1054868T3 (https=) |
| ES (1) | ES2209468T3 (https=) |
| HU (1) | HUP0100781A3 (https=) |
| IL (2) | IL137954A0 (https=) |
| NO (1) | NO317103B1 (https=) |
| NZ (1) | NZ506462A (https=) |
| PL (1) | PL342339A1 (https=) |
| PT (1) | PT1054868E (https=) |
| TR (1) | TR200003220T2 (https=) |
| TW (1) | TW565555B (https=) |
| WO (1) | WO1999042448A1 (https=) |
| ZA (1) | ZA991315B (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA001904B1 (ru) * | 1997-05-12 | 2001-10-22 | ОРТО МакНЕЙЛ ФАРМАСЬЮТИКАЛ, ИНК. | Арилзамещенные пиперазины для лечения доброкачественной гиперплазии простаты |
| CZ2003686A3 (cs) | 2000-08-08 | 2003-08-13 | Ortho Mcneil Pharmaceutical, Inc. | Neimidazolové aryloxypiperidiny |
| KR20060005009A (ko) | 2001-12-28 | 2006-01-16 | 다케다 야쿠힌 고교 가부시키가이샤 | 배뇨 장애 예방제/치료제 |
| USD545208S1 (en) | 2006-09-27 | 2007-06-26 | 001 Corporation | Perfume bottle and cap |
| EP2077262A4 (en) * | 2006-10-23 | 2011-12-28 | Takeda Pharmaceutical | IMINOPYRIDINE DERIVATIVE AND USE THEREOF |
| CL2009000964A1 (es) * | 2008-04-23 | 2010-03-26 | Takeda Pharmaceuticals Co | Compuestos derivados de 1-aril-2-imino-1,2-dihidropiridina-3-carboxamida, antagonista del receptor adrenergico alfa 1d, composicion farmaceutica que los comprende; y su uso para el tratamiento o profilaxis de enfermedades del tracto urinario inferior. |
| US20110039892A1 (en) * | 2008-04-23 | 2011-02-17 | Takeda Pharmaceutical Company Limited | Iminopyridine derivative and use thereof |
| US8481569B2 (en) * | 2008-04-23 | 2013-07-09 | Takeda Pharmaceutical Company Limited | Iminopyridine derivatives and use thereof |
| CN103980195A (zh) * | 2014-04-28 | 2014-08-13 | 广州医科大学 | 酰胺类苯基哌嗪衍生物及其盐与在制备治疗良性前列腺增生症药物中的应用 |
| CN108530391B (zh) * | 2018-05-17 | 2022-05-17 | 袁牧 | 一种酰胺类芳基哌嗪衍生物及其制备方法与应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2027898A6 (es) * | 1991-01-24 | 1992-06-16 | Espanola Prod Quimicos | Procedimiento de preparacion de nuevos derivados de la 2-metoxifenilpiperacina. |
| US5403847A (en) | 1992-11-13 | 1995-04-04 | Synaptic Pharmaceutical Corporation | Use of α1C specific compounds to treat benign prostatic hyperlasia |
| IT1266582B1 (it) * | 1993-07-30 | 1997-01-09 | Recordati Chem Pharm | Derivati (di)azacicloesanici e diazacicloeptanici |
| DE4425146A1 (de) * | 1994-07-15 | 1996-01-18 | Basf Ag | Verwendung heterocyclischer Verbindungen |
| US5688795A (en) * | 1994-11-08 | 1997-11-18 | Syntex (U.S.A.) Inc. | 3-(4-phenylpiperazin-1-yl)propyl-amino, thio and oxy!-pyridine, pyrimidine and benzene derivatives as α1 -adrenoceptor antagonists |
| WO1999003833A1 (fr) * | 1997-07-15 | 1999-01-28 | Sankyo Company, Limited | Derives de piperazine |
-
1999
- 1999-02-18 US US09/252,313 patent/US6218396B1/en not_active Expired - Lifetime
- 1999-02-18 ZA ZA9901315A patent/ZA991315B/xx unknown
