AR032466A1 - Ciclilamina sulfonamidas, utilizacion de las mismas para la manufactura de un medicamento y composiciones farmaceuticas utiles como agonistas de los receptores beta-3 adrenergicos - Google Patents
Ciclilamina sulfonamidas, utilizacion de las mismas para la manufactura de un medicamento y composiciones farmaceuticas utiles como agonistas de los receptores beta-3 adrenergicosInfo
- Publication number
- AR032466A1 AR032466A1 ARP010103379A ARP010103379A AR032466A1 AR 032466 A1 AR032466 A1 AR 032466A1 AR P010103379 A ARP010103379 A AR P010103379A AR P010103379 A ARP010103379 A AR P010103379A AR 032466 A1 AR032466 A1 AR 032466A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- het
- alkyl chain
- chain
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Fodder In General (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
Ciclilamina sulfonamidas, que comprende un compuesto de la formula (1) en la cual W es (CH2)m; X es (CH2)n; Y es OCH2, SCH2, o un enlace; Z es SO2, CO, o P(O)OR; R es alquilo o arilo; R1 es fenilo sustituido con R4 y R5, o Het sustituido con R4 y R5; R2 es hidrogeno, trifluormetilo, alquilo C1-6, alquenilo de C2 û 7; alquinilo de C2 - 7 o cicloalquilo de C4 - 8 R3 es alquilo de C1 - 6 , alquenilo de C2 - 7 , alquinilo de C2 - 7, cicloalquilo de C4 - 8 , arilo sustituido con R4 y R5, Het sustituido con R4 y R5, ariloxi, -NHCOR7, -NR8R8, arilamino, Het-amino, arilalquilamino que tiene de C1 - 6 en la cadena alquilo, Het-alquilamino que tiene de C1 - 6 en la cadena alquilo, alcoxicarbonilalquilo de C3 - 13 , carboxialquilo de C2 - 7 alquilcarbonilalquilo de C3 - 13 arilcarbonilalquilo que tiene de C1 - 6 en la cadena alquilo, Het-carbonilalquilo que tiene de C1 - 6 en la cadena alquilo, aminocarbonilalquilo de C2 - 7 , alquilamino carbonilalquilo de C3 - 13 , arilaminocarbonilalquilo que tiene de C1 - 6 átomos de carbono en la cadena alquilo, Het-aminocarbonilalquilo que tiene de C1 - 6 en la cadena alquilo, aminosulfonilalquilo de C1 - 6 , alquilsulfonilalquilo de C2 - 12, arilsulfonil alquilo que tiene de C1 - 6 en la cadena alquilo, alquilamino sulfonilalquilo de C2 - 12 , arilaminosulfonilamino que tiene de C1 - 5 en la cadena alquilo, Het-aminosulfonilalquilo que tiene de C1 - 6 en la cadena alquilo, fosfonoalquilo de C1 - 6 , fosforilalquilo de C1-6; R4 y R5, cada uno de ellos e independientemente entre si, hidrogeno, trifluormetilo, alquilo de C1-6, alquenilo de C2-7, alquinilo de C2-7, cicloalquilo de C4-8, arilo, Het, arilalquilo que tiene de C1-6 en la cadena alquilo, Het-alquilo que tiene de C1-6 en la cadena alquilo, halogeno, ciano, nitro, hidroxi, alcoxi, de C1-6 ariloxi, arilalquil oxi que tiene de C1-6 en la cadena alquilo, alquiltio que tiene de C1-6, ariltio, arilamino, Het-amino, arilalquilamino de C1-6en la cadena alquilo, Het-alquilamino que tiene de C1-6 en la cadena alquilo, hidroxi amino, -NHCOR7, -NHSO2R7, -NHP(O)(R7)2, -COR8, -SO2R8, -NR8R8, carboxi, alquil carbonilo de C2-7, fosforilo, alcoxicarbonilalquilo de C3-13 , carboxialquil de C2-7, alquilcarbonil alquilo de C2-13 , arilcarbonilalquilo que tiene de C1-6 en la cadena alquilo, Het-carbonilalquilo que tiene de C1-6 en la cadena alquilo, aminocarbonilalquilo de C2 û 7, alquilaminocarbonilalquilo