TR200003220T2 - İyi huylu prostat hiperplasianın tedavisinde yararlı olan yeni sübstitüe edilmiş piridino arilpiperazinler - Google Patents

İyi huylu prostat hiperplasianın tedavisinde yararlı olan yeni sübstitüe edilmiş piridino arilpiperazinler

Info

Publication number
TR200003220T2
TR200003220T2 TR2000/03220T TR200003220T TR200003220T2 TR 200003220 T2 TR200003220 T2 TR 200003220T2 TR 2000/03220 T TR2000/03220 T TR 2000/03220T TR 200003220 T TR200003220 T TR 200003220T TR 200003220 T2 TR200003220 T2 TR 200003220T2
Authority
TR
Turkey
Prior art keywords
treatment
benign prostatic
prostatic hyperplasia
newly substituted
substituted pyridino
Prior art date
Application number
TR2000/03220T
Other languages
English (en)
Inventor
Kuo Gee-Hong
V. Murray William
P. Prouty Catherine
Original Assignee
Ortho-Mcneil Pharmaceutical, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho-Mcneil Pharmaceutical, Inc. filed Critical Ortho-Mcneil Pharmaceutical, Inc.
Publication of TR200003220T2 publication Critical patent/TR200003220T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Bu bulus Formül I'nin heterosiklik sübstitüe edilmis piperazin türevlerinin bir serisi, tedavi yöntemleri, bunlari içeren farmasötik bilesimler ve bunlarin yapiminda kullanilan ara-bilesiklerle ilgilidir. Bulusun bilesikleri seçici olarak iyi huylu prostat hiperplasiada mevcut olan bir reseptör olan alfa1a adrenerjik reseptörüne baglanmayi inhibe eder. Dolayisiyla bilesikler bu hastaligin tedavisinde potansiyel olarak yararlidir.
TR2000/03220T 1998-02-20 1999-02-19 İyi huylu prostat hiperplasianın tedavisinde yararlı olan yeni sübstitüe edilmiş piridino arilpiperazinler TR200003220T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7532198P 1998-02-20 1998-02-20

Publications (1)

Publication Number Publication Date
TR200003220T2 true TR200003220T2 (tr) 2001-04-20

Family

ID=22124955

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/03220T TR200003220T2 (tr) 1998-02-20 1999-02-19 İyi huylu prostat hiperplasianın tedavisinde yararlı olan yeni sübstitüe edilmiş piridino arilpiperazinler

Country Status (24)

Country Link
US (1) US6218396B1 (tr)
EP (1) EP1054868B1 (tr)
JP (1) JP2002503724A (tr)
KR (1) KR100591028B1 (tr)
CN (1) CN1121390C (tr)
AR (1) AR014626A1 (tr)
AT (1) ATE250580T1 (tr)
AU (1) AU766398B2 (tr)
BR (1) BR9909647A (tr)
CZ (1) CZ294136B6 (tr)
DE (1) DE69911582T2 (tr)
DK (1) DK1054868T3 (tr)
ES (1) ES2209468T3 (tr)
HK (1) HK1030776A1 (tr)
HU (1) HUP0100781A3 (tr)
IL (2) IL137954A0 (tr)
NO (1) NO317103B1 (tr)
NZ (1) NZ506462A (tr)
PL (1) PL342339A1 (tr)
PT (1) PT1054868E (tr)
TR (1) TR200003220T2 (tr)
TW (1) TW565555B (tr)
WO (1) WO1999042448A1 (tr)
ZA (1) ZA991315B (tr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1515556A (zh) * 1997-05-12 2004-07-28 ����-������ҩƷ��˾ 用以制备芳基取代哌嗪的中间体化合物
WO2002012190A2 (en) 2000-08-08 2002-02-14 Ortho Mcneil Pharmaceutical, Inc. Non-imidazole aryloxypiperidines as h3 receptor ligands
MXPA04006344A (es) * 2001-12-28 2005-03-31 Takeda Pharmaceutical Preventivos/remedios para la perturbacion de miccion.
WO2008050732A1 (fr) * 2006-10-23 2008-05-02 Takeda Pharmaceutical Company Limited Dérivé de l'iminopyridine et son utilisation
UY31781A (es) * 2008-04-23 2009-12-14 Takeda Pharmaceutical Derivados de iminopiridina y su uso
US20110039892A1 (en) * 2008-04-23 2011-02-17 Takeda Pharmaceutical Company Limited Iminopyridine derivative and use thereof
US8481569B2 (en) 2008-04-23 2013-07-09 Takeda Pharmaceutical Company Limited Iminopyridine derivatives and use thereof
CN103980195A (zh) * 2014-04-28 2014-08-13 广州医科大学 酰胺类苯基哌嗪衍生物及其盐与在制备治疗良性前列腺增生症药物中的应用
CN108530391B (zh) * 2018-05-17 2022-05-17 袁牧 一种酰胺类芳基哌嗪衍生物及其制备方法与应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2027898A6 (es) * 1991-01-24 1992-06-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados de la 2-metoxifenilpiperacina.
US5403847A (en) 1992-11-13 1995-04-04 Synaptic Pharmaceutical Corporation Use of α1C specific compounds to treat benign prostatic hyperlasia
IT1266582B1 (it) * 1993-07-30 1997-01-09 Recordati Chem Pharm Derivati (di)azacicloesanici e diazacicloeptanici
DE4425146A1 (de) * 1994-07-15 1996-01-18 Basf Ag Verwendung heterocyclischer Verbindungen
US5688795A (en) * 1994-11-08 1997-11-18 Syntex (U.S.A.) Inc. 3-(4-phenylpiperazin-1-yl)propyl-amino, thio and oxy!-pyridine, pyrimidine and benzene derivatives as α1 -adrenoceptor antagonists
WO1999003833A1 (en) * 1997-07-15 1999-01-28 Sankyo Company, Limited Piperazine derivatives

Also Published As

Publication number Publication date
EP1054868A1 (en) 2000-11-29
BR9909647A (pt) 2000-11-21
ZA991315B (en) 2000-11-20
CZ20003044A3 (cs) 2001-04-11
TW565555B (en) 2003-12-11
NO317103B1 (no) 2004-08-09
IL137954A (en) 2007-06-03
AU766398B2 (en) 2003-10-16
EP1054868B1 (en) 2003-09-24
DE69911582D1 (de) 2003-10-30
AU3302599A (en) 1999-09-06
DE69911582T2 (de) 2005-09-15
HUP0100781A2 (hu) 2001-08-28
KR20010041115A (ko) 2001-05-15
PL342339A1 (en) 2001-06-04
HUP0100781A3 (en) 2002-12-28
KR100591028B1 (ko) 2006-06-22
NZ506462A (en) 2003-07-25
NO20004141L (no) 2000-10-19
HK1030776A1 (en) 2001-05-18
NO20004141D0 (no) 2000-08-18
JP2002503724A (ja) 2002-02-05
CZ294136B6 (cs) 2004-10-13
WO1999042448A1 (en) 1999-08-26
AR014626A1 (es) 2001-03-28
IL137954A0 (en) 2001-10-31
CN1121390C (zh) 2003-09-17
DK1054868T3 (da) 2003-12-22
US6218396B1 (en) 2001-04-17
PT1054868E (pt) 2004-01-30
ATE250580T1 (de) 2003-10-15
CN1291188A (zh) 2001-04-11
ES2209468T3 (es) 2004-06-16

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