WO2002006221A3 - Cyclylamine sulfonamides as beta-3 adrenergic receptor agonists - Google Patents

Cyclylamine sulfonamides as beta-3 adrenergic receptor agonists Download PDF

Info

Publication number
WO2002006221A3
WO2002006221A3 PCT/US2001/022359 US0122359W WO0206221A3 WO 2002006221 A3 WO2002006221 A3 WO 2002006221A3 US 0122359 W US0122359 W US 0122359W WO 0206221 A3 WO0206221 A3 WO 0206221A3
Authority
WO
WIPO (PCT)
Prior art keywords
cyclylamine
sulfonamides
beta
receptor agonists
adrenergic receptor
Prior art date
Application number
PCT/US2001/022359
Other languages
French (fr)
Other versions
WO2002006221A2 (en
Inventor
Fuk-Wah Sum
Baihua Hu
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Priority to JP2002512127A priority Critical patent/JP2004504296A/en
Priority to BR0112582-6A priority patent/BR0112582A/en
Priority to AU2002222929A priority patent/AU2002222929A1/en
Priority to MXPA03000450A priority patent/MXPA03000450A/en
Priority to EP01984233A priority patent/EP1328512A2/en
Priority to CA002416667A priority patent/CA2416667A1/en
Publication of WO2002006221A2 publication Critical patent/WO2002006221A2/en
Publication of WO2002006221A3 publication Critical patent/WO2002006221A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

This invention provides compounds of Formula (I), wherein R1, R2, R3, W, X, and Z are as defined hereinbefore or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.
PCT/US2001/022359 2000-07-17 2001-07-16 Cyclylamine sulfonamides as beta-3 adrenergic receptor agonists WO2002006221A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2002512127A JP2004504296A (en) 2000-07-17 2001-07-16 Cycylamine sulfonamides as beta-3 adrenergic receptor agonists
BR0112582-6A BR0112582A (en) 2000-07-17 2001-07-16 Cyclylamine sulfonamides as beta-3 adrenergic receptor agonists
AU2002222929A AU2002222929A1 (en) 2000-07-17 2001-07-16 Cyclylamine sulfonamides as beta-3 adrenergic receptor agonists
MXPA03000450A MXPA03000450A (en) 2000-07-17 2001-07-16 Cyclylamine sulfonamides as beta-3 adrenergic receptor agonists.
EP01984233A EP1328512A2 (en) 2000-07-17 2001-07-16 Cyclylamine sulfonamides as beta-3 adrenergic receptor agonists
CA002416667A CA2416667A1 (en) 2000-07-17 2001-07-16 Cyclylamine sulfonamides as beta-3 adrenergic receptor agonists

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21876400P 2000-07-17 2000-07-17
US60/218,764 2000-07-17

Publications (2)

Publication Number Publication Date
WO2002006221A2 WO2002006221A2 (en) 2002-01-24
WO2002006221A3 true WO2002006221A3 (en) 2002-06-13

Family

ID=22816416

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/022359 WO2002006221A2 (en) 2000-07-17 2001-07-16 Cyclylamine sulfonamides as beta-3 adrenergic receptor agonists

Country Status (10)

Country Link
US (2) US6498170B2 (en)
EP (1) EP1328512A2 (en)
JP (1) JP2004504296A (en)
CN (1) CN1455769A (en)
AR (1) AR032466A1 (en)
AU (1) AU2002222929A1 (en)
BR (1) BR0112582A (en)
CA (1) CA2416667A1 (en)
MX (1) MXPA03000450A (en)
WO (1) WO2002006221A2 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK285908B6 (en) * 1998-04-01 2007-10-04 Nortran Pharmaceuticals Inc. Aminocyclohexyl ether compound, composition comprising it and use thereof in the manufacture of medicaments and in the treatment of diseases
US6979685B1 (en) * 1999-02-12 2005-12-27 Cardiome Pharma Corp. Cycloalkyl amine compounds and uses thereof
US7507545B2 (en) 1999-03-31 2009-03-24 Cardiome Pharma Corp. Ion channel modulating activity method
US6410734B1 (en) * 2000-07-17 2002-06-25 Wyeth 2-substituted thiazolidinones as beta-3 adrenergic receptor agonists
US6537994B2 (en) 2000-07-17 2003-03-25 Wyeth Heterocyclic β3 adrenergic receptor agonists
US6525202B2 (en) * 2000-07-17 2003-02-25 Wyeth Cyclic amine phenyl beta-3 adrenergic receptor agonists
US6465501B2 (en) 2000-07-17 2002-10-15 Wyeth Azolidines as β3 adrenergic receptor agonists
US7057053B2 (en) * 2000-10-06 2006-06-06 Cardiome Pharma Corp. Ion channel modulating compounds and uses thereof
US7524879B2 (en) * 2000-10-06 2009-04-28 Cardiome Pharma Corp. Ion channel modulating compounds and uses thereof
US6376514B1 (en) * 2000-10-17 2002-04-23 The Procter & Gamble Co. Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
US6693099B2 (en) * 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
US6885903B2 (en) * 2001-07-10 2005-04-26 General Electric Company Method and system for tracking repair of components
US6856733B2 (en) * 2001-12-07 2005-02-15 Intel Corporation 1xN fanout waveguide photodetector
US7345086B2 (en) * 2003-05-02 2008-03-18 Cardiome Pharma Corp. Uses of ion channel modulating compounds
NZ543921A (en) * 2003-05-02 2008-11-28 Cardiome Pharma Corp Aminocyclohexyl ether compounds and uses thereof
US20090041841A1 (en) * 2003-05-02 2009-02-12 Cardiome Pharma Corp. Controlled release tablet formulations for the prevention of arrhythmias
US7674820B2 (en) * 2003-08-07 2010-03-09 Cardiome Pharma Corp. Ion channel modulating activity I
US7345087B2 (en) * 2003-10-31 2008-03-18 Cardiome Pharma Corp. Aminocyclohexyl ether compounds and uses thereof
US7977373B2 (en) 2004-04-01 2011-07-12 Cardiome Pharma Corp. Prodrugs of ion channel modulating compounds and uses thereof
US8058304B2 (en) * 2004-04-01 2011-11-15 Cardiome Pharma Corp. Merged ion channel modulating compounds and uses thereof
US7572792B2 (en) * 2004-04-29 2009-08-11 Merck & Co., Inc. Azetidine glycine transporter inhibitors
CA2586918C (en) * 2004-11-08 2021-01-19 Cardiome Pharma Corp. Use of ion channel modulating compounds for treating acute atrial fibrillation in a human
US20070054590A1 (en) * 2005-08-24 2007-03-08 Schmidt Christopher B Photo-chromic toys
WO2007037187A1 (en) 2005-09-27 2007-04-05 Shionogi & Co., Ltd. Sulfonamide derivative having pgd2 receptor antagonistic activity
CA2625219A1 (en) * 2005-10-13 2007-04-19 Orchid Research Laboratories Limited Heterocyclic compounds as pstat3/il-6 inhibitors
EP1947103A1 (en) 2007-01-22 2008-07-23 4Sc Ag Aryloxypropanolamines, methods of preparation thereof and use of aryloxypropanolamines as medicaments
WO2011025690A1 (en) * 2009-08-27 2011-03-03 Merck Sharp & Dohme Corp. Novel pyrrolidine derived beta 3 adrenergic receptor agonists

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2163150A (en) * 1984-07-19 1986-02-19 Sandoz Ltd 3-Aminopropoxyaryl derivatives
WO1995029159A1 (en) * 1994-04-26 1995-11-02 Merck & Co., Inc. SUBSTITUTED SULFONAMIDES AS SELECTIVE β3 AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY
EP0801060A1 (en) * 1996-04-09 1997-10-15 Pfizer Inc. Heterocyclic Beta-3 Adrenergenic Agonists
WO1997046556A1 (en) * 1996-06-07 1997-12-11 Merck & Co., Inc. OXADIAZOLE BENZENESULFONAMIDES AS SELECTIVE β3 AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY
EP0827746A1 (en) * 1996-09-05 1998-03-11 Eli Lilly And Company Carbazole analogues as selective B3 adrenergic agonists
WO1998022480A1 (en) * 1996-11-18 1998-05-28 Smithkline Beecham Plc Phosphorus containing aryloxy or arylthio propanolamine derivatives
WO1998032753A1 (en) * 1997-01-28 1998-07-30 Merck & Co., Inc. THIAZOLE BENZENESULFONAMIDES AS β3 AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY
EP0940387A1 (en) * 1995-10-26 1999-09-08 Tokyo Tanabe Company Limited Phenylethanolamine compounds useful as beta3 agonist, process for producing the same, and intermediates in the production of the same
FR2780057A1 (en) * 1998-06-18 1999-12-24 Sanofi Sa PHENOXYPROPANOLAMINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
FR2798126A1 (en) * 1999-09-08 2001-03-09 Sanofi Synthelabo HETEROARYLOXYPROPANOLAMINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4348393A (en) 1978-06-09 1982-09-07 Delalande S.A. N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones
US4775670A (en) * 1980-09-29 1988-10-04 E. R. Squibb & Sons, Inc. 2-oxo-1-azetidinesulfonic acid salts
EP0089154A3 (en) 1982-03-12 1984-08-08 Beecham Group Plc Ethanolamine derivatives, their preparation and use in pharmaceutical compositions
US4499100A (en) * 1983-05-18 1985-02-12 Syntex (U.S.A.) Inc. Benzodioxanyl-hydroxyethyleneamino-piperidinyl acetanilides, ketones, esters and carbamates which effect immunity and calcium entry and β-blockade
GB8528633D0 (en) 1985-11-21 1985-12-24 Beecham Group Plc Compounds
US4813998A (en) 1986-02-27 1989-03-21 Janssen Pharmaceutica N.V. Herbicidal 1H-imidazole-5-carboxylic acid derivatives
EP0449261A3 (en) 1990-03-29 1992-02-26 Kabushiki Kaisha Toshiba Resin composition for an optical disc and an optical disc using it
DK0590793T3 (en) 1992-08-31 2000-01-31 Sankyo Co Oxazolidine derivatives with anti-diabetic and anti-obesity properties, their preparation and their therapeutic use
US5998452A (en) 1993-06-23 1999-12-07 Chugai Seiyaku Kabushiki Kaisha Benzene derivatives, compositions and methods for treating ischemic diseases
US5776983A (en) 1993-12-21 1998-07-07 Bristol-Myers Squibb Company Catecholamine surrogates useful as β3 agonists
IL113084A (en) 1994-03-23 1999-01-26 Sankyo Co Thiazolidine and oxazolidine derivatives processes for the preparation thereof and pharmaceutical compositions containing the same
US5561142A (en) 1994-04-26 1996-10-01 Merck & Co., Inc. Substituted sulfonamides as selective β3 agonists for the treatment of diabetes and obesity
US5541204A (en) 1994-12-02 1996-07-30 Bristol-Myers Squibb Company Aryloxypropanolamine β 3 adrenergic agonists
US5741789A (en) 1995-01-17 1998-04-21 Eli Lilly And Company Compounds having effects on serotonin-related systems
US5614523A (en) 1995-01-17 1997-03-25 Eli Lilly And Company Compounds having effects on serotonin-related systems
US5789402A (en) 1995-01-17 1998-08-04 Eli Lilly Company Compounds having effects on serotonin-related systems
ZA967892B (en) 1995-09-21 1998-03-18 Lilly Co Eli Selective β3 adrenergic agonists.
WO1997041120A1 (en) 1996-07-26 1997-11-06 Dr. Reddy's Research Foundation Thiazolidinedione compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions thereof
US6150378A (en) 1997-10-07 2000-11-21 Cephalon, Inc. Peptidyl-containing α-ketoamide cysteine and serine protease inhibitors
ID23989A (en) 1997-10-17 2000-06-14 Yamanouchi Pharma Co Ltd THE AMIDA DOWNS OR THE SALT
US6214842B1 (en) 1999-05-12 2001-04-10 Michael S. Malamas Amino-thiazolidinediones useful in the treatment of insulin resistance and hyperglycemia
FR2802533B1 (en) 1999-12-17 2002-02-15 Sanofi Synthelabo PHENOXYPROPANOLAMINES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
WO2001043744A1 (en) 1999-12-17 2001-06-21 Sanofi-Synthelabo Phenoxypropanolamines, method for producing them and pharmaceutical compositions containing them
US6509358B2 (en) 2000-07-17 2003-01-21 Wyeth Piperidino-phenyl amino squarate and thiadiazole dioxide beta-3 adrenergic receptor agonists
US6458817B1 (en) 2000-07-17 2002-10-01 Wyeth Substituted arylsulfides, arylsulfoxides and arylsulfones as beta-3 adrenergic receptor agonists
US6395762B1 (en) 2000-07-17 2002-05-28 American Home Products Corporation Phenyl amino squarate and thiadiazole dioxide beta-3 adrenergic receptor agonists
US6444685B1 (en) 2000-07-17 2002-09-03 Wyeth N-(4-sulfonylaryl)Cyclylamine 2-hydroxyethylamines as beta-3 adrenergic receptor agonists
US6537994B2 (en) 2000-07-17 2003-03-25 Wyeth Heterocyclic β3 adrenergic receptor agonists
US6451814B1 (en) 2000-07-17 2002-09-17 Wyeth Heterocyclic β-3 adrenergic receptor agonists
US6514991B2 (en) 2000-07-17 2003-02-04 Wyeth Phenyl-oxo-tetrahydroquinolin-3-yl beta-3 adrenergic receptor agonists
US6465501B2 (en) 2000-07-17 2002-10-15 Wyeth Azolidines as β3 adrenergic receptor agonists
US6410734B1 (en) 2000-07-17 2002-06-25 Wyeth 2-substituted thiazolidinones as beta-3 adrenergic receptor agonists
US6506901B2 (en) 2000-07-17 2003-01-14 Wyeth Substituted 2-(S)-hydroxy-3-(piperidin-4-yl-methylamino)-propyl ethers and substituted 2-aryl-2-(R)-hydroxy-1-(piperidin-4-yl-methyl)-ethylamine β-3 adrenergic receptor agonists
US6525202B2 (en) 2000-07-17 2003-02-25 Wyeth Cyclic amine phenyl beta-3 adrenergic receptor agonists

