AP2037A - Use of substituted quinoline derivatives for the treatment of drug resistant mycobacterial diseases - Google Patents

Use of substituted quinoline derivatives for the treatment of drug resistant mycobacterial diseases

Info

Publication number
AP2037A
AP2037A AP2006003828A AP2006003828A AP2037A AP 2037 A AP2037 A AP 2037A AP 2006003828 A AP2006003828 A AP 2006003828A AP 2006003828 A AP2006003828 A AP 2006003828A AP 2037 A AP2037 A AP 2037A
Authority
AP
ARIPO
Prior art keywords
treatment
drug resistant
quinoline derivatives
substituted quinoline
mycobacterial diseases
Prior art date
Application number
AP2006003828A
Other languages
English (en)
Other versions
AP2006003828A0 (en
Inventor
Koenraad Jozef Lodewijkmarcel Andries
Gestel Jozef Frans Elisabetha Van
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34929150&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP2037(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of AP2006003828A0 publication Critical patent/AP2006003828A0/xx
Application granted granted Critical
Publication of AP2037A publication Critical patent/AP2037A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AP2006003828A 2004-05-28 2005-05-24 Use of substituted quinoline derivatives for the treatment of drug resistant mycobacterial diseases AP2037A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04102402 2004-05-28
PCT/EP2005/052371 WO2005117875A1 (en) 2004-05-28 2005-05-24 Use of substituted quinoline derivatives for the treatment of drug resistant mycobacterial diseases

Publications (2)

Publication Number Publication Date
AP2006003828A0 AP2006003828A0 (en) 2006-12-31
AP2037A true AP2037A (en) 2009-10-09

Family

ID=34929150

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2006003828A AP2037A (en) 2004-05-28 2005-05-24 Use of substituted quinoline derivatives for the treatment of drug resistant mycobacterial diseases

Country Status (34)

Country Link
US (2) US20070249667A1 (ja)
EP (1) EP1753427B1 (ja)
JP (2) JP5081617B2 (ja)
KR (2) KR101371653B1 (ja)
CN (2) CN1976704B (ja)
AP (1) AP2037A (ja)
AR (1) AR049127A1 (ja)
AT (1) ATE390925T1 (ja)
AU (1) AU2005249231B2 (ja)
BR (1) BRPI0510414B1 (ja)
CA (1) CA2566544C (ja)
CL (1) CL2009001980A1 (ja)
CY (1) CY1110388T1 (ja)
DE (1) DE602005005810T2 (ja)
DK (1) DK1753427T3 (ja)
EA (1) EA010651B1 (ja)
ES (1) ES2306146T3 (ja)
HR (1) HRP20080307T3 (ja)
IL (1) IL179630A (ja)
JO (1) JO2524B1 (ja)
ME (1) ME01105B (ja)
MX (1) MXPA06013888A (ja)
MY (1) MY140611A (ja)
NO (1) NO338624B1 (ja)
NZ (1) NZ550840A (ja)
PA (1) PA8635201A1 (ja)
PL (1) PL1753427T3 (ja)
PT (1) PT1753427E (ja)
RS (1) RS50585B (ja)
SI (1) SI1753427T1 (ja)
TW (1) TWI363625B (ja)
UA (1) UA90267C2 (ja)
WO (1) WO2005117875A1 (ja)
ZA (1) ZA200609899B (ja)

