AP2514A - HIV reverse transcriptase inhibitors - Google Patents

HIV reverse transcriptase inhibitors

Info

Publication number
AP2514A
AP2514A AP2009004759A AP2009004759A AP2514A AP 2514 A AP2514 A AP 2514A AP 2009004759 A AP2009004759 A AP 2009004759A AP 2009004759 A AP2009004759 A AP 2009004759A AP 2514 A AP2514 A AP 2514A
Authority
AP
ARIPO
Prior art keywords
reverse transcriptase
transcriptase inhibitors
hiv reverse
hiv
inhibitors
Prior art date
Application number
AP2009004759A
Other languages
English (en)
Other versions
AP2009004759A0 (en
Inventor
Hongyan Guo
Choung U Kim
Young Lee Iii
Original Assignee
Korea Res Inst Chem Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Korea Res Inst Chem Tech filed Critical Korea Res Inst Chem Tech
Publication of AP2009004759A0 publication Critical patent/AP2009004759A0/xx
Application granted granted Critical
Publication of AP2514A publication Critical patent/AP2514A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AP2009004759A 2006-07-24 2007-07-24 HIV reverse transcriptase inhibitors AP2514A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83280606P 2006-07-24 2006-07-24
PCT/US2007/016703 WO2008016522A2 (en) 2006-07-24 2007-07-24 Hiv reverse transcriptase inhibitors

Publications (2)

Publication Number Publication Date
AP2009004759A0 AP2009004759A0 (en) 2009-02-28
AP2514A true AP2514A (en) 2012-11-23

Family

ID=38997642

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2009004759A AP2514A (en) 2006-07-24 2007-07-24 HIV reverse transcriptase inhibitors

Country Status (18)