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2163150A (en) * 1984-07-19 1986-02-19 Sandoz Ltd 3-Aminopropoxyaryl derivatives
WO1995029159A1 (en) * 1994-04-26 1995-11-02 Merck & Co., Inc. SUBSTITUTED SULFONAMIDES AS SELECTIVE β3 AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY
EP0940387A1 (en) * 1995-10-26 1999-09-08 Tokyo Tanabe Company Limited Phenylethanolamine compounds useful as beta3 agonist, process for producing the same, and intermediates in the production of the same
EP0801060A1 (en) * 1996-04-09 1997-10-15 Pfizer Inc. Heterocyclic Beta-3 Adrenergenic Agonists
WO1997046556A1 (en) * 1996-06-07 1997-12-11 Merck & Co., Inc. OXADIAZOLE BENZENESULFONAMIDES AS SELECTIVE β3 AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY
EP0827746A1 (en) * 1996-09-05 1998-03-11 Eli Lilly And Company Carbazole analogues as selective B3 adrenergic agonists
WO1998022480A1 (en) * 1996-11-18 1998-05-28 Smithkline Beecham Plc Phosphorus containing aryloxy or arylthio propanolamine derivatives
WO1998032753A1 (en) * 1997-01-28 1998-07-30 Merck & Co., Inc. THIAZOLE BENZENESULFONAMIDES AS β3 AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY
FR2780057A1 (en) * 1998-06-18 1999-12-24 Sanofi Sa PHENOXYPROPANOLAMINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
FR2798126A1 (en) * 1999-09-08 2001-03-09 Sanofi Synthelabo HETEROARYLOXYPROPANOLAMINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Also Published As