de C3-13 arilaminocarbonilalquilo que tiene de C1-6 en la cadena alquilo, Het-aminocarbonilaquilo que tiene de C1-6 en la cadena alquilo, aminosulfonil alquilo de C1-6, alquilsulfonilalquilo de C2-12, arilsulfonilalquilo que tiene de C1-6 en la cadena alquilo, alquilaminosulfonilalquilo de C2-12. Arilaminosulfonil alquilo de C1-6, Het-aminosulfonilalquilo de C1-6, fosfonoalquil de C1-6, o fosforilalquilo de C1-6; R7 es hidrogeno, trifluormetilo, alquilo de C1-6, cicloalquilo de C4-8, alquenilo de C2-7, alquinilo de C2-7, arilo, alcoxi de C1-6, NR8R9, o ûNR9(CH2)p-R8, R8 es hidrogeno, alcoxi de C1-6, hidroxi, -(CH2)p-COR9, o (CH2)p-R9; R9 es hidrogeno, hidroxi, alquilo de C1-6, alcoxi de C1-6 o ûNR10R10; R10 es hidrogeno, alquilo de C1-6 átomos de carbono, arilo o Het; Het es un heterociclo monocíclico, o bicíclico de 5 a 10 átomos de anillo, que tiene de 1 a 4 heteroátomos seleccionados de entre el grupo consistente en oxígeno, nitrogeno, y azufre, pudiendo el heterociclo estar saturado, no saturado, parcialmente no saturado y puede estar opcionalmente fusionado a un anillo fenilo; m es de 1 a 3; n es de 1 a 3; p es de 0 a 6; o una sal farmacéuticamente aceptable de los mismos; utilizacion de las mismas para la manufactura de un medicamento y composiciones farmacéuticas utiles, en el tratamiento de los trastornos metabolicos relacionados con la resistencia contra la insulina o con la hiperglicemia.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21876400P | 2000-07-17 | 2000-07-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR032466A1 true AR032466A1 (es) | 2003-11-12 |
Family
ID=22816416
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP010103379A AR032466A1 (es) | 2000-07-17 | 2001-07-16 | Ciclilamina sulfonamidas, utilizacion de las mismas para la manufactura de un medicamento y composiciones farmaceuticas utiles como agonistas de los receptores beta-3 adrenergicos |
Country Status (10)
Country | Link |
---|---|
US (2) | US6498170B2 (es) |
EP (1) | EP1328512A2 (es) |
JP (1) | JP2004504296A (es) |
CN (1) | CN1455769A (es) |
AR (1) | AR032466A1 (es) |
AU (1) | AU2002222929A1 (es) |
BR (1) | BR0112582A (es) |
CA (1) | CA2416667A1 (es) |
MX (1) | MXPA03000450A (es) |
WO (1) | WO2002006221A2 (es) |
Families Citing this family (27)
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CA2326777C (en) * | 1998-04-01 | 2011-12-20 | Nortran Pharmaceuticals Inc. | Aminocyclohexyl ether compounds and uses thereof |
US6979685B1 (en) * | 1999-02-12 | 2005-12-27 | Cardiome Pharma Corp. | Cycloalkyl amine compounds and uses thereof |
US7507545B2 (en) | 1999-03-31 | 2009-03-24 | Cardiome Pharma Corp. | Ion channel modulating activity method |
US6410734B1 (en) * | 2000-07-17 | 2002-06-25 | Wyeth | 2-substituted thiazolidinones as beta-3 adrenergic receptor agonists |
US6525202B2 (en) * | 2000-07-17 | 2003-02-25 | Wyeth | Cyclic amine phenyl beta-3 adrenergic receptor agonists |
US6537994B2 (en) | 2000-07-17 | 2003-03-25 | Wyeth | Heterocyclic β3 adrenergic receptor agonists |
US6465501B2 (en) | 2000-07-17 | 2002-10-15 | Wyeth | Azolidines as β3 adrenergic receptor agonists |
US7057053B2 (en) * | 2000-10-06 | 2006-06-06 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
US7524879B2 (en) * | 2000-10-06 | 2009-04-28 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
US6376514B1 (en) * | 2000-10-17 | 2002-04-23 | The Procter & Gamble Co. | Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof |
US6693099B2 (en) * | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
US6885903B2 (en) * | 2001-07-10 | 2005-04-26 | General Electric Company | Method and system for tracking repair of components |
US6856733B2 (en) * | 2001-12-07 | 2005-02-15 | Intel Corporation | 1xN fanout waveguide photodetector |
US7345086B2 (en) * | 2003-05-02 | 2008-03-18 | Cardiome Pharma Corp. | Uses of ion channel modulating compounds |
BRPI0318278B8 (pt) * | 2003-05-02 | 2024-01-09 | Cardiome Pharma Corp | Compostos de éter aminocicloexílico, composição compreendendo ditos compostos, usos dos mesmos e método para modular a atividade do canal iônico em um ambiente in vitro |
US20090041841A1 (en) * | 2003-05-02 | 2009-02-12 | Cardiome Pharma Corp. | Controlled release tablet formulations for the prevention of arrhythmias |
US7674820B2 (en) * | 2003-08-07 | 2010-03-09 | Cardiome Pharma Corp. | Ion channel modulating activity I |
US7345087B2 (en) * | 2003-10-31 | 2008-03-18 | Cardiome Pharma Corp. | Aminocyclohexyl ether compounds and uses thereof |
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WO2005097087A2 (en) * | 2004-04-01 | 2005-10-20 | Cardiome Pharma Corp. | Merged ion channel modulating compounds and uses thereof |
US7572792B2 (en) * | 2004-04-29 | 2009-08-11 | Merck & Co., Inc. | Azetidine glycine transporter inhibitors |
JP5583325B2 (ja) * | 2004-11-08 | 2014-09-03 | カーディオム ファーマ コーポレイション | イオンチャネル調節化合物の投与レジメ |
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WO2011025690A1 (en) * | 2009-08-27 | 2011-03-03 | Merck Sharp & Dohme Corp. | Novel pyrrolidine derived beta 3 adrenergic receptor agonists |
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2001
- 2001-07-12 US US09/904,158 patent/US6498170B2/en not_active Expired - Fee Related
- 2001-07-16 CA CA002416667A patent/CA2416667A1/en not_active Abandoned
- 2001-07-16 EP EP01984233A patent/EP1328512A2/en not_active Withdrawn
- 2001-07-16 AU AU2002222929A patent/AU2002222929A1/en not_active Abandoned
- 2001-07-16 CN CN01815501A patent/CN1455769A/zh active Pending
- 2001-07-16 JP JP2002512127A patent/JP2004504296A/ja active Pending
- 2001-07-16 AR ARP010103379A patent/AR032466A1/es unknown
- 2001-07-16 WO PCT/US2001/022359 patent/WO2002006221A2/en not_active Application Discontinuation
- 2001-07-16 MX MXPA03000450A patent/MXPA03000450A/es unknown
- 2001-07-16 BR BR0112582-6A patent/BR0112582A/pt not_active Application Discontinuation
-
2002
- 2002-09-05 US US10/235,911 patent/US6649603B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
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CA2416667A1 (en) | 2002-01-24 |
EP1328512A2 (en) | 2003-07-23 |
US20030027797A1 (en) | 2003-02-06 |
WO2002006221A3 (en) | 2002-06-13 |
JP2004504296A (ja) | 2004-02-12 |
US20020022605A1 (en) | 2002-02-21 |
BR0112582A (pt) | 2003-05-20 |
US6498170B2 (en) | 2002-12-24 |
AU2002222929A1 (en) | 2002-01-30 |
WO2002006221A2 (en) | 2002-01-24 |
CN1455769A (zh) | 2003-11-12 |
MXPA03000450A (es) | 2003-06-06 |
US6649603B2 (en) | 2003-11-18 |
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