AR003488A1 - Un metodo para la produccion de magnesio piridoxal-5'-fosfato glutamato y un metodo para la produccion del producto intermediario piridoxal 5' fosfato. - Google Patents
Un metodo para la produccion de magnesio piridoxal-5'-fosfato glutamato y un metodo para la produccion del producto intermediario piridoxal 5' fosfato.Info
- Publication number
- AR003488A1 AR003488A1 ARP960104206A AR10420696A AR003488A1 AR 003488 A1 AR003488 A1 AR 003488A1 AR P960104206 A ARP960104206 A AR P960104206A AR 10420696 A AR10420696 A AR 10420696A AR 003488 A1 AR003488 A1 AR 003488A1
- Authority
- AR
- Argentina
- Prior art keywords
- phosphate
- pyridoxal
- production
- piridoxal
- magnesium
- Prior art date
Links
- RADKZDMFGJYCBB-UHFFFAOYSA-N Pyridoxal Chemical compound CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 title abstract 3
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 title abstract 2
- 239000013067 intermediate product Substances 0.000 title abstract 2
- 229910052749 magnesium Inorganic materials 0.000 title abstract 2
- 239000011777 magnesium Substances 0.000 title abstract 2
- 229910019142 PO4 Inorganic materials 0.000 title 2
- 239000010452 phosphate Substances 0.000 title 2
- 229930195712 glutamate Natural products 0.000 title 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 title 1
- 239000011589 pyridoxal 5'-phosphate Substances 0.000 abstract 5
- 229960001327 pyridoxal phosphate Drugs 0.000 abstract 5
- 229960003581 pyridoxal Drugs 0.000 abstract 4
- 239000011674 pyridoxal Substances 0.000 abstract 4
- 235000007682 pyridoxal 5'-phosphate Nutrition 0.000 abstract 3
- NGVDGCNFYWLIFO-UHFFFAOYSA-N pyridoxal 5'-phosphate Chemical compound CC1=NC=C(COP(O)(O)=O)C(C=O)=C1O NGVDGCNFYWLIFO-UHFFFAOYSA-N 0.000 abstract 3
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 229940063286 magnesium pyridoxal 5-phosphate glutamate Drugs 0.000 abstract 2
- NUJOXMJBOLGQSY-UHFFFAOYSA-N manganese dioxide Chemical compound O=[Mn]=O NUJOXMJBOLGQSY-UHFFFAOYSA-N 0.000 abstract 2
- BHGSMEHRLYVYEI-ZPFSJBFKSA-D pentamagnesium (2S)-2-[[2-methyl-3-oxido-5-(phosphonatooxymethyl)pyridin-4-yl]methylideneamino]pentanedioate Chemical compound CC1=NC=C(C(=C1[O-])C=N[C@@H](CCC(=O)[O-])C(=O)[O-])COP(=O)([O-])[O-].CC1=NC=C(C(=C1[O-])C=N[C@@H](CCC(=O)[O-])C(=O)[O-])COP(=O)([O-])[O-].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2] BHGSMEHRLYVYEI-ZPFSJBFKSA-D 0.000 abstract 2
- 235000008164 pyridoxal Nutrition 0.000 abstract 2
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 abstract 2
- 239000002262 Schiff base Substances 0.000 abstract 1
- 150000004753 Schiff bases Chemical class 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 229910001413 alkali metal ion Inorganic materials 0.000 abstract 1
- -1 alkali metal salt Chemical class 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 229960002989 glutamic acid Drugs 0.000 abstract 1
- 235000008160 pyridoxine Nutrition 0.000 abstract 1
- 239000011677 pyridoxine Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940011671 vitamin b6 Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
- C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyridine Compounds (AREA)
Abstract
La invención se refiere a un método para la producción de magnesio piridoxal-5-fosfato glutamato, en donde piridoxina o una sal de adición deácido de la misma es oxidada con óxido de manganeso (IV) a piridoxal; piridoxal se hace reaccionar c on p-fenetidina con formación de la base de Schiff p-piridoxal; el p-fenetidil-piridoxal es fosforilado selectivamente en el grupo 5-hidroximetilo con formación de p-fenetidil-piridoxal-5-fosfato; p-fenetidil-piridoxal-5-fosfato es hidrolizado conformación de una sal de metal alcalino del piridoxal-5-fosfato; los iones de metal alcalino son retirados paraobtener piridoxal-5-fosfato; piridoxal-5-fosfato se hace reaccionar con un producto de reacción de un alcoholato de magnesio y ácido L-gl utámico; y seaisla el magnesio piridoxal-5-fosfato glutamato. Además, la invención se refiere a productos intermediarios obtenidos con este método.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19532625A DE19532625C2 (de) | 1995-09-04 | 1995-09-04 | Verfahren zur Herstellung von Magnesium-pyridoxal-5'-phosphat-glutamat und dabei erhaltene Zwischenprodukte |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR003488A1 true AR003488A1 (es) | 1998-08-05 |
Family
ID=7771233
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960104206A AR003488A1 (es) | 1995-09-04 | 1996-09-03 | Un metodo para la produccion de magnesio piridoxal-5'-fosfato glutamato y un metodo para la produccion del producto intermediario piridoxal 5' fosfato. |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5962687A (es) |
| EP (1) | EP0861258B1 (es) |
| JP (1) | JPH11512103A (es) |
| KR (1) | KR19990044359A (es) |
| CN (1) | CN1199402A (es) |
| AR (1) | AR003488A1 (es) |
| AT (1) | ATE209210T1 (es) |
| AU (1) | AU706162B2 (es) |
| BA (1) | BA96127A (es) |
| CA (1) | CA2230555A1 (es) |
| CO (1) | CO4750659A1 (es) |
| CZ (1) | CZ292662B6 (es) |
| DE (2) | DE19532625C2 (es) |
| DK (1) | DK0861258T3 (es) |
| EG (1) | EG20974A (es) |
| ES (1) | ES2165521T3 (es) |
| HK (1) | HK1014958A1 (es) |
| HR (1) | HRP960401B1 (es) |
| HU (1) | HUP9802778A3 (es) |
| JO (1) | JO1921B1 (es) |
| NZ (1) | NZ318374A (es) |
| PL (1) | PL325333A1 (es) |
| PT (1) | PT861258E (es) |
| TW (1) | TW442472B (es) |
| WO (1) | WO1997009334A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050288258A1 (en) * | 2002-04-23 | 2005-12-29 | Diana Guy D | Compounds, compositions and methods for treating or preventing viral infections and associated diseases |
| EP2224925B1 (en) * | 2007-12-14 | 2015-09-09 | Pledpharma AB | Compounds for use in the treatment of cancer |
| CN106946932A (zh) * | 2017-03-21 | 2017-07-14 | 上海津力生物科技股份有限公司 | 一种吡哆醛‑5‑磷酸酯的制备方法 |
| CN108976259A (zh) * | 2017-06-01 | 2018-12-11 | 上海凯赛生物技术研发中心有限公司 | 一种磷酸吡哆醛的合成方法 |
| CN107652323A (zh) * | 2017-09-20 | 2018-02-02 | 精晶药业股份有限公司 | 一种磷酸吡哆醛的合成方法 |
| CN108754160B (zh) * | 2018-07-26 | 2020-05-08 | 江苏理工学院 | 一种吡哆醛含锰废水的回收利用方法 |
| CN110016049A (zh) * | 2019-03-18 | 2019-07-16 | 武汉工程大学 | 一种磷酸吡哆醛的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3663557A (en) * | 1966-06-08 | 1972-05-16 | Kogerim Ets | Biologically active forms of pyridoxine coenzymes |
| US3854559A (en) * | 1973-10-01 | 1974-12-17 | Deere & Co | Control system for a hydraulically-operable brake and transmission |
| ES421396A3 (es) * | 1973-12-12 | 1976-04-16 | Vila Busquets | Procedimiento para la fabricacion del fosfato de piridoxal. |
| DE2461742C2 (de) * | 1974-12-28 | 1983-01-27 | Steigerwald Arzneimittelwerk Gmbh, 6100 Darmstadt | Pyridoxin-5'-phosphorsäureester-Derivate sowie deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| DE4016963A1 (de) * | 1990-05-25 | 1991-11-28 | Steigerwald Arzneimittelwerk | Verwendung von magnesium-pyridoxal-5'-phosphat-glutaminat zur verhinderung von erkrankungen, die sich infolge von gefaessschaeden ergeben |
-
1995
- 1995-09-04 DE DE19532625A patent/DE19532625C2/de not_active Expired - Fee Related
-
1996
- 1996-08-26 CN CN96197528A patent/CN1199402A/zh active Pending
- 1996-08-26 JP JP9510820A patent/JPH11512103A/ja active Pending
- 1996-08-26 EP EP96930965A patent/EP0861258B1/en not_active Expired - Lifetime
- 1996-08-26 PT PT96930965T patent/PT861258E/pt unknown
- 1996-08-26 NZ NZ318374A patent/NZ318374A/xx unknown
- 1996-08-26 PL PL96325333A patent/PL325333A1/xx unknown
- 1996-08-26 CA CA002230555A patent/CA2230555A1/en not_active Abandoned
- 1996-08-26 DE DE69617261T patent/DE69617261T2/de not_active Expired - Fee Related
- 1996-08-26 CZ CZ1998591A patent/CZ292662B6/cs not_active IP Right Cessation
- 1996-08-26 ES ES96930965T patent/ES2165521T3/es not_active Expired - Lifetime
- 1996-08-26 AT AT96930965T patent/ATE209210T1/de not_active IP Right Cessation
- 1996-08-26 AU AU69845/96A patent/AU706162B2/en not_active Ceased
- 1996-08-26 KR KR1019980701601A patent/KR19990044359A/ko not_active Application Discontinuation
- 1996-08-26 US US09/029,426 patent/US5962687A/en not_active Expired - Fee Related
- 1996-08-26 HU HU9802778A patent/HUP9802778A3/hu unknown
- 1996-08-26 DK DK96930965T patent/DK0861258T3/da active
- 1996-08-26 WO PCT/EP1996/003749 patent/WO1997009334A1/en active IP Right Grant
- 1996-08-30 BA BA960127A patent/BA96127A/bs unknown
- 1996-08-31 EG EG79496A patent/EG20974A/xx active
- 1996-09-02 JO JO19961921A patent/JO1921B1/en active
- 1996-09-03 HR HR960401A patent/HRP960401B1/xx not_active IP Right Cessation
- 1996-09-03 TW TW085110753A patent/TW442472B/zh not_active IP Right Cessation
- 1996-09-03 AR ARP960104206A patent/AR003488A1/es active IP Right Grant
- 1996-09-04 CO CO96047151A patent/CO4750659A1/es unknown
-
1999
- 1999-01-04 HK HK99100006A patent/HK1014958A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE19532625A1 (de) | 1997-03-06 |
| AU706162B2 (en) | 1999-06-10 |
| US5962687A (en) | 1999-10-05 |
| PT861258E (pt) | 2002-05-31 |
| JO1921B1 (en) | 1997-01-15 |
| HRP960401B1 (en) | 2001-10-31 |
| EP0861258B1 (en) | 2001-11-21 |
| DE69617261D1 (de) | 2002-01-03 |
| DE69617261T2 (de) | 2002-05-08 |
| EP0861258A1 (en) | 1998-09-02 |
| HUP9802778A2 (hu) | 1999-09-28 |
| CZ59198A3 (cs) | 1998-07-15 |
| HUP9802778A3 (en) | 2001-02-28 |
| DK0861258T3 (da) | 2002-05-21 |
| HK1014958A1 (en) | 1999-10-08 |
| HRP960401A2 (en) | 1998-02-28 |
| DE19532625C2 (de) | 2000-04-20 |
| JPH11512103A (ja) | 1999-10-19 |
| WO1997009334A1 (en) | 1997-03-13 |
| PL325333A1 (en) | 1998-07-20 |
| BA96127A (bs) | 1998-12-28 |
| KR19990044359A (ko) | 1999-06-25 |
| TW442472B (en) | 2001-06-23 |
| AU6984596A (en) | 1997-03-27 |
| NZ318374A (en) | 1999-06-29 |
| EG20974A (en) | 2000-08-30 |
| ES2165521T3 (es) | 2002-03-16 |
| ATE209210T1 (de) | 2001-12-15 |
| CO4750659A1 (es) | 1999-03-31 |
| CN1199402A (zh) | 1998-11-18 |
| CA2230555A1 (en) | 1997-03-13 |
| CZ292662B6 (cs) | 2003-11-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |