AP2048A - Diazepinoindole derivatives as kinase inhibitors - Google Patents
Diazepinoindole derivatives as kinase inhibitorsInfo
- Publication number
- AP2048A AP2048A AP2005003353A AP2005003353A AP2048A AP 2048 A AP2048 A AP 2048A AP 2005003353 A AP2005003353 A AP 2005003353A AP 2005003353 A AP2005003353 A AP 2005003353A AP 2048 A AP2048 A AP 2048A
- Authority
- AP
- ARIPO
- Prior art keywords
- kinase inhibitors
- diazepinoindole
- derivatives
- diazepinoindole derivatives
- kinase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43939603P | 2003-01-09 | 2003-01-09 | |
PCT/IB2004/000026 WO2004063198A1 (en) | 2003-01-09 | 2004-01-05 | Diazepinoindole derivatives as kinase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
AP2005003353A0 AP2005003353A0 (en) | 2005-09-30 |
AP2048A true AP2048A (en) | 2009-09-24 |
Family
ID=32713475
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AP2005003353A AP2048A (en) | 2003-01-09 | 2004-01-05 | Diazepinoindole derivatives as kinase inhibitors |
Country Status (35)
Country | Link |
---|---|
US (3) | US6967198B2 (el) |
EP (2) | EP1947102A1 (el) |
JP (1) | JP3990718B2 (el) |
KR (1) | KR100697746B1 (el) |
CN (1) | CN1759118B (el) |
AP (1) | AP2048A (el) |
AT (1) | ATE404564T1 (el) |
AU (1) | AU2004203977B2 (el) |
BR (1) | BRPI0406701A (el) |
CA (1) | CA2512683C (el) |
CR (1) | CR7899A (el) |
CY (1) | CY1108408T1 (el) |
DE (1) | DE602004015724D1 (el) |
DK (1) | DK1585749T3 (el) |
EA (1) | EA009337B1 (el) |
EC (1) | ECSP055911A (el) |
ES (1) | ES2309484T3 (el) |
GE (1) | GEP20084367B (el) |
HK (1) | HK1086257A1 (el) |
HR (1) | HRP20050624A2 (el) |
IL (1) | IL169082A (el) |
IS (1) | IS7884A (el) |
MA (1) | MA27703A1 (el) |
MX (1) | MXPA05007352A (el) |
NO (1) | NO20053775L (el) |
NZ (1) | NZ540638A (el) |
OA (1) | OA13017A (el) |
PL (1) | PL378372A1 (el) |
PT (1) | PT1585749E (el) |
RS (1) | RS20050522A (el) |
SI (1) | SI1585749T1 (el) |
TN (1) | TNSN05176A1 (el) |
UA (1) | UA80733C2 (el) |
WO (1) | WO2004063198A1 (el) |
ZA (1) | ZA200504674B (el) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003214879B2 (en) * | 2002-01-22 | 2008-02-07 | The Regents Of The University Of California | Non-steroidal ligands for the glucocorticoid receptor, compositions and uses thereof |
EP1947102A1 (en) * | 2003-01-09 | 2008-07-23 | Pfizer, Inc. | Compositions comprising diazepinoindole derivatives as kinase inhibitors |
EP1853721B1 (en) * | 2005-02-18 | 2010-04-14 | AstraZeneca AB | Method for determining responsiveness to chk1 inhibitors |
PT1869020E (pt) | 2005-03-29 | 2010-12-23 | Icos Corp | Derivados de heteroaril-ureia úteis para a inibição de chk1 |
GB0510390D0 (en) * | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
US8003625B2 (en) | 2005-06-29 | 2011-08-23 | Threshold Pharmaceuticals, Inc. | Phosphoramidate alkylator prodrugs |
US8324169B2 (en) * | 2005-08-15 | 2012-12-04 | The Regents Of The University Of California | VEGF-activated ligands |
WO2007023948A1 (ja) | 2005-08-25 | 2007-03-01 | Ube Industries, Ltd. | 光学活性(S又はR)-α-アミノ酸及び光学活性(R又はS)-α-アミノ酸エステルの製造方法 |
CA2620275A1 (en) * | 2005-08-26 | 2007-03-01 | Thomas S. Scanlan | Non-steroidal antiandrogens |
WO2007113647A1 (en) * | 2006-04-04 | 2007-10-11 | Pfizer Products Inc. | Polymorphic forms of (2r,z)-2-amino-2-cyclohexyl-n-(5-(1-methyl-1h-pyrazol-4υl)-1-oxo-2,6-dihydro-1h-[1,2]diazepino[4,5,6-cd]indol-8-yl)acetamide |
CN101415417A (zh) * | 2006-04-04 | 2009-04-22 | 辉瑞产品公司 | (2r,z)-2-氨基-2-环己基-n-(5-(1-甲基-1h-吡唑-4-基)-1-氧代-2,6-二氢-1h-[1,2]二氮杂卓并[4,5,6-cd]吲哚-8-基)乙酰胺的组合疗法 |
JP2010510222A (ja) * | 2006-11-17 | 2010-04-02 | シェーリング コーポレイション | 増殖性障害に対する併用療法 |
US8158656B2 (en) * | 2008-05-16 | 2012-04-17 | Shenzhen Chipscreen Biosciences Ltd. | 2-indolinone derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors |
CA2731368C (en) * | 2008-08-06 | 2013-05-14 | Pfizer Inc. | 6 substituted 2-heterocyclylamino pyrazine compounds as chk-1 inhibitors |
WO2010040527A1 (en) * | 2008-10-10 | 2010-04-15 | Priaxon Ag | Novel compounds which modulate kinase activity |
US8314108B2 (en) | 2008-12-17 | 2012-11-20 | Eli Lilly And Company | 5-(5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile, pharmaceutically acceptable salts thereof, or solvate of salts |
US8663210B2 (en) | 2009-05-13 | 2014-03-04 | Novian Health, Inc. | Methods and apparatus for performing interstitial laser therapy and interstitial brachytherapy |
US8211901B2 (en) | 2009-05-22 | 2012-07-03 | Shenzhen Chipscreen Biosciences Ltd. | Naphthamide derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors |
CN101906076B (zh) | 2009-06-04 | 2013-03-13 | 深圳微芯生物科技有限责任公司 | 作为蛋白激酶抑制剂和组蛋白去乙酰化酶抑制剂的萘酰胺衍生物、其制备方法及应用 |
CA2835195A1 (en) | 2011-05-06 | 2012-11-15 | Zafgen, Inc. | Tricyclic sulfonamide compounds and methods of making and using same |
EP2793882A4 (en) * | 2011-12-22 | 2015-04-29 | Threshold Pharmaceuticals Inc | ADMINISTRATION OF HYPOXIA ACTIVATED DRUGS IN COMBINATION WITH CHK1 INHIBITORS FOR THE TREATMENT OF CANCER |
EP3315500B1 (en) | 2011-12-31 | 2020-03-18 | BeiGene, Ltd. | Fused tetra or penta-cyclic dihydrodiazepinocarbazolones as parp inhibitors |
BR112014016163A8 (pt) | 2011-12-31 | 2017-07-04 | Beigene Ltd | piridoftalazinonas tetra ou penta-cíclicas fundidas como inibidores de parp |
CN102746211B (zh) * | 2012-06-27 | 2015-05-27 | 上海泰坦化学有限公司 | 一种取代吲哚-3-甲醛类化合物的制备方法 |
TWI633107B (zh) * | 2013-05-22 | 2018-08-21 | 開曼群島商百濟神州生物科技有限公司 | 作為parp抑制劑的稠合四或五環二氫二氮呯并咔唑酮 |
CA2928568A1 (en) | 2013-07-26 | 2015-01-29 | Update Pharma Inc. | Combinatorial methods to improve the therapeutic benefit of bisantrene |
WO2015069489A1 (en) | 2013-11-06 | 2015-05-14 | Merck Patent Gmbh | Predictive biomarker for hypoxia-activated prodrug therapy |
SG10201811175WA (en) | 2014-06-17 | 2019-01-30 | Vertex Pharma | Method for treating cancer using a combination of chk1 and atr inhibitors |
IL257442B2 (en) | 2015-08-25 | 2023-03-01 | Beigene Ltd | Process for preparing parp inhibitor, crystalline forms and their uses |
AU2016331955B2 (en) | 2015-09-30 | 2022-07-21 | Vertex Pharmaceuticals Incorporated | Method for treating cancer using a combination of DNA damaging agents and ATR inhibitors |
US11202782B2 (en) | 2016-09-27 | 2021-12-21 | Beigene, Ltd. | Treatment cancers using a combination comprising PARP inhibitors |
JP6541635B2 (ja) * | 2016-10-28 | 2019-07-10 | ベイジーン リミテッド | Parp阻害剤としての縮合四環式または縮合五環式ジヒドロジアゼピノカルバゾロン |
CN110392687B (zh) | 2017-02-28 | 2022-08-02 | 百济神州(苏州)生物科技有限公司 | 稠合的四环或五环二氢二氮杂䓬并咔唑酮的盐的结晶形式及其用途 |
US11661581B2 (en) * | 2017-05-25 | 2023-05-30 | University Of Massachusetts | Use of CDK inhibitors to enhance growth and self-renewal of progenitor cells |
MX2020003242A (es) * | 2017-09-22 | 2020-09-18 | Jubilant Epipad LLC | Compuestos heterociclicos como inhibidores de pad. |
EP3461480A1 (en) | 2017-09-27 | 2019-04-03 | Onxeo | Combination of a dna damage response cell cycle checkpoint inhibitors and belinostat for treating cancer |
WO2020154608A1 (en) * | 2019-01-25 | 2020-07-30 | Numedii, Inc. | Method for treating idiopathic pulmonary fibrosis |
WO2021018298A1 (zh) * | 2019-08-01 | 2021-02-04 | 南京明德新药研发有限公司 | 作为parp抑制剂吲哚并七元酰肟化合物 |
WO2021104461A1 (zh) | 2019-11-29 | 2021-06-03 | 南京明德新药研发有限公司 | 二氮杂吲哚类衍生物及其作为Chk1抑制剂的应用 |
CA3184988A1 (en) * | 2020-07-13 | 2022-01-20 | Ahmed Mamai | Nicotinamide phosphoribosyltransferase (nampt) inhibitor-conjugates and uses thereof |
EP4190790A1 (en) * | 2020-07-31 | 2023-06-07 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Indolo heptamyl oxime analog crystal as parp inhibitor and method for preparing same |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000042040A1 (en) * | 1999-01-11 | 2000-07-20 | Agouron Pharmaceuticals, Inc. | Tricyclic inhibitors of poly(adp-ribose) polymerases |
WO2002044183A2 (en) * | 2000-12-01 | 2002-06-06 | Guilford Pharmaceuticals Inc. | Benzoazepine and benzodiazepine derivatives and their use as parp inhibitors |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9722320D0 (en) | 1997-10-22 | 1997-12-17 | Janssen Pharmaceutica Nv | Human cell cycle checkpoint proteins |
US6383744B1 (en) | 1998-07-10 | 2002-05-07 | Incyte Genomics, Inc. | Human checkpoint kinase |
JP2002526450A (ja) | 1998-09-18 | 2002-08-20 | スミスクライン・ビーチャム・コーポレイション | Chk1キナーゼ阻害物質 |
AU7070800A (en) | 1999-08-27 | 2001-03-26 | Chiron Corporation | Chimeric antisense oligonucleotides and cell transfecting formulations thereof |
ECSP003637A (es) | 1999-08-31 | 2002-03-25 | Agouron Pharma | Inhibidores triciclicos de poli (adp-ribosa) polimerasas |
US6670167B1 (en) | 1999-11-01 | 2003-12-30 | Agouron Pharmaceuticals, Inc. | Catalytic domain of the human effector cell cycle checkpoint protein kinase materials and methods for identification of inhibitors thereof |
ES2239037T3 (es) | 1999-09-22 | 2005-09-16 | Canbas Co., Ltd. | Metodos y composiciones para inhibir la deteccion del ciclo celular en g2 y sensibilizar celulas a agentes dañinos del dna. |
US6211164B1 (en) | 2000-03-10 | 2001-04-03 | Abbott Laboratories | Antisense oligonucleotides of the human chk1 gene and uses thereof |
UA76977C2 (en) | 2001-03-02 | 2006-10-16 | Icos Corp | Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers |
EP1947102A1 (en) * | 2003-01-09 | 2008-07-23 | Pfizer, Inc. | Compositions comprising diazepinoindole derivatives as kinase inhibitors |
-
2004
- 2004-01-05 EP EP08155745A patent/EP1947102A1/en not_active Withdrawn
- 2004-01-05 CA CA2512683A patent/CA2512683C/en not_active Expired - Fee Related
- 2004-01-05 JP JP2006500278A patent/JP3990718B2/ja not_active Expired - Fee Related
- 2004-01-05 EA EA200500893A patent/EA009337B1/ru not_active IP Right Cessation
- 2004-01-05 BR BR0406701-0A patent/BRPI0406701A/pt not_active IP Right Cessation
- 2004-01-05 RS YUP-2005/0522A patent/RS20050522A/sr unknown
- 2004-01-05 CN CN2004800063838A patent/CN1759118B/zh not_active Expired - Fee Related
- 2004-01-05 KR KR1020057012806A patent/KR100697746B1/ko not_active IP Right Cessation
- 2004-01-05 EP EP04700145A patent/EP1585749B1/en not_active Expired - Lifetime
- 2004-01-05 AU AU2004203977A patent/AU2004203977B2/en not_active Ceased
- 2004-01-05 WO PCT/IB2004/000026 patent/WO2004063198A1/en active IP Right Grant
- 2004-01-05 NZ NZ540638A patent/NZ540638A/en unknown
- 2004-01-05 DE DE602004015724T patent/DE602004015724D1/de not_active Expired - Lifetime
- 2004-01-05 OA OA1200500197A patent/OA13017A/en unknown
- 2004-01-05 AP AP2005003353A patent/AP2048A/xx active
- 2004-01-05 GE GEAP20048886A patent/GEP20084367B/en unknown
- 2004-01-05 SI SI200430830T patent/SI1585749T1/sl unknown
- 2004-01-05 MX MXPA05007352A patent/MXPA05007352A/es active IP Right Grant
- 2004-01-05 PT PT04700145T patent/PT1585749E/pt unknown
- 2004-01-05 ES ES04700145T patent/ES2309484T3/es not_active Expired - Lifetime
- 2004-01-05 PL PL378372A patent/PL378372A1/pl not_active Application Discontinuation
- 2004-01-05 DK DK04700145T patent/DK1585749T3/da active
- 2004-01-05 AT AT04700145T patent/ATE404564T1/de not_active IP Right Cessation
- 2004-01-09 US US10/754,171 patent/US6967198B2/en not_active Expired - Fee Related
- 2004-05-01 UA UAA200506730A patent/UA80733C2/uk unknown
-
2005
- 2005-06-08 ZA ZA200504674A patent/ZA200504674B/en unknown
- 2005-06-08 IL IL169082A patent/IL169082A/en not_active IP Right Cessation
- 2005-06-09 IS IS7884A patent/IS7884A/is unknown
- 2005-07-07 HR HR20050624A patent/HRP20050624A2/hr not_active Application Discontinuation
- 2005-07-08 TN TNP2005000176A patent/TNSN05176A1/fr unknown
- 2005-07-08 MA MA28375A patent/MA27703A1/fr unknown
- 2005-07-08 EC EC2005005911A patent/ECSP055911A/es unknown
- 2005-07-08 CR CR7899A patent/CR7899A/es unknown
- 2005-07-22 US US11/187,089 patent/US7132533B2/en not_active Expired - Fee Related
- 2005-08-08 NO NO20053775A patent/NO20053775L/no unknown
-
2006
- 2006-05-26 HK HK06106153.4A patent/HK1086257A1/xx not_active IP Right Cessation
- 2006-06-23 US US11/426,132 patent/US7462713B2/en not_active Expired - Fee Related
-
2008
- 2008-10-13 CY CY20081101127T patent/CY1108408T1/el unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000042040A1 (en) * | 1999-01-11 | 2000-07-20 | Agouron Pharmaceuticals, Inc. | Tricyclic inhibitors of poly(adp-ribose) polymerases |
WO2002044183A2 (en) * | 2000-12-01 | 2002-06-06 | Guilford Pharmaceuticals Inc. | Benzoazepine and benzodiazepine derivatives and their use as parp inhibitors |
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