AP750A - Method for preparing 4,10-diacetoxy-2a-benzoyloxy-5b, 20-epoxy-1, 7b-dihydroxy-9-oxo-tax-11-en-13a-y) (2r,3s) -3-benzoylamono-2-hydroxy-3-Phenylpropionate trihydrate. - Google Patents

Method for preparing 4,10-diacetoxy-2a-benzoyloxy-5b, 20-epoxy-1, 7b-dihydroxy-9-oxo-tax-11-en-13a-y) (2r,3s) -3-benzoylamono-2-hydroxy-3-Phenylpropionate trihydrate. Download PDF

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Publication number
AP750A
AP750A APAP/P/1997/001035A AP9701035A AP750A AP 750 A AP750 A AP 750A AP 9701035 A AP9701035 A AP 9701035A AP 750 A AP750 A AP 750A
Authority
AP
ARIPO
Prior art keywords
hydroxy
diacetoxy
benzoyloxy
dihydroxy
epoxy
Prior art date
Application number
APAP/P/1997/001035A
Other languages
English (en)
Other versions
AP9701035A0 (en
Inventor
Jean Rean Authelin
Eric Didier
Franck Leveiller
Isabelle Tailepied
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of AP9701035A0 publication Critical patent/AP9701035A0/xx
Application granted granted Critical
Publication of AP750A publication Critical patent/AP750A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
APAP/P/1997/001035A 1995-01-25 1996-01-23 Method for preparing 4,10-diacetoxy-2a-benzoyloxy-5b, 20-epoxy-1, 7b-dihydroxy-9-oxo-tax-11-en-13a-y) (2r,3s) -3-benzoylamono-2-hydroxy-3-Phenylpropionate trihydrate. AP750A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9500816A FR2729666A1 (fr) 1995-01-25 1995-01-25 Procede de preparation du trihydrate du (2r, 3s)- benzoylamino-2-hydroxy-3-phenylpropionate de 4,10-diacetoxy- 2alpha-benzoyloxy-5beta,20-epoxy-1,7beta-dihydroxy-9-oxo- tax-11-en-13alpha-yle

Publications (2)

Publication Number Publication Date
AP9701035A0 AP9701035A0 (en) 1997-07-31
AP750A true AP750A (en) 1999-07-06

Family

ID=9475464

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1997/001035A AP750A (en) 1995-01-25 1996-01-23 Method for preparing 4,10-diacetoxy-2a-benzoyloxy-5b, 20-epoxy-1, 7b-dihydroxy-9-oxo-tax-11-en-13a-y) (2r,3s) -3-benzoylamono-2-hydroxy-3-Phenylpropionate trihydrate.

Country Status (43)

Country Link
US (1) US6002022A (fr)
EP (1) EP0805806B1 (fr)
JP (1) JP3782449B2 (fr)
KR (1) KR100384773B1 (fr)
CN (1) CN1067997C (fr)
AP (1) AP750A (fr)
AT (1) ATE187719T1 (fr)
AU (1) AU707603B2 (fr)
BG (1) BG62769B1 (fr)
BR (1) BR9606853A (fr)
CO (1) CO4700286A1 (fr)
CZ (1) CZ287079B6 (fr)
DE (1) DE69605651T2 (fr)
DK (1) DK0805806T3 (fr)
DZ (1) DZ1977A1 (fr)
EE (1) EE03396B1 (fr)
ES (1) ES2139332T3 (fr)
FI (1) FI119245B (fr)
FR (1) FR2729666A1 (fr)
GE (1) GEP19991833B (fr)
GR (1) GR3032110T3 (fr)
HU (1) HU223352B1 (fr)
IL (1) IL116903A (fr)
IN (1) IN184427B (fr)
IS (1) IS2033B (fr)
MA (1) MA23782A1 (fr)
MY (1) MY113230A (fr)
NO (1) NO316987B1 (fr)
NZ (1) NZ300958A (fr)
OA (1) OA10438A (fr)
PE (1) PE64896A1 (fr)
PL (1) PL183773B1 (fr)
PT (1) PT805806E (fr)
RO (1) RO115728B1 (fr)
RU (1) RU2154642C2 (fr)
SK (1) SK281958B6 (fr)
TN (1) TNSN96011A1 (fr)
TR (1) TR199700676T1 (fr)
TW (1) TW356469B (fr)
UA (1) UA47420C2 (fr)
UY (1) UY24149A1 (fr)
WO (1) WO1996022984A1 (fr)
ZA (1) ZA96523B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6891050B2 (en) * 2001-08-10 2005-05-10 Dabur India Limited Process for the preparation of taxanes such as paclitaxel, docetaxel and structurally similar analogs
US6881852B2 (en) * 2002-02-05 2005-04-19 Dabur India Limited Process of purification of paclitaxel and docetaxel
US7247738B2 (en) * 2002-05-07 2007-07-24 Dabur India Limited Method of preparation of anticancer taxanes using 3-[(substituted-2-trialkylsilyl) ethoxycarbonyl]-5-oxazolidine carboxylic acids
US6900342B2 (en) * 2002-05-10 2005-05-31 Dabur India Limited Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof
US6838569B2 (en) * 2002-12-16 2005-01-04 Dabur India Limited Process for preparation of paclitaxel trihydrate and docetaxel trihydrate
DK1694660T3 (da) 2003-12-12 2009-08-10 Biorganica Ltda Fremgangsmåde til fremstilling af vandfri og hydrerede aktive farmaceutiske bestanddele (API's); stabile farmaceutiske sammensætninger fremstillet af disse og anvendelser af disse sammensætninger
CN100420681C (zh) * 2005-04-29 2008-09-24 上海奥锐特国际贸易有限公司 多烯紫杉醇三水物的制备方法
EP2285792A2 (fr) * 2008-05-07 2011-02-23 Ivax Research, Llc Processus de préparation des taxanes et de leurs intermédiaires
US8633240B2 (en) * 2012-06-01 2014-01-21 The University Of Utah Research Foundation Paclitaxel trihydrates and methods of making thereof
CN103833693B (zh) * 2014-03-04 2016-02-24 悦康药业集团有限公司 一种紫杉醇化合物及含该紫杉醇化合物的药物组合物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994021662A1 (fr) * 1993-03-15 1994-09-29 Yale University Diagnostic de maladies inflammatoires intestinales chez l'homme et reactifs d'acides nucleiques utilises a cette fin

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2703049B1 (fr) * 1993-03-22 1995-04-21 Rhone Poulenc Rorer Sa Procédé de purification des taxoïdes.
CA2163837C (fr) * 1994-12-13 1999-07-20 Robert K. Perrone Hydrates de paclitaxel cristallises

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994021662A1 (fr) * 1993-03-15 1994-09-29 Yale University Diagnostic de maladies inflammatoires intestinales chez l'homme et reactifs d'acides nucleiques utilises a cette fin

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 113, no. 75, 1990 Columbus, Ohio, US; abstract no. 14264k, GUERITE-VOEGELEIN ET AL. "STRUCTURE OF A SYNTHETIC TAXOL PRECURSOR." PAGE 723; & ACTA CRYSTALLOGR. SECT. C: CRYST. STRUCT. COMM., vol C46, no. 5, 1990 ENGL., pages 781-784 *

Also Published As

Publication number Publication date
EE03396B1 (et) 2001-04-16
JPH10512871A (ja) 1998-12-08
ZA96523B (en) 1996-10-15
EP0805806B1 (fr) 1999-12-15
RU2154642C2 (ru) 2000-08-20
SK281958B6 (sk) 2001-09-11
BG101794A (en) 1998-10-30
PT805806E (pt) 2000-05-31
WO1996022984A1 (fr) 1996-08-01
HUP9801437A3 (en) 2001-02-28
TW356469B (en) 1999-04-21
CN1067997C (zh) 2001-07-04
AU707603B2 (en) 1999-07-15
FR2729666A1 (fr) 1996-07-26
GEP19991833B (en) 1999-11-05
HUP9801437A1 (hu) 1999-09-28
BG62769B1 (bg) 2000-07-31
FI973105A (fi) 1997-07-24
NZ300958A (en) 1999-09-29
RO115728B1 (ro) 2000-05-30
CZ236297A3 (en) 1997-11-12
AP9701035A0 (en) 1997-07-31
PE64896A1 (es) 1997-02-23
ES2139332T3 (es) 2000-02-01
NO316987B1 (no) 2004-07-19
MA23782A1 (fr) 1996-10-01
ATE187719T1 (de) 2000-01-15
FI973105A0 (fi) 1997-07-24
TNSN96011A1 (fr) 2005-03-15
IL116903A0 (en) 1996-05-14
FR2729666B1 (fr) 1997-02-28
TR199700676T1 (xx) 1998-01-21
DE69605651T2 (de) 2000-07-06
FI119245B (fi) 2008-09-15
BR9606853A (pt) 1997-11-25
DZ1977A1 (fr) 2002-07-20
IL116903A (en) 2003-01-12
GR3032110T3 (en) 2000-03-31
UA47420C2 (uk) 2002-07-15
KR100384773B1 (ko) 2003-08-21
JP3782449B2 (ja) 2006-06-07
EP0805806A1 (fr) 1997-11-12
IN184427B (fr) 2000-08-26
PL321493A1 (en) 1997-12-08
PL183773B1 (pl) 2002-07-31
DK0805806T3 (da) 2000-05-01
UY24149A1 (es) 1996-05-20
OA10438A (fr) 2002-03-22
IS2033B (is) 2005-08-15
NO973247D0 (no) 1997-07-11
KR19980701623A (ko) 1998-06-25
NO973247L (no) 1997-07-11
CN1169724A (zh) 1998-01-07
CO4700286A1 (es) 1998-12-29
EE9700157A (et) 1997-12-15
MX9705460A (es) 1997-10-31
MY113230A (en) 2001-12-31
AU4625596A (en) 1996-08-14
US6002022A (en) 1999-12-14
IS4529A (is) 1997-07-22
SK100897A3 (en) 1998-01-14
DE69605651D1 (de) 2000-01-20
HU223352B1 (hu) 2004-06-28
CZ287079B6 (en) 2000-08-16

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