- 1999-02-19 CZ CZ20003044A patent/CZ294136B6/cs not_active IP Right Cessation
- 1999-02-19 TR TR2000/03220T patent/TR200003220T2/xx unknown
- 1999-02-19 HU HU0100781A patent/HUP0100781A3/hu unknown
- 1999-02-19 BR BR9909647-1A patent/BR9909647A/pt not_active Application Discontinuation
- 1999-02-19 DE DE69911582T patent/DE69911582T2/de not_active Expired - Fee Related
- 1999-02-19 DK DK99934281T patent/DK1054868T3/da active
- 1999-02-19 ES ES99934281T patent/ES2209468T3/es not_active Expired - Lifetime
- 1999-02-19 IL IL13795499A patent/IL137954A0/xx active IP Right Grant
- 1999-02-19 KR KR1020007009156A patent/KR100591028B1/ko not_active Expired - Fee Related
- 1999-02-19 JP JP2000532400A patent/JP2002503724A/ja active Pending
- 1999-02-19 PT PT99934281T patent/PT1054868E/pt unknown
- 1999-02-19 PL PL99342339A patent/PL342339A1/xx unknown
- 1999-02-19 AT AT99934281T patent/ATE250580T1/de not_active IP Right Cessation
- 1999-02-19 EP EP99934281A patent/EP1054868B1/en not_active Expired - Lifetime
- 1999-02-19 CN CN99803027A patent/CN1121390C/zh not_active Expired - Fee Related
- 1999-02-19 WO PCT/US1999/003608 patent/WO1999042448A1/en not_active Ceased
- 1999-02-19 NZ NZ506462A patent/NZ506462A/en unknown
- 1999-02-19 AU AU33025/99A patent/AU766398B2/en not_active Ceased
- 1999-02-23 AR ARP990100675A patent/AR014626A1/es active IP Right Grant
- 1999-04-02 TW TW088102511A patent/TW565555B/zh not_active IP Right Cessation
-
2000
- 2000-08-18 IL IL137954A patent/IL137954A/en not_active IP Right Cessation
- 2000-08-18 NO NO20004141A patent/NO317103B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HK1030776A1 (en) | 2001-05-18 |
| DE69911582D1 (de) | 2003-10-30 |
| BR9909647A (pt) | 2000-11-21 |
| IL137954A (en) | 2007-06-03 |
| EP1054868A1 (en) | 2000-11-29 |
| AU3302599A (en) | 1999-09-06 |
| CN1291188A (zh) | 2001-04-11 |
| ES2209468T3 (es) | 2004-06-16 |
| NZ506462A (en) | 2003-07-25 |
| ZA991315B (en) | 2000-11-20 |
| NO20004141L (no) | 2000-10-19 |
| IL137954A0 (en) | 2001-10-31 |
| DE69911582T2 (de) | 2005-09-15 |
| EP1054868B1 (en) | 2003-09-24 |
| CZ294136B6 (cs) | 2004-10-13 |
| KR20010041115A (ko) | 2001-05-15 |
| DK1054868T3 (da) | 2003-12-22 |
| US6218396B1 (en) | 2001-04-17 |
| WO1999042448A1 (en) | 1999-08-26 |
| HUP0100781A3 (en) | 2002-12-28 |
| ATE250580T1 (de) | 2003-10-15 |
| AU766398B2 (en) | 2003-10-16 |
| HUP0100781A2 (hu) | 2001-08-28 |
| PL342339A1 (en) | 2001-06-04 |
| PT1054868E (pt) | 2004-01-30 |
| CN1121390C (zh) | 2003-09-17 |
| NO317103B1 (no) | 2004-08-09 |
| TR200003220T2 (tr) | 2001-04-20 |
| TW565555B (en) | 2003-12-11 |
| KR100591028B1 (ko) | 2006-06-22 |
| CZ20003044A3 (cs) | 2001-04-11 |
| NO20004141D0 (no) | 2000-08-18 |
| JP2002503724A (ja) | 2002-02-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |