AP2011005546A0 - Blood transcriptional signature of mycobacterium tuberculosis infection. - Google Patents
Blood transcriptional signature of mycobacterium tuberculosis infection.Info
- Publication number
- AP2011005546A0 AP2011005546A0 AP2011005546A AP2011005546A AP2011005546A0 AP 2011005546 A0 AP2011005546 A0 AP 2011005546A0 AP 2011005546 A AP2011005546 A AP 2011005546A AP 2011005546 A AP2011005546 A AP 2011005546A AP 2011005546 A0 AP2011005546 A0 AP 2011005546A0
- Authority
- AP
- ARIPO
- Prior art keywords
- mycobacterium tuberculosis
- tuberculosis infection
- transcriptional signature
- blood transcriptional
- blood
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
- G01N33/5695—Mycobacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Biophysics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7572808P | 2008-06-25 | 2008-06-25 | |
PCT/US2009/048698 WO2009158521A2 (en) | 2008-06-25 | 2009-06-25 | Blood transcriptional signature of mycobacterium tuberculosis infection |
Publications (1)
Publication Number | Publication Date |
---|---|
AP2011005546A0 true AP2011005546A0 (en) | 2011-02-28 |
Family
ID=41445303
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AP2011005546A AP2011005546A0 (en) | 2008-06-25 | 2009-06-25 | Blood transcriptional signature of mycobacterium tuberculosis infection. |
Country Status (17)
Country | Link |
---|---|
US (1) | US20110196614A1 (xx) |
EP (1) | EP2300823A4 (xx) |
JP (1) | JP2011526152A (xx) |
KR (1) | KR20110036590A (xx) |
CN (1) | CN102150043A (xx) |
AP (1) | AP2011005546A0 (xx) |
AU (1) | AU2009262112A1 (xx) |
CA (1) | CA2729000A1 (xx) |
EA (1) | EA201170088A1 (xx) |
IL (1) | IL210121A0 (xx) |
MX (1) | MX2010014556A (xx) |
NZ (1) | NZ590341A (xx) |
PE (1) | PE20110386A1 (xx) |
SG (1) | SG182951A1 (xx) |
TW (1) | TW201022492A (xx) |
WO (1) | WO2009158521A2 (xx) |
ZA (1) | ZA201009307B (xx) |
Families Citing this family (72)
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US20110129817A1 (en) * | 2009-11-30 | 2011-06-02 | Baylor Research Institute | Blood transcriptional signature of active versus latent mycobacterium tuberculosis infection |
US8691510B2 (en) | 2008-11-07 | 2014-04-08 | Sequenta, Inc. | Sequence analysis of complex amplicons |
US9528160B2 (en) | 2008-11-07 | 2016-12-27 | Adaptive Biotechnolgies Corp. | Rare clonotypes and uses thereof |
US9506119B2 (en) | 2008-11-07 | 2016-11-29 | Adaptive Biotechnologies Corp. | Method of sequence determination using sequence tags |
US8628927B2 (en) | 2008-11-07 | 2014-01-14 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
US8748103B2 (en) | 2008-11-07 | 2014-06-10 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
US9365901B2 (en) | 2008-11-07 | 2016-06-14 | Adaptive Biotechnologies Corp. | Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia |
GB2497007B (en) | 2008-11-07 | 2013-08-07 | Sequenta Inc | Methods of monitoring disease conditions by analysis of the full repertoire of the V-D junction or D-J junction sequences of an individual |
WO2010083456A1 (en) | 2009-01-15 | 2010-07-22 | Imdaptive Inc. | Adaptive immunity profiling and methods for generation of monoclonal antibodies |
SG176691A1 (en) | 2009-06-25 | 2012-01-30 | Hutchinson Fred Cancer Res | Method of measuring adaptive immunity |
