AP2011005546A0 - Blood transcriptional signature of mycobacterium tuberculosis infection. - Google Patents

Blood transcriptional signature of mycobacterium tuberculosis infection.

Info

Publication number
AP2011005546A0
AP2011005546A0 AP2011005546A AP2011005546A AP2011005546A0 AP 2011005546 A0 AP2011005546 A0 AP 2011005546A0 AP 2011005546 A AP2011005546 A AP 2011005546A AP 2011005546 A AP2011005546 A AP 2011005546A AP 2011005546 A0 AP2011005546 A0 AP 2011005546A0
Authority
AP
ARIPO
Prior art keywords
mycobacterium tuberculosis
tuberculosis infection
transcriptional signature
blood transcriptional
blood
Prior art date
Application number
AP2011005546A
Other languages
English (en)
Inventor
Onn Min Kon
Anne O'garra
Damien Chaussabel
Original Assignee
Baylor Res Intitute
Medical Res Council
Imp College Healthcare Nhs Trust
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baylor Res Intitute, Medical Res Council, Imp College Healthcare Nhs Trust filed Critical Baylor Res Intitute
Publication of AP2011005546A0 publication Critical patent/AP2011005546A0/xx

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911Bacteria
    • G01N33/5695Mycobacteria
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/112Disease subtyping, staging or classification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/60Complex ways of combining multiple protein biomarkers for diagnosis

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AP2011005546A 2008-06-25 2009-06-25 Blood transcriptional signature of mycobacterium tuberculosis infection. AP2011005546A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7572808P 2008-06-25 2008-06-25
PCT/US2009/048698 WO2009158521A2 (en) 2008-06-25 2009-06-25 Blood transcriptional signature of mycobacterium tuberculosis infection

Publications (1)

Publication Number Publication Date
AP2011005546A0 true AP2011005546A0 (en) 2011-02-28

Family

ID=41445303

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2011005546A AP2011005546A0 (en) 2008-06-25 2009-06-25 Blood transcriptional signature of mycobacterium tuberculosis infection.

Country Status (17)

