AR013222A1 - Derivados de 3-oxadiazolil-1,6-naftiridin-2(1h)-ona-5-sustituidos; compuestos intermedios utiles en la preparacion de dichos derivados; composiciones farmaceuticas que comprenden dichos derivados y medicamentos capaces de actuar sobre receptores de benzodiacepinas que incluyen dichos derivados. - Google Patents
Derivados de 3-oxadiazolil-1,6-naftiridin-2(1h)-ona-5-sustituidos; compuestos intermedios utiles en la preparacion de dichos derivados; composiciones farmaceuticas que comprenden dichos derivados y medicamentos capaces de actuar sobre receptores de benzodiacepinas que incluyen dichos derivados.Info
- Publication number
- AR013222A1 AR013222A1 ARP980103452A ARP980103452A AR013222A1 AR 013222 A1 AR013222 A1 AR 013222A1 AR P980103452 A ARP980103452 A AR P980103452A AR P980103452 A ARP980103452 A AR P980103452A AR 013222 A1 AR013222 A1 AR 013222A1
- Authority
- AR
- Argentina
- Prior art keywords
- derivatives
- substituted
- intermediate compounds
- oxadiazolil
- benzodiacepine
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Se trata de derivados 5-sustituído-3-oxadiazolil-1,6-naftiridin-2(1H)-ona de la formula I; en la cual Het es oxadiazolico, R1 es H, alquilo inferior,alquilo ciclo-inferior, trifluorometilo, alquenilo inferior, alquinilo inferior alcoxi inferior,al quilo alcoxi-inferior inferior, alquilo hidroxi-inferior,arilo sustituído o no sustituído, grupo heteroaromático sustituído o no sustituído, y R2 es H, alquilo inferior, alquilo ciclo-inferior, alquilmetilociclo-inferior, alqueniloinferior, alquenilo ciclo-inferior, alquinilo inferior, arilo sustituído o no sustituído, o grupo heteroaromático sustituídoo no sustituído, o una sal de adicion de ácido parmacéuticamente aceptable del mismo agonista inverso de labenzodiacepina, por ejemplo, como drogapsicoanaléptica o como droga para el tratamiento de dismencia senil o el mal de Alzheimer. También se preparan compuestos intermediarios para la síntesis dedichos derivados y composiciones y drogas queincluyen dichos derivados
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20717997 | 1997-07-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR013222A1 true AR013222A1 (es) | 2000-12-13 |
Family
ID=16535559
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980103452A AR013222A1 (es) | 1997-07-15 | 1998-07-15 | Derivados de 3-oxadiazolil-1,6-naftiridin-2(1h)-ona-5-sustituidos; compuestos intermedios utiles en la preparacion de dichos derivados; composiciones farmaceuticas que comprenden dichos derivados y medicamentos capaces de actuar sobre receptores de benzodiacepinas que incluyen dichos derivados. |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US6172079B1 (es) |
| EP (1) | EP1010699B1 (es) |
| JP (1) | JP3390453B2 (es) |
| KR (1) | KR100508392B1 (es) |
| CN (1) | CN1134437C (es) |
| AR (1) | AR013222A1 (es) |
| AT (1) | ATE297923T1 (es) |
| AU (1) | AU735960B2 (es) |
| BR (1) | BR9811474B1 (es) |
| CA (1) | CA2296427C (es) |
| DE (1) | DE69830595T2 (es) |
| DK (1) | DK1010699T3 (es) |
| EE (1) | EE04372B1 (es) |
| ES (1) | ES2244065T3 (es) |
| HK (1) | HK1028895A1 (es) |
| HU (1) | HUP0004671A3 (es) |
| ID (1) | ID24047A (es) |
| IL (2) | IL133512A0 (es) |
| NO (1) | NO314999B1 (es) |
| NZ (1) | NZ501814A (es) |
| PL (1) | PL191200B1 (es) |
| PT (1) | PT1010699E (es) |
| RU (1) | RU2188199C2 (es) |
| SI (1) | SI1010699T1 (es) |
| SK (1) | SK285913B6 (es) |
| TR (1) | TR200000103T2 (es) |
| TW (1) | TW486479B (es) |
| WO (1) | WO1999003857A1 (es) |
| ZA (1) | ZA985870B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI298068B (en) * | 2000-06-21 | 2008-06-21 | Dainippon Sumitomo Pharma Co | Pharmaceutical composition for schizophrenia |