US9043160B1 (en) | 2009-11-09 | 2015-05-26 | Sequenta, Inc. | Method of determining clonotypes and clonotype profiles |
US9709565B2 (en) | 2010-04-21 | 2017-07-18 | Memed Diagnostics Ltd. | Signatures and determinants for distinguishing between a bacterial and viral infection and methods of use thereof |
US10385475B2 (en) | 2011-09-12 | 2019-08-20 | Adaptive Biotechnologies Corp. | Random array sequencing of low-complexity libraries |
EP2768982A4 (en) | 2011-10-21 | 2015-06-03 | Adaptive Biotechnologies Corp | QUANTIFICATION OF ADAPTIVE IMMUNOCELL GENOMES IN A COMPLEX MIX OF CELLS |
AU2012347460B2 (en) | 2011-12-09 | 2017-05-25 | Adaptive Biotechnologies Corporation | Diagnosis of lymphoid malignancies and minimal residual disease detection |
US9499865B2 (en) | 2011-12-13 | 2016-11-22 | Adaptive Biotechnologies Corp. | Detection and measurement of tissue-infiltrating lymphocytes |
CN104272111B (zh) * | 2012-01-27 | 2017-10-03 | 豌豆属植物研究所股份公司 | 检测结核的方法 |
KR102145677B1 (ko) * | 2012-02-03 | 2020-08-18 | 캘리포니아 인스티튜트 오브 테크놀로지 | 다중화된 생화학적 분석에서의 시그널 인코딩 및 디코딩 |
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JP6302847B2 (ja) | 2012-03-05 | 2018-03-28 | アダプティヴ バイオテクノロジーズ コーポレーション | 頻度が一致したサブユニットからの、対をなす免疫受容体鎖の決定 |
WO2013138497A1 (en) * | 2012-03-13 | 2013-09-19 | Baylor Research Institute | Early detection of tuberculosis treatment response |
CA2867481A1 (en) | 2012-04-13 | 2013-10-17 | Somalogic, Inc. | Tuberculosis biomarkers and uses thereof |
KR101621643B1 (ko) | 2012-05-08 | 2016-05-16 | 어댑티브 바이오테크놀로지스 코포레이션 | 다중 pcr 반응에서 증폭 바이어스를 측정 및 교정하기 위한 조성물 및 방법 |
GB201211158D0 (en) * | 2012-06-22 | 2012-08-08 | Univ Nottingham Trent | Biomarkers and uses thereof |
GB201213567D0 (en) * | 2012-07-31 | 2012-09-12 | Proteinlogic Ltd | Biomarkers |
JP6449160B2 (ja) | 2012-10-01 | 2019-01-09 | アダプティブ バイオテクノロジーズ コーポレイション | 適応免疫受容体多様性およびクローン性特性決定による免疫能力評価関連出願の相互参照 |
EP2914740B1 (en) * | 2012-10-30 | 2017-09-13 | Imperial Innovations Ltd | Method of detecting active tuberculosis in children in the presence of a co-morbidity |
WO2014093872A1 (en) * | 2012-12-13 | 2014-06-19 | Baylor Research Institute | Blood transcriptional signatures of active pulmonary tuberculosis and sarcoidosis |
US20160017424A1 (en) * | 2013-02-25 | 2016-01-21 | The Research Foundation Of State University Of New York | Collection of probes for autistic spectrum disorders and their use |
WO2014133855A1 (en) | 2013-02-28 | 2014-09-04 | Caprion Proteomics Inc. | Tuberculosis biomarkers and uses thereof |
US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
GB201315748D0 (en) | 2013-09-04 | 2013-10-16 | Imp Innovations Ltd | Biological methods and materials for use therein |
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US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
RU2016144359A (ru) * | 2014-04-15 | 2018-05-15 | Стелленбос Юниверсити | Способ диагностики туберкулезного менингита |
ES2777529T3 (es) | 2014-04-17 | 2020-08-05 | Adaptive Biotechnologies Corp | Cuantificación de genomas de células inmunitarias adaptativas en una mezcla compleja de células |
GB201408100D0 (en) * | 2014-05-07 | 2014-06-18 | Sec Dep For Health The | Detection method |
CN111624346A (zh) | 2014-08-14 | 2020-09-04 | 米密德诊断学有限公司 | 用于预测及/或决定预后的套组 |