Country Link
US (1) US20110196614A1 (ja)
EP (1) EP2300823A4 (ja)
JP (1) JP2011526152A (ja)
KR (1) KR20110036590A (ja)
CN (1) CN102150043A (ja)
AP (1) AP2011005546A0 (ja)
AU (1) AU2009262112A1 (ja)
CA (1) CA2729000A1 (ja)
EA (1) EA201170088A1 (ja)
IL (1) IL210121A0 (ja)
MX (1) MX2010014556A (ja)
NZ (1) NZ590341A (ja)
PE (1) PE20110386A1 (ja)
SG (1) SG182951A1 (ja)
TW (1) TW201022492A (ja)
WO (1) WO2009158521A2 (ja)
ZA (1) ZA201009307B (ja)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110129817A1 (en) * 2009-11-30 2011-06-02 Baylor Research Institute Blood transcriptional signature of active versus latent mycobacterium tuberculosis infection
US8691510B2 (en) 2008-11-07 2014-04-08 Sequenta, Inc. Sequence analysis of complex amplicons
US9528160B2 (en) 2008-11-07 2016-12-27 Adaptive Biotechnolgies Corp. Rare clonotypes and uses thereof
US9506119B2 (en) 2008-11-07 2016-11-29 Adaptive Biotechnologies Corp. Method of sequence determination using sequence tags
US8628927B2 (en) 2008-11-07 2014-01-14 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US8748103B2 (en) 2008-11-07 2014-06-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US9365901B2 (en) 2008-11-07 2016-06-14 Adaptive Biotechnologies Corp. Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia
GB2497007B (en) 2008-11-07 2013-08-07 Sequenta Inc Methods of monitoring disease conditions by analysis of the full repertoire of the V-D junction or D-J junction sequences of an individual
WO2010083456A1 (en) 2009-01-15 2010-07-22 Imdaptive Inc. Adaptive immunity profiling and methods for generation of monoclonal antibodies
SG176691A1 (en) 2009-06-25 2012-01-30 Hutchinson Fred Cancer Res Method of measuring adaptive immunity
US9043160B1 (en) 2009-11-09 2015-05-26 Sequenta, Inc. Method of determining clonotypes and clonotype profiles
US9709565B2 (en) 2010-04-21 2017-07-18 Memed Diagnostics Ltd. Signatures and determinants for distinguishing between a bacterial and viral infection and methods of use thereof
US10385475B2 (en) 2011-09-12 2019-08-20 Adaptive Biotechnologies Corp. Random array sequencing of low-complexity libraries
EP2768982A4 (en) 2011-10-21 2015-06-03 Adaptive Biotechnologies Corp QUANTIFICATION OF ADAPTIVE IMMUNOCELL GENOMES IN A COMPLEX MIX OF CELLS
AU2012347460B2 (en) 2011-12-09 2017-05-25 Adaptive Biotechnologies Corporation Diagnosis of lymphoid malignancies and minimal residual disease detection
US9499865B2 (en) 2011-12-13 2016-11-22 Adaptive Biotechnologies Corp. Detection and measurement of tissue-infiltrating lymphocytes
CN104272111B (zh) * 2012-01-27 2017-10-03 豌豆属植物研究所股份公司 检测结核的方法
KR102145677B1 (ko) * 2012-02-03 2020-08-18 캘리포니아 인스티튜트 오브 테크놀로지 다중화된 생화학적 분석에서의 시그널 인코딩 및 디코딩
WO2013117746A1 (en) 2012-02-09 2013-08-15 Memed Diagnostics Ltd. Signatures and determinants for diagnosing infections and methods of use thereof
JP6302847B2 (ja) 2012-03-05 2018-03-28 アダプティヴ バイオテクノロジーズ コーポレーション 頻度が一致したサブユニットからの、対をなす免疫受容体鎖の決定
WO2013138497A1 (en) * 2012-03-13 2013-09-19 Baylor Research Institute Early detection of tuberculosis treatment response
CA2867481A1 (en) 2012-04-13 2013-10-17 Somalogic, Inc. Tuberculosis biomarkers and uses thereof
KR101621643B1 (ko) 2012-05-08 2016-05-16 어댑티브 바이오테크놀로지스 코포레이션 다중 pcr 반응에서 증폭 바이어스를 측정 및 교정하기 위한 조성물 및 방법
GB201211158D0 (en) * 2012-06-22 2012-08-08 Univ Nottingham Trent Biomarkers and uses thereof
GB201213567D0 (en) * 2012-07-31 2012-09-12 Proteinlogic Ltd Biomarkers
JP6449160B2 (ja) 2012-10-01 2019-01-09 アダプティブ バイオテクノロジーズ コーポレイション 適応免疫受容体多様性およびクローン性特性決定による免疫能力評価関連出願の相互参照
EP2914740B1 (en) * 2012-10-30 2017-09-13 Imperial Innovations Ltd Method of detecting active tuberculosis in children in the presence of a co-morbidity
WO2014093872A1 (en) * 2012-12-13 2014-06-19 Baylor Research Institute Blood transcriptional signatures of active pulmonary tuberculosis and sarcoidosis
US20160017424A1 (en) * 2013-02-25 2016-01-21 The Research Foundation Of State University Of New York Collection of probes for autistic spectrum disorders and their use
WO2014133855A1 (en) 2013-02-28 2014-09-04 Caprion Proteomics Inc. Tuberculosis biomarkers and uses thereof
US9708657B2 (en) 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
GB201315748D0 (en) 2013-09-04 2013-10-16 Imp Innovations Ltd Biological methods and materials for use therein
GB201401603D0 (en) 2014-01-30 2014-03-19 Proteinlogic Ltd Biomarkers
EP3114240B1 (en) 2014-03-05 2019-07-24 Adaptive Biotechnologies Corporation Methods using randomer-containing synthetic molecules
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
RU2016144359A (ru) * 2014-04-15 2018-05-15 Стелленбос Юниверсити Способ диагностики туберкулезного менингита
ES2777529T3 (es) 2014-04-17 2020-08-05 Adaptive Biotechnologies Corp Cuantificación de genomas de células inmunitarias adaptativas en una mezcla compleja de células
GB201408100D0 (en) * 2014-05-07 2014-06-18 Sec Dep For Health The Detection method
CN111624346A (zh) 2014-08-14 2020-09-04 米密德诊断学有限公司 用于预测及/或决定预后的套组
CN107076745A (zh) * 2014-08-29 2017-08-18 贝克顿·迪金森公司 在受试者中获得结核病评价的方法和组合物
US20170234873A1 (en) 2014-10-14 2017-08-17 Memed Diagnostics Ltd. Signatures and determinants for diagnosing infections in non-human subjects and methods of use thereof
EP3715455A1 (en) 2014-10-29 2020-09-30 Adaptive Biotechnologies Corp. Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
CA2968543C (en) 2014-11-25 2024-04-02 Adaptive Biotechnologies Corporation Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing
CN104459129A (zh) * 2015-01-05 2015-03-25 复旦大学附属华山医院 一种鉴别活动性与潜伏性结核分枝杆菌感染的诊断试剂盒
ES2858306T3 (es) 2015-02-24 2021-09-30 Adaptive Biotechnologies Corp Método para determinar el estado de HLA mediante secuenciación del repertorio inmunitario
EP3277294B1 (en) 2015-04-01 2024-05-15 Adaptive Biotechnologies Corp. Method of identifying human compatible t cell receptors specific for an antigenic target
KR20170027258A (ko) 2015-09-01 2017-03-09 제이더블유바이오사이언스 주식회사 트립토파닐 티알엔에이 합성효소를 이용한 패혈증의 진단용 조성물과 진단 마커 검출 방법
WO2017066641A1 (en) * 2015-10-14 2017-04-20 The Board Of Trustees Of The Leland Stanford Junior University Methods for diagnosis of tuberculosis
CN108699583B (zh) 2016-03-03 2022-11-01 米密德诊断学有限公司 用于区分细菌和病毒感染的rna决定子
CN107312823A (zh) * 2016-04-26 2017-11-03 安徽祥升生物科技有限公司 一种tnfrsf12a基因的实时荧光pcr检测试剂盒
AU2017277666B2 (en) * 2016-06-08 2023-07-27 University Of Iowa Research Foundation Compositions and methods for detecting predisposition to cardiovascular disease
CN109804245B (zh) 2016-07-10 2022-10-25 米密德诊断学有限公司 感染的早期诊断
EP4141448A1 (en) 2016-07-10 2023-03-01 MeMed Diagnostics Ltd. Protein signatures for distinguishing between bacterial and viral infections
US10428325B1 (en) 2016-09-21 2019-10-01 Adaptive Biotechnologies Corporation Identification of antigen-specific B cell receptors
WO2018060998A1 (en) 2016-09-29 2018-04-05 Memed Diagnostics Ltd. Methods of prognosis and treatment
WO2018060999A1 (en) 2016-09-29 2018-04-05 Memed Diagnostics Ltd. Methods of risk assessment and disease classification
JP6306124B2 (ja) * 2016-11-01 2018-04-04 国立大学法人高知大学 結核検査用バイオマーカー
US10209260B2 (en) 2017-07-05 2019-02-19 Memed Diagnostics Ltd. Signatures and determinants for diagnosing infections and methods of use thereof
CN107267659B (zh) * 2017-08-21 2020-10-16 首都医科大学附属北京胸科医院 检测trim基因和/或蛋白水平的产品的用途
CN107653313B (zh) * 2017-09-12 2021-07-09 首都医科大学附属北京胸科医院 Retn和klk1在作为结核病检测标志物中的应用
CN107523626B (zh) * 2017-09-21 2021-04-13 顾万君 一组用于活动性肺结核无创诊断的外周血基因标记物
CN109609614B (zh) * 2017-09-30 2022-07-15 首都医科大学附属北京胸科医院 检测trim2、trim4、trim32和/或trim46基因或蛋白产品的用途
CN107653315B (zh) * 2017-10-16 2020-06-05 苏州大学附属第一医院 lncRNAs作为活动性肺结核病特异性标志物的应用
US11254980B1 (en) 2017-11-29 2022-02-22 Adaptive Biotechnologies Corporation Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements
CN108387745B (zh) * 2018-03-02 2020-12-15 首都医科大学附属北京胸科医院 Cd4+t淋巴细胞特征蛋白在鉴定潜伏结核感染和活动性肺结核中的应用
CN108828235A (zh) * 2018-08-23 2018-11-16 中国人民解放军第三〇九医院 Pglyrp1蛋白作为标志物在诊断活动性结核病中的应用
CN109061191B (zh) * 2018-08-23 2021-08-24 中国人民解放军第三〇九医院 S100p蛋白作为标志物在诊断活动性结核病中的应用
CN111172269B (zh) * 2019-12-13 2022-12-16 南方医科大学 一种检测calm2基因表达水平的试剂的应用
CN112725434B (zh) * 2021-01-20 2022-05-03 首都医科大学附属北京胸科医院 一种利福平耐药结核病分子标志物、检测试剂及其应用
WO2022238515A1 (en) * 2021-05-11 2022-11-17 University College Dublin, Rna markers for tuberculosis and methods of detecting thereof
CN113817776A (zh) * 2021-10-25 2021-12-21 中国人民解放军军事科学院军事医学研究院 Gbp2在调控间充质干细胞成骨分化中的用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6627198B2 (en) * 1997-03-13 2003-09-30 Corixa Corporation Fusion proteins of Mycobacterium tuberculosis antigens and their uses
US20020086289A1 (en) * 1999-06-15 2002-07-04 Don Straus Genomic profiling: a rapid method for testing a complex biological sample for the presence of many types of organisms
US6713257B2 (en) * 2000-08-25 2004-03-30 Rosetta Inpharmatics Llc Gene discovery using microarrays
AU2002314358C1 (en) * 2001-07-04 2009-03-26 The Secretary Of State For Health Mycobacterial antigens expressed during latency
KR20030028059A (ko) * 2001-09-27 2003-04-08 (주)시로텍코리아 항-결핵균 항체를 포함하는 결핵균 항원 진단키트
AU2003241055A1 (en) * 2002-06-20 2004-01-06 Glaxo Group Limited Surrogate markers for the determination of the disease status of an individual infected by mycobacterium tuberculosis
US20040157220A1 (en) * 2003-02-10 2004-08-12 Purnima Kurnool Methods and apparatus for sample tracking
US20070231816A1 (en) * 2005-12-09 2007-10-04 Baylor Research Institute Module-Level Analysis of Peripheral Blood Leukocyte Transcriptional Profiles
PT2128612E (pt) * 2006-09-05 2011-07-06 Hvidovre Hospital Monitorização imunológica baseada em ip-10
CN101196526A (zh) * 2006-12-06 2008-06-11 许洋 一种结核快速诊断的质谱分析试剂盒和方法