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RS50585B (sr) * 2004-05-28 2010-05-07 Janssen Pharmaceutica N.V. Upotreba supstituisanih kinolinskih derivata za tretman bolesti uzrokovanih mikobakterijama otpornima na lekove
BG66437B1 (bg) * 2004-12-24 2014-07-31 Janssen Pharmaceutica N.V. Използване на хинолинови съединения за лечение на латентна туберкулоза
EE05697B1 (et) * 2005-06-08 2014-02-17 Janssen Pharmaceutica N.V. Kinoliini derivaadid kui antibakteriaalsed toimeained
JP5349730B2 (ja) * 2005-06-09 2013-11-20 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 抗バクテリア剤としてのキノリン誘導体
HRP20170044T1 (hr) * 2005-06-28 2017-03-10 Janssen Pharmaceutica Nv Derivati kinolina kao antibakterijska sredstva
JO3270B1 (ar) * 2005-06-28 2018-09-16 Janssen Pharmaceutica Nv مشتقات كوينولين بصفة عوامل مضادة للبكتيريا
JO2752B1 (en) * 2005-06-28 2014-03-15 شركة جانسين فارماسوتيكا ان. في Quinoline derivatives acting as antibacterial agents
EP1917245A1 (de) 2005-08-21 2008-05-07 Abbott GmbH & Co. KG Heterocyclische verbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren
UA97813C2 (uk) * 2006-12-05 2012-03-26 Янссен Фармацевтика Н.В. Фумаратна сіль (альфа s, бета r)-6-бром-альфа-[2-(диметиламіно)етил]-2-метоксі-альфа-1-нафталеніл-бета-феніл-3-хінолінетанолу
JO2684B1 (en) * 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان في Quinoline antibacterial derivatives
JO2725B1 (en) * 2006-12-06 2013-09-15 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives
JO2683B1 (en) * 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives
JO2970B1 (en) 2006-12-06 2016-03-15 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives
JO2685B1 (en) * 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان في Quinoline antibacterial derivatives
JO3271B1 (ar) * 2006-12-06 2018-09-16 Janssen Pharmaceutica Nv مشتقات الكوينولين المضادة للجراثيم
MD4009C2 (ro) * 2008-07-15 2010-08-31 Институт Химии Академии Наук Молдовы Utilizarea 1-metil-4-(N-metilaminobutil-4)-β-carbolinei în calitate de remediu antituberculos
RU2404971C2 (ru) * 2008-12-02 2010-11-27 ЗАО "Фарм-Синтез" Новые производные хинолина, способ их получения, их применение для лечения микобактериальных инфекций, фармацевтическая композиция на их основе
WO2011031926A1 (en) * 2009-09-11 2011-03-17 Vertex Pharmaceuticals Incorporated Compositions of n-benzyl-3-(4-chlorophenyl)-2-[methyl-[2-oxo-2-(3,4,5-trimethoxyphenyl) acetyl]amino]-n-[3-(4-pyridyl)-1-[2-[4-pyridyl)ethyl]propanamide and uses thereof
CN102249935B (zh) * 2010-05-17 2015-05-20 中国人民解放军军事医学科学院毒物药物研究所 芳香2-丁醇类化合物及其医药用途
PT2841426T (pt) 2012-04-27 2016-11-23 Janssen Pharmaceutica Nv Derivados de quinolina antibacterianos
JP6153604B2 (ja) 2012-04-27 2017-06-28 ヤンセン ファーマシューティカ エヌ．ベー． 抗菌性キノリン誘導体
CN105330595B (zh) * 2014-07-14 2019-12-10 上海嘉坦医药科技有限公司 吡啶衍生物及其作为抗分支杆菌的应用
RU2664587C1 (ru) * 2014-07-14 2018-08-21 Шанхай Цзя Тань Фарматек Ко. Лтд. Производные пиридина и их применение против микобактерий
HRP20230616T1 (hr) * 2015-01-27 2023-09-29 Janssen Pharmaceutica Nv Disperzivni pripravci
CN106279017A (zh) * 2015-05-21 2017-01-04 重庆圣华曦药业股份有限公司 贝达喹啉晶型、组合物及其制备方法
KR102106318B1 (ko) 2015-10-20 2020-05-06 쯔지앙 하이썬 파머슈티컬 컴퍼니, 리미티드 베다퀼린 푸마레이트의 결정형 및 그의 제조방법
WO2017121323A1 (zh) * 2016-01-13 2017-07-20 辰欣药业股份有限公司 一种吡啶衍生物类化合物的制备方法及其中间体和晶型
KR102480410B1 (ko) * 2016-03-07 2022-12-22 더 글로벌 얼라이언스 포 티비 드러그 디벨롭먼트, 잉크. 항박테리아 화합물 및 그의 용도
CN107243008B (zh) * 2017-04-13 2021-03-30 中国科学院广州生物医药与健康研究院 吡唑并[1,5-a]吡啶类化合物的新应用及一种治疗脓肿分枝杆菌感染的组合物
JP7184260B2 (ja) * 2017-09-01 2022-12-06 学校法人北里研究所 マイコバクテリウム・アビウム複合感染症に対する治療活性を有する新規化合物及びその製造方法
WO2020047596A1 (en) * 2018-09-04 2020-03-12 Monash University Antibacterial compounds and methods of use
KR20210113628A (ko) 2019-01-09 2021-09-16 얀센 파마슈티카 엔.브이. 비결핵성 마이코박테리아 질환의 치료에서의 조합물
WO2021107876A1 (en) * 2019-11-26 2021-06-03 Nanyang Technological University Compounds for treating tuberculosis
CN110804016B (zh) * 2019-12-05 2022-11-04 福建省微生物研究所 抗结核分枝杆菌的二芳基喹啉衍生物
JP2023549605A (ja) 2020-11-12 2023-11-28 ヤンセン ファーマシューティカ エヌ．ベー． 非結核性マイコバクテリア疾患の治療におけるベダキリン、エタンブトール、及びマクロライドの組合せ
WO2023217279A1 (zh) * 2022-05-13 2023-11-16 广州嘉越医药科技有限公司 一种吡啶衍生物、中间体、制备方法和应用
WO2023227123A1 (zh) * 2022-05-27 2023-11-30 广州嘉越医药科技有限公司 吡啶衍生物的用途
WO2023232838A1 (en) 2022-05-31 2023-12-07 Janssen Pharmaceutica Nv Bedaquiline for use in the treatment of leprosy
PE20251588A1 (es) * 2022-11-15 2025-06-16 Lilly Co Eli Agonistas de ahr
WO2025068448A1 (en) 2023-09-28 2025-04-03 Janssen Pharmaceutica Nv Atp synthase inhibitors for use in the treatment of non-tuberculosis mycobacteria