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US20170234873A1 (en) | 2014-10-14 | 2017-08-17 | Memed Diagnostics Ltd. | Signatures and determinants for diagnosing infections in non-human subjects and methods of use thereof |
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US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
CA2968543C (en) | 2014-11-25 | 2024-04-02 | Adaptive Biotechnologies Corporation | Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing |
CN104459129A (zh) * | 2015-01-05 | 2015-03-25 | 复旦大学附属华山医院 | 一种鉴别活动性与潜伏性结核分枝杆菌感染的诊断试剂盒 |
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WO2017066641A1 (en) * | 2015-10-14 | 2017-04-20 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for diagnosis of tuberculosis |
CN108699583B (zh) | 2016-03-03 | 2022-11-01 | 米密德诊断学有限公司 | 用于区分细菌和病毒感染的rna决定子 |
CN107312823A (zh) * | 2016-04-26 | 2017-11-03 | 安徽祥升生物科技有限公司 | 一种tnfrsf12a基因的实时荧光pcr检测试剂盒 |
AU2017277666B2 (en) * | 2016-06-08 | 2023-07-27 | University Of Iowa Research Foundation | Compositions and methods for detecting predisposition to cardiovascular disease |
CN109804245B (zh) | 2016-07-10 | 2022-10-25 | 米密德诊断学有限公司 | 感染的早期诊断 |
EP4141448A1 (en) | 2016-07-10 | 2023-03-01 | MeMed Diagnostics Ltd. | Protein signatures for distinguishing between bacterial and viral infections |
US10428325B1 (en) | 2016-09-21 | 2019-10-01 | Adaptive Biotechnologies Corporation | Identification of antigen-specific B cell receptors |
WO2018060998A1 (en) | 2016-09-29 | 2018-04-05 | Memed Diagnostics Ltd. | Methods of prognosis and treatment |
WO2018060999A1 (en) | 2016-09-29 | 2018-04-05 | Memed Diagnostics Ltd. | Methods of risk assessment and disease classification |
JP6306124B2 (ja) * | 2016-11-01 | 2018-04-04 | 国立大学法人高知大学 | 結核検査用バイオマーカー |
US10209260B2 (en) | 2017-07-05 | 2019-02-19 | Memed Diagnostics Ltd. | Signatures and determinants for diagnosing infections and methods of use thereof |
CN107267659B (zh) * | 2017-08-21 | 2020-10-16 | 首都医科大学附属北京胸科医院 | 检测trim基因和/或蛋白水平的产品的用途 |
CN107653313B (zh) * | 2017-09-12 | 2021-07-09 | 首都医科大学附属北京胸科医院 | Retn和klk1在作为结核病检测标志物中的应用 |
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CN109609614B (zh) * | 2017-09-30 | 2022-07-15 | 首都医科大学附属北京胸科医院 | 检测trim2、trim4、trim32和/或trim46基因或蛋白产品的用途 |
CN107653315B (zh) * | 2017-10-16 | 2020-06-05 | 苏州大学附属第一医院 | lncRNAs作为活动性肺结核病特异性标志物的应用 |
US11254980B1 (en) | 2017-11-29 | 2022-02-22 | Adaptive Biotechnologies Corporation | Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements |
CN108387745B (zh) * | 2018-03-02 | 2020-12-15 | 首都医科大学附属北京胸科医院 | Cd4+t淋巴细胞特征蛋白在鉴定潜伏结核感染和活动性肺结核中的应用 |
CN108828235A (zh) * | 2018-08-23 | 2018-11-16 | 中国人民解放军第三〇九医院 | Pglyrp1蛋白作为标志物在诊断活动性结核病中的应用 |
CN109061191B (zh) * | 2018-08-23 | 2021-08-24 | 中国人民解放军第三〇九医院 | S100p蛋白作为标志物在诊断活动性结核病中的应用 |
CN111172269B (zh) * | 2019-12-13 | 2022-12-16 | 南方医科大学 | 一种检测calm2基因表达水平的试剂的应用 |
CN112725434B (zh) * | 2021-01-20 | 2022-05-03 | 首都医科大学附属北京胸科医院 | 一种利福平耐药结核病分子标志物、检测试剂及其应用 |
WO2022238515A1 (en) * | 2021-05-11 | 2022-11-17 | University College Dublin, | Rna markers for tuberculosis and methods of detecting thereof |
CN113817776A (zh) * | 2021-10-25 | 2021-12-21 | 中国人民解放军军事科学院军事医学研究院 | Gbp2在调控间充质干细胞成骨分化中的用途 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6627198B2 (en) * | 1997-03-13 | 2003-09-30 | Corixa Corporation | Fusion proteins of Mycobacterium tuberculosis antigens and their uses |