Country Link
US (2) US8106064B2 (zh)
EP (1) EP2044037A2 (zh)
JP (1) JP2009544710A (zh)
KR (2) KR20110089463A (zh)
CN (1) CN101495461A (zh)
AP (1) AP2514A (zh)
AU (1) AU2007281604A1 (zh)
BR (1) BRPI0714880A2 (zh)
CA (1) CA2658479A1 (zh)
EA (1) EA200900213A1 (zh)
HR (1) HRP20090114A2 (zh)
IL (1) IL196675A0 (zh)
MX (1) MX2009000871A (zh)
NO (1) NO20090835L (zh)
NZ (1) NZ573793A (zh)
SG (1) SG174016A1 (zh)
UA (1) UA95955C2 (zh)
WO (1) WO2008016522A2 (zh)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008016522A2 (en) 2006-07-24 2008-02-07 Gilead Sciences, Inc. Hiv reverse transcriptase inhibitors
KR20100041798A (ko) * 2007-06-29 2010-04-22 한국화학연구원 신규 ｈｉｖ 역전사효소 억제제
CN101784532B (zh) * 2007-06-29 2014-10-22 韩国化学研究院 Hiv逆转录酶抑制剂
WO2009085797A1 (en) 2007-12-21 2009-07-09 Gilead Sciences, Inc. Processes for preparing hiv reverse transcriptase inhibitors
CA2726579C (en) * 2008-06-03 2015-02-17 Taiho Pharmaceutical Co., Ltd. Novel uracil compound or salt thereof having human deoxyuridine triphosphatase inhibitory activity
WO2010068899A1 (en) * 2008-12-12 2010-06-17 Creighton University Nanoparticles comprising combinations of antiretroviral agents and use thereof
US8921415B2 (en) 2009-01-29 2014-12-30 Mapi Pharma Ltd. Polymorphs of darunavir
PL2399910T3 (pl) 2009-02-13 2014-09-30 Shionogi & Co Pochodne triazyny jako antagoniści receptora p2x3 i/albo p2x2/3 i kompozycja farmaceutyczna zawierająca je
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
UA106972C2 (uk) * 2009-06-22 2014-11-10 Емк'Юр Фармас'Ютікалз Лімітед Спосіб синтезу діарилпіримідинового ненуклеозидного інгібітора зворотної транскриптази
GB0913636D0 (en) * 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
ES2516916T3 (es) 2010-01-28 2014-10-31 Mapi Pharma Limited Procedimiento para la preparación de darunavir e intermedios de darunavir
US20110262406A1 (en) 2010-04-21 2011-10-27 Yale University Compositions and methods for targeted inactivation of hiv cell surface receptors
WO2011133802A1 (en) 2010-04-21 2011-10-27 Helix Therapeutics, Inc. Compositions and methods for treatment of lysosomal storage disorders
KR101867110B1 (ko) 2010-08-10 2018-06-12 시오노기 앤드 컴파니, 리미티드 트라이아진 유도체 및 그것을 함유하는 진통 작용을 갖는 의약 조성물
US9212130B2 (en) 2010-08-10 2015-12-15 Shionogi & Co., Ltd. Heterocyclic derivative and pharmaceutical composition comprising the same
MY158809A (en) * 2010-09-22 2016-11-15 Craun Res Sdn Bhd Pharmaceutical compositions for calanolides, their derivatives and analogues, and process for producing the same
CA2817165A1 (en) 2010-11-15 2012-05-24 Patrick Chaltin Novel antiviral compounds
KR20200090975A (ko) * 2011-10-07 2020-07-29 길리애드 사이언시즈, 인코포레이티드 항-바이러스 뉴클레오티드 유사체의 제조 방법
CN104185420B (zh) 2011-11-30 2017-06-09 埃默里大学 用于治疗或预防逆转录病毒和其它病毒感染的抗病毒jak抑制剂
CA2863632C (en) 2012-01-19 2017-07-11 The Johns Hopkins University Nanoparticle formulations with enhanced mucosal penetration
WO2013118855A1 (ja) 2012-02-09 2013-08-15 塩野義製薬株式会社 複素環および炭素環誘導体
US9809571B2 (en) 2013-01-07 2017-11-07 University Of Southern California Deoxyuridine triphosphatase inhibitors
US10568975B2 (en) 2013-02-05 2020-02-25 The Johns Hopkins University Nanoparticles for magnetic resonance imaging tracking and methods of making and using thereof
TWI637949B (zh) 2013-06-14 2018-10-11 塩野義製藥股份有限公司 胺基三衍生物及含有其等之醫藥組合物
WO2015103489A1 (en) 2014-01-03 2015-07-09 University Of Southern California Heteroatom containing deoxyuridine triphosphatase inhibitors
WO2015127389A1 (en) 2014-02-23 2015-08-27 The Johns Hopkins University Hypotonic enema formulations and methods of use
KR20230130175A (ko) 2014-12-26 2023-09-11 에모리 유니버시티 Ｎ4-하이드록시시티딘, 이와 관련된 유도체 및 이의 항 바이러스적 용도
CA2974715C (en) 2015-01-27 2020-05-05 The Johns Hopkins University Hypotonic hydrogel formulations for enhanced transport of active agents at mucosal surfaces
WO2017006270A1 (en) 2015-07-08 2017-01-12 University Of Southern California Deoxyuridine triphosphatase inhibitors
EA037990B1 (ru) 2015-07-08 2021-06-21 Св6 Терапьютикс (Най) Лимитед Ингибиторы дезоксиуридинтрифосфатазы, содержащие гидантоин
US10570100B2 (en) 2015-07-08 2020-02-25 University Of Southern California Deoxyuridine triphosphatase inhibitors containing amino sulfonyl linkage
WO2017006283A1 (en) 2015-07-08 2017-01-12 Cv6 Therapeutics (Ni) Limited Deoxyuridine triphosphatase inhibitors containing cyclopropano linkage
WO2018098209A1 (en) 2016-11-23 2018-05-31 Cv6 Therapeutics (Ni) Limited Amino sulfonyl compounds
WO2018098204A1 (en) 2016-11-23 2018-05-31 Cv6 Therapeutics (Ni) Limited 6-membered uracil isosteres
US11014924B2 (en) 2016-11-23 2021-05-25 Cv6 Therapeutics (Ni) Limited Hydantoin containing deoxyuridine triphosphatase inhibitors
WO2018098206A1 (en) 2016-11-23 2018-05-31 Cv6 Therapeutics (Ni) Limited Hydantoin containing deoxyuridine triphosphatase inhibitors
WO2018098208A1 (en) 2016-11-23 2018-05-31 Cv6 Therapeutics (Ni) Limited Nitrogen ring linked deoxyuridine triphosphatase inhibitors
US11247984B2 (en) 2017-01-05 2022-02-15 Cv6 Therapeutics (Ni) Limited Uracil containing compounds
UA125227C2 (uk) * 2017-03-17 2022-02-02 Мейджі Сейка Фарма Ко., Лтд. Агент для контролю захворювань рослин
AU2018378832B9 (en) 2017-12-07 2021-05-27 Emory University N4-hydroxycytidine and derivatives and anti-viral uses related thereto
CN115536596A (zh) * 2022-11-08 2022-12-30 巨鑫生物制药股份有限公司 一种acc007中间体的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000051990A1 (en) * 1999-03-04 2000-09-08 Korea Research Institute Of Chemical Technology Antiviral 2,4-pyrimidinedione derivatives and process for the preparation thereof
WO2000061564A1 (en) * 1999-04-10 2000-10-19 Samjin Pharmaceutical Co., Ltd. Antiviral pyrimidinedione derivatives and process for the preparation thereof

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4656209A (en) * 1982-05-26 1987-04-07 Ciba-Geigy Corporation Chlorinated thermoplastics stabilized with aminouracils
KR0155168B1 (ko) * 1989-09-29 1998-11-16 미우라 아끼라 6-치환된 아시클로피리미딘 뉴클레오시드 유도체 및 이를 활성성분으로 함유하는 항비루스제
ATE169915T1 (de) * 1990-02-15 1998-09-15 Takeda Chemical Industries Ltd Pyrimidindionderivate, deren herstellung und verwendung
IL99731A0 (en) * 1990-10-18 1992-08-18 Merck & Co Inc Hydroxylated pyridine derivatives,their preparation and pharmaceutical compositions containing them
EP0748316B1 (en) * 1994-02-28 2002-05-08 Sunkyong Industries Co., Ltd. Pyrimidine acyclonucleoside derivatives
JPH083143A (ja) 1994-06-21 1996-01-09 Mitsubishi Chem Corp ６−アラルキル置換ピリミジン誘導体の製造方法
US6174998B1 (en) * 1996-03-12 2001-01-16 Roche Diagnostics Gmbh C-nucleoside derivatives and their use in the detection of nucleic acids
WO1997030979A1 (en) * 1996-02-22 1997-08-28 Samjin Pharmaceutical Co., Ltd. New antiviral substituted pyrimidinedione homocarbocyclic nucleoside derivatives and methods for the preparation thereof and compositions containing the same as active ingredients
KR100219922B1 (ko) * 1996-05-16 1999-09-01 이서봉 신규한 항바이러스성 6-아릴옥시 및 6-아릴카르보닐 2,4-피리미딘디온 유도체 및 그의 제조 방법
JPH10130244A (ja) 1996-09-06 1998-05-19 Mitsubishi Chem Corp アシクロヌクレオシドの製造方法
JPH10130245A (ja) 1996-09-06 1998-05-19 Mitsubishi Chem Corp アシクロヌクレオシドの製造方法
EP0929533B1 (en) 1996-10-02 2003-09-03 Bristol-Myers Squibb Pharma Company 4,4-disubstituted-1,4-dihydro-2h-3,1-benzoxazin-2-ones useful as hiv reverse transcriptase inhibitors and intermediates and processes for making the same
JPH10168068A (ja) 1996-12-05 1998-06-23 Mitsubishi Chem Corp アシクロヌクレオシドの製造方法
US5998411A (en) * 1998-03-17 1999-12-07 Hughes Institute Heterocyclic nonnucleoside inhibitors of reverse transcriptase
CA2322203A1 (en) * 1998-03-27 1999-10-07 Jeffrey W. Corbett 4,4-disubstituted-3,4-dihydro-2(1h)-quinazolinthione derivatives, their preparation and their use as hiv reverse transcriptase inhibitors
FR2779722A1 (fr) 1998-06-15 1999-12-17 Expansia Sa Hydrogenation de 6-alpha-alkylcarboxy methylaryl-1,5-dialkyl uracile
FR2779721A1 (fr) 1998-06-15 1999-12-17 Expansia Sa Substitution d'une 1,5-dialkyl uracile en position 6
WO2001023363A1 (fr) 1999-09-29 2001-04-05 Sankyo Company, Limited Derives de sulfonamide
JP2001114767A (ja) 1999-10-15 2001-04-24 Sumika Fine Chemicals Co Ltd ピリミジン化合物の製造方法、およびその中間体の製造方法
KR100638954B1 (ko) * 2001-03-02 2006-10-25 스미스클라인 비참 코포레이션 역전사 효소 억제제로서의 벤조페논
JP2002284686A (ja) 2001-03-28 2002-10-03 Sankyo Co Ltd スルホンアミド化合物を含有する医薬組成物
WO2003029226A1 (en) 2001-09-26 2003-04-10 Basf Aktiengesellschaft Heterocyclyl substituted phenoxyalkyl-, phenylthioalkyl-, phenylaminoalkyl- and phenylalkyl-sulfamoylcarboxamides
WO2003057677A1 (en) 2002-01-11 2003-07-17 Syddansk Universitet Anti-retroviral 5,6-disubstituted acyclopyrimidine nucleoside derivatives
AU2003215542A1 (en) 2002-01-31 2003-09-02 Ciba Specialty Chemicals Holding Inc. Stabilization of polyolefins in permanent contact with chlorinated water
BR0313747A (pt) * 2002-08-23 2005-06-21 Ribapharm Inc Inibidores de transcriptase reversa de não-nucleosìdeo
WO2006070292A2 (en) 2004-10-12 2006-07-06 Queen's University At Kingston Pyrimidine compounds as anti-ictogenic and/or anti-epileptogenic agents
US7250421B2 (en) * 2005-01-31 2007-07-31 University Of Georgia Research Foundation, Inc. Diketo acids with nucleobase scaffolds: anti-HIV replication inhibitors targeted at HIV integrase
US20060223834A1 (en) * 2005-04-04 2006-10-05 Vasu Nair Diketo acids on nucleobase scaffolds as inhibitors of Flaviviridae
WO2007079163A2 (en) * 2005-12-29 2007-07-12 Janssen Pharmaceutica N.V. Prokineticin 1 receptor antagonists
EP1976528A2 (en) * 2005-12-29 2008-10-08 Janssen Pharmaceutica, N.V. Prokineticin 2 receptor antagonists
WO2007106450A2 (en) 2006-03-10 2007-09-20 University Of Georgia Research Foundation, Inc. Diketo acids with nucleobase scaffolds: anti-hiv replication inhibitors targeted at hiv integrase in combination therapy
WO2008016522A2 (en) * 2006-07-24 2008-02-07 Gilead Sciences, Inc. Hiv reverse transcriptase inhibitors
CN101784532B (zh) * 2007-06-29 2014-10-22 韩国化学研究院 Hiv逆转录酶抑制剂

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000051990A1 (en) * 1999-03-04 2000-09-08 Korea Research Institute Of Chemical Technology Antiviral 2,4-pyrimidinedione derivatives and process for the preparation thereof
WO2000061564A1 (en) * 1999-04-10 2000-10-19 Samjin Pharmaceutical Co., Ltd. Antiviral pyrimidinedione derivatives and process for the preparation thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JI, LEI ET AL.: CHEM. PHARM. BULL., vol. 54, no. 9, 2006, pages 1248-1253, XP002494625 *

Also Published As

Publication number Publication date
WO2008016522A2 (en) 2008-02-07
EP2044037A2 (en) 2009-04-08
KR20110089463A (ko) 2011-08-08
CA2658479A1 (en) 2008-02-07
NO20090835L (no) 2009-04-23
NZ573793A (en) 2012-01-12
US8106064B2 (en) 2012-01-31
US20080070920A1 (en) 2008-03-20
MX2009000871A (es) 2009-05-08
SG174016A1 (en) 2011-09-29
WO2008016522A3 (en) 2008-12-11
US20100034827A1 (en) 2010-02-11
BRPI0714880A2 (pt) 2013-05-21
HRP20090114A2 (hr) 2010-03-31
KR20090040449A (ko) 2009-04-24
CN101495461A (zh) 2009-07-29
AP2009004759A0 (en) 2009-02-28
UA95955C2 (ru) 2011-09-26
EA200900213A1 (ru) 2009-06-30
AU2007281604A1 (en) 2008-02-07
JP2009544710A (ja) 2009-12-17
IL196675A0 (en) 2009-11-18

Similar Documents

Publication Publication Date Title
AP2514A (en) HIV reverse transcriptase inhibitors
IL188615A0 (en) Hiv reverse transcriptase inhibitors
ZA201000023B (en) Novel hiv reverse transcriptase inhibitors
ZA200903395B (en) Non-nucleoside reverse transcriptase inhibitors
EP2220091A4 (en) REVERSE transcriptase inhibitors
IL196655A0 (en) Non-nucleoside reverse transcriptase inhibitors
EP2076492A4 (en) NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
EP2217069A4 (en) INHIBITORS OF NON-NUCLEOSIDE INHIBITORS OF THE REVERSE TRANSCRIPTASE
IL205386A0 (en) Non - nucleoside reverse transcriptase inhibitors
IL200748A0 (en) Non-nucleoside reverse transcriptse inhibitors
IL197777A0 (en) Enantiomerically pure phosphoindoles as hiv inhibitors
TWI372619B (en) Non-nucleoside reverse transcriptase inhibitors
IL180495A0 (en) Benzyltriazolone compounds as nin-nucleoside reverse transcriptase inhibitors
IL194434A0 (en) Hcv/hiv inhibitors and their uses
ZA201101975B (en) Imidazopyridines and imidazopyrimidines as hiv-i reverse transcriptase inhibitors
EP2099789A4 (en) INHIBITORS OF HIV REPLICATION
EP2139883A4 (en) INHIBITORS OF HIV-1 PROTEASE
SI2094702T1 (sl) Virusni inhibitorji
HK1127351A1 (zh) 抗病毒蛋白酶抑制劑
EP1756091A4 (en) NON-NUCLEOSIDIC REVERSE TRANSCRIPTASE INHIBITORS
IL200886A0 (en) Non-nucleoside reverse transcriptase inhibitors
ZA200900071B (en) Non-nucleoside reverse transcriptase inhibitors
EP2134336A4 (en) HIV PROTEASE INHIBITORS DERIVED FROM BENZOFURAN
EP1899340A4 (en) NON-NUCLEOSIDIC REVERSE TRANSCRIPTASE INHIBITORS
ZA200800185B (en) Hiv reverse transcriptase inhibitors