| TW200533371A (en) * | 2004-04-15 | 2005-10-16 | Dainippon Pharmaceutical Co | Medicament comprising a combination of an acetylcholinesterase inhibitor and a 5-substituted-3-oxadiazolyl-1,6-naphthyridin-2(1h)-one derivative |
| CN101541311B (zh) | 2006-10-25 | 2013-01-23 | 大日本住友制药株式会社 | 不易结块的颗粒制剂 |
| MX2010009207A (es) * | 2008-02-22 | 2011-03-03 | Irm Llc | Compuestos y composiciones heterociclicos como inhibidores de c-kit y pdgfr cinasa. |
| WO2010002451A1 (en) * | 2008-07-01 | 2010-01-07 | Concert Pharmaceuticals, Inc. | Naphthyridin derivatives |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4415580A (en) | 1982-08-02 | 1983-11-15 | Sterling Drug Inc. | Certain 2-(1H)-pyridinones cardiotonic compositions containing same and method of using same |
| US4650806A (en) * | 1985-01-14 | 1987-03-17 | Sterling Drug Inc. | Cardiotonic 5-(heterylcarbonyl)-pyridones |
| US4567186A (en) * | 1985-01-14 | 1986-01-28 | Sterling Drug Inc. | 5-Heteryl-1,6-naphthyridin-2(1H)-ones, cardiotonic use thereof and intermediates therefor |
| DK151890D0 (da) * | 1990-06-22 | 1990-06-22 | Ferrosan As | Heterocykliske forbindelser deres fremstilling og brug |
| AU1625192A (en) * | 1991-05-31 | 1992-12-03 | Zeneca Limited | Heterocyclic derivatives |
| AU664912B2 (en) * | 1992-09-02 | 1995-12-07 | Dainippon Pharmaceutical Co. Ltd. | Novel 3-oxadiazolyl-1,6-naphthyridine derivatives |
| JP2002241379A (ja) * | 1997-03-21 | 2002-08-28 | Dainippon Pharmaceut Co Ltd | ３−オキサジアゾリルキノキサリン誘導体 |
-
1998
- 1998-07-03 TW TW087110767A patent/TW486479B/zh not_active IP Right Cessation
- 1998-07-03 ZA ZA985870A patent/ZA985870B/xx unknown
- 1998-07-14 TR TR2000/00103T patent/TR200000103T2/xx unknown
- 1998-07-14 PT PT98931076T patent/PT1010699E/pt unknown
- 1998-07-14 WO PCT/JP1998/003134 patent/WO1999003857A1/ja active IP Right Grant
- 1998-07-14 AT AT98931076T patent/ATE297923T1/de not_active IP Right Cessation
- 1998-07-14 AU AU81294/98A patent/AU735960B2/en not_active Ceased
- 1998-07-14 JP JP50689699A patent/JP3390453B2/ja not_active Expired - Fee Related
- 1998-07-14 NZ NZ501814A patent/NZ501814A/en unknown
- 1998-07-14 EP EP98931076A patent/EP1010699B1/en not_active Expired - Lifetime
- 1998-07-14 ID IDW991683A patent/ID24047A/id unknown
- 1998-07-14 ES ES98931076T patent/ES2244065T3/es not_active Expired - Lifetime
- 1998-07-14 BR BRPI9811474-3A patent/BR9811474B1/pt not_active IP Right Cessation
- 1998-07-14 US US09/462,412 patent/US6172079B1/en not_active Expired - Fee Related
- 1998-07-14 HU HU0004671A patent/HUP0004671A3/hu unknown
- 1998-07-14 KR KR10-2000-7000388A patent/KR100508392B1/ko not_active IP Right Cessation
- 1998-07-14 RU RU2000103445/04A patent/RU2188199C2/ru not_active IP Right Cessation
- 1998-07-14 EE EEP200000029A patent/EE04372B1/xx not_active IP Right Cessation
- 1998-07-14 CN CNB988072262A patent/CN1134437C/zh not_active Expired - Fee Related
- 1998-07-14 DK DK98931076T patent/DK1010699T3/da active
- 1998-07-14 IL IL13351298A patent/IL133512A0/xx active IP Right Grant
- 1998-07-14 CA CA002296427A patent/CA2296427C/en not_active Expired - Fee Related
- 1998-07-14 SI SI9830774T patent/SI1010699T1/xx unknown
- 1998-07-14 SK SK53-2000A patent/SK285913B6/sk not_active IP Right Cessation
- 1998-07-14 PL PL338085A patent/PL191200B1/pl not_active IP Right Cessation
- 1998-07-14 DE DE69830595T patent/DE69830595T2/de not_active Expired - Fee Related
- 1998-07-15 AR ARP980103452A patent/AR013222A1/es active IP Right Grant
-
1999
- 1999-12-14 IL IL133512A patent/IL133512A/en not_active IP Right Cessation
-
2000
- 2000-01-14 NO NO20000183A patent/NO314999B1/no not_active IP Right Cessation
- 2000-09-01 US US09/654,782 patent/US6277993B1/en not_active Expired - Fee Related
- 2000-12-21 HK HK00108261A patent/HK1028895A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
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| FG | Grant, registration |