US20020086289A1 (en) * | 1999-06-15 | 2002-07-04 | Don Straus | Genomic profiling: a rapid method for testing a complex biological sample for the presence of many types of organisms |
US6713257B2 (en) * | 2000-08-25 | 2004-03-30 | Rosetta Inpharmatics Llc | Gene discovery using microarrays |
AU2002314358C1 (en) * | 2001-07-04 | 2009-03-26 | The Secretary Of State For Health | Mycobacterial antigens expressed during latency |
KR20030028059A (ko) * | 2001-09-27 | 2003-04-08 | (주)시로텍코리아 | 항-결핵균 항체를 포함하는 결핵균 항원 진단키트 |
AU2003241055A1 (en) * | 2002-06-20 | 2004-01-06 | Glaxo Group Limited | Surrogate markers for the determination of the disease status of an individual infected by mycobacterium tuberculosis |
US20040157220A1 (en) * | 2003-02-10 | 2004-08-12 | Purnima Kurnool | Methods and apparatus for sample tracking |
US20070231816A1 (en) * | 2005-12-09 | 2007-10-04 | Baylor Research Institute | Module-Level Analysis of Peripheral Blood Leukocyte Transcriptional Profiles |
PT2128612E (pt) * | 2006-09-05 | 2011-07-06 | Hvidovre Hospital | Monitorização imunológica baseada em ip-10 |
CN101196526A (zh) * | 2006-12-06 | 2008-06-11 | 许洋 | 一种结核快速诊断的质谱分析试剂盒和方法 |
-
2009
- 2009-06-25 SG SG2012039715A patent/SG182951A1/en unknown
- 2009-06-25 JP JP2011516672A patent/JP2011526152A/ja not_active Ceased
- 2009-06-25 KR KR1020117001755A patent/KR20110036590A/ko not_active Application Discontinuation
- 2009-06-25 EA EA201170088A patent/EA201170088A1/ru unknown
- 2009-06-25 AU AU2009262112A patent/AU2009262112A1/en not_active Abandoned
- 2009-06-25 MX MX2010014556A patent/MX2010014556A/es active IP Right Grant
- 2009-06-25 CN CN2009801334543A patent/CN102150043A/zh active Pending
- 2009-06-25 EP EP09771053A patent/EP2300823A4/en not_active Withdrawn
- 2009-06-25 AP AP2011005546A patent/AP2011005546A0/xx unknown
- 2009-06-25 PE PE2010001182A patent/PE20110386A1/es not_active Application Discontinuation
- 2009-06-25 WO PCT/US2009/048698 patent/WO2009158521A2/en active Application Filing
- 2009-06-25 NZ NZ590341A patent/NZ590341A/en not_active IP Right Cessation
- 2009-06-25 CA CA2729000A patent/CA2729000A1/en not_active Abandoned
- 2009-06-25 US US12/602,488 patent/US20110196614A1/en not_active Abandoned
- 2009-06-25 TW TW098121444A patent/TW201022492A/zh unknown
-
2010
- 2010-12-20 IL IL210121A patent/IL210121A0/en unknown
- 2010-12-23 ZA ZA2010/09307A patent/ZA201009307B/en unknown
Also Published As
Publication number | Publication date |
---|---|
SG182951A1 (en) | 2012-08-30 |
US20110196614A1 (en) | 2011-08-11 |
EP2300823A2 (en) | 2011-03-30 |
NZ590341A (en) | 2012-07-27 |
CN102150043A (zh) | 2011-08-10 |
EA201170088A1 (ru) | 2011-10-31 |
TW201022492A (en) | 2010-06-16 |
PE20110386A1 (es) | 2011-07-03 |
EP2300823A4 (en) | 2012-03-14 |
CA2729000A1 (en) | 2009-12-30 |
MX2010014556A (es) | 2011-07-28 |
JP2011526152A (ja) | 2011-10-06 |
WO2009158521A3 (en) | 2010-05-14 |
WO2009158521A2 (en) | 2009-12-30 |
IL210121A0 (en) | 2011-02-28 |
ZA201009307B (en) | 2012-10-31 |
KR20110036590A (ko) | 2011-04-07 |
AU2009262112A1 (en) | 2009-12-30 |
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