Also Published As

Publication number Publication date
SG182951A1 (en) 2012-08-30
US20110196614A1 (en) 2011-08-11
EP2300823A2 (en) 2011-03-30
NZ590341A (en) 2012-07-27
CN102150043A (zh) 2011-08-10
EA201170088A1 (ru) 2011-10-31
TW201022492A (en) 2010-06-16
PE20110386A1 (es) 2011-07-03
EP2300823A4 (en) 2012-03-14
CA2729000A1 (en) 2009-12-30
MX2010014556A (es) 2011-07-28
JP2011526152A (ja) 2011-10-06
WO2009158521A3 (en) 2010-05-14
WO2009158521A2 (en) 2009-12-30
IL210121A0 (en) 2011-02-28
ZA201009307B (en) 2012-10-31
KR20110036590A (ko) 2011-04-07
AU2009262112A1 (en) 2009-12-30

Similar Documents

Publication Publication Date Title
AP2011005546A0 (en) Blood transcriptional signature of mycobacterium tuberculosis infection.
AP2012006346A0 (en) Blood transcriptional signature af active versus latent mycobacterium tuberculosis infection.
IT1391555B1 (it) Apparato trattamento extracorporeo sangue
HUE056076T2 (hu) Szívsegítõ készülék és rendszer
ZA201101814B (en) Prevention, treatment and diagnosis of p.gingivalis infection
PL2512547T3 (pl) Urządzenie bilansujące, zewnętrzne medyczne urządzenie funkcyjne, urządzenie obróbkowe
EP2344106B8 (en) Heart help device
EP2280761A4 (en) MEDICAL DEVICE DETECTING CARDIAC INSUFFICIENCY
HK1160371A1 (en) Flat lancet immobilization
AU2009902138A0 (en) Methods of diagnosis and treatment of M. tuberculosis infection and reagents therefor IX
AU2007904078A0 (en) Assessment of mycobacterium infection
AU2009902136A0 (en) Methods of diagnosis and treatment of M. tuberculosis infection and reagents therefor VII
AU2008902453A0 (en) Methods of diagnosis and treatment of M. tuberculosis infection and reagents therefor VII
AU2010902130A0 (en) Methods of diagnosis and treatment of M. tuberculosis infection and reagents therefor VIII
AU2008902452A0 (en) Methods of diagnosis and treatment of M. tuberculosis infection and reagents therefor IX
AU2009902137A0 (en) Methods of diagnosis and treatment of M. tuberculosis infection and reagents therefor VIII
AU2010902131A0 (en) Methods of diagnosis and treatment of M. tuberculosis infection and reagents therefor VII
AU2010902132A0 (en) Methods of diagnosis and treatment of M. tuberculosis infection and reagents therefor IX
AU2008902451A0 (en) Methods of diagnosis and treatment of M. tuberculosis infection and reagents therefor VIII
GB0813618D0 (en) Blood motitoring device
AU2008904476A0 (en) Prevention, treatment and diagnosis of P.gingivalis infection
AU2008905483A0 (en) Prevention, treatment and diagnosis of P.gingivalis infection
CL2007002470S1 (es) Dispositivo medico.
AU2007902670A0 (en) Methods of diagnosis and treatment of M. tuberculosis infection and reagents therefor IX
LT2349383T (lt) Širdies pagalbinis prietaisas ir sistema