Publication number Publication date
CA2416667A1 (en) 2002-01-24
AR032466A1 (en) 2003-11-12
WO2002006221A2 (en) 2002-01-24
BR0112582A (en) 2003-05-20
US20030027797A1 (en) 2003-02-06
EP1328512A2 (en) 2003-07-23
AU2002222929A1 (en) 2002-01-30
US6649603B2 (en) 2003-11-18
CN1455769A (en) 2003-11-12
JP2004504296A (en) 2004-02-12
US6498170B2 (en) 2002-12-24
MXPA03000450A (en) 2003-06-06
US20020022605A1 (en) 2002-02-21

Similar Documents

Publication Publication Date Title
WO2002006221A3 (en) Cyclylamine sulfonamides as beta-3 adrenergic receptor agonists
EP1630157A4 (en) CaSR ANTAGONIST
WO2004048345A3 (en) 2,5-diketopiperazines for the treatment of obesity
AP1614A (en) New heterocyclic compounds, their preparation and their use as medicaments, in particular as anti-bacterial agents.
WO2000054765A8 (en) Method of treating eating disorders
WO2002100860A3 (en) Heterocyclic compounds, method for preparing same and use thereof as medicines, in particular as anti-bacterial agents
MXPA04001500A (en) Compounds effecting glucokinase.
CA2382480A1 (en) Glucopyranosyloxypyrazole derivatives, medicinal compositions containing the same and intermediates in the production thereof
CA2429844A1 (en) Mch antagonists and their use in the treatment of obesity
WO2004106279A3 (en) CRYSTALLINE FORM OF β2 ADRENERGIC RECEPTOR AGONIST
BR0307351A (en) Compound, pharmaceutical composition, method for treating a p38 kinase activity-mediated or cytokine-mediated condition or condition produced by p38 kinase activity, use of a compound, and process for preparing a compound
WO2003093269A3 (en) Substituted pyrazolo-pyrimidine-4-ones
WO2005121097A3 (en) Pyrazole derivatives, compositions containing such compounds and methods of use
EP1741712A3 (en) Nebivolol and its pharmaceutically acceptable salts, process for preparation and pharmaceutical compositions of Nebivolol
AU2003229772A1 (en) Derivatives of 2-(1-benzyl-1h-pyrazolo (3, 4-b)pyridine-3yl) -5-(4-pyridinyl)-4-pyrimidine amine and the use thereof as guanylate cyclase stimulators
SE0201544D0 (en) Novel compounds and thier use
WO2003024928A3 (en) Novel aminoazetidine, -pyrrolidine and -piperidine derivatives
HK1155146A1 (en) Indene derivatives as pharmaceutical agents
WO2003014079A8 (en) Stable polymorph of flibanserin, technical process for its preparation and the use thereof for preparing medicaments
WO2006027798A3 (en) A process for preparation of an antidepressant compound
TW200505823A (en) CaSR antagonist
AU2003239389A1 (en) Opioid receptor antagonists
WO2005058890A3 (en) Hydronopol derivatives as agonists on human orl1 receptors
PT1222159E (en) INTERMEDIARIES FOR THE MANUFACTURE OF A BENZOFURAN OR BENZOYOPHENE TYPE DERIVED NITRATED IN POSITION 5 AND ITS UTILIZATIONS
WO2003053971A8 (en) Pyridoquinoxaline antivirals

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

ENP Entry into the national phase

Ref document number: 2002 2002126611

Country of ref document: RU

Kind code of ref document: A

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWE Wipo information: entry into national phase

Ref document number: 2001984233

Country of ref document: EP

Ref document number: 2416667

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: PA/a/2003/000450

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 018155014

Country of ref document: CN

WWP Wipo information: published in national office

Ref document number: 2001984233

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 2001984233

Country of ref document: EP