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004011436A1 (en) * 2002-07-25 2004-02-05 Janssen Pharmaceutica N.V. Quinoline derivatives and their use as mycobacterial inhibitors

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US5399558A (en) * 1993-11-24 1995-03-21 Pathogenesis Corporation Isoflavonoid antibacterial compounds, compositions and use
CA2270123A1 (en) * 1996-10-28 1998-05-07 Department Of The Army, U.S. Government Compounds, compositions and methods for treating antibiotic-resistant infections
US6103905A (en) * 1997-06-19 2000-08-15 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
RS50585B (sr) * 2004-05-28 2010-05-07 Janssen Pharmaceutica N.V. Upotreba supstituisanih kinolinskih derivata za tretman bolesti uzrokovanih mikobakterijama otpornima na lekove
EE05697B1 (et) * 2005-06-08 2014-02-17 Janssen Pharmaceutica N.V. Kinoliini derivaadid kui antibakteriaalsed toimeained

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2004011436A1 (en) * 2002-07-25 2004-02-05 Janssen Pharmaceutica N.V. Quinoline derivatives and their use as mycobacterial inhibitors

Also Published As

Publication number Publication date
CA2566544C (en) 2012-04-17
US20070249667A1 (en) 2007-10-25
KR20130024969A (ko) 2013-03-08
UA90267C2 (ru) 2010-04-26
KR101371653B1 (ko) 2014-03-07
JO2524B1 (en) 2010-03-17
CN1976704A (zh) 2007-06-06
ME01105B (me) 2013-03-20
PL1753427T3 (pl) 2008-09-30
EP1753427A1 (en) 2007-02-21
JP2012229239A (ja) 2012-11-22
SI1753427T1 (sl) 2008-10-31
EA010651B1 (ru) 2008-10-30
US20100168133A1 (en) 2010-07-01
JP2008500992A (ja) 2008-01-17
HRP20080307T3 (hr) 2008-07-31
WO2005117875A1 (en) 2005-12-15
ZA200609899B (en) 2009-01-28
AU2005249231A1 (en) 2005-12-15
IL179630A0 (en) 2007-07-04
AP2006003828A0 (en) 2006-12-31
NO338624B1 (no) 2016-09-19
RS50585B (sr) 2010-05-07
HK1106136A1 (en) 2008-03-07
NZ550840A (en) 2010-01-29
CN1976704B (zh) 2012-12-05
CL2009001980A1 (es) 2010-04-16
CA2566544A1 (en) 2005-12-15
NO20066041L (no) 2007-02-27
ATE390925T1 (de) 2008-04-15
AU2005249231B2 (en) 2010-11-11
DK1753427T3 (da) 2008-07-21
EA200602260A1 (ru) 2007-04-27
BRPI0510414B1 (pt) 2022-04-05
TW200608974A (en) 2006-03-16
CN102908347A (zh) 2013-02-06
CY1110388T1 (el) 2015-04-29
ES2306146T3 (es) 2008-11-01
TWI363625B (en) 2012-05-11
KR20070017393A (ko) 2007-02-09
IL179630A (en) 2011-05-31
JP5081617B2 (ja) 2012-11-28
DE602005005810T2 (de) 2009-04-09
MY140611A (en) 2009-12-31
MXPA06013888A (es) 2007-01-26
PT1753427E (pt) 2008-07-04
AR049127A1 (es) 2006-06-28
PA8635201A1 (es) 2006-05-16
EP1753427B1 (en) 2008-04-02
DE602005005810D1 (de) 2008-05-15
BRPI0510414A (pt) 2007-10-23
JP5675718B2 (ja) 2015